| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaki Taka. [Dementia of the Oldest-Old]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 12. 2020-12-10. PMID:33293469. |
the neuropathologic changes of dementia in the oldest-old individuals are associated with alzheimer's disease, lewy body disease, cerebrovascular disease, primary age-related tauopathy (part), limbic-predominant age-related tdp-43 encephalopathy (late), and aging-related tau astrogliopathy (artag). |
2020-12-10 |
2023-08-13 |
Not clear |
| Alex Crowe, Mark J Henderson, Johnathon Anderson, Steven A Titus, Alexey Zakharov, Anton Simeonov, Arjan Buist, Charlotte Delay, Diederik Moechars, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunde. Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays. The Journal of biological chemistry. vol 295. issue 12. 2020-12-08. PMID:32034092. |
the hallmark pathological features of alzheimer's disease (ad) brains are senile plaques, comprising β-amyloid (aβ) peptides, and neuronal inclusions formed from tau protein. |
2020-12-08 |
2023-08-13 |
rat |
| Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara, Subashchandrabose Chinnathamb. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32704015. |
the intracellular tau aggregates are known to be associated with alzheimer's disease. |
2020-12-08 |
2023-08-13 |
drosophila_melanogaster |
| Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara, Subashchandrabose Chinnathamb. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32704015. |
the inhibition of tau aggregation is an important strategy for screening of therapeutic molecules in alzheimer's disease. |
2020-12-08 |
2023-08-13 |
drosophila_melanogaster |
| Xingzhi Guo, Yanying Liu, David Morgan, Li-Ru Zha. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging and disease. vol 11. issue 6. 2020-12-08. PMID:33269098. |
alzheimer's disease (ad), characterized by the accumulation of β-amyloid (aβ) plaques and tau neurofibrillary tangles in the brain, neuroinflammation and neurodegeneration, is the most common form of neurodegenerative disease among the elderly. |
2020-12-08 |
2023-08-13 |
mouse |
| Sebastian S Oakley, Mahmoud B Maina, Karen E Marshall, Youssra K Al-Hilaly, Charlie R Harrington, Claude M Wischik, Louise C Serpel. Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target. Frontiers in neurology. vol 11. 2020-12-08. PMID:33281730. |
tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including alzheimer's disease, pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. |
2020-12-08 |
2023-08-13 |
Not clear |
| Sebastian S Oakley, Mahmoud B Maina, Karen E Marshall, Youssra K Al-Hilaly, Charlie R Harrington, Claude M Wischik, Louise C Serpel. Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target. Frontiers in neurology. vol 11. 2020-12-08. PMID:33281730. |
recent work has suggested that the prevention of tau self-assembly may be effective in slowing the progression of alzheimer's disease and other tauopathies. |
2020-12-08 |
2023-08-13 |
Not clear |
| Juliana C S Chaves, Felippe T Machado, Michael F Almeida, Tatiana B Bacovsky, Merari F R Ferrar. microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing. Neuroscience letters. vol 714. 2020-12-07. PMID:31605772. |
down syndrome (ds) patients are more susceptible to alzheimer's disease (ad) due to the presence of three copies of genes on chromosome 21 such as dyrk1a, which encodes a broad acting kinase, and app (amyloid precursor protein), leading to formation of amyloid beta (aβ) peptide and hyperphosphorylation of tau. |
2020-12-07 |
2023-08-13 |
mouse |
| Tong-Yao Hou, Yang Zhou, Ling-Shuang Zhu, Xiong Wang, Pei Pang, Ding-Qi Wang, Zhen-Yu Liuyang, Hengye Man, Youming Lu, Ling-Qiang Zhu, Dan Li. Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. Journal of neurochemistry. vol 154. issue 4. 2020-12-07. PMID:31951013. |
correcting abnormalities in mir-124/ptpn1 signaling rescues tau pathology in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
mouse |
| Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kon. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2020-12-07. PMID:32093751. |
the behavioural and neuropathologic sexual dimorphism and absence of mip-3α in tau p301s mouse model of alzheimer's disease. |
2020-12-07 |
2023-08-13 |
mouse |
| Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kon. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2020-12-07. PMID:32093751. |
tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in alzheimer's disease (ad) and related tauopathies, and has gained prominence in therapeutic development for ad. |
2020-12-07 |
2023-08-13 |
mouse |
| Niklas Mattsson-Carlgren, Emelie Andersson, Shorena Janelidze, Rik Ossenkoppele, Philip Insel, Olof Strandberg, Henrik Zetterberg, Howard J Rosen, Gil Rabinovici, Xiyun Chai, Kaj Blennow, Jeffrey L Dage, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Oskar Hansso. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease. Science advances. vol 6. issue 16. 2020-12-07. PMID:32426454. |
aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive tau pet in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Niklas Mattsson-Carlgren, Emelie Andersson, Shorena Janelidze, Rik Ossenkoppele, Philip Insel, Olof Strandberg, Henrik Zetterberg, Howard J Rosen, Gil Rabinovici, Xiyun Chai, Kaj Blennow, Jeffrey L Dage, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Oskar Hansso. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease. Science advances. vol 6. issue 16. 2020-12-07. PMID:32426454. |
the links between β-amyloid (aβ) and tau in alzheimer's disease are unclear. |
2020-12-07 |
2023-08-13 |
Not clear |
| Lucia Buccarello, Jessica Dragotto, Federico Iorio, Kambiz Hassanzadeh, Massimo Corbo, Marco Feligion. The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32502496. |
the imbalanced redox state modifies several molecular processes including protein sumoylation, jnk and tau protein activation, important actors in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Dewenter, Lukas Frontzkowski, Martin Dichgans, Anna Rubinski, Julia Neitzel, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Katharina Buerger, Marco Duering, Oskar Hansson, Michael Ewer. Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease. Science advances. vol 6. issue 48. 2020-12-07. PMID:33246962. |
patient-centered connectivity-based prediction of tau pathology spread in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Dewenter, Lukas Frontzkowski, Martin Dichgans, Anna Rubinski, Julia Neitzel, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Katharina Buerger, Marco Duering, Oskar Hansson, Michael Ewer. Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease. Science advances. vol 6. issue 48. 2020-12-07. PMID:33246962. |
in alzheimer's disease (ad), the braak staging scheme suggests a stereotypical tau spreading pattern that does, however, not capture interindividual variability in tau deposition. |
2020-12-07 |
2023-08-13 |
Not clear |
| Mohammad Abdullah, Noriyuki Kimura, Hiroyasu Akatsu, Yoshio Hashizume, Taslima Ferdous, Takuto Tachita, Shinsuke Iida, Kun Zou, Etsuro Matsubara, Makoto Michikaw. Flotillin is a Novel Diagnostic Blood Marker of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683489. |
currently, best-characterized indicators for alzheimer's disease (ad) diagnosis are the decreased levels of amyloid-β protein 42 and increased levels of phosphorylated tau in cerebrospinal fluid (csf). |
2020-12-04 |
2023-08-13 |
Not clear |
| Dhiraj Kumar, Rashmi K Ambasta, Pravir Kuma. Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies. Ageing research reviews. vol 61. 2020-12-04. PMID:32407951. |
the anomalous proteins, such as aβ, tau in alzheimer's disease and α-synuclein in parkinson's disease, perturb the neuronal physiology and cellular homeostasis in the brain thereby affecting the millions of human lives across the globe. |
2020-12-04 |
2023-08-13 |
human |
| Tzu-An Song, Fan Yang, Samadrita Roy Chowdhury, Kyungsang Kim, Keith A Johnson, Georges El Fakhri, Quanzheng Li, Joyita Dutt. PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior. IEEE transactions on computational imaging. vol 5. issue 4. 2020-12-01. PMID:31723575. |
finally, clinical amyloid and tau imaging studies for alzheimer's disease showed lowering of the coefficient of variation in several key brain regions associated with two target pathologies. |
2020-12-01 |
2023-08-13 |
Not clear |
| Kayoung Kim, Chan Beum Par. Femtomolar sensing of Alzheimer's tau proteins by water oxidation-coupled photoelectrochemical platform. Biosensors & bioelectronics. vol 154. 2020-12-01. PMID:32056970. |
femtomolar sensing of alzheimer's tau proteins by water oxidation-coupled photoelectrochemical platform. |
2020-12-01 |
2023-08-13 |
Not clear |