| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rában. Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. Brain : a journal of neurology. 2024-04-18. PMID:38634687. |
a mediation analysis provided additional support for the role of astrocytic activation as a link between amyloid and tau pathology in alzheimer's disease. |
2024-04-18 |
2024-04-20 |
Not clear |
| Pascual Sánchez-Juan, Elizabeth Valeriano-Lorenzo, Alicia Ruiz-González, Ana Belén Pastor, Hector Rodrigo Lara, Francisco López-González, María Ascensión Zea-Sevilla, Meritxell Valentí, Belen Frades, Paloma Ruiz, Laura Saiz, Iván Burgueño-García, Miguel Calero, Teodoro Del Ser, Alberto Rában. Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles. Brain : a journal of neurology. 2024-04-18. PMID:38634687. |
our results contribute to increasing evidence suggesting a role for blood gfap as an alzheimer's disease biomarker, and the findings offer mechanistic insights into the relationship between blood gfap and alzheimer's disease neuropathology, highlighting its ties with tau burden. |
2024-04-18 |
2024-04-20 |
Not clear |
| Agneta Nordber. Insights into the progression of genetic Alzheimer's disease from tau PET. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631755. |
insights into the progression of genetic alzheimer's disease from tau pet. |
2024-04-17 |
2024-04-20 |
Not clear |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
comparison of tau spread in people with down syndrome versus autosomal-dominant alzheimer's disease: a cross-sectional study. |
2024-04-17 |
2024-04-20 |
Not clear |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
in people with genetic forms of alzheimer's disease, such as in down syndrome and autosomal-dominant alzheimer's disease, pathological changes specific to alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. |
2024-04-17 |
2024-04-20 |
Not clear |
| Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ance. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. vol 23. issue 5. 2024-04-17. PMID:38631766. |
we compared the magnitude, spatial extent, and temporal ordering of tau spread in people with down syndrome and autosomal-dominant alzheimer's disease. |
2024-04-17 |
2024-04-20 |
Not clear |
| Zhengyun Han, Xingmao Yang, Shuiqing Huan. Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease. Heliyon. vol 10. issue 7. 2024-04-16. PMID:38623196. |
sleep deprivation promotes aβ deposition and tau hyperphosphorylation, which is a risk factor for the pathogenesis and progression of alzheimer's disease (ad). |
2024-04-16 |
2024-04-18 |
Not clear |
| Subha Kalyaanamoorthy, Stanley Kojo Opare, Xiaoxiao Xu, Aravindhan Ganesan, Praveen P N Ra. Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology. Current Alzheimer research. 2024-04-16. PMID:38623984. |
post-translational modifications in tau and their roles in alzheimer's pathology. |
2024-04-16 |
2024-04-18 |
Not clear |
| Subha Kalyaanamoorthy, Stanley Kojo Opare, Xiaoxiao Xu, Aravindhan Ganesan, Praveen P N Ra. Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology. Current Alzheimer research. 2024-04-16. PMID:38623984. |
microtubule-associated protein tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of alzheimer's disease (ad) pathology. |
2024-04-16 |
2024-04-18 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
cryo-em structures reveal tau filaments from down syndrome adopt alzheimer's disease fold. |
2024-04-15 |
2024-04-17 |
Not clear |
| Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Suyeon Ju, R Todd Constable, Carolyn Frederick. Whole-brain functional connectivity predicts groupwise and sex-specific tau PET in preclincal Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617320. |
whole-brain functional connectivity predicts groupwise and sex-specific tau pet in preclincal alzheimer's disease. |
2024-04-15 |
2024-04-17 |
Not clear |
| Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Suyeon Ju, R Todd Constable, Carolyn Frederick. Whole-brain functional connectivity predicts groupwise and sex-specific tau PET in preclincal Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617320. |
preclinical alzheimer's disease, characterized by the initial accumulation of amyloid and tau pathologies without symptoms, presents a critical opportunity for early intervention. |
2024-04-15 |
2024-04-17 |
Not clear |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
the occurrence and development of alzheimer's disease (ad) is closely related to neuronal loss, inflammatory response, cholinergic imbalance, and tau protein hyperphosphorylation. |
2024-04-14 |
2024-04-17 |
rat |
| Peter T Nelson, David W Fardo, Xian Wu, Khine Zin Aung, Matthew D Cykowski, Yuriko Katsumat. Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis. Journal of neuropathology and experimental neurology. 2024-04-13. PMID:38613823. |
although "pure" late-nc is not rare, late-nc often coexists in the same brains with alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (artag). |
2024-04-13 |
2024-04-16 |
human |
| Helena Colvee-Martin, Juan Rayo Parra, Gabriel Antonio Gonzalez, Warren Barker, Ranjan Duar. Neuropathology, Neuroimaging, and Fluid Biomarkers in Alzheimer's Disease. Diagnostics (Basel, Switzerland). vol 14. issue 7. 2024-04-13. PMID:38611617. |
the known hallmarks of alzheimer's disease include amyloid-β plaques and neurofibrillary tau tangles. |
2024-04-13 |
2024-04-15 |
Not clear |
| Helena Colvee-Martin, Juan Rayo Parra, Gabriel Antonio Gonzalez, Warren Barker, Ranjan Duar. Neuropathology, Neuroimaging, and Fluid Biomarkers in Alzheimer's Disease. Diagnostics (Basel, Switzerland). vol 14. issue 7. 2024-04-13. PMID:38611617. |
it is now clear that an imbalance between production and clearance of the amyloid beta protein and related aβ peptides, especially aβ42, is a very early, initiating factor in alzheimer's disease (ad) pathogenesis, leading to aggregates of hyperphosphorylation and misfolded tau protein, inflammation, and neurodegeneration. |
2024-04-13 |
2024-04-15 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of alzheimer's disease (ad). |
2024-04-12 |
2024-04-14 |
mouse |
| Liara Rizzi, Lea T Grinber. Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-04-12. PMID:38610041. |
publisher correction: exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-04-12 |
2024-04-15 |
Not clear |
| Jacob Ziontz, Theresa M Harrison, Xi Chen, Joseph Giorgio, Jenna N Adams, Zehao Wang, William Jagus. Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 4. 2024-04-11. PMID:38602736. |
tau pathology is associated with cognitive impairment in both aging and alzheimer's disease, but the functional and structural bases of this relationship remain unclear. |
2024-04-11 |
2024-04-13 |
Not clear |
| Motonobu Fujishima, Yohei Kawasaki, Toshiharu Mitsuhashi, Hiroshi Matsud. Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-10. PMID:38600602. |
individuals on the preclinical alzheimer's continuum, particularly those with both amyloid and tau positivity (a + t +), display a rapid cognitive decline and elevated disease progression risk. |
2024-04-10 |
2024-04-13 |
Not clear |