| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon Maziuk, Heather I Ballance, Benjamin Wolozi. Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28420962. |
the interaction of tau with stress granules also promotes tau aggregation, accelerating formation of the tau pathology that we associate with diseases such as alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| b' Anna Chiarini, Ubaldo Armato, Emanuela Gardenal, Li Gui, Ilaria Dal Pr\\xc3\\xa. Amyloid \\xce\\xb2-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143-Further Implications for Alzheimer\'s Therapy. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28473749.' |
the two main drivers of alzheimer's disease (ad), amyloid-β (aβ) and hyperphosphorylated tau (p-tau) oligomers, cooperatively accelerate ad progression, but a hot debate is still ongoing about which of the two appears first. |
2020-10-01 |
2023-08-13 |
human |
| Mariana Vargas-Caballero, Franziska Denk, Heike J Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L Oliver, Olivia A Shipton, Ole Paulsen, Richard Wade-Martin. Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28484365. |
wild-type, but not mutant n296h, human tau restores aβ-mediated inhibition of ltp in microtubule associated protein tau (mapt) is involved in the pathogenesis of alzheimer's disease and many forms of frontotemporal dementia (ftd). |
2020-10-01 |
2023-08-13 |
mouse |
| Haihong Wang, Tao Wang, Shixing Qian, Li Ba, Zhiguang Lin, Shifu Xia. A Pilot Longitudinal Study on Cerebrospinal Fluid (CSF) Tau Protein in Alzheimer's Disease and Vascular Dementia. Shanghai archives of psychiatry. vol 28. issue 5. 2020-10-01. PMID:28638201. |
a pilot longitudinal study on cerebrospinal fluid (csf) tau protein in alzheimer's disease and vascular dementia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matthias Pawlowski, Sven G Meuth, Thomas Dunin. Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside. Diagnostics (Basel, Switzerland). vol 7. issue 3. 2020-10-01. PMID:28703785. |
here, we summarise the development of the core alzheimer's disease cerebrospinal fluid biomarkers: amyloid-β and tau. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alejandro Ibáñez-Salazar, Bernardo Bañuelos-Hernández, Ildefonso Rodríguez-Leyva, Erika Chi-Ahumada, Elizabeth Monreal-Escalante, María E Jiménez-Capdeville, Sergio Rosales-Mendoz. Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28936161. |
since the tau protein is closely involved in the physiopathology of alzheimer's disease (ad), studying its behavior in cellular models might lead to new insights on understanding this devastating disease at molecular levels. |
2020-10-01 |
2023-08-13 |
human |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in alzheimer disease (ad) brains. |
2020-10-01 |
2023-08-13 |
human |
| Vanessa de Jesus R de Paula, Fabiana Meira Guimarães, Breno Satler Diniz, Orestes Vicente Forlenz. Neurobiological pathways to Alzheimer's disease: Amyloid-beta, TAU protein or both? Dementia & neuropsychologia. vol 3. issue 3. 2020-10-01. PMID:29213627. |
neurobiological pathways to alzheimer's disease: amyloid-beta, tau protein or both? |
2020-10-01 |
2023-08-13 |
Not clear |
| Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen, Joel Ros. Role of Tau Acetylation in Alzheimer's Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment. Journal of neurology and neurosurgery. vol 4. issue 2. 2020-10-01. PMID:29276758. |
role of tau acetylation in alzheimer's disease and chronic traumatic encephalopathy: the way forward for successful treatment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen, Joel Ros. Role of Tau Acetylation in Alzheimer's Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment. Journal of neurology and neurosurgery. vol 4. issue 2. 2020-10-01. PMID:29276758. |
the current pathology of progressive neurodegenerative tauopathies, such as alzheimer's disease (ad), pick's disease, frontotemporal dementia (ftd), and progressive supranuclear palsy, primarily revolves around phosphorylation and hyperphosphorylation of the tau protein. |
2020-10-01 |
2023-08-13 |
Not clear |
| Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen, Joel Ros. Role of Tau Acetylation in Alzheimer's Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment. Journal of neurology and neurosurgery. vol 4. issue 2. 2020-10-01. PMID:29276758. |
histopathological examination using the ac tau 280 antibody was performed in three alzheimer's cases and three cte patients. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yang Yang, Xingxing Jia, Jianchao Feng, Zhiyong Wang, Yu Cao, Jiangang Liu, Hao L. Fuzheng Quxie Decoction Ameliorates Learning and Memory Impairment in SAMP8 Mice by Decreasing Tau Hyperphosphorylation. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:29422936. |
hyperphosphorylation of the microtubule-associated protein, tau, is critical to the progression of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
mouse |
| Fuyuki Kametani, Masato Hasegaw. Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29440986. |
reconsideration of amyloid hypothesis and tau hypothesis in alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Frank Matthes, Moritz M Hettich, Judith Schilling, Diana Flores-Dominguez, Nelli Blank, Thomas Wiglenda, Alexander Buntru, Hanna Wolf, Stephanie Weber, Ina Vorberg, Alina Dagane, Gunnar Dittmar, Erich Wanker, Dan Ehninger, Sybille Kraus. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell death discovery. vol 4. 2020-10-01. PMID:29531801. |
alzheimer's disease (ad) is characterized by two neuropathological hallmarks: senile plaques, which are composed of amyloid-β (aβ) peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated tau protein. |
2020-10-01 |
2023-08-13 |
mouse |
| Aleksandar Jovalekic, Norman Koglin, Andre Mueller, Andrew W Stephen. New protein deposition tracers in the pipeline. EJNMMI radiopharmacy and chemistry. vol 1. issue 1. 2020-10-01. PMID:29564387. |
aggregations of proteins such as tau, α-synuclein, and β-amyloid (aβ) have been identified in neurodegenerative diseases, including alzheimer's disease (ad) and other dementias, and parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Satoru Matsuda, Yukie Nakagawa, Ai Tsuji, Yasuko Kitagishi, Atsuko Nakanishi, Toshiyuki Mura. Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer's Disease. Diseases (Basel, Switzerland). vol 6. issue 2. 2020-10-01. PMID:29677102. |
alzheimer’s disease is described by the construction of neuronal plaques and neurofibrillary tangles composed of phosphorylated tau protein. |
2020-10-01 |
2023-08-13 |
Not clear |
| Satoru Matsuda, Yukie Nakagawa, Ai Tsuji, Yasuko Kitagishi, Atsuko Nakanishi, Toshiyuki Mura. Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer's Disease. Diseases (Basel, Switzerland). vol 6. issue 2. 2020-10-01. PMID:29677102. |
this pathway appears to be crucial in alzheimer’s disease because it is related to the tau protein hyper-phosphorylation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ao Huang, Luning Zhang, Weiwei Li, Zeyu Ma, Shi Shuo, Tianming Ya. Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein. Royal Society open science. vol 5. issue 4. 2020-10-01. PMID:29765647. |
we report an ultrasensitive immunoassay for tau protein-a key marker of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Laetitia Lemoine, Antoine Leuzy, Konstantinos Chiotis, Elena Rodriguez-Vieitez, Agneta Nordber. Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2020-10-01. PMID:29780868. |
ligands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with alzheimer's disease and related non-alzheimer's disease tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cecily G Swinford, Shannon L Risacher, Arnaud Charil, Adam J Schwarz, Andrew J Sayki. Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2020-10-01. PMID:29780876. |
memory concerns in the early alzheimer's disease prodrome: regional association with tau deposition. |
2020-10-01 |
2023-08-13 |
Not clear |