All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Liseth K Lavado, Michelle H Zhang, Karan Patel, Sohim Khan, Urvish K Pate. Biometals as Potential Predictors of the Neurodegenerative Decline in Alzheimer's Disease. Cureus. vol 11. issue 9. 2020-09-28. PMID:31695992. most of the research on alzheimer's disease focuses on the correlation of its neuropathological changes in the neurofibrillary tangles caused by hyper-phosphorylated tau protein and β-amyloid plaques with respect to cognitive impairment. 2020-09-28 2023-08-13 Not clear
Chia-Lin Tsai, Chih-Sung Liang, Jiunn-Tay Lee, Ming-Wei Su, Chun-Chieh Lin, Hsuan-Te Chu, Chia-Kuang Tsai, Guan-Yu Lin, Yu-Kai Lin, Fu-Chi Yan. Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study. Journal of clinical medicine. vol 8. issue 11. 2020-09-28. PMID:31698867. brain degeneration in patients with alzheimer's disease (ad) results from the accumulation of pathological amyloid- (aβ) plaques and tau protein tangles, leading to altered plasma levels of biomarkers. 2020-09-28 2023-08-13 Not clear
Per K Eide, Geir Ringsta. In Vivo Imaging of Molecular Clearance From Human Entorhinal Cortex: A Possible Method for Preclinical Testing of Dementia. Gerontology & geriatric medicine. vol 5. 2020-09-28. PMID:31819895. accumulation in the brain of metabolic waste products such as amyloid-β and hyperphosporylated tau (tau) is a hallmark of dementia (e.g., alzheimer's disease). 2020-09-28 2023-08-13 human
Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwat. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31861888. in alzheimer's disease (ad), we previously reported mislocalization of the dna repair nuclear protein brca1, its coaggregation with tau, and the possible importance of the subsequent dna repair dysfunction. 2020-09-28 2023-08-13 human
Daniel J Apicco, Cheng Zhang, Brandon Maziuk, Lulu Jiang, Heather I Ballance, Samantha Boudeau, Choong Ung, Hu Li, Benjamin Wolozi. Dysregulation of RNA Splicing in Tauopathies. Cell reports. vol 29. issue 13. 2020-09-28. PMID:31875547. pathological aggregation of rna binding proteins (rbps) is associated with dysregulation of rna splicing in ps19 p301s tau transgenic mice and in alzheimer's disease brain tissues. 2020-09-28 2023-08-13 mouse
Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. toxic tau: structural origins of tau aggregation in alzheimer's disease. 2020-09-28 2023-08-13 Not clear
Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. 2020-09-28 2023-08-13 Not clear
Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. particularly, tau pathology connects greatly in the pathogenesis of alzheimer's disease. 2020-09-28 2023-08-13 Not clear
Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. furthermore, the shape-shifting nature of tau advocates to comprehend the progression of alzheimer's disease precisely. 2020-09-28 2023-08-13 Not clear
Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. in this review, we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of alzheimer's disease. 2020-09-28 2023-08-13 Not clear
Baruh Polis, Abraham O Samso. Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997805. continual failures to offer a competent treatment strategy directed against amyloid-beta or tau proteins-related lesions, which could face all challenges of the multifaceted alzheimer's disease pathology, led to the hypothesis that hyperphosphorylated tau and deposited amyloid-beta proteins are just hallmarks or epiphenomena, but not the ultimate causes of alzheimer's disease. 2020-09-28 2023-08-13 human
Kanet Pakdeepak, Ratchanaporn Chokchaisiri, Jiraporn Tocharus, Pranglada Jearjaroen, Chainarong Tocharus, Apichart Suksamrar. 5,6,7,4'-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice. EXCLI journal. vol 19. 2020-09-28. PMID:32038114. long-term exposure to high glucocorticoid levels induces memory impairment and neurodegeneration in alzheimer's disease (ad) by increasing the expression of amyloid β and tau hyperphosphorylation (ptau). 2020-09-28 2023-08-13 mouse
Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32051933. is tau in the absence of amyloid on the alzheimer's continuum? 2020-09-28 2023-08-13 Not clear
Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32051933. we used positron emission tomography imaging to investigate amyloid beta and tau positivity and associations with cognition to better inform the conceptualization of biomarker changes in alzheimer's pathogenesis. 2020-09-28 2023-08-13 Not clear
Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32051933. among our sample of older adults across the alzheimer's pathological spectrum, 7-fold fewer individuals have positron emission tomography evidence of amyloid beta pathology in the absence of tau pathology than the converse, challenging prevailing models of amyloid beta's primacy in alzheimer's pathogenesis. 2020-09-28 2023-08-13 Not clear
Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32051933. given that cognitive performance in the a-/t+ group was poorer than in individuals without either pathology, our results suggest that medial temporal lobe tau without cortical amyloid beta may reflect an early stage on the alzheimer's pathological continuum. 2020-09-28 2023-08-13 Not clear
Félix Hernández, Jesús Merchán-Rubira, Laura Vallés-Saiz, Alberto Rodríguez-Matellán, Jesús Avil. Differences Between Human and Murine Tau at the N-terminal End. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32063841. human tauopathies, such as alzheimer's disease (ad), have been widely studied in transgenic mice overexpressing human tau in the brain. 2020-09-28 2023-08-13 mouse
Mireia Tondo, Brandi Wasek, Joan Carles Escola-Gil, David de Gonzalo-Calvo, Clinton Harmon, Erland Arning, Teodoro Bottiglier. Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy. Metabolites. vol 10. issue 2. 2020-09-28. PMID:32075035. alzheimer's disease (ad) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. 2020-09-28 2023-08-13 mouse
Xiaoguang Yao, Xiaohui Xian, Mingxing Fang, Shujuan Fan, Wenbin L. Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:32082134. loss of mir-369 promotes tau phosphorylation by targeting the fyn and serine/threonine-protein kinase 2 signaling pathways in alzheimer's disease mice. 2020-09-28 2023-08-13 mouse
Xiaoguang Yao, Xiaohui Xian, Mingxing Fang, Shujuan Fan, Wenbin L. Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice. Frontiers in aging neuroscience. vol 11. 2020-09-28. PMID:32082134. alzheimer's disease (ad) is a progressive neurodegenerative dementia with the key pathological hallmarks amyloid-beta deposition and neurofibrillary tangles composed of hyperphosphorylated tau. 2020-09-28 2023-08-13 mouse