| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heesun Choi, Haeng Jun Kim, Jinhee Yang, Sehyun Chae, Wonik Lee, Sunwoo Chung, Jisoo Kim, Hyunjung Choi, Hyeseung Song, Chang Kon Lee, Jae Hyun Jun, Yong Jae Lee, Kyunghyeon Lee, Semi Kim, Hye-Ri Sim, Young Il Choi, Keun Ho Ryu, Jong-Chan Park, Dongjoon Lee, Sun-Ho Han, Daehee Hwang, Jangbeen Kyung, Inhee Mook-Jun. Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31763743. |
acetylation changes tau interactome to degrade tau in alzheimer's disease animal and organoid models. |
2021-01-13 |
2023-08-13 |
Not clear |
| Eliana Nachman, Anne S Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A McEwan, Thomas R Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Kramme. Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. The Journal of biological chemistry. vol 295. issue 28. 2021-01-13. PMID:32467226. |
the accumulation of amyloid tau aggregates is implicated in alzheimer's disease (ad) and other tauopathies. |
2021-01-13 |
2023-08-13 |
human |
| Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenber. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of biological chemistry. vol 295. issue 31. 2021-01-13. PMID:32493775. |
crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with alzheimer's disease. |
2021-01-13 |
2023-08-13 |
Not clear |
| Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenber. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of biological chemistry. vol 295. issue 31. 2021-01-13. PMID:32493775. |
soluble oligomers of aggregated tau accompany the accumulation of insoluble amyloid fibrils, a histological hallmark of alzheimer disease (ad) and two dozen related neurodegenerative diseases. |
2021-01-13 |
2023-08-13 |
Not clear |
| Nirmal Chandra Barman, Niuz Morshed Khan, Maidul Islam, Zulkar Nain, Rajib Kanti Roy, Anwarul Haque, Shital Kumar Barma. CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review. Neurology and therapy. vol 9. issue 2. 2021-01-12. PMID:33089409. |
alzheimer's disease (ad) is a chronic and irreversible neurodegenerative disorder characterized by cognitive deficiency and development of amyloid-β (aβ) plaques and neurofibrillary tangles, comprising hyperphosphorylated tau. |
2021-01-12 |
2023-08-13 |
Not clear |
| Amelie Schäfer, Elizabeth C Mormino, Ellen Kuh. Network Diffusion Modeling Explains Longitudinal Tau PET Data. Frontiers in neuroscience. vol 14. 2021-01-12. PMID:33424532. |
alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-01-12 |
2023-08-13 |
human |
| Manisha Prajapat, Phulen Sarma, Nishant Shekhar, Hardeep Kaur, Sanjay Singh, Subodh Kumar, Harpinder Kaur, Saniya Mahendiratta, Amit Raj Sharma, Sukhmandeep Kaur, Vidya M Mahalmani, Bikash Medh. Journal of advanced pharmaceutical technology & research. vol 11. issue 4. 2021-01-12. PMID:33425704. |
glycogen synthase kinase 3 beta (gsk3 β) plays a key role in pathologic hyper phosphorylation of tau and plays an important role in the pathogenesis of alzheimer's disease. |
2021-01-12 |
2023-08-13 |
Not clear |
| Stefan M Ivanov, Mariyana Atanasova, Ivan Dimitrov, Irini A Doytchinov. Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer's disease. Scientific reports. vol 10. issue 1. 2021-01-11. PMID:32572101. |
cellular polyamines condense hyperphosphorylated tau, triggering alzheimer's disease. |
2021-01-11 |
2023-08-13 |
Not clear |
| Abdullahi Alausa, Sunday Ogundepo, Barakat Olaleke, Rofiat Adeyemi, Mercy Olatinwo, Aminat Ismai. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chinese medicine. vol 16. issue 1. 2021-01-11. PMID:33407732. |
this condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of corticobasal degeneration, pick's diseases, progressive supranuclear palsy, argyrophilic grains disease, alzheimer's diseases etc. |
2021-01-11 |
2023-08-13 |
human |
| Xiaowen Jiang, Hongyuan Lu, Jingda Li, Wenwu Liu, Qiong Wu, Zihua Xu, Qinglong Qiao, Haotian Zhang, Huiyuan Gao, Qingchun Zha. A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology. Clinical and translational medicine. vol 10. issue 3. 2021-01-10. PMID:32652879. |
a natural bace1 and gsk3β dual inhibitor notopterol effectively ameliorates the cognitive deficits in app/ps1 alzheimer's mice by attenuating amyloid-β and tau pathology. |
2021-01-10 |
2023-08-13 |
mouse |
| Masami Masuda-Suzukake, Genjiro Suzuki, Masato Hosokawa, Takashi Nonaka, Michel Goedert, Masato Hasegaw. Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice. Brain communications. vol 2. issue 2. 2021-01-10. PMID:33005889. |
accumulation of assembled tau protein in the central nervous system is characteristic of alzheimer's disease and several other neurodegenerative diseases, called tauopathies. |
2021-01-10 |
2023-08-13 |
mouse |
| Robert Y K Lai, Charles R Harrington, Claude M Wischi. Erratum: Lai, R.Y.K.; Harrington, C.R.; Wischik, C.M. Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease. Biomolecules 2016, 6, 19. Biomolecules. vol 6. issue 3. 2021-01-09. PMID:27529285. |
absence of a role for phosphorylation in the tau pathology of alzheimer's disease. |
2021-01-09 |
2023-08-13 |
Not clear |
| Feng Zhang, Rujia Zhong, Song Li, Zhenfa Fu, Cheng Cheng, Huaibin Cai, Weidong L. Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease Mice and Wild-Type Littermates. Frontiers in aging neuroscience. vol 9. 2021-01-09. PMID:28890695. |
alzheimer's disease (ad) is the most common neurodegenerative disease mainly caused by abnormal tau phosphorylation, amyloid β (aβ) deposition and neuroinflammation. |
2021-01-09 |
2023-08-13 |
mouse |
| Azadeh Firouzian, Alex Whittington, Graham E Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone, Roger N Gun. Imaging Aβ and tau in early stage Alzheimer's disease with [ EJNMMI research. vol 8. issue 1. 2021-01-09. PMID:29500717. |
imaging aβ and tau in early stage alzheimer's disease with [ ad is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, aβ plaques and hyperphosphorylated tau. |
2021-01-09 |
2023-08-13 |
Not clear |
| Li Su, Yujing Huang, Yi Wang, James Rowe, John O'Brie. Predict Disease Progression With Reaction Rate Equation Modeling of Multimodal MRI and PET. Frontiers in aging neuroscience. vol 10. 2021-01-09. PMID:30349473. |
neurodegenerative dementia often has multiple types of underlying pathology, for example, beta-amyloid, misfolded tau, chronic neuroinflammation and neurodegeneration may coexist in alzheimer's disease. |
2021-01-09 |
2023-08-13 |
Not clear |
| Heather Pekeles, Hamid Y Qureshi, Hemant K Paudel, Hyman M Schipper, Mervyn Gornistky, Howard Chertko. Development and validation of a salivary tau biomarker in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2021-01-09. PMID:30623019. |
development and validation of a salivary tau biomarker in alzheimer's disease. |
2021-01-09 |
2023-08-13 |
Not clear |
| Heather Pekeles, Hamid Y Qureshi, Hemant K Paudel, Hyman M Schipper, Mervyn Gornistky, Howard Chertko. Development and validation of a salivary tau biomarker in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2021-01-09. PMID:30623019. |
total tau (t-tau) and phosphorylated tau (p-tau) are abnormally elevated in the brain and cerebrospinal fluid of individuals with alzheimer's disease (ad). |
2021-01-09 |
2023-08-13 |
Not clear |
| Michel Goedert, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, Sjors H W Schere. Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases. Cold Spring Harbor symposia on quantitative biology. vol 83. 2021-01-09. PMID:30886056. |
distinct conformers of assembled tau in alzheimer's and pick's diseases. |
2021-01-09 |
2023-08-13 |
human |
| Michel Goedert, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, Sjors H W Schere. Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases. Cold Spring Harbor symposia on quantitative biology. vol 83. 2021-01-09. PMID:30886056. |
paired helical and straight tau filaments of alzheimer's disease (ad) are ultrastructural polymorphs. |
2021-01-09 |
2023-08-13 |
human |
| Carlos Areche, Francisca Zapata, Mathias González, Esteban Díaz, Rubén Montecinos, Marcos Hernández, Francisco Melo, Alberto Cornej. Anthraquinone Derivative Reduces Tau Oligomer Progression by Inhibiting Cysteine-Cysteine Interaction. ChemistryOpen. vol 8. issue 5. 2021-01-09. PMID:31065505. |
neurodegenerative disorders including alzheimer's disease and tauopathies involved tau protein that is found hyperphosphorylated |
2021-01-09 |
2023-08-13 |
Not clear |