| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yachen Shi, Lihua Gu, Qing Wang, Lijuan Gao, Jianli Zhu, Xiang Lu, Fangfang Zhou, Dan Zhu, Haisan Zhang, Chunming Xie, Zhijun Zhan. Platelet Amyloid-β Protein Precursor (AβPP) Ratio and Phosphorylated Tau as Promising Indicators for Early Alzheimer's Disease. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 4. 2021-01-08. PMID:31336382. |
platelet amyloid-β protein precursor (aβpp) ratio and phosphorylated tau as promising indicators for early alzheimer's disease. |
2021-01-08 |
2023-08-13 |
human |
| Yachen Shi, Lihua Gu, Qing Wang, Lijuan Gao, Jianli Zhu, Xiang Lu, Fangfang Zhou, Dan Zhu, Haisan Zhang, Chunming Xie, Zhijun Zhan. Platelet Amyloid-β Protein Precursor (AβPP) Ratio and Phosphorylated Tau as Promising Indicators for Early Alzheimer's Disease. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 4. 2021-01-08. PMID:31336382. |
to identify whether platelet amyloid-β protein precursor (aβpp) ratio, phosphorylated-tau (p-tau) 231, p-tau181, and serine 396 and 404 (ser396/404) phosphorylated tau are potential peripheral indicators for early alzheimer's disease (ad). |
2021-01-08 |
2023-08-13 |
human |
| Xin Wang, Lei Zhang, Hui Lu, Juan-Li Wu, Hua-Zheng Liang, Chong Liu, Qing-Qing Tao, Zhi-Ying Wu, Ke-Qing Zh. Primary age-related tauopathy in a Chinese cohort. Journal of Zhejiang University. Science. B. vol 21. issue 3. 2021-01-07. PMID:32133802. |
primary age-related tauopathy (part) is characterized by the presence of tau neurofibrillary tangles (nfts) which are typically observed in alzheimer's disease (ad) brains, with few or without β-amyloid (aβ) plaques. |
2021-01-07 |
2023-08-13 |
human |
| Xiaofeng Xing, Chengqiang Liu, Aqsa Ali, Baotao Kang, Ping Li, Hongqi A. Novel Disassembly Mechanisms of Sigmoid Aβ ACS chemical neuroscience. vol 11. issue 1. 2021-01-06. PMID:31697060. |
novel disassembly mechanisms of sigmoid aβ alzheimer's disease (ad) is characterized by fibrillar deposits of amyloid-β (aβ) peptides and neurofibrillary tangles of tau proteins. |
2021-01-06 |
2023-08-13 |
Not clear |
| Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöl. Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies. Biological psychiatry. vol 87. issue 9. 2021-01-06. PMID:31735253. |
cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as alzheimer's disease, progressive supranuclear palsy, and chronic traumatic encephalopathy. |
2021-01-06 |
2023-08-13 |
human |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. |
in alzheimer's disease, one of the pathological proteins involved is tau protein, and microtubule-associated protein upon abnormal phosphorylation detaches from the microtubule and forms insoluble aggregates. |
2021-01-06 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. Role of dietary fatty acids in microglial polarization in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-01-06. PMID:32209097. |
we hypothesize that tuning microglia towards anti-inflammatory phenotype would reduce the propagation of tau in alzheimer's disease. |
2021-01-06 |
2023-08-13 |
Not clear |
| Sun Ah Park, Jin Myung Jung, Jun Sung Park, Jeong Ho Lee, Bumhee Park, Hyung Jun Kim, Jeong-Ho Park, Won Seok Chae, Jee Hyang Jeong, Seong Hye Choi, Je-Hyun Bae. SWATH-MS analysis of cerebrospinal fluid to generate a robust battery of biomarkers for Alzheimer's disease. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32366888. |
cerebrospinal fluid (csf) aβ42 and tau protein levels are established diagnostic biomarkers of alzheimer's disease (ad). |
2021-01-06 |
2023-08-13 |
Not clear |
| Taeho Jo, Kwangsik Nho, Shannon L Risacher, Andrew J Sayki. Deep learning detection of informative features in tau PET for Alzheimer's disease classification. BMC bioinformatics. vol 21. issue Suppl 21. 2021-01-06. PMID:33371874. |
deep learning detection of informative features in tau pet for alzheimer's disease classification. |
2021-01-06 |
2023-08-13 |
Not clear |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
the aim of the present study was to examine the association of cerebrospinal fluid levels (csf) hemopexin and hemoglobin subunits (α and β) to alzheimer's pathological proteins (amyloid and tau), hippocampal volume and metabolism, and cognitive performance. |
2021-01-06 |
2023-08-13 |
human |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
we analyzed baseline csf heme/iron proteins (multiplexed mass spectrometry-based assay), amyloid and tau (luminex platform), baseline/longitudinal neuroimaging (mri, fdg-pet) and cognitive outcomes in 86 cognitively normal, 135 mild-cognitive impairment and 66 alzheimer's participants from the alzheimer's disease neuroimaging initiative-1 (adni-1) cohort. |
2021-01-06 |
2023-08-13 |
human |
| Nicolas Rouleau, William L Cantley, Volha Liaudanskaya, Alexander Berk, Chuang Du, William Rusk, Emily Peirent, Cole Koester, Thomas J F Nieland, David L Kapla. A Long-Living Bioengineered Neural Tissue Platform to Study Neurodegeneration. Macromolecular bioscience. vol 20. issue 3. 2021-01-05. PMID:32065736. |
diseased samples display decreased spontaneous electrical activity and a subset displays sporadic-like indicators of increased pathological β-amyloid and tau markers characteristic of alzheimer's disease with concomitant increases in oxidative stress. |
2021-01-05 |
2023-08-13 |
human |
| Bin Peng, Qiang Yang, Rachna B Joshi, Yuancai Liu, Mohammed Akbar, Byoung-Joon Song, Shuanhu Zhou, Xin Wan. Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 7. 2021-01-05. PMID:32230811. |
epidemiological studies have reported a reduction in the prevalence of alzheimer's disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of aβ and tau phosphorylation. |
2021-01-05 |
2023-08-13 |
Not clear |
| Masako Nakano, Kenta Kubota, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Naoto Konari, Mineko Fujimiy. Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus. Scientific reports. vol 10. issue 1. 2021-01-05. PMID:32612165. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β and tau. |
2021-01-05 |
2023-08-13 |
mouse |
| Jing Zhao, Yanan Zhu, Xuehong Song, Yuanyuan Xiao, Guowei Su, Xinyue Liu, Zhangjie Wang, Yongmei Xu, Jian Liu, David Eliezer, Trudy F Ramlall, Guy Lippens, James Gibson, Fuming Zhang, Robert J Linhardt, Lianchun Wang, Chunyu Wan. 3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Angewandte Chemie (International ed. in English). vol 59. issue 5. 2021-01-04. PMID:31692167. |
prion-like transcellular spreading of tau in alzheimer's disease (ad) is mediated by tau binding to cell surface heparan sulfate (hs). |
2021-01-04 |
2023-08-13 |
Not clear |
| Pragati, Soram Idiyasan Chanu, Surajit Sarka. Reduced expression of dMyc mitigates Tau Neuroscience letters. vol 715. 2021-01-04. PMID:31715291. |
reduced expression of dmyc mitigates tau tauopathies such as alzheimer's disease (ad), pick's disease (pid), frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) etc. |
2021-01-04 |
2023-08-13 |
human |
| Ana I Duarte, Emanuel Candeias, Inês N Alves, Débora Mena, Daniela F Silva, Nuno J Machado, Elisa J Campos, Maria S Santos, Catarina R Oliveira, Paula I Moreir. Liraglutide Protects Against Brain Amyloid-β International journal of molecular sciences. vol 21. issue 5. 2021-01-04. PMID:32143329. |
liraglutide protects against brain amyloid-β alzheimer's disease (ad) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (aβ) peptide and hyperphosphorylated tau (p-tau), respectively) and memory loss. |
2021-01-04 |
2023-08-13 |
mouse |
| Chi-Chang Weng, Ing-Tsung Hsiao, Qing-Fang Yang, Cheng-Hsiang Yao, Chin-Yin Tai, Meng-Fang Wu, Tzu-Chen Yen, Ming-Kuei Jang, Kun-Ju Li. Characterization of Molecules (Basel, Switzerland). vol 25. issue 7. 2021-01-04. PMID:32290239. |
characterization of misfolding, aggregation, and cerebral accumulation of tau deposits are hallmark features of alzheimer's disease. |
2021-01-04 |
2023-08-13 |
Not clear |
| Zall Hirschstein, Gautam Reddy Vanga, Guirong Wang, Zachary M Novakovic, Patricia Grass. MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus. Biochimica et biophysica acta. General subjects. vol 1864. issue 11. 2021-01-04. PMID:32738275. |
extracellular beta-amyloid (aβ), intra-neuronal hyper-phosphorylated tau protein, and chronic inflammation are neuropathological hallmarks of alzheimer's disease (ad). |
2021-01-04 |
2023-08-13 |
mouse |
| Haibo Zhang, Aihua Lin, Ping Gong, Yanqing Chen, Richard D Ye, Feng Qian, Yan Zhang, Yang Y. The Chemokine-like Receptor 1 Deficiency Improves Cognitive Deficits of AD Mice and Attenuates Tau Hyperphosphorylation via Regulating Tau Seeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32801154. |
pathologic features of alzheimer's disease (ad) include accumulation of amyloid β (aβ) and hyperphosphorylated tau protein. |
2021-01-01 |
2023-08-13 |
mouse |