| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jorge A Sierra-Fonseca, Kristin L Gosselin. Tauopathy and neurodegeneration: A role for stress. Neurobiology of stress. vol 9. 2020-10-01. PMID:30450376. |
the present review focuses on the influence of stress on a key feature of alzheimer's disease pathology, emphasizing the relationship between tau phosphorylation and accumulation and its connection to hpa axis dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| David J Irwin, Howard I Hurti. The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders. Journal of Alzheimer's disease & Parkinsonism. vol 8. issue 4. 2020-10-01. PMID:30473927. |
in particular, amyloid plaque and tau tangle pathology characteristic of alzheimer's disease (ad) (~50% of all lbd patients have sufficient pathology at autopsy for a secondary neuropathologic diagnosis of ad), appear to contribute to cognitive impairment in lbd, and the combination is associated with a shorter interval between onset of motor symptoms and development of dementia and a shorter life span. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tomoyuki Nishizak. IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway. Heliyon. vol 4. issue 11. 2020-10-01. PMID:30533546. |
the present study was conducted to explore the effect of interleukin-33 (il-33) on glycogen synthase kinase-3β (gsk-3β) activation involving tau phosphorylation, a critical causative factor for alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Irfan A Qureshi, Giridhar Tirucherai, Michael K Ahlijanian, Gerry Kolaitis, Clifford Bechtold, Michael Grundma. A randomized, single ascending dose study of intravenous BIIB092 in healthy participants. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-10-01. PMID:30581980. |
extracellular tau is hypothesized to mediate the onset and progression of tauopathies, including alzheimer's disease, progressive supranuclear palsy, and a subset of frontotemporal lobar degenerations. |
2020-10-01 |
2023-08-13 |
human |
| Li-Ge Zhao, Ying Tang, Jia-Ze Tan, Jing-Wen Wang, Guo-Jun Chen, Bing-Lin Zh. The effect of NR4A1 on APP metabolism and tau phosphorylation. Genes & diseases. vol 5. issue 4. 2020-10-01. PMID:30591936. |
alzheimer's disease (ad) is characterized by senile plaques (sp) composed of β-amyloid protein (aβ) and neurofibrillary tangles (nfts) composed of intracellular hyperphosphorylated tau. |
2020-10-01 |
2023-08-13 |
mouse |
| Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicosta. Heparan Sulfate as a Therapeutic Target in Tauopathies: Insights From Zebrafish. Frontiers in cell and developmental biology. vol 6. 2020-10-01. PMID:30619849. |
in many tauopathies, including alzheimer's disease (ad), progressive supranuclear palsy (psp) and pick's disease, tau aggregates are found associated with highly sulfated polysaccharides known as heparan sulfates (hss). |
2020-10-01 |
2023-08-13 |
zebrafish |
| Nahid Ahmadian, Sajjad Hejazi, Javad Mahmoudi, Mahnaz Taleb. Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation. Basic and clinical neuroscience. vol 9. issue 5. 2020-10-01. PMID:30719245. |
tau pathology of alzheimer disease: possible role of sleep deprivation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bridget Martinez, Philip V Peplo. Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease. Neural regeneration research. vol 14. issue 7. 2020-10-01. PMID:30804241. |
the most common age-related neurodegenerative disease is alzheimer's disease (ad) characterized by aggregated amyloid-β (aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles, together with loss of cholinergic neurons, synaptic alterations, and chronic inflammation within the brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. |
the link between tau and insulin signaling: implications for alzheimer's disease and other tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. |
we further highlight the deleterious consequences of tau pathology-induced insulin resistance to the brain and/or peripheral tissues, suggesting that these are key events mediating cognitive decline in alzheimer's disease (ad) and other tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. |
neurodegenerative diseases such as alzheimer's disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain. |
2020-10-01 |
2023-08-13 |
mouse |
| Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890929. |
pathological tau from alzheimer's brain induces site-specific hyperphosphorylation and sds- and reducing agent-resistant aggregation of tau neurofibrillary tangles (nfts) made up of hyperphosphorylated tau are a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. |
2020-10-01 |
2023-08-13 |
mouse |
| Oh Dae Kwo. Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging. Dementia and neurocognitive disorders. vol 15. issue 3. 2020-10-01. PMID:30906344. |
apolipoprotein e ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Andreas Nabers, Henning Hafermann, Jens Wiltfang, Klaus Gerwer. Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2020-10-01. PMID:30911600. |
aβ and tau structure-based biomarkers for a blood- and csf-based two-step recruitment strategy to identify patients with dementia due to alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Anele Romeo, Alberto Faggioni, Mara Ciron. Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease? Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089040. |
indeed autophagosome accumulation, indicating an unbalance between autophagosome formation and autophagosome degradation, has been observed in neurons of alzheimer's disease patients and may play a role in the intracellular and extracellular accumulation of amyloid β and in the altered protein tau metabolism. |
2020-10-01 |
2023-08-13 |
human |
| Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeir. Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31105524. |
alzheimer's disease (ad) and parkinson's disease (pd) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (asyn) and tau, respectively. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. |
phagocytosis of apoptotic cells is specifically upregulated in apoe4 expressing microglia alzheimer's disease (ad) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (aβ). |
2020-10-01 |
2023-08-13 |
human |
| Andrzej Stanisław Ciepla. Tau Inclusions in Alzheimer's, Chronic Traumatic Encephalopathy and Pick's Disease. A Speculation on How Differences in Backbone Polarization Underlie Divergent Pathways of Tau Aggregation. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31156372. |
tau inclusions in alzheimer's, chronic traumatic encephalopathy and pick's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Miren Ettcheto, Oriol Busquets, Antoni Camin. Potential preventive disease-modifying pharmacological strategies to delay late onset Alzheimer's disease. Neural regeneration research. vol 14. issue 10. 2020-10-01. PMID:31169189. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that was histopathologically characterized in the brain by the presence of extracellular senile plaques made of amyloid β peptides and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Nipun Mallipeddi, Paul Moiseyev, Chihiro Sato, Randall J Batema. Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31178717. |
tau phosphorylation rates measured by mass spectrometry differ in the intracellular brain vs. extracellular cerebrospinal fluid compartments and are differentially affected by alzheimer's disease. |
2020-10-01 |
2023-08-13 |
human |