| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ignacio Illán-Gala, Alberto Lleo, Anna Karydas, Adam M Staffaroni, Henrik Zetterberg, Rajeev Sivasankaran, Lea T Grinberg, Salvatore Spina, Joel H Kramer, Eliana M Ramos, Giovanni Coppola, Renaud La Joie, Gil D Rabinovici, David C Perry, Maria Luisa Gorno-Tempini, William W Seeley, Bruce L Miller, Howard J Rosen, Kaj Blennow, Adam L Boxer, Julio C Roja. Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. vol 96. issue 5. 2021-02-22. PMID:33199433. |
plasma tau and neurofilament light in frontotemporal lobar degeneration and alzheimer disease. |
2021-02-22 |
2023-08-13 |
Not clear |
| Ignacio Illán-Gala, Alberto Lleo, Anna Karydas, Adam M Staffaroni, Henrik Zetterberg, Rajeev Sivasankaran, Lea T Grinberg, Salvatore Spina, Joel H Kramer, Eliana M Ramos, Giovanni Coppola, Renaud La Joie, Gil D Rabinovici, David C Perry, Maria Luisa Gorno-Tempini, William W Seeley, Bruce L Miller, Howard J Rosen, Kaj Blennow, Adam L Boxer, Julio C Roja. Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. vol 96. issue 5. 2021-02-22. PMID:33199433. |
to test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (nfl) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (ftld-s) and clinically diagnosed alzheimer disease syndromes (ad-s), we determined their diagnostic and prognostic value in ftld-s and ad-s and their sensitivity to pathologic diagnoses. |
2021-02-22 |
2023-08-13 |
Not clear |
| Timna Hitrec, Fabio Squarcio, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Domenico Tupone, Roberto Amici, Marco Lupp. Reversible Tau Phosphorylation Induced by Synthetic Torpor in the Spinal Cord of the Rat. Frontiers in neuroanatomy. vol 15. 2021-02-20. PMID:33603651. |
the hyperphosphorylation of tau (pp-tau) commonly leads to the formation of neurofibrillary tangles, as it occurs in tauopathies, a group of neurodegenerative diseases, including alzheimer's. |
2021-02-20 |
2023-08-13 |
rat |
| Hiroyuki Watanabe, Yuta Tarumizu, Sho Kaide, Yoichi Shimizu, Shimpei Iikuni, Yuji Nakamoto, Masahiro On. Structure-Activity and Brain Kinetics Relationships of ACS medicinal chemistry letters. vol 12. issue 2. 2021-02-20. PMID:33603973. |
structure-activity and brain kinetics relationships of noninvasive imaging of tau aggregates with a positron emission tomography (pet) tracer is useful for the diagnosis and staging of alzheimer's disease (ad). |
2021-02-20 |
2023-08-13 |
Not clear |
| Eunjoo Nam, Yeong-Bae Lee, Cheil Moon, Keun-A Chan. Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. International journal of molecular sciences. vol 21. issue 14. 2021-02-19. PMID:32679907. |
serum tau proteins as potential biomarkers for the assessment of alzheimer's disease progression. |
2021-02-19 |
2023-08-13 |
Not clear |
| Eunjoo Nam, Yeong-Bae Lee, Cheil Moon, Keun-A Chan. Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. International journal of molecular sciences. vol 21. issue 14. 2021-02-19. PMID:32679907. |
total tau (t-tau) and phosphorylated tau (p-tau) protein elevations in cerebrospinal fluid (cfs) are well-established hallmarks of alzheimer's disease (ad), while the associations of serum t-tau and p-tau levels with ad have been inconsistent across studies. |
2021-02-19 |
2023-08-13 |
Not clear |
| Vincent Paquin, Joseph Therriault, Tharick Ali Pascoal, Pedro Rosa-Neto, Serge Gauthie. Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 33. issue 4. 2021-02-19. PMID:33264158. |
frontal variant of alzheimer disease differentiated from frontotemporal dementia using in vivo amyloid and tau imaging. |
2021-02-19 |
2023-08-13 |
Not clear |
| Vincent Paquin, Joseph Therriault, Tharick Ali Pascoal, Pedro Rosa-Neto, Serge Gauthie. Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 33. issue 4. 2021-02-19. PMID:33264158. |
considering past and emerging evidence that tau topography in alzheimer disease (ad) matches the clinical features of ad, we discuss the potential utility of in vivo tau imaging using f-mk6240 for identifying fvad. |
2021-02-19 |
2023-08-13 |
Not clear |
| Ashvini Keshavan, Henrietta Wellington, Zhongbo Chen, Ayesha Khatun, Miles Chapman, Melanie Hart, David M Cash, William Coath, Thomas D Parker, Sarah M Buchanan, Sarah E Keuss, Matthew J Harris, Heidi Murray-Smith, Amanda Heslegrave, Nick C Fox, Henrik Zetterberg, Jonathan M Schot. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-02-19. PMID:33598527. |
we assessed the concordance of cerebrospinal fluid (csf) amyloid beta (aβ) and tau measured on the fully automated lumipulse platform with pre-symptomatic alzheimer's disease (ad) pathology on amyloid positron emission tomography (pet). |
2021-02-19 |
2023-08-13 |
Not clear |
| Brianna M Lutz, Junmin Pen. Deep Profiling of the Aggregated Proteome in Alzheimer's Disease: From Pathology to Disease Mechanisms. Proteomes. vol 6. issue 4. 2021-02-18. PMID:30424485. |
hallmarks of alzheimer's disease (ad), a progressive neurodegenerative disease causing dementia, include protein aggregates such as amyloid beta plaques and tau neurofibrillary tangles in a patient's brain. |
2021-02-18 |
2023-08-13 |
Not clear |
| Sakulrat Mankhong, Sujin Kim, Sohee Moon, Kyoung-Hee Lee, Hyeong-Eun Jeon, Byeong-Hun Hwang, Jong-Won Beak, Kyung-Lim Joa, Ju-Hee Kan. Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion. International journal of molecular sciences. vol 21. issue 16. 2021-02-18. PMID:32823945. |
although alzheimer's disease (ad)-like pathology is frequently found in patients with post-stroke dementia, little is known about the effects of aerobic exercise on the modifications of tau and related proteins. |
2021-02-18 |
2023-08-13 |
rat |
| Md Ataur Rahman, Md Saidur Rahman, M D Hasanur Rahman, Mohammad Rasheduzzaman, Anm Mamun-Or-Rashid, Md Jamal Uddin, Md Rezanur Rahman, Hongik Hwang, Myung-Geol Pang, Hyewhon Rhi. Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer's Disease. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33374126. |
alzheimer's disease (ad) is characterized by the formation of intracellular aggregate composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (aβ) plaques derived from proteolysis cleavage of amyloid precursor protein (app). |
2021-02-18 |
2023-08-13 |
Not clear |
| Simon M Bell, Katy Barnes, Matteo De Marco, Pamela J Shaw, Laura Ferraiuolo, Daniel J Blackburn, Annalena Venneri, Heather Mortiboy. Mitochondrial Dysfunction in Alzheimer's Disease: A Biomarker of the Future? Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33440662. |
alzheimer's disease (ad) is the most common cause of dementia worldwide and is characterised pathologically by the accumulation of amyloid beta and tau protein aggregates. |
2021-02-18 |
2023-08-13 |
Not clear |
| Jackson A Gartman, Uttam K Tamba. Total Synthesis of (+)-Rubellin C. Organic letters. vol 22. issue 23. 2021-02-17. PMID:32806220. |
the rubellin architecture has been shown to inhibit and reverse the aggregation of tau protein, a therapeutically relevant target for alzheimer's disease. |
2021-02-17 |
2023-08-13 |
Not clear |
| Ashvini Keshavan, Henrietta Wellington, Zhongbo Chen, Ayesha Khatun, Miles Chapman, Melanie Hart, David M Cash, William Coath, Thomas D Parker, Sarah M Buchanan, Sarah E Keuss, Matthew J Harris, Heidi Murray-Smith, Amanda Heslegrave, Nick C Fox, Henrik Zetterberg, Jonathan M Schot. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-02-17. PMID:32999915. |
we assessed the concordance of cerebrospinal fluid (csf) amyloid beta (aβ) and tau measured on the fully automated lumipulse platform with pre-symptomatic alzheimer's disease (ad) pathology on amyloid positron emission tomography (pet). |
2021-02-17 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Chul Hyoung Lyoo, Jonas Jester-Broms, Carole H Sudre, Hanna Cho, Young Hoon Ryu, Jae Yong Choi, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Renaud La Joie, Gil D Rabinovici, Oskar Hansso. Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease. JAMA neurology. vol 77. issue 5. 2021-02-16. PMID:32091549. |
assessment of demographic, genetic, and imaging variables associated with brain resilience and cognitive resilience to pathological tau in patients with alzheimer disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Chul Hyoung Lyoo, Jonas Jester-Broms, Carole H Sudre, Hanna Cho, Young Hoon Ryu, Jae Yong Choi, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Renaud La Joie, Gil D Rabinovici, Oskar Hansso. Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease. JAMA neurology. vol 77. issue 5. 2021-02-16. PMID:32091549. |
better understanding is needed of the degree to which individuals tolerate alzheimer disease (ad)-like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). |
2021-02-16 |
2023-08-13 |
Not clear |
| Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. Behavioral Abnormalities in Knockout and Humanized Tau Mice. Frontiers in endocrinology. vol 11. 2021-02-16. PMID:32226410. |
microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in alzheimer's disease (ad). |
2021-02-16 |
2023-08-13 |
mouse |
| Francesca Munari, Carlo Giorgio Barracchia, Francesca Parolini, Roberto Tira, Luigi Bubacco, Michael Assfalg, Mariapina D'Onofri. Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies. International journal of molecular sciences. vol 21. issue 12. 2021-02-16. PMID:32575755. |
in alzheimer's disease, the microtubule associated tau protein accumulates within damaged neurons in the form of cross-beta structured filaments. |
2021-02-16 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
braak stages of tau neurofibrillary tangle accumulation have been incorporated in the criteria for the neuropathological diagnosis of alzheimer's disease. |
2021-02-16 |
2023-08-13 |
human |