| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastian S Oakley, Mahmoud B Maina, Karen E Marshall, Youssra K Al-Hilaly, Charlie R Harrington, Claude M Wischik, Louise C Serpel. Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target. Frontiers in neurology. vol 11. 2020-12-08. PMID:33281730. |
tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including alzheimer's disease, pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. |
2020-12-08 |
2023-08-13 |
Not clear |
| Sebastian S Oakley, Mahmoud B Maina, Karen E Marshall, Youssra K Al-Hilaly, Charlie R Harrington, Claude M Wischik, Louise C Serpel. Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target. Frontiers in neurology. vol 11. 2020-12-08. PMID:33281730. |
recent work has suggested that the prevention of tau self-assembly may be effective in slowing the progression of alzheimer's disease and other tauopathies. |
2020-12-08 |
2023-08-13 |
Not clear |
| Juliana C S Chaves, Felippe T Machado, Michael F Almeida, Tatiana B Bacovsky, Merari F R Ferrar. microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing. Neuroscience letters. vol 714. 2020-12-07. PMID:31605772. |
down syndrome (ds) patients are more susceptible to alzheimer's disease (ad) due to the presence of three copies of genes on chromosome 21 such as dyrk1a, which encodes a broad acting kinase, and app (amyloid precursor protein), leading to formation of amyloid beta (aβ) peptide and hyperphosphorylation of tau. |
2020-12-07 |
2023-08-13 |
mouse |
| Tong-Yao Hou, Yang Zhou, Ling-Shuang Zhu, Xiong Wang, Pei Pang, Ding-Qi Wang, Zhen-Yu Liuyang, Hengye Man, Youming Lu, Ling-Qiang Zhu, Dan Li. Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. Journal of neurochemistry. vol 154. issue 4. 2020-12-07. PMID:31951013. |
correcting abnormalities in mir-124/ptpn1 signaling rescues tau pathology in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
mouse |
| Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kon. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2020-12-07. PMID:32093751. |
the behavioural and neuropathologic sexual dimorphism and absence of mip-3α in tau p301s mouse model of alzheimer's disease. |
2020-12-07 |
2023-08-13 |
mouse |
| Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kon. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2020-12-07. PMID:32093751. |
tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in alzheimer's disease (ad) and related tauopathies, and has gained prominence in therapeutic development for ad. |
2020-12-07 |
2023-08-13 |
mouse |
| Niklas Mattsson-Carlgren, Emelie Andersson, Shorena Janelidze, Rik Ossenkoppele, Philip Insel, Olof Strandberg, Henrik Zetterberg, Howard J Rosen, Gil Rabinovici, Xiyun Chai, Kaj Blennow, Jeffrey L Dage, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Oskar Hansso. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease. Science advances. vol 6. issue 16. 2020-12-07. PMID:32426454. |
aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive tau pet in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Niklas Mattsson-Carlgren, Emelie Andersson, Shorena Janelidze, Rik Ossenkoppele, Philip Insel, Olof Strandberg, Henrik Zetterberg, Howard J Rosen, Gil Rabinovici, Xiyun Chai, Kaj Blennow, Jeffrey L Dage, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Oskar Hansso. Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease. Science advances. vol 6. issue 16. 2020-12-07. PMID:32426454. |
the links between β-amyloid (aβ) and tau in alzheimer's disease are unclear. |
2020-12-07 |
2023-08-13 |
Not clear |
| Lucia Buccarello, Jessica Dragotto, Federico Iorio, Kambiz Hassanzadeh, Massimo Corbo, Marco Feligion. The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32502496. |
the imbalanced redox state modifies several molecular processes including protein sumoylation, jnk and tau protein activation, important actors in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Dewenter, Lukas Frontzkowski, Martin Dichgans, Anna Rubinski, Julia Neitzel, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Katharina Buerger, Marco Duering, Oskar Hansson, Michael Ewer. Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease. Science advances. vol 6. issue 48. 2020-12-07. PMID:33246962. |
patient-centered connectivity-based prediction of tau pathology spread in alzheimer's disease. |
2020-12-07 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Dewenter, Lukas Frontzkowski, Martin Dichgans, Anna Rubinski, Julia Neitzel, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Katharina Buerger, Marco Duering, Oskar Hansson, Michael Ewer. Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease. Science advances. vol 6. issue 48. 2020-12-07. PMID:33246962. |
in alzheimer's disease (ad), the braak staging scheme suggests a stereotypical tau spreading pattern that does, however, not capture interindividual variability in tau deposition. |
2020-12-07 |
2023-08-13 |
Not clear |
| Mohammad Abdullah, Noriyuki Kimura, Hiroyasu Akatsu, Yoshio Hashizume, Taslima Ferdous, Takuto Tachita, Shinsuke Iida, Kun Zou, Etsuro Matsubara, Makoto Michikaw. Flotillin is a Novel Diagnostic Blood Marker of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683489. |
currently, best-characterized indicators for alzheimer's disease (ad) diagnosis are the decreased levels of amyloid-β protein 42 and increased levels of phosphorylated tau in cerebrospinal fluid (csf). |
2020-12-04 |
2023-08-13 |
Not clear |
| Dhiraj Kumar, Rashmi K Ambasta, Pravir Kuma. Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies. Ageing research reviews. vol 61. 2020-12-04. PMID:32407951. |
the anomalous proteins, such as aβ, tau in alzheimer's disease and α-synuclein in parkinson's disease, perturb the neuronal physiology and cellular homeostasis in the brain thereby affecting the millions of human lives across the globe. |
2020-12-04 |
2023-08-13 |
human |
| Tzu-An Song, Fan Yang, Samadrita Roy Chowdhury, Kyungsang Kim, Keith A Johnson, Georges El Fakhri, Quanzheng Li, Joyita Dutt. PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior. IEEE transactions on computational imaging. vol 5. issue 4. 2020-12-01. PMID:31723575. |
finally, clinical amyloid and tau imaging studies for alzheimer's disease showed lowering of the coefficient of variation in several key brain regions associated with two target pathologies. |
2020-12-01 |
2023-08-13 |
Not clear |
| Kayoung Kim, Chan Beum Par. Femtomolar sensing of Alzheimer's tau proteins by water oxidation-coupled photoelectrochemical platform. Biosensors & bioelectronics. vol 154. 2020-12-01. PMID:32056970. |
femtomolar sensing of alzheimer's tau proteins by water oxidation-coupled photoelectrochemical platform. |
2020-12-01 |
2023-08-13 |
Not clear |
| Douglas J Marcotte, Kerri A Spilker, Dingyi Wen, Thomas Hesson, Thomas A Patterson, P Rajesh Kumar, Jayanth V Chodaparambi. The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor. Acta crystallographica. Section F, Structural biology communications. vol 76. issue Pt 3. 2020-12-01. PMID:32133995. |
hyperphosphorylation of tau by kinases such as tau tubulin kinase (ttbk) has been hypothesized to cause the aggregation of tau and the formation of neurofibrillary tangles (nfts) that lead to the destabilization of microtubules, thereby contributing to neurodegenerative diseases such as alzheimer's disease (ad). |
2020-12-01 |
2023-08-13 |
human |
| Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C Robinson, David M A Mann, Masato Hasegaw. Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies. Frontiers in neuroscience. vol 14. 2020-12-01. PMID:33250706. |
we analyzed sarkosyl-insoluble pathological tau proteins prepared from brains of patients with alzheimer's disease, pick's disease, progressive supranuclear palsy, corticobasal degeneration, globular glial tauopathy, and frontotemporal dementia and parkinsonisms linked to chromosome 17 with tau inclusions using liquid chromatography mass spectrometry. |
2020-12-01 |
2023-08-13 |
Not clear |
| Tharun Selvam Mahendran, S N Suresh, Lakshmi Garimella, Ravi Manjithay. Soluble 4R0N Tau Abrogates Endocytic Vesicular Dynamics. Frontiers in aging neuroscience. vol 12. 2020-12-01. PMID:33250760. |
in sporadic alzheimer's disease (ad), the relevance of soluble tau pathology in endolysosomal dysfunction and autophagic stress, some of the earliest disease manifestations, is unclear. |
2020-12-01 |
2023-08-13 |
Not clear |
| David E Kang, Jung A Wo. Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:31594228. |
the defining pathological hallmarks of alzheimer's disease (ad) are proteinopathies marked by the amyloid-β (aβ) peptide and hyperphosphorylated tau. |
2020-11-30 |
2023-08-13 |
Not clear |
| Tanja Fuchsberger, Raquel Yuste, Sergio Martinez-Bellver, Mari-Carmen Blanco-Gandia, Isabel Torres-Cuevas, Arantxa Blasco-Serra, Román Arango, Jose Miñarro, Marta Rodríguez-Arias, Vicent Teruel-Marti, Ana Lloret, Jose Viñ. Oral Monosodium Glutamate Administration Causes Early Onset of Alzheimer's Disease-Like Pathophysiology in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31658055. |
glutamate excitotoxicity has long been related to alzheimer's disease (ad) pathophysiology, and it has been shown to affect the major ad-related hallmarks, amyloid-β peptide (aβ) accumulation and tau phosphorylation (p-tau). |
2020-11-30 |
2023-08-13 |
mouse |