All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
James A R Nicoll, George R Buckland, Charlotte H Harrison, Anton Page, Scott Harris, Seth Love, James W Neal, Clive Holmes, Delphine Boch. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 7. 2020-05-18. PMID:31157360. despite modification of alzheimer's pathology, most patients had progressed to severe dementia, notably including the five with very extensive plaque removal, possibly due to continued tau propagation. 2020-05-18 2023-08-13 human
Yin Xu, Sheng Zhang, Hui Zhen. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. vol 15. issue 4. 2020-05-11. PMID:30290707. abbreviations: aav: adeno-associated virus; ad: alzheimer disease; alp: autophagy-lysosomal pathway; als: amyotrophic lateral sclerosis; calcoco2/ndp52: calcium binding and coiled-coil domain 2; ftd: frontotemporal dementias; hd: huntington disease; htt: huntingtin; lir: lc3-interacting region; nbr1: autophagy cargo receptor; nfe2l2/nrf2: nuclear factor, erythroid derived 2, like 2; nfts: neurofibrillary tangles; mapt: microtubule associated protein tau; optn: optineurin; p-mapt: hyperphosphorylated mapt; pfa: paraformaldehyde; tardbp/tdp-43: tar dna binding protein; tax1bp1 tax1: binding protein 1; thios: thioflavin-s; uba: ubiquitin-associated. 2020-05-11 2023-08-13 mouse
Alan D Snow, Gerardo M Castillo, Beth P Nguyen, Paula Y Choi, Joel A Cummings, Judy Cam, Qubai Hu, Thomas Lake, Weihong Pan, Abba J Kastin, Daniel A Kirschner, Steven G Wood, Edward Rockenstein, Eliezer Masliah, Stephen Lorimer, Rudolph E Tanzi, Lesley Larse. The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Scientific reports. vol 9. issue 1. 2020-05-11. PMID:30728442. brain aging and alzheimer's disease both demonstrate the accumulation of beta-amyloid protein containing "plaques" and tau protein containing "tangles" that contribute to accelerated memory loss and cognitive decline. 2020-05-11 2023-08-13 mouse
Emily J Koller, Elsa Gonzalez De La Cruz, Timothy Machula, Kristen R Ibanez, Wen-Lang Lin, Tosha Williams, Cara J Riffe, Daniel Ryu, Kevin H Strang, Xuefei Liu, Christopher Janus, Todd E Golde, Dennis Dickson, Benoit I Giasson, Paramita Chakrabart. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy. Human molecular genetics. vol 28. issue 19. 2020-05-11. PMID:31261380. understanding the biological functions of tau variants can illuminate differential etiologies of alzheimer's disease (ad) and primary tauopathies. 2020-05-11 2023-08-13 mouse
Carla M Startin, Nicholas J Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K Wiseman, Kin Y Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, André Strydo. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:30902060. plasma biomarkers for amyloid, tau, and cytokines in down syndrome and sporadic alzheimer's disease. 2020-05-08 2023-08-13 Not clear
J S Miners, P G Kehoe, S Love, H Zetterberg, K Blenno. CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31521199. we aimed to assess the relationship between levels of a cerebrospinal fluid (csf) marker of pericyte damage, soluble platelet-derived growth factor receptor β (spdgfrβ) and csf markers of blood-brain barrier (bbb) integrity (csf albumin and csf/serum albumin ratio) and disease pathology (reduced csf aβ42 and elevated csf total and phosphorylated tau) in alzheimer's disease (ad). 2020-05-08 2023-08-13 Not clear
Cecilia A Brunello, Maria Merezhko, Riikka-Liisa Uronen, Henri J Huttune. Mechanisms of secretion and spreading of pathological tau protein. Cellular and molecular life sciences : CMLS. vol 77. issue 9. 2020-05-08. PMID:31667556. accumulation of misfolded and aggregated forms of tau protein in the brain is a neuropathological hallmark of tauopathies, such as alzheimer's disease and frontotemporal lobar degeneration. 2020-05-08 2023-08-13 Not clear
Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman, Viviana Gradinaru, Martin Kampmann, Kenneth S Kosi. LRP1 is a master regulator of tau uptake and spread. Nature. vol 580. issue 7803. 2020-05-08. PMID:32296178. the microtubule-associated protein tau has a central role in the pathogenesis of several forms of dementia known as tauopathies-including alzheimer's disease, frontotemporal dementia and chronic traumatic encephalopathy 2020-05-08 2023-08-13 Not clear
Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in alzheimer's disease. 2020-05-07 2023-08-13 human
Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. individuals with alzheimer's disease (ad) dementia exhibit significant heterogeneity across clinical symptoms, atrophy patterns, and spatial distribution of tau deposition. 2020-05-07 2023-08-13 human
Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. taken together, these results suggest that distinct atrophy-cognitive patterns exist in typical alzheimer's disease, and are associated with distinct patterns of tau depositions before clinical dementia emerges. 2020-05-07 2023-08-13 human
Sepideh Shokouhi, Alexander C Conley, Suzanne L Baker, Kimberly Albert, Hakmook Kang, Harry E Gwirtsman, Paul A Newhous. The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults. Neurobiology of aging. vol 81. 2020-05-06. PMID:31207466. we evaluated the associations of subjective (self-reported everyday cognition [ecog]) and objective cognitive measures with regional amyloid-β (aβ) and tau accumulation in 86 clinically normal elderly subjects from the alzheimer's disease neuroimaging initiative. 2020-05-06 2023-08-13 human
Edmond Teng, Michael Ward, Paul T Manser, Sandra Sanabria-Bohorquez, Rebecca D Ray, Kristin R Wildsmith, Suzanne Baker, Geoffrey A Kerchner, Robby M Weime. Cross-sectional associations between [ Neurobiology of aging. vol 81. 2020-05-06. PMID:31280117. cross-sectional associations between [ the regional relationships between tau positron emission tomography (pet) imaging and cognitive impairment in alzheimer's disease (ad) remain uncertain. 2020-05-06 2023-08-13 Not clear
Rik van der Kant, Lawrence S B Goldstein, Rik Ossenkoppel. Amyloid-β-independent regulators of tau pathology in Alzheimer disease. Nature reviews. Neuroscience. vol 21. issue 1. 2020-05-06. PMID:31780819. amyloid-β-independent regulators of tau pathology in alzheimer disease. 2020-05-06 2023-08-13 mouse
Zhicheng Chen, David Mengel, Ashvini Keshavan, Robert A Rissman, Andrew Billinton, Michael Perkinton, Jennifer Percival-Alwyn, Aaron Schultz, Michael Properzi, Keith Johnson, Dennis J Selkoe, Reisa A Sperling, Purvish Patel, Henrik Zetterberg, Douglas Galasko, Jonathan M Schott, Dominic M Wals. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30419228. learnings about the complexity of extracellular tau aid development of a blood-based screen for alzheimer's disease. 2020-05-05 2023-08-13 Not clear
Zhicheng Chen, David Mengel, Ashvini Keshavan, Robert A Rissman, Andrew Billinton, Michael Perkinton, Jennifer Percival-Alwyn, Aaron Schultz, Michael Properzi, Keith Johnson, Dennis J Selkoe, Reisa A Sperling, Purvish Patel, Henrik Zetterberg, Douglas Galasko, Jonathan M Schott, Dominic M Wals. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30419228. the tau protein plays a central role in alzheimer's disease (ad), and there is huge interest in measuring tau in blood and cerebrospinal fluid (csf). 2020-05-05 2023-08-13 Not clear
Xiao-Guang Li, Xiao-Yue Hong, Ya-Li Wang, Shu-Juan Zhang, Jun-Fei Zhang, Xia-Chun Li, Yan-Chao Liu, Dong-Shen Sun, Qiong Feng, Jin-Wang Ye, Yuan Gao, Dan Ke, Qun Wang, Hong-Lian Li, Keqiang Ye, Gong-Ping Liu, Jian-Zhi Wan. Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression. EMBO reports. vol 20. issue 6. 2020-05-05. PMID:31085626. intracellular tau accumulation forming neurofibrillary tangles is hallmark pathology of alzheimer's disease (ad), but how tau accumulation induces synapse impairment is elusive. 2020-05-05 2023-08-13 human
Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenber. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. eLife. vol 8. 2020-05-05. PMID:31612856. alzheimer's disease (ad) pathology is characterized by plaques of amyloid beta (aβ) and neurofibrillary tangles of tau. 2020-05-05 2023-08-13 Not clear
Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. grk5 influences the phosphorylation of tau via gsk3β and contributes to alzheimer's disease. 2020-05-04 2023-08-13 mouse
Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. taken together, our findings suggest that grk5 deficiency contributes to the pathogenesis of alzheimer's disease by influencing the hyperphosphorylation of tau through the activation of gsk3β. 2020-05-04 2023-08-13 mouse