| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrica Pietronigro, Elena Zenaro, Vittorina Della Bianca, Silvia Dusi, Eleonora Terrabuio, Giulia Iannoto, Anna Slanzi, Somayehsadat Ghasemi, Rajasekar Nagarajan, Gennj Piacentino, Gabriele Tosadori, Barbara Rossi, Gabriela Constanti. Blockade of α4 integrins reduces leukocyte-endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31427644. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by cognitive decline associated with the deposition of amyloid-β (aβ) plaques, hyperphosphorylation of tau protein, and neuronal loss. |
2020-11-02 |
2023-08-13 |
mouse |
| Ting-Bin Chen, Yi-Jung Lee, Szu-Ying Lin, Jun-Peng Chen, Chaur-Jong Hu, Pei-Ning Wang, Irene H Chen. Plasma Aβ42 and Total Tau Predict Cognitive Decline in Amnestic Mild Cognitive Impairment. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31562355. |
levels of amyloid-β (aβ) and tau peptides in brain have been associated with alzheimer disease (ad). |
2020-11-02 |
2023-08-13 |
human |
| Athanasios Metaxas, Camilla Thygesen, Stefan J Kempf, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Hélène Audrain, Jessica L Teeling, Sultan Darvesh, David J Brooks, Martin R Larsen, Bente Finse. Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31673052. |
ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial alzheimer's disease. |
2020-10-28 |
2023-08-13 |
mouse |
| Athanasios Metaxas, Camilla Thygesen, Stefan J Kempf, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Hélène Audrain, Jessica L Teeling, Sultan Darvesh, David J Brooks, Martin R Larsen, Bente Finse. Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31673052. |
despite compelling evidence that the accumulation of amyloid-beta (aβ) promotes neocortical mapt (tau) aggregation in familial and idiopathic alzheimer's disease (ad), murine models of cerebral amyloidosis are not considered to develop tau-associated pathology. |
2020-10-28 |
2023-08-13 |
mouse |
| Simon Dujardin, Caitlin Commins, Aurelien Lathuiliere, Pieter Beerepoot, Analiese R Fernandes, Tarun V Kamath, Mark B De Los Santos, Naomi Klickstein, Diana L Corjuc, Bianca T Corjuc, Patrick M Dooley, Arthur Viode, Derek H Oakley, Benjamin D Moore, Kristina Mullin, Dinorah Jean-Gilles, Ryan Clark, Kevin Atchison, Renee Moore, Lori B Chibnik, Rudolph E Tanzi, Matthew P Frosch, Alberto Serrano-Pozo, Fiona Elwood, Judith A Steen, Matthew E Kennedy, Bradley T Hyma. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature medicine. vol 26. issue 8. 2020-10-28. PMID:32572268. |
tau molecular diversity contributes to clinical heterogeneity in alzheimer's disease. |
2020-10-28 |
2023-08-13 |
Not clear |
| Eva Ausó, Violeta Gómez-Vicente, Gema Esquiv. Biomarkers for Alzheimer's Disease Early Diagnosis. Journal of personalized medicine. vol 10. issue 3. 2020-10-28. PMID:32899797. |
alzheimer's disease (ad) is the most common cause of dementia, affecting the central nervous system (cns) through the accumulation of intraneuronal neurofibrillary tau tangles (nfts) and β-amyloid plaques. |
2020-10-28 |
2023-08-13 |
Not clear |
| Philipp Spitzer, Linda-Marie Mulzer, Timo Jan Oberstein, Luis Enrique Munoz, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann, Juan Manuel Male. Microvesicles from cerebrospinal fluid of patients with Alzheimer's disease display reduced concentrations of tau and APP protein. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31068645. |
microvesicles from cerebrospinal fluid of patients with alzheimer's disease display reduced concentrations of tau and app protein. |
2020-10-27 |
2023-08-13 |
Not clear |
| Philipp Spitzer, Linda-Marie Mulzer, Timo Jan Oberstein, Luis Enrique Munoz, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann, Juan Manuel Male. Microvesicles from cerebrospinal fluid of patients with Alzheimer's disease display reduced concentrations of tau and APP protein. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31068645. |
microvesicles in the csf of 15 patients with alzheimer's disease and 15 controls were analyzed by flow cytometry regarding the levels of cd3, cd4, cd45, cd64, bace1, aβ, app and tau. |
2020-10-27 |
2023-08-13 |
Not clear |
| Philipp Spitzer, Linda-Marie Mulzer, Timo Jan Oberstein, Luis Enrique Munoz, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann, Juan Manuel Male. Microvesicles from cerebrospinal fluid of patients with Alzheimer's disease display reduced concentrations of tau and APP protein. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31068645. |
the levels of tau and app were reduced in microvesicles of alzheimer's disease patients. |
2020-10-27 |
2023-08-13 |
Not clear |
| Philipp Spitzer, Linda-Marie Mulzer, Timo Jan Oberstein, Luis Enrique Munoz, Piotr Lewczuk, Johannes Kornhuber, Martin Herrmann, Juan Manuel Male. Microvesicles from cerebrospinal fluid of patients with Alzheimer's disease display reduced concentrations of tau and APP protein. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31068645. |
tau and app in microvesicles separated patients with alzheimer's disease from controls with an auc of 0.84 and 0.89 respectively. |
2020-10-27 |
2023-08-13 |
Not clear |
| Phillip W Janowicz, Gerhard Leinenga, Jürgen Götz, Rebecca M Nisbe. Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31239479. |
the microtubule-associated protein tau is an attractive therapeutic target for the treatment of alzheimer's disease and related tauopathies as its aggregation strongly correlates with disease progression and is considered a key mediator of neuronal toxicity. |
2020-10-27 |
2023-08-13 |
mouse |
| Rik Ossenkoppele, Chul Hyoung Lyoo, Carole H Sudre, Danielle van Westen, Hanna Cho, Young Hoon Ryu, Jae Yong Choi, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Eric Westman, Richard Tsai, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Renaud La Joie, Bruce L Miller, Gil D Rabinovici, Oskar Hansso. Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 2. 2020-10-27. PMID:31672482. |
distinct tau pet patterns in atrophy-defined subtypes of alzheimer's disease. |
2020-10-27 |
2023-08-13 |
Not clear |
| Chen Chen, Di Xu, Zhong-Hao Zhang, Shi-Zheng Jia, Xian-Chun Cao, Yu-Bin Chen, Guo-Li Song, Man Shing Wong, Hung Wing L. Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca Experimental neurology. vol 327. 2020-10-27. PMID:31987831. |
cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in ad mice model through regulation of ca accumulation of β-amyloid (aβ) peptide and hyperphosphorylated tau in the brain is one of the pathological characteristics of alzheimer's disease (ad) and attractive therapeutic targets in its treatment. |
2020-10-27 |
2023-08-13 |
mouse |
| Svetlana Piatnitskaia, Masahiko Takahashi, Hiroki Kitaura, Yoshinori Katsuragi, Taichi Kakihana, Lu Zhang, Akiyoshi Kakita, Yuriko Iwakura, Hiroyuki Nawa, Takeshi Miura, Takeshi Ikeuchi, Toshifumi Hara, Masahiro Fuji. USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31332267. |
tau aggregates in neurons of brain lesions is a hallmark pathology of tauopathies, including alzheimer's disease (ad). |
2020-10-26 |
2023-08-13 |
Not clear |
| Xi Sun, Shengxiang Liang, Liping Fu, Xiaojun Zhang, Ting Feng, Panlong Li, Tianhao Zhang, Luying Wang, Xiaolong Yin, Wei Zhang, Yichao Hu, Hua Liu, Shujun Zhao, Binbin Nie, Baixuan Xu, Baoci Sha. A human brain tau PET template in MNI space for the voxel-wise analysis of Alzheimer's disease. Journal of neuroscience methods. vol 328. 2020-10-23. PMID:31542346. |
a human brain tau pet template in mni space for the voxel-wise analysis of alzheimer's disease. |
2020-10-23 |
2023-08-13 |
human |
| Xi Sun, Shengxiang Liang, Liping Fu, Xiaojun Zhang, Ting Feng, Panlong Li, Tianhao Zhang, Luying Wang, Xiaolong Yin, Wei Zhang, Yichao Hu, Hua Liu, Shujun Zhao, Binbin Nie, Baixuan Xu, Baoci Sha. A human brain tau PET template in MNI space for the voxel-wise analysis of Alzheimer's disease. Journal of neuroscience methods. vol 328. 2020-10-23. PMID:31542346. |
positron emission tomography (pet) imaging techniques of tau retention in the human brain are important for mechanistic studies of alzheimer's disease (ad). |
2020-10-23 |
2023-08-13 |
human |
| Hui Wei, Hui-Liang Zhang, Jia-Zhao Xie, Dong-Li Meng, Xiao-Chuan Wang, Dan Ke, Ji Zeng, Rong Li. Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease. Current medical science. vol 40. issue 1. 2020-10-23. PMID:32166659. |
in the brains of alzheimer's disease (ad) patients, decreased pp2a activity also plays a key role in promoting tau hyperphosphorylation and aβ generation. |
2020-10-23 |
2023-08-13 |
Not clear |
| Hongli Liu, Haiyang Zhong, Zerong Xu, Qianqian Zhang, Syed Jawad Ali Shah, Huanxiang Liu, Xiaojun Ya. The misfolding mechanism of the key fragment R3 of tau protein: a combined molecular dynamics simulation and Markov state model study. Physical chemistry chemical physics : PCCP. vol 22. issue 19. 2020-10-23. PMID:32392276. |
the formation of neurofibrillary tangles (nft) by abnormal aggregation of misfolded microtubule-associated protein tau is a hallmark of tauopathies, including alzheimer's disease. |
2020-10-23 |
2023-08-13 |
Not clear |
| Paolo d'Errico, Melanie Meyer-Luehman. Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-22. PMID:33061903. |
mechanisms of pathogenic tau and aβ protein spreading in alzheimer's disease. |
2020-10-22 |
2023-08-13 |
Not clear |
| Paolo d'Errico, Melanie Meyer-Luehman. Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-22. PMID:33061903. |
alzheimer's disease (ad) is pathologically defined by extracellular accumulation of amyloid-β (aβ) peptides generated by the cleavage of amyloid precursor protein (app), strings of hyperphosphorylated tau proteins accumulating inside neurons known as neurofibrillary tangles (nfts) and neuronal loss. |
2020-10-22 |
2023-08-13 |
Not clear |