| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel-Ángel García-Chamé, Óscar Gutiérrez-Sanz, Ebru Ercan-Herbst, Natalie Haustein, Marcin S Filipiak, Dagmar E Ehrnhöfer, Alexey Taraso. A transistor-based label-free immunosensor for rapid detection of tau protein. Biosensors & bioelectronics. vol 159. 2021-02-08. PMID:32364931. |
tau protein in cerebrospinal fluid (csf) is a central and relevant biomarker of alzheimer's disease (ad) that correlates with the severity of dementia. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
peptide interference with app and tau association: relevance to alzheimer's disease amelioration. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
the two major proteins involved in alzheimer's disease (ad) are the amyloid precursor protein (app) and tau. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arno. Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration. International journal of molecular sciences. vol 21. issue 9. 2021-02-08. PMID:32380752. |
in vivo studies were performed in an alzheimer disease animal model-app double transgenic (tg) 5xfad-as well as in 5xfad crossed with tau transgenic 5xfadxtau (ft), which exhibit declined cognitive reduction at four months of age. |
2021-02-08 |
2023-08-13 |
Not clear |
| Waqar Ahmad, Khadija Shabbiri, Ishtiaq Ahma. Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer's disease: C. elegans as a suitable model to study these interactions in vivo. Biochemical and biophysical research communications. vol 528. issue 3. 2021-02-08. PMID:32499112. |
prediction of human tau 3d structure, and interplay between o-β-glcnac and phosphorylation modifications in alzheimer's disease: c. elegans as a suitable model to study these interactions in vivo. |
2021-02-08 |
2023-08-13 |
human |
| Waqar Ahmad, Khadija Shabbiri, Ishtiaq Ahma. Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer's disease: C. elegans as a suitable model to study these interactions in vivo. Biochemical and biophysical research communications. vol 528. issue 3. 2021-02-08. PMID:32499112. |
hyper-phosphorylation of tau in alzheimer's disease (ad) resulted in aggregated neurofibrillary tangles (nfts) formation. |
2021-02-08 |
2023-08-13 |
human |
| Daniela Puzzo, Elentina K Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa', Domenica D Li Puma, Claudio Grassi, Luciano D'Adamio, Nicholas M Kanaan, Paul E Fraser, Ottavio Aranci. Tau is not necessary for amyloid-β-induced synaptic and memory impairments. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544084. |
the amyloid hypothesis posits that the amyloid-beta (aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to alzheimer's disease (ad) pathology. |
2021-02-08 |
2023-08-13 |
mouse |
| Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. |
alzheimer's disease (ad) is characterized by plaques containing amyloid-β (aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. |
2021-02-08 |
2023-08-13 |
mouse |
| Kenjiro Ono, Daisy Zhao, Qingli Wu, James Simon, Jun Wang, Aurelian Radu, Giulio Maria Pasinett. Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-02-08. PMID:32894246. |
pine bark polyphenolic extract attenuates amyloid-β and tau misfolding in a model system of alzheimer's disease neuropathology. |
2021-02-08 |
2023-08-13 |
Not clear |
| Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni, Nicole Déglo. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease. Nature neuroscience. vol 23. issue 12. 2021-02-08. PMID:33169029. |
tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in alzheimer's disease. |
2021-02-08 |
2023-08-13 |
mouse |
| Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni, Nicole Déglo. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease. Nature neuroscience. vol 23. issue 12. 2021-02-08. PMID:33169029. |
alzheimer's disease (ad) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. |
2021-02-08 |
2023-08-13 |
mouse |
| Rui Shi, Chang-Bo Zheng, Hongyan Wang, Qiang Rao, Tingyan Du, Chunyun Bai, Chuang Xiao, Zelan Dai, Changhong Zhang, Chen Chen, Xian Li, Menghua Tian, Xianlun Yu, Baixi Ji, Zhiying Weng, Weimin Yan. Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. vol 105. issue 7-8. 2021-02-05. PMID:31752010. |
vad is caused by cerebrovascular disease, and most patients with vad have been reported to also have alzheimer's pathologies, which is the formation of neurofibrillary tangles and amyloid plaques that are mainly composed of hyperphosphorylated tau and amyloid β (aβ) respectively. |
2021-02-05 |
2023-08-13 |
rat |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia. International journal of molecular sciences. vol 21. issue 9. 2021-02-04. PMID:32366028. |
shared genomic and proteomic contribution of amyloid and tau protein characteristic of alzheimer's disease to brain ischemia. |
2021-02-04 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer's Disease to Brain Ischemia. International journal of molecular sciences. vol 21. issue 9. 2021-02-04. PMID:32366028. |
in this review, we summarize the protein changes associated with alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after ischemia-reperfusion brain injury and their role in the post-ischemic injury. |
2021-02-04 |
2023-08-13 |
Not clear |
| Tomohiro Utsumi, Fumitoshi Kodaka, Norihide Maikusa, Ryuichi Yamazaki, Masahiro Shiget. Inter-method reliability between automatic region of interest analytic application with multi-atlas segmentation and FreeSurfer. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 20. issue 5. 2021-02-04. PMID:32510746. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the aggregation of amyloid-β and phosphorylated tau proteins. |
2021-02-04 |
2023-08-13 |
Not clear |
| Fumihiko Yasuno, Akinori Nakamura, Takashi Kato, Kaori Iwata, Takashi Sakurai, Yutaka Arahata, Yukihiko Washimi, Hideyuki Hattori, Kengo It. An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 21. issue 1. 2021-02-04. PMID:32783314. |
the amyloid cascade hypothesis posits that the accumulation of amyloid β (aβ) is the triggering factor for alzheimer's disease, which consecutively induces aggregation of tau, synaptic loss, and cell death. |
2021-02-04 |
2023-08-13 |
Not clear |
| Mengyu Liu, Thomas Dexheimer, Dexin Sui, Stacy Hovde, Xiexiong Deng, Roland Kwok, Daniel A Bochar, Min-Hao Ku. Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions. Scientific reports. vol 10. issue 1. 2021-02-04. PMID:33024171. |
hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to alzheimer's disease and cognitive functions. |
2021-02-04 |
2023-08-13 |
mouse |
| Nicole M Maphis, Julianne Peabody, Erin Crossey, Shanya Jiang, Fadi A Jamaleddin Ahmad, Maria Alvarez, Soiba Khalid Mansoor, Amanda Yaney, Yirong Yang, Laurel O Sillerud, Colin M Wilson, Reed Selwyn, Jonathan L Brigman, Judy L Cannon, David S Peabody, Bryce Chackerian, Kiran Bhaska. Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy. NPJ vaccines. vol 4. 2021-02-03. PMID:31231552. |
tauopathies, including frontotemporal dementia (ftd) and alzheimer's disease (ad) are progressive neurodegenerative diseases clinically characterized by cognitive decline and could be caused by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles (nfts) inside neurons. |
2021-02-03 |
2023-08-13 |
mouse |
| Olga Zolochevska, Giulio Taglialatel. Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer's Disease Amyloid Beta Oligomers. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:31997075. |
non-demented individuals with alzheimer's neuropathology (ndan) are capable of withstanding aβ and tau toxicity, thus remaining cognitively intact despite presence of ad neuropathology. |
2021-02-03 |
2023-08-13 |
mouse |
| Zhonglei Bao, Huixue Zhang, Hong Jiao, Xiaojie Chu, Jin Fu, Lihua Wan. Dihydrotanshinone I Increase Amyloid-β Clearance and Decrease Tau Phosphorylation via Enhancing Autophagy. Pharmacology. vol 105. issue 5-6. 2021-02-03. PMID:32200384. |
the plaques formed by amyloid-β (aβ) accumulation and neurofibrillary tangles formed by hyper-phosphorylated tau protein are the 2 major pathologies of alzheimer's disease (ad). |
2021-02-03 |
2023-08-13 |
Not clear |