All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jiwana Sherin Midani-Kurçak, Maja Dinekov, Behrus Puladi, Thomas Arzberger, Christoph Köhle. Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B). Brain research. vol 1706. 2020-05-29. PMID:30414727. we analyzed immunolabeled brain sections from tau-transgenic mice, app-transgenic mice, non-transgenic mice, and human hippocampi to investigate the relation between chmp2b and tau and plaque pathology that are major histopathological features of alzheimer's disease. 2020-05-29 2023-08-13 mouse
Ci-Di Chen, Ella Zeldich, Christina Khodr, Kaddy Camara, Tze Yu Tung, Emma C Lauder, Patrick Mullen, Taryn J Polanco, Yen-Yu Liu, Dean Zeldich, Weiming Xia, William E Van Nostrand, Lauren E Brown, John A Porco, Carmela R Abraha. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-05-29. PMID:30776010. alzheimer's disease (ad) is characterized by the accumulation of neurotoxic amyloid-β (aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (aβpp), and the accumulation of the hyperphosphorylated microtubule-associated protein tau. 2020-05-29 2023-08-13 Not clear
Yusra Mansour, Kaitlyn Blackburn, Luis Oscar González-González, Lilian Calderón-Garcidueñas, Randy J Kulesz. Auditory Brainstem Dysfunction, Non-Invasive Biomarkers for Early Diagnosis and Monitoring of Alzheimer's Disease in Young Urban Residents Exposed to Air Pollution. Journal of Alzheimer's disease : JAD. vol 67. issue 4. 2020-05-27. PMID:30741678. alzheimer's disease (ad) is a biological construct defined by abnormal deposits of hyperphosphorylated tau and amyloid-β. 2020-05-27 2023-08-13 Not clear
Ricardo F Allegri, Lucia Pertierra, Gabriela Cohen, Patricio Chrem Méndez, María Julieta Russo, Ismael Calandri, Pablo Bagnati, Fernanda Tapajóz, Florencia Clarens, Jorge Campos, Federico E Nahas, Ezequiel Surace, Silvia Vázquez, Gustavo Sevleve. A biological classification for Alzheimer's disease - Amyloid, Tau and Neurodegeneration (A/T/N): results from the Argentine-Alzheimer's Disease Neuroimaging Initiative. International psychogeriatrics. vol 31. issue 12. 2020-05-27. PMID:30859920. a biological classification for alzheimer's disease - amyloid, tau and neurodegeneration (a/t/n): results from the argentine-alzheimer's disease neuroimaging initiative. 2020-05-27 2023-08-13 Not clear
Maotian Zhou, Duc M Duong, Erik C B Johnson, Jingting Dai, James J Lah, Allan I Levey, Nicholas T Seyfrie. Mass Spectrometry-Based Quantification of Tau in Human Cerebrospinal Fluid Using a Complementary Tryptic Peptide Standard. Journal of proteome research. vol 18. issue 6. 2020-05-27. PMID:30983353. as a proof of concept, an isotope-labeled comptryp standard was synthesized for tau, a well-established biomarker in alzheimer's disease (ad), which included both n- and c-terminal heavy isotope-labeled ( 2020-05-27 2023-08-13 human
Santosh Rudrawar, Philip Rya. Sugar Kick Prevents Memory Impairment. Journal of medicinal chemistry. vol 62. issue 22. 2020-05-27. PMID:31668062. pathological hyperphosphorylation of tau and subsequent aggregation to form neurofibrillary tangles (nfts) is closely related to progression of neurodegenerative diseases such as alzheimer's disease (ad) and progressive supranuclear palsy. 2020-05-27 2023-08-13 Not clear
Hannah E R Baughman, Thanh-Hau T Pham, Chloe S Adams, Abhinav Nath, Rachel E Klevi. Release of a disordered domain enhances HspB1 chaperone activity toward tau. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 6. 2020-05-27. PMID:31974309. here we characterize interactions between the human shsp hspb1 (hsp27) and microtubule-associated protein tau, which is implicated in multiple dementias, including alzheimer's disease. 2020-05-27 2023-08-13 human
Jennifer L Whitwell, Peter Martin, Jonathan Graff-Radford, Mary M Machulda, Matthew L Senjem, Christopher G Schwarz, Stephen D Weigand, Anthony J Spychalla, Daniel A Drubach, Clifford R Jack, Val J Lowe, Keith A Joseph. The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 5. 2020-05-26. PMID:30853465. the role of age on tau pet uptake and gray matter atrophy in atypical alzheimer's disease. 2020-05-26 2023-08-13 Not clear
Jonathan Graff-Radford, Eider M Arenaza-Urquijo, David S Knopman, Christopher G Schwarz, Robert D Brown, Alejandro A Rabinstein, Jeffrey L Gunter, Matthew L Senjem, Scott A Przybelski, Timothy Lesnick, Chadwick Ward, Michelle M Mielke, Val J Lowe, Ronald C Petersen, Walter K Kremers, Kejal Kantarci, Clifford R Jack, Prashanthi Vemur. White matter hyperintensities: relationship to amyloid and tau burden. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199475. we used statistical parametric mapping 12-based, voxel-wise, multiple-regression analyses to detect white matter hyperintense regions associated with alzheimer's biomarkers (global amyloid from amyloid-pet and meta-regions of interest tau uptake from tau-pet) after adjusting for age, sex and hypertension. 2020-05-26 2023-08-13 human
Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. alzheimer's disease researchers have been intrigued by the selective regional vulnerability of the brain to amyloid-β plaques and tau neurofibrillary tangles. 2020-05-26 2023-08-13 Not clear
Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. post-mortem studies indicate that in ageing and alzheimer's disease tau tangles deposit early in the transentorhinal cortex, a region located in the anterior-temporal lobe that is critical for object memory. 2020-05-26 2023-08-13 Not clear
Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. in the current study, we tested whether anterior-temporal and posterior-medial brain regions are selectively vulnerable to tau and amyloid-β deposition in the progression from ageing to alzheimer's disease and whether this is reflected in domain-specific behavioural deficits and neural dysfunction. 2020-05-26 2023-08-13 Not clear
Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. tau burden was relatively higher in anterior-temporal regions in normal ageing and this difference was further pronounced in the presence of amyloid-β and cognitive impairment, indicating exacerbation of ageing-related processes in alzheimer's disease. 2020-05-26 2023-08-13 Not clear
Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. as alzheimer's disease develops, amyloid-β deposits preferentially in posterior-medial regions additionally compromising scene discrimination and anterior-temporal tau deposition worsens further. 2020-05-26 2023-08-13 Not clear
Kevin Carvalho, Emilie Faivre, Marie J Pietrowski, Xavier Marques, Victoria Gomez-Murcia, Aude Deleau, Vincent Huin, Jan N Hansen, Stanislav Kozlov, Clément Danis, Mariana Temido-Ferreira, Joana E Coelho, Céline Mériaux, Sabiha Eddarkaoui, Stéphanie Le Gras, Mélanie Dumoulin, Lucrezia Cellai, Isabelle Landrieu, Yijuang Chern, Malika Hamdane, Luc Buée, Anne-Laurence Boutillier, Sabine Levi, Annett Halle, Luisa V Lopes, David Blu. Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31599329. accumulating data support the role of tau pathology in cognitive decline in ageing and alzheimer's disease, but underlying mechanisms remain ill-defined. 2020-05-26 2023-08-13 mouse
Joana B Pereira, Rik Ossenkoppele, Sebastian Palmqvist, Tor Olof Strandberg, Ruben Smith, Eric Westman, Oskar Hansso. Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity. eLife. vol 8. 2020-05-26. PMID:31815669. the abnormal accumulation of amyloid-β and tau targets specific spatial networks in alzheimer's disease. 2020-05-26 2023-08-13 Not clear
Antoine Leuzy, Claudia Cicognola, Konstantinos Chiotis, Laure Saint-Aubert, Laetitia Lemoine, Niels Andreasen, Henrik Zetterberg, Keqiang Ye, Kaj Blennow, Kina Höglund, Agneta Nordber. Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 46. issue 5. 2020-05-25. PMID:30610252. longitudinal tau and metabolic pet imaging in relation to novel csf tau measures in alzheimer's disease. 2020-05-25 2023-08-13 Not clear
Katarina Ilic, Kristina Mlinac-Jerkovic, Natasa Jovanov-Milosevic, Goran Simic, Nikola Habek, Nenad Bogdanovic, Svjetlana Kalanj-Bogna. Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease. Journal of cellular and molecular medicine. vol 23. issue 2. 2020-05-21. PMID:30488668. here, we investigated the hippocampal expression of brain-specific neuroplastin isoform (np65), its relationship with amyloid and tau pathology in alzheimer's disease (ad), and potential involvement of neuroplastin in tissue response during the disease progression. 2020-05-21 2023-08-13 human
Philip Ryan, Mingming Xu, Andrew K Davey, Jonathan J Danon, George D Mellick, Michael Kassiou, Santosh Rudrawa. O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease. ACS chemical neuroscience. vol 10. issue 5. 2020-05-21. PMID:30985105. in alzheimer's disease (ad), dysregulated phosphorylation is reported to promote pathogenic processing of the microtubule-associated tau protein. 2020-05-21 2023-08-13 Not clear
Swikrity Upadhyay Baskota, Oscar L Lopez, J Timothy Greenamyre, Julia Kofle. Spectrum of tau pathologies in Huntington's disease. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573872. recently, a new role for tau has been implicated in the pathogenesis of hd, whereas others have argued that postmortem tau pathology findings are attributable to concurrent alzheimer's disease pathology. 2020-05-18 2023-08-13 Not clear