All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Pei-Pei Guan, Xin Yu, Yan-Hui Zou, Pu Wan. Cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in Alzheimer's disease. Cellular & molecular immunology. vol 16. issue 11. 2020-08-14. PMID:31551514. cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in alzheimer's disease. 2020-08-14 2023-08-13 Not clear
Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-Ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asan. Development of Pin1 Inhibitors and their Potential as Therapeutic Agents. Current medicinal chemistry. vol 27. issue 20. 2020-08-12. PMID:30394205. notably, pin1 deficiency or inactivation is a potential cause of alzheimer's disease, since pin1 induces the degradation of tau. 2020-08-12 2023-08-13 mouse
Masanori Kurihara, Taro Bannai, Atsushi Iwat. [Factors Influencing Brain Interstitial Fluid Concentrations of Amyloid β and Tau]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 5. 2020-08-12. PMID:32381750. in this review, we summarize our current understanding of factors influencing brain interstitial fluid concentrations of amyloid-β and tau, mainly focusing on known epidemiological risk factors for alzheimer's disease. 2020-08-12 2023-08-13 Not clear
Chen Wei Tsai, Chia Fan Tsai, Kuan Hung Lin, Wei Jung Chen, Muh Shi Lin, Cho Chen Hsieh, Chai Ching Li. An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer's disease progression. PloS one. vol 15. issue 5. 2020-08-11. PMID:32469899. alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by two aggregates, namely, amyloid-β (aβ) plaques and neurofibrillary tangles (nfts) of hyperphosphorylated tau protein (tau-p), which are released into the blood in a very small amount and cannot be easily detected. 2020-08-11 2023-08-13 Not clear
Nenad Bogdanovic, Oskar Hansson, Henrik Zetterberg, Hans Basun, Martin Ingelsson, Lars Lannfelt, Kaj Blenno. [Alzheimer's disease - the most common cause of dementia]. Lakartidningen. vol 117. 2020-08-10. PMID:32154904. the latest clinical development of potential therapy for alzheimer's is active or passive immunotherapy against brain β-amyloid and tau, where several studies have shown varying but promising treatment effects. 2020-08-10 2023-08-13 Not clear
Markus Mandler, Edward Rockenstein, Cassia Overk, Michael Mante, Jazmin Florio, Anthony Adame, Changyoun Kim, Radmila Santic, Achim Schneeberger, Frank Mattner, Sabine Schmidhuber, Gergana Galabova, Brian Spencer, Eliezer Masliah, Robert A Rissma. Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 9. 2020-08-07. PMID:31378574. immunotherapeutic approaches targeting amyloid β (aβ) protein and tau in alzheimer's disease and α-synuclein (α-syn) in parkinson's disease are being developed for treating dementia with lewy bodies. 2020-08-07 2023-08-13 Not clear
Isabelle Bos, Stephanie J B Vos, Suzanne E Schindler, Jason Hassenstab, Chengjie Xiong, Elizabeth Grant, Frans Verhey, John C Morris, Pieter Jelle Visser, Anne M Faga. Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 9. 2020-08-07. PMID:31378575. vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical alzheimer's disease. 2020-08-07 2023-08-13 Not clear
Lok-Kin Yeung, Christiane Hale, Briana S Last, Howard Andrews, Richard P Sloan, Lawrence S Honig, Scott A Small, Adam M Brickma. Cerebrospinal fluid amyloid levels are associated with delayed memory retention in cognitively normal biomarker-negative older adults. Neurobiology of aging. vol 84. 2020-08-06. PMID:31520793. alzheimer's disease is defined by abnormal levels of amyloid and tau biomarkers. 2020-08-06 2023-08-13 Not clear
Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikya. Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31847886. alzheimer disease (ad) is characterized by the accumulation of beta-amyloid (aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. 2020-08-06 2023-08-13 mouse
Jing Li, Weian Chen, Yanhong Yi, Qiuling Ton. miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30556160. mir-219-5p inhibits tau phosphorylation by targeting ttbk1 and gsk-3β in alzheimer's disease. 2020-08-05 2023-08-13 mouse
Maud Gratuze, Nicolas Josset, Franck R Petry, Mathieu Pflieger, Laura Eyoum Jong, Geoffrey Truchetti, Isabelle Poitras, Jacinthe Julien, François Bezeau, Françoise Morin, Pershia Samadi, Francesca Cicchetti, Frédéric Bretzner, Emmanuel Plane. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research. vol 1711. 2020-08-04. PMID:30641037. studies have also documented the presence of other proteins within lewy bodies, particularly tau, a microtubule-associated protein implicated in a wide range of neurodegenerative diseases, including alzheimer's disease (ad). 2020-08-04 2023-08-13 mouse
Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herledan, Nicolas Malmanche, Petra Mäkinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Anaïs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, Benoit Déprez, François-Xavier Cantrelle, Damien Maréchal, Laurent Pradier, Mikko Hiltunen, Isabelle Landrieu, Devrim Kilinc, Yann Herault, Jocelyn Laporte, Jean-Charles Lamber. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31065832. bin1 recovers tauopathy-induced long-term memory deficits in mice and interacts with tau through thr the bridging integrator 1 gene (bin1) is a major genetic risk factor for alzheimer's disease (ad). 2020-08-04 2023-08-13 mouse
Minkyung Lee, Hae-June Lee, Ye Ji Jeong, Se Jong Oh, Kyung Jun Kang, Sang Jin Han, Kyung Rok Nam, Yong Jin Lee, Kyo Chul Lee, Young Hoon Ryu, In Young Hyun, Jae Yong Cho. Age dependency of mGluR5 availability in 5xFAD mice measured by PET. Neurobiology of aging. vol 84. 2020-08-04. PMID:31570178. the major pathologies of alzheimer's disease (ad) are amyloid plaques and hyperphosphorylated tau. 2020-08-04 2023-08-13 mouse
P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. neurofibrillary tau protein pathology is closely associated with the progression and phenotype of cognitive decline in alzheimer's disease and other tauopathies, and a high-priority target for disease-modifying therapies. 2020-08-03 2023-08-13 mouse
P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. the vaccine was highly immunogenic in humans, inducing production of igg antibodies against the tau peptide in 29/30 treated elderly patients with mild-to-moderate alzheimer's. 2020-08-03 2023-08-13 mouse
P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. these antibodies were able to recognise insoluble tau proteins in alzheimer patients' brains. 2020-08-03 2023-08-13 mouse
P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. aadvac1 is currently being investigated in a phase 2 study in alzheimer's disease, and a phase 1 study in non-fluent primary progressive aphasia, a neurodegenerative disorder with a high tau pathology component. 2020-08-03 2023-08-13 mouse
G Amadoro, V Latina, V Corsetti, P Calissan. N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approach. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31676377. n-terminal tau truncation in the pathogenesis of alzheimer's disease (ad): developing a novel diagnostic and therapeutic approach. 2020-08-03 2023-08-13 human
G Amadoro, V Latina, V Corsetti, P Calissan. N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approach. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31676377. tau truncation occurs at early stages during the development of human alzheimer's disease (ad) and other tauopathy dementias. 2020-08-03 2023-08-13 human
Maria Anele Romeo, Maria Saveria Gilardini Montani, Aurelia Gaeta, Gabriella D'Orazi, Alberto Faggioni, Mara Ciron. HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31866416. hhv-6a infection dysregulates autophagy/upr interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to alzheimer's disease. 2020-08-03 2023-08-13 Not clear