| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. |
role of trem2 in alzheimer's disease and its consequences on β- amyloid, tau and neurofibrillary tangles. |
2020-10-06 |
2023-08-13 |
Not clear |
| Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. |
we have also addressed the impact of trem2 on β-amyloid plaques and tau pathology in alzheimer's disease. |
2020-10-06 |
2023-08-13 |
Not clear |
| Hong Hao Chan, Rhun Yian Koh, Chooi Ling Lim, Chee Onn Leon. Receptor-Interacting Protein Kinase 1 (RIPK1) as a Potential Therapeutic Target: An Overview of Its Possible Role in the Pathogenesis of Alzheimer's Disease. Current Alzheimer research. vol 16. issue 10. 2020-10-06. PMID:31642777. |
alzheimer's disease (ad) is an age-dependent neurodegenerative disorder, the most common type of dementia that is clinically characterized by the presence of beta-amyloid (aβ) extracellularly and intraneuronal tau protein tangles that eventually leads to the onset of memory and cognition impairment, development of psychiatric symptoms and behavioral disorders that affect basic daily activities. |
2020-10-06 |
2023-08-13 |
Not clear |
| Liping Huang, Xiaoqin Zhong, Shaochen Qin, Minzhen Den. Protocatechuic acid attenuates β‑secretase activity and okadaic acid‑induced autophagy via the Akt/GSK‑3β/MEF2D pathway in PC12 cells. Molecular medicine reports. vol 21. issue 3. 2020-10-06. PMID:31894327. |
okadaic acid (oa) can be used to induce an alzheimer's disease (ad) model characterized by tau hyperphosphorylation, the formation of neurofibrillary tangles formation and β‑amyloid (aβ) deposition. |
2020-10-06 |
2023-08-13 |
Not clear |
| Blake Highet, Birger Victor Dieriks, Helen C Murray, Richard L M Faull, Maurice A Curti. Huntingtin Aggregates in the Olfactory Bulb in Huntington's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-06. PMID:33013352. |
in other neurodegenerative diseases where olfactory deficits occur, such as alzheimer's disease and parkinson's disease, pathological protein aggregates (tau, β-amyloid, α-synuclein) accumulate in the anterior olfactory nucleus (aon) of the olfactory bulb (ofb). |
2020-10-06 |
2023-08-13 |
human |
| Kan Yin Wong, Jaydeep Roy, Man Lung Fung, Boon Chin Heng, Chengfei Zhang, Lee Wei Li. Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer's Disease. Aging and disease. vol 11. issue 5. 2020-10-06. PMID:33014538. |
besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the brains of patients with alzheimer's disease (ad), the pathogenesis of ad is also thought to involve mitochondrial dysfunctions and altered neurotransmission systems. |
2020-10-06 |
2023-08-13 |
Not clear |
| Alessandra Webers, Michael T Heneka, Paul A Gleeso. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunology and cell biology. vol 98. issue 1. 2020-10-05. PMID:31654430. |
alzheimer's disease (ad) is characterized by amyloid beta (aβ) accumulation, tau pathology and neuroinflammation. |
2020-10-05 |
2023-08-13 |
mouse |
| Youssra K Al-Hilaly, Bronwen E Foster, Luca Biasetti, Liisa Lutter, Saskia J Pollack, Janet E Rickard, John M D Storey, Charles R Harrington, Wei-Feng Xue, Claude M Wischik, Louise C Serpel. Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain. FEBS letters. vol 594. issue 5. 2020-10-05. PMID:31721178. |
tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in alzheimer's disease brain. |
2020-10-05 |
2023-08-13 |
Not clear |
| Xue-Ning Shen, Jie-Qiong Li, Hui-Fu Wang, Hong-Qi Li, Yu-Yuan Huang, Yu-Xiang Yang, Lan Tan, Qiang Dong, Jin-Tai Y. Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-10-04. PMID:33005724. |
plasma amyloid, tau, and neurodegeneration biomarker profiles predict alzheimer's disease pathology and clinical progression in older adults without dementia. |
2020-10-04 |
2023-08-13 |
Not clear |
| Lars Lau Raket, Line Kühnel, Ellen Schmidt, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson-Carlgre. Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-10-02. PMID:32995466. |
utility of plasma neurofilament light and total tau for clinical trials in alzheimer's disease. |
2020-10-02 |
2023-08-13 |
Not clear |
| Lars Lau Raket, Line Kühnel, Ellen Schmidt, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson-Carlgre. Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-10-02. PMID:32995466. |
this study retrospectively evaluated the utility of plasma neurofilament light (nfl) and total tau (t-tau) in an 18-month trial in mild alzheimer's disease (ad). |
2020-10-02 |
2023-08-13 |
Not clear |
| Yu Cao, Xingxing Jia, Yun Wei, Meixia Liu, Jiangang Liu, Hao L. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by A Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2020-10-01. PMID:28018474. |
traditional chinese medicine huannao yicong decoction extract decreases tau hyperphosphorylation in the brain of alzheimer's disease model rats induced by a |
2020-10-01 |
2023-08-13 |
rat |
| Santosh Jadhav, Veronika Cubinkova, Ivana Zimova, Veronika Brezovakova, Aladar Madari, Viera Cigankova, Norbert Zilk. Tau-mediated synaptic damage in Alzheimer's disease. Translational neuroscience. vol 6. issue 1. 2020-10-01. PMID:28123806. |
in alzheimer's disease and related tauopathies, synapses are exposed to disease modified protein tau, which may cause the loss of synaptic contacts that culminate in dementia. |
2020-10-01 |
2023-08-13 |
human |
| Sayad Kocahan, Zumrut Doğa. Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 15. issue 1. 2020-10-01. PMID:28138104. |
mechanisms of alzheimer's disease pathogenesis and prevention: the brain, neural pathology, n-methyl-d-aspartate receptors, tau protein and other risk factors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hitoshi Shimada, Soichiro Kitamura, Hitoshi Shinotoh, Hironobu Endo, Fumitoshi Niwa, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuch. Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [ Alzheimer's & dementia (Amsterdam, Netherlands). vol 6. 2020-10-01. PMID:28138509. |
association between aβ and tau accumulations and their influence on clinical features in aging and alzheimer's disease spectrum brains: a [ amyloid-β (aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and alzheimer's disease (ad), respectively. |
2020-10-01 |
2023-08-13 |
Not clear |
| Prashanthi Vemuri, Val J Lowe, David S Knopman, Matthew L Senjem, Bradley J Kemp, Christopher G Schwarz, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jac. Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition. Alzheimer's & dementia (Amsterdam, Netherlands). vol 6. 2020-10-01. PMID:28138510. |
tau-positron emission tomography (pet) imaging with av1451 is sensitive to alzheimer disease (ad)-related tau deposition in the brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ni-Chung Lee, Shieh-Yueh Yang, Jen-Jie Chieh, Po-Tsang Huang, Lih-Maan Chang, Yen-Nan Chiu, Ai-Chiu Huang, Yin-Hsiu Chien, Wuh-Liang Hwu, Ming-Jang Chi. Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease. Frontiers in aging neuroscience. vol 8. 2020-10-01. PMID:28144219. |
blood beta-amyloid and tau in down syndrome: a comparison with alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liqin Qi, Zhou Chen, Yanping Wang, Xiaoying Liu, Xiaohong Liu, Linfang Ke, Zhongjie Zheng, Xiaowei Lin, Yu Zhou, Lijuan Wu, Libin Li. Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337257. |
memory deterioration and synapse damage with accumulation of β-amyloid and hyperphosphorylated tau are hallmark lesions of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Yi Mo, Julie Stromswold, Kimberly Wilson, Daniel Holder, Cyrille Sur, Omar Laterza, Mary J Savage, Arie Struyk, Philip Scheltens, Charlotte E Teunissen, James Burke, S Lance Macaulay, Geir Bråthen, Sigrid Botne Sando, Linda R White, Christy Weiss, Arturo Cowes, Michele M Bush, Ganga DeSilva, David G Darby, Stephanie R Rainey-Smith, Jackie Surls, Eileen Sagini, Michael Tanen, Amy Altman, Johan Luthman, Michael F Ega. A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging. Alzheimer's & dementia (Amsterdam, Netherlands). vol 6. 2020-10-01. PMID:28349119. |
changes in cerebrospinal fluid (csf) tau and amyloid β (aβ)42 accompany development of alzheimer's brain pathology. |
2020-10-01 |
2023-08-13 |
human |
| Yi Mo, Julie Stromswold, Kimberly Wilson, Daniel Holder, Cyrille Sur, Omar Laterza, Mary J Savage, Arie Struyk, Philip Scheltens, Charlotte E Teunissen, James Burke, S Lance Macaulay, Geir Bråthen, Sigrid Botne Sando, Linda R White, Christy Weiss, Arturo Cowes, Michele M Bush, Ganga DeSilva, David G Darby, Stephanie R Rainey-Smith, Jackie Surls, Eileen Sagini, Michael Tanen, Amy Altman, Johan Luthman, Michael F Ega. A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging. Alzheimer's & dementia (Amsterdam, Netherlands). vol 6. 2020-10-01. PMID:28349119. |
robust tau and aβ42 immunoassays were developed to establish a tau/aβ42 cutoff distinguishing mild-to-moderate alzheimer's disease (ad) subjects from healthy elderly control (hc) subjects. |
2020-10-01 |
2023-08-13 |
human |