| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Qiao Chen, William C Moble. Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293377. |
alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric aβ and tau species. |
2020-09-30 |
2023-08-13 |
human |
| Kwang Hun Li. Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31338019. |
there is an increasing body of evidence that suggests other aggregation-prone proteins including tau and α-synuclein associated with alzheimer's and parkinson's diseases, respectively, also behave like a prion that has conformational strains with self-propagation (seeding) property. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuan Zhang, Yanfang Zhao, Lei Zhang, Wanpeng Yu, Yu Wang, Wenguang Chan. Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31417361. |
the pathological features of alzheimer's disease (ad) include senile plaques induced by amyloid-β (aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alfonso Grimaldi, Natalia Pediconi, Francesca Oieni, Rocco Pizzarelli, Maria Rosito, Maria Giubettini, Tiziana Santini, Cristina Limatola, Giancarlo Ruocco, Davide Ragozzino, Silvia Di Angelantoni. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31551688. |
alzheimer's disease (ad), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Fumiaki Tanak. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in neurology. vol 10. 2020-09-30. PMID:31551922. |
tau pathology in chronic traumatic encephalopathy and alzheimer's disease: similarities and differences. |
2020-09-30 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Fumiaki Tanak. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in neurology. vol 10. 2020-09-30. PMID:31551922. |
traumatic brain injury (tbi) has been associated with the development of alzheimer's disease (ad) because these conditions share common pathological hallmarks: amyloid-β and hyperphosphorylated tau accumulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Viktoriya Morozova, Leah S Cohen, Ali El-Hadi Makki, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Alejandra D Alons. Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31555098. |
in neurodegenerative diseases, like alzheimer's disease (ad), pathological tau spreads from neuron to neuron enhancing neurodegeneration. |
2020-09-30 |
2023-08-13 |
human |
| Nataliya I Trushina, Lidia Bakota, Armen Y Mulkidjanian, Roland Brand. The Evolution of Tau Phosphorylation and Interactions. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31619983. |
in alzheimer's disease (ad) and other tauopathies, tau exhibits pathologically increased phosphorylation (hyperphosphorylation) at selected sites and aggregates into neurofibrillary tangles (nfts). |
2020-09-30 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabi. Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest. Frontiers in cell and developmental biology. vol 7. 2020-09-30. PMID:31620438. |
alzheimer's disease (ad) is a progressive, irreversible brain disorder characterized by pathological aggregation of the amyloid-β peptide (aβ) and tau protein; both of these are toxic to neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Vinod G Landge, Pramod Gudigenahally Nagaraju, Poornima Priyadarshini Cg, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer's Disease. ACS omega. vol 4. issue 16. 2020-09-30. PMID:31646215. |
molecular cobalt(ii) complexes for tau polymerization in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Vinod G Landge, Pramod Gudigenahally Nagaraju, Poornima Priyadarshini Cg, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer's Disease. ACS omega. vol 4. issue 16. 2020-09-30. PMID:31646215. |
tau is an axonal protein known to form abnormal aggregates and is the biomarker of alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Stefania Zappettini, Emilie Faivre, Antoine Ghestem, Sébastien Carrier, Luc Buée, David Blum, Monique Esclapez, Christophe Bernar. Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31680863. |
here, we tested the long-term consequences of early life exposure to caffeine in thy-tau22 transgenic mice, a model of alzheimer's disease-like tau pathology. |
2020-09-30 |
2023-08-13 |
mouse |
| Shuko Taked. Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31920473. |
a unique clinical course of alzheimer's disease (ad), beginning with memory deficit as the earliest symptom, is well-correlated with a progressive pattern of intracellular aggregates of tau (neurofibrillary tangles), which spread from the medial temporal lobe to other brain areas in a stereotypical manner. |
2020-09-30 |
2023-08-13 |
Not clear |
| Onder Albayram, Megan K Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou, Kun Ping L. Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration. Cell & bioscience. vol 6. 2020-09-29. PMID:27980715. |
one of the two common hallmark lesions of alzheimer's disease (ad) brains is neurofibrillary tangles (nfts), which are composed of hyperphosphorylated tau protein (p-tau). |
2020-09-29 |
2023-08-13 |
Not clear |
| Diana L Castillo-Carranza, Ashley N Nilson, Candice E Van Skike, Jordan B Jahrling, Kishan Patel, Prajesh Garach, Julia E Gerson, Urmi Sengupta, Jose Abisambra, Peter Nelson, Juan Troncoso, Zoltan Ungvari, Veronica Galvan, Rakez Kaye. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging and disease. vol 8. issue 3. 2020-09-29. PMID:28580182. |
cerebral microvascular accumulation of tau oligomers in alzheimer's disease and related tauopathies. |
2020-09-29 |
2023-08-13 |
mouse |
| Christiana Kontaxi, Pedro Piccardo, Andrew C Gil. Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies. Frontiers in molecular biosciences. vol 4. 2020-09-29. PMID:28848737. |
lysine-directed post-translational modifications of tau protein in alzheimer's disease and related tauopathies. |
2020-09-29 |
2023-08-13 |
Not clear |
| Christiana Kontaxi, Pedro Piccardo, Andrew C Gil. Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies. Frontiers in molecular biosciences. vol 4. 2020-09-29. PMID:28848737. |
altered tau forms characteristic pathogenic inclusions in alzheimer's disease and related tauopathies. |
2020-09-29 |
2023-08-13 |
Not clear |
| Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Hiroshi Matsud. Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer's disease: A combined positron emission tomography/magnetic resonance imaging study. Alzheimer's & dementia (Amsterdam, Netherlands). vol 9. 2020-09-29. PMID:28856235. |
regional tau deposition and subregion atrophy of medial temporal structures in early alzheimer's disease: a combined positron emission tomography/magnetic resonance imaging study. |
2020-09-29 |
2023-08-13 |
Not clear |
| Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M S Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Cho. Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:29163138. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the progressive accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yoori Choi, Seunggyun Ha, Yun-Sang Lee, Yun Kyung Kim, Dong Soo Lee, Dong Jin Ki. Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies. Nuclear medicine and molecular imaging. vol 52. issue 1. 2020-09-29. PMID:29391909. |
the development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |