| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Claudia Amaral, Beatriz G Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P Frosch, Susanne Wegmann, Teresa Gomez-Isl. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. vol 24. issue 2. 2021-02-10. PMID:33554064. |
it has been suggested that aberrant activation of glycogen synthase kinase-3-beta (gsk-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in alzheimer disease (ad). |
2021-02-10 |
2023-08-13 |
mouse |
| Julia van der Hoven, Annika van Hummel, Magdalena Przybyla, Prita R Asih, Mehul Gajwani, Astrid F Feiten, Yazi D Ke, Arne Ittner, Janet van Eersel, Lars M Ittne. Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice. Scientific reports. vol 10. issue 1. 2021-02-09. PMID:32796905. |
antibodies have been explored extensively as a potential therapeutic for alzheimer's disease, where amyloid-β (aβ) peptides and the tau protein deposit in patient brains. |
2021-02-09 |
2023-08-13 |
mouse |
| Kenji Tagai, Maiko Ono, Manabu Kubota, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinotoh, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuoka, Hiroyuki Takuwa, Masafumi Shimojo, Manami Takahashi, Kazunori Kawamura, Tatsuya Kikuchi, Maki Okada, Haruhiko Akiyama, Hisaomi Suzuki, Mitsumoto Onaya, Takahiro Takeda, Kimihito Arai, Nobutaka Arai, Nobuyuki Araki, Yuko Saito, John Q Trojanowski, Virginia M Y Lee, Sushil K Mishra, Yoshiki Yamaguchi, Yasuyuki Kimura, Masanori Ichise, Yutaka Tomita, Ming-Rong Zhang, Tetsuya Suhara, Masahiro Shigeta, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimad. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron. vol 109. issue 1. 2021-02-09. PMID:33125873. |
high-contrast in vivo imaging of tau pathologies in alzheimer's and non-alzheimer's disease tauopathies. |
2021-02-09 |
2023-08-13 |
Not clear |
| Kenji Tagai, Maiko Ono, Manabu Kubota, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinotoh, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuoka, Hiroyuki Takuwa, Masafumi Shimojo, Manami Takahashi, Kazunori Kawamura, Tatsuya Kikuchi, Maki Okada, Haruhiko Akiyama, Hisaomi Suzuki, Mitsumoto Onaya, Takahiro Takeda, Kimihito Arai, Nobutaka Arai, Nobuyuki Araki, Yuko Saito, John Q Trojanowski, Virginia M Y Lee, Sushil K Mishra, Yoshiki Yamaguchi, Yasuyuki Kimura, Masanori Ichise, Yutaka Tomita, Ming-Rong Zhang, Tetsuya Suhara, Masahiro Shigeta, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimad. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron. vol 109. issue 1. 2021-02-09. PMID:33125873. |
a panel of radiochemicals has enabled in vivo positron emission tomography (pet) of tau pathologies in alzheimer's disease (ad), although sensitive detection of frontotemporal lobar degeneration (ftld) tau inclusions has been unsuccessful. |
2021-02-09 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Jonathan J Sabbagh, Margaret R Jones, Dale Chaput, Chad A Dickey, Laura J Blai. Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice. Cells. vol 9. issue 1. 2021-02-08. PMID:31947657. |
tau dysfunction is common in several neurodegenerative diseases including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-02-08 |
2023-08-13 |
mouse |
| Miguel-Ángel García-Chamé, Óscar Gutiérrez-Sanz, Ebru Ercan-Herbst, Natalie Haustein, Marcin S Filipiak, Dagmar E Ehrnhöfer, Alexey Taraso. A transistor-based label-free immunosensor for rapid detection of tau protein. Biosensors & bioelectronics. vol 159. 2021-02-08. PMID:32364931. |
tau protein in cerebrospinal fluid (csf) is a central and relevant biomarker of alzheimer's disease (ad) that correlates with the severity of dementia. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
peptide interference with app and tau association: relevance to alzheimer's disease amelioration. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
the two major proteins involved in alzheimer's disease (ad) are the amyloid precursor protein (app) and tau. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
in vivo studies were performed in an alzheimer disease animal model-app double transgenic (tg) 5xfad-as well as in 5xfad crossed with tau transgenic 5xfadxtau (ft), which exhibit declined cognitive reduction at four months of age. |
2021-02-08 |
2023-08-13 |
Not clear |
| Waqar Ahmad, Khadija Shabbiri, Ishtiaq Ahma. Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer's disease: C. elegans as a suitable model to study these interactions in vivo. Biochemical and biophysical research communications. vol 528. issue 3. 2021-02-08. PMID:32499112. |
prediction of human tau 3d structure, and interplay between o-β-glcnac and phosphorylation modifications in alzheimer's disease: c. elegans as a suitable model to study these interactions in vivo. |
2021-02-08 |
2023-08-13 |
human |
| Waqar Ahmad, Khadija Shabbiri, Ishtiaq Ahma. Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer's disease: C. elegans as a suitable model to study these interactions in vivo. Biochemical and biophysical research communications. vol 528. issue 3. 2021-02-08. PMID:32499112. |
hyper-phosphorylation of tau in alzheimer's disease (ad) resulted in aggregated neurofibrillary tangles (nfts) formation. |
2021-02-08 |
2023-08-13 |
human |
| Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. |
the amyloid hypothesis posits that the amyloid-beta (aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to alzheimer's disease (ad) pathology. |
2021-02-08 |
2023-08-13 |
mouse |
| Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. |
alzheimer's disease (ad) is characterized by plaques containing amyloid-β (aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. |
2021-02-08 |
2023-08-13 |
mouse |
| Kenjiro Ono, Daisy Zhao, Qingli Wu, James Simon, Jun Wang, Aurelian Radu, Giulio Maria Pasinett. Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-02-08. PMID:32894246. |
pine bark polyphenolic extract attenuates amyloid-β and tau misfolding in a model system of alzheimer's disease neuropathology. |
2021-02-08 |
2023-08-13 |
Not clear |
| Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni, Nicole Déglo. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease. Nature neuroscience. vol 23. issue 12. 2021-02-08. PMID:33169029. |
tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in alzheimer's disease. |
2021-02-08 |
2023-08-13 |
mouse |
| Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni, Nicole Déglo. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease. Nature neuroscience. vol 23. issue 12. 2021-02-08. PMID:33169029. |
alzheimer's disease (ad) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. |
2021-02-08 |
2023-08-13 |
mouse |
| Rui Shi, Chang-Bo Zheng, Hongyan Wang, Qiang Rao, Tingyan Du, Chunyun Bai, Chuang Xiao, Zelan Dai, Changhong Zhang, Chen Chen, Xian Li, Menghua Tian, Xianlun Yu, Baixi Ji, Zhiying Weng, Weimin Yan. Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. vol 105. issue 7-8. 2021-02-05. PMID:31752010. |
vad is caused by cerebrovascular disease, and most patients with vad have been reported to also have alzheimer's pathologies, which is the formation of neurofibrillary tangles and amyloid plaques that are mainly composed of hyperphosphorylated tau and amyloid β (aβ) respectively. |
2021-02-05 |
2023-08-13 |
rat |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia. International journal of molecular sciences. vol 21. issue 9. 2021-02-04. PMID:32366028. |
shared genomic and proteomic contribution of amyloid and tau protein characteristic of alzheimer's disease to brain ischemia. |
2021-02-04 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia. International journal of molecular sciences. vol 21. issue 9. 2021-02-04. PMID:32366028. |
in this review, we summarize the protein changes associated with alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after ischemia-reperfusion brain injury and their role in the post-ischemic injury. |
2021-02-04 |
2023-08-13 |
Not clear |
| Tomohiro Utsumi, Fumitoshi Kodaka, Norihide Maikusa, Ryuichi Yamazaki, Masahiro Shiget. Inter-method reliability between automatic region of interest analytic application with multi-atlas segmentation and FreeSurfer. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 20. issue 5. 2021-02-04. PMID:32510746. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the aggregation of amyloid-β and phosphorylated tau proteins. |
2021-02-04 |
2023-08-13 |
Not clear |