All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D Johnson, Michael G Kharas, Rakez Kaye. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature communications. vol 11. issue 1. 2020-09-21. PMID:32855391. here, we investigated the expression and cellular localization of msi1 and msi2 in the brains tissues of alzheimer's disease (ad), amyotrophic lateral sclerosis (als) and frontotemporal dementia (ftd) as well as in the wild-type mice and tau knock-out and p301l tau mouse models. 2020-09-21 2023-08-13 mouse
Nobuya Kitaguchi, Harutsugu Tatebe, Kazuyoshi Sakai, Kazunori Kawaguchi, Shinji Matsunaga, Tomoko Kitajima, Hiroshi Tomizawa, Masao Kato, Satoshi Sugiyama, Nobuo Suzuki, Masao Mizuno, Hajime Takechi, Shigeru Nakai, Yoshiyuki Hiki, Hiroko Kushimoto, Midori Hasegawa, Yukio Yuzawa, Takahiko Tokud. Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156161. influx of tau and amyloid-β proteins into the blood during hemodialysis as a therapeutic extracorporeal blood amyloid-β removal system for alzheimer's disease. 2020-09-18 2023-08-13 human
Nobuya Kitaguchi, Harutsugu Tatebe, Kazuyoshi Sakai, Kazunori Kawaguchi, Shinji Matsunaga, Tomoko Kitajima, Hiroshi Tomizawa, Masao Kato, Satoshi Sugiyama, Nobuo Suzuki, Masao Mizuno, Hajime Takechi, Shigeru Nakai, Yoshiyuki Hiki, Hiroko Kushimoto, Midori Hasegawa, Yukio Yuzawa, Takahiko Tokud. Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156161. the accumulation of amyloid-β protein (aβ) and tau in the brain is a major pathological change related to alzheimer's disease. 2020-09-18 2023-08-13 human
Hong-Bin Cai, Zhen-Zhen Fan, Ting Tian, Chon-Chon Zhao, Zhao-Ming G. Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156174. cyclin-dependent kinase-5 (cdk5) is activated by p35 and then binds to both p35 and its truncated form p25 to promote hyperphosphorylation of tau protein, thereby facilitating the pathological progression of alzheimer's disease (ad). 2020-09-18 2023-08-13 rat
Huan Sun, Mengying Liu, Tao Sun, Yutong Chen, Zhen Lan, Biyao Lian, Chengjun Zhao, Zhi Liu, Jiqiang Zhang, Yan Li. Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice. Behavioural brain research. vol 376. 2020-09-17. PMID:31472195. alzheimer's disease (ad) is the most common form of dementia in the elderly, characterized by amyloid-beta (aβ) plaques and tau neurofibrillary tangles (nfts). 2020-09-17 2023-08-13 mouse
Jan Aaseth, Aleksandra Buha, David R Wallace, Geir Bjørklun. Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies. International journal of environmental research and public health. vol 17. issue 4. 2020-09-17. PMID:32079163. the tau hypotheses of parkinson's and alzheimer's diseases contain a clinically diverse spectrum of tauopathies. 2020-09-17 2023-08-13 Not clear
Ruihua Sun, Huayuan Wang, Yingying Shi, Dandan Gao, Zhikun Sun, Zhongcan Chen, Haisong Jiang, Jiewen Zhan. A Pilot Study of Urinary Exosomes in Alzheimer's Disease. Neuro-degenerative diseases. vol 19. issue 5-6. 2020-09-17. PMID:32375155. exosomes can spread toxic amyloid-beta (aβ) and hyperphosphorylated tau between cells, contributing to neuronal loss in alzheimer's disease (ad). 2020-09-17 2023-08-13 Not clear
Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. these data strongly support the hypothesis that in alzheimer's disease (ad), aβ-associated hyperactivity accelerates the progression of pathological tau along vulnerable neuronal circuits, and demonstrates the utility of chronic, neuromodulatory approaches in ameliorating ad pathology in vivo. 2020-09-17 2023-08-13 mouse
Niyatee Samudra, Michael Motes, Hanzhang Lu, Min Sheng, Ramon Diaz-Arrastia, Michael Devous, John Hart, Kyle B Womac. A Pilot Study of Changes in Medial Temporal Lobe Fractional Amplitude of Low Frequency Fluctuations after Sildenafil Administration in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 1. 2020-09-16. PMID:31156166. alzheimer's disease (ad) is the most common cause of neurodegenerative cognitive impairment, defined by abnormal accumulations of amyloid-β and tau. 2020-09-16 2023-08-13 mouse
Adrià Tort-Merino, Jaume Olives, María León, Claudia Peñaloza, Natalia Valech, Miguel A Santos-Santos, Estela Càmara, Petra Grönholm-Nyman, Pablo Martínez-Lage, Juan Fortea, José L Molinuevo, Raquel Sánchez-Valle, Matti Laine, Antoni Rodríguez-Fornells, Lorena Ram. Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels. Journal of Alzheimer's disease : JAD. vol 70. issue 1. 2020-09-16. PMID:31177219. tau protein is associated with longitudinal memory decline in cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels. 2020-09-16 2023-08-13 human
Hui-Qin Li, Siu-Po Ip, Qiu-Ju Yuan, Guo-Qing Zheng, Karl K W Tsim, Tina T X Dong, Ge Lin, Yifan Han, Yue Liu, Yan-Fang Xian, Zhi-Xiu Li. Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer's disease. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31476414. isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: studies in a transgenic mouse model of alzheimer's disease. 2020-09-16 2023-08-13 mouse
Yichen Lee, Bo H Lee, William Yip, Pingchen Chou, Bak-Sau Yi. Neurofilament Proteins as Prognostic Biomarkers in Neurological Disorders. Current pharmaceutical design. vol 25. issue 43. 2020-09-16. PMID:31820696. in addition, those pathological neurofilament accumulations are known in α-synuclein in parkinson's disease (pd), aβ and tau in alzheimer's disease (ad), polyglutamine in cag trinucleotide repeat disorders, superoxide dismutase 1 (sod1), tar dna-binding protein 43 (tdp43), neuronal fus proteins, optineurin (optn), ubiquilin 2 (ubqln2), and dipeptide repeat protein (drp) in amyotrophic lateral sclerosis (als). 2020-09-16 2023-08-13 human
Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705825. to observe the effect of electroacupuncture (ea) and manual acupuncture (ma) on learning-memory ability, changes of ultrastructure of neurons and expression of cdk5 and tau proteins in hippocampus of samp8 mice,so as to explore its mechanisms underlying improvement of alzheimer's disease (ad).. 2020-09-16 2023-08-13 mouse
Frances A Edward. A Unifying Hypothesis for Alzheimer's Disease: From Plaques to Neurodegeneration. Trends in neurosciences. vol 42. issue 5. 2020-09-15. PMID:31006494. however, as plaque load increases, as seen in alzheimer's disease, an individual axon may suffer multiple points of damage, leading to dissociation of tau, formation of a tangle, and loss of the axon. 2020-09-15 2023-08-13 Not clear
Mengyu Liu, Luwen Wang, Ju Gao, Qing Dong, George Perry, Xuemei Ma, Xinglong Wan. Inhibition of Calpain Protects Against Tauopathy in Transgenic P301S Tau Mice. Journal of Alzheimer's disease : JAD. vol 69. issue 4. 2020-09-15. PMID:31156179. alzheimer's disease (ad) and other tauopathies are characterized by intracellular accumulation of microtubule-associated tau protein leading to neurodegeneration. 2020-09-15 2023-08-13 mouse
Sho Kaide, Hiroyuki Watanabe, Yoichi Shimizu, Haruka Tatsumi, Shimpei Iikuni, Yuji Nakamoto, Kaori Togashi, Masafumi Ihara, Hideo Saji, Masahiro On. Bioorganic & medicinal chemistry. vol 27. issue 16. 2020-09-15. PMID:31285098. hyperphosphorylated tau proteins are one of the neuropathological hallmarks in the alzheimer's disease (ad) brain. 2020-09-15 2023-08-13 Not clear
Dominic M Walsh, Dennis J Selko. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current opinion in neurobiology. vol 61. 2020-09-15. PMID:32197217. basic research on the biological mechanism of alzheimer's disease has focused for decades on the age-related aggregation of the amyloid β-protein and its apparent downstream effects on microglia, astrocytes and neurons, including the posttranslational modification of the tau protein that seems necessary for symptom expression. 2020-09-15 2023-08-13 Not clear
Ao-Ji Xie, Tong-Yao Hou, Wan Xiong, He-Zhou Huang, Jie Zheng, Ke Li, Heng-Ye Man, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Na Wei, Jian-Zhi Wang, Dan Liu, Youming Lu, Ling-Qiang Zh. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway. Aging cell. vol 18. issue 3. 2020-09-14. PMID:30809933. here, we report that forced expression of human tau (htau) in mouse cortical neurons impairs endocytosis by decreasing the level of the gtpase dynamin 1 via disruption of the mir-132-mecp2 pathway; this process can also be detected in the brains of alzheimer's patients and htau mice. 2020-09-14 2023-08-13 mouse
Marion Tible, François Mouton Liger, Julien Schmitt, Albert Giralt, Karim Farid, Sylvie Thomasseau, Sarah Gourmaud, Claire Paquet, Laure Rondi Reig, Eliane Meurs, Jean-Antoine Girault, Jacques Hugo. PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions. Aging cell. vol 18. issue 3. 2020-09-14. PMID:30821420. brain lesions in alzheimer's disease (ad) include amyloid plaques made of aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. 2020-09-14 2023-08-13 mouse
Sunil Thomas, Kevther Hoxha, Allison Tran, George C Prendergas. Bin1 antibody lowers the expression of phosphorylated Tau in Alzheimer's disease. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31211444. bin1 antibody lowers the expression of phosphorylated tau in alzheimer's disease. 2020-09-14 2023-08-13 mouse