| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nasratullah Wahidi, Alan J Lerne. Blood Pressure Control and Protection of the Aging Brain. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 3. 2020-06-25. PMID:31161491. |
blood pressure interacts with alzheimer disease pathology in numerous and unpredictable ways, affecting both β-amyloid and tau deposition, while also interacting with ad genetic risk factors and other metabolic processes. |
2020-06-25 |
2023-08-13 |
Not clear |
| Deepti Putcha, Michael Brickhouse, Alexandra Touroutoglou, Jessica A Collins, Megan Quimby, Bonnie Wong, Mark Eldaief, Aaron Schultz, Georges El Fakhri, Keith Johnson, Bradford C Dickerson, Scott M McGinni. Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy. NeuroImage. Clinical. vol 23. 2020-06-25. PMID:31200149. |
visual cognition in non-amnestic alzheimer's disease: relations to tau, amyloid, and cortical atrophy. |
2020-06-25 |
2023-08-13 |
Not clear |
| Joseph R Winer, Bryce A Mander, Randolph F Helfrich, Anne Maass, Theresa M Harrison, Suzanne L Baker, Robert T Knight, William J Jagust, Matthew P Walke. Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 32. 2020-06-25. PMID:31209175. |
recent proposals suggest that sleep may be a factor associated with accumulation of two core pathological features of alzheimer's disease (ad): tau and β-amyloid (aβ). |
2020-06-25 |
2023-08-13 |
human |
| Saffire H Krance, Hugo Cogo-Moreira, Jennifer S Rabin, Sandra E Black, Walter Swardfage. Reciprocal Predictive Relationships between Amyloid and Tau Biomarkers in Alzheimer's Disease Progression: An Empirical Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 37. 2020-06-25. PMID:31350262. |
reciprocal predictive relationships between amyloid and tau biomarkers in alzheimer's disease progression: an empirical model. |
2020-06-25 |
2023-08-13 |
Not clear |
| Saffire H Krance, Hugo Cogo-Moreira, Jennifer S Rabin, Sandra E Black, Walter Swardfage. Reciprocal Predictive Relationships between Amyloid and Tau Biomarkers in Alzheimer's Disease Progression: An Empirical Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 37. 2020-06-25. PMID:31350262. |
there is an urgent need to understand the relationships between amyloid-β (aβ) and tau in the progression of alzheimer's disease to identify treatment targets. |
2020-06-25 |
2023-08-13 |
Not clear |
| Luiza Kvitko Axelrud, João Ricardo Sato, Marcos Leite Santoro, Fernanda Talarico, Daniel Samuel Pine, Luis Augusto Rohde, Andre Zugman, Edson Amaro Junior, Rodrigo Affonseca Bressan, Rodrigo Grassi-Oliveira, Pedro Mario Pan, Maurício Scopel Hoffmann, Andre Rafael Simioni, Salvador Martin Guinjoan, Hakon Hakonarson, Elisa Brietzke, Ary Gadelha, Renata Pellegrino da Silva, Marcelo Queiroz Hoexter, Euripedes Constantino Miguel, Sintia Iole Belangero, Giovanni Abrahão Salu. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents. Neurobiology of aging. vol 82. 2020-06-25. PMID:31376729. |
here, we aim to investigate whether the polygenic risk score for alzheimer's disease (ad-prs) influences the connectivity among regions susceptible to tau pathology during childhood and adolescence. |
2020-06-25 |
2023-08-13 |
human |
| Rachel L Nosheny, Philip S Insel, Niklas Mattsson, Duygu Tosun, Shannon Buckley, Diana Truran, N Schuff, Paul S Aisen, Michael W Weine. Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. Neurobiology of aging. vol 82. 2020-06-25. PMID:31437719. |
in 80 cu participants from the alzheimer's disease neuroimaging initiative, we determined effects of aβ and age on longitudinal, regional atrophy rates, while accounting for confounding variables including sex, apoe ε4 genotype, white matter lesions, and cerebrospinal fluid total and phosphorylated tau levels. |
2020-06-25 |
2023-08-13 |
human |
| Stephanie L Leal, Lorena A Ferguson, Theresa M Harrison, William J Jagus. Development of a mnemonic discrimination task using naturalistic stimuli with applications to aging and preclinical Alzheimer's disease. Learning & memory (Cold Spring Harbor, N.Y.). vol 26. issue 7. 2020-06-24. PMID:31209116. |
while both young and older adults showed similar patterns of forgetting of repeated emotional and neutral clips, older adults showed preserved neutral compared to emotional discrimination after 24 h. further, lure discrimination performance correlated with medial temporal lobe tau in older adults with preclinical alzheimer's disease. |
2020-06-24 |
2023-08-13 |
human |
| Daniel Twohig, Henrietta M Nielse. α-synuclein in the pathophysiology of Alzheimer's disease. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31186026. |
the alzheimer's disease (ad) afflicted brain is neuropathologically defined by extracellular amyloid-β (aβ) plaques and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2020-06-23 |
2023-08-13 |
human |
| Erica Acquarone, Elentina K Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D'Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorit. Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31248451. |
soluble aggregates of oligomeric forms of tau protein (otau) have been associated with impairment of synaptic plasticity and memory in alzheimer's disease. |
2020-06-23 |
2023-08-13 |
Not clear |
| Peng Liu, Benjamin R Smith, Eric S Huang, Abhishek Mahesh, Jean Paul G Vonsattel, Ashley J Petersen, Rocio Gomez-Pastor, Karen H Ash. A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients. Acta neuropathologica communications. vol 7. issue 1. 2020-06-23. PMID:31358058. |
our recent study indicates that casp2-catalyzed tau cleavage at aspartate 314 (tau 2n4r isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Δtau314, the soluble, n-terminal cleavage product, are elevated in individuals with mild cognitive impairment and alzheimer's disease, compared with cognitively normal individuals. |
2020-06-23 |
2023-08-13 |
mouse |
| Benjamin R Smith, Kathryn M Nelson, Lisa J Kemper, Kailee Leinonen-Wright, Ashley Petersen, C Dirk Keene, Karen H Ash. A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta neuropathologica communications. vol 7. issue 1. 2020-06-23. PMID:31362787. |
recently, a soluble form of tau, Δtau314, which is generated when caspase-2 (casp2) cleaves tau at asp314, was reported to be associated with impaired cognition in mice modeling frontotemporal dementia, and with mild cognitive impairment and alzheimer's disease (ad) in humans. |
2020-06-23 |
2023-08-13 |
mouse |
| Michael A DeTure, Dennis W Dickso. The neuropathological diagnosis of Alzheimer's disease. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31375134. |
confounding efforts to develop effective diagnostic tools and disease-modifying therapies is the realization that alzheimer's disease is a mixed proteinopathy (amyloid and tau) frequently associated with other age-related processes such as cerebrovascular disease and lewy body disease. |
2020-06-23 |
2023-08-13 |
Not clear |
| Jorge J Llibre-Guerra, Yan Li, Suzanne E Schindler, Brian A Gordon, Anne M Fagan, John C Morris, Tammie L S Benzinger, Jason Hassenstab, Guoqiao Wang, Ricardo Allegri, Sarah B Berman, Jasmeer Chhatwal, Martin R Farlow, David M Holtzman, Mathias Jucker, Johannes Levin, James M Noble, Stephen Salloway, Peter Schofield, Celeste Karch, Nick C Fox, Chengjie Xiong, Randall J Bateman, Eric McDad. Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. JAMA network open. vol 2. issue 12. 2020-06-23. PMID:31825500. |
association of longitudinal changes in cerebrospinal fluid total tau and phosphorylated tau 181 and brain atrophy with disease progression in patients with alzheimer disease. |
2020-06-23 |
2023-08-13 |
Not clear |
| Ting-Bin Chen, Yu-Hua Lai, Ting-Ling Ke, Jun-Peng Chen, Yi-Jung Lee, Szu-Ying Lin, Po-Chen Lin, Pei-Ning Wang, Irene H Chen. Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease. Dementia and geriatric cognitive disorders. vol 48. issue 3-4. 2020-06-23. PMID:31991443. |
changes in plasma amyloid and tau in a longitudinal study of normal aging, mild cognitive impairment, and alzheimer's disease. |
2020-06-23 |
2023-08-13 |
human |
| Adeline M Fanni, Crystal M Vander Zanden, Paulina V Majewska, Jaroslaw Majewski, Eva Y Ch. Membrane-mediated fibrillation and toxicity of the tau hexapeptide PHF6. The Journal of biological chemistry. vol 294. issue 42. 2020-06-22. PMID:31439664. |
the aggregation of the tau protein into neurofibrillary tangles is believed to correlate with cognitive decline in several neurodegenerative disorders, including alzheimer's disease. |
2020-06-22 |
2023-08-13 |
Not clear |
| Yuxing Xia, Zachary A Sorrentino, Justin D Kim, Kevin H Strang, Cara J Riffe, Benoit I Giasso. Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations. The Journal of biological chemistry. vol 294. issue 48. 2020-06-22. PMID:31653695. |
tau can aberrantly aggregate into pathological inclusions that define alzheimer's disease, frontotemporal dementias, and other tauopathies. |
2020-06-22 |
2023-08-13 |
Not clear |
| Stephanie L Garrett, Darius McDaniel, Malik Obideen, Antoine R Trammell, Leslie M Shaw, Felicia C Goldstein, Ihab Hajja. Racial Disparity in Cerebrospinal Fluid Amyloid and Tau Biomarkers and Associated Cutoffs for Mild Cognitive Impairment. JAMA network open. vol 2. issue 12. 2020-06-22. PMID:31834392. |
prior evidence suggests that racial differences exist in tau biomarkers in mild cognitive impairment (mci) and alzheimer disease (ad). |
2020-06-22 |
2023-08-13 |
Not clear |
| Jessica L Binder, Praveen Chander, Vojo Deretic, Jason P Weick, Kiran Bhaska. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. PloS one. vol 15. issue 3. 2020-06-22. PMID:32208437. |
pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of alzheimer's disease (ad) and related tauopathies. |
2020-06-22 |
2023-08-13 |
human |
| Atsuko Kubo, Shouyou Ueda, Ayaka Yamane, Satoko Wada-Kakuda, Mai Narita, Makoto Matsuyama, Akane Nomori, Akihiko Takashima, Taisuke Kato, Osamu Onodera, Motohito Goto, Mamoru Ito, Takami Tomiyama, Hiroshi Mori, Shigeo Murayama, Yasuo Ihara, Hiroaki Misonou, Tomohiro Miyasak. Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 34. 2020-06-19. PMID:31235644. |
in alzheimer's disease, the distribution of tau undergoes a remarkable alteration, leading to the formation of tau inclusions in the somatodendritic compartment. |
2020-06-19 |
2023-08-13 |
mouse |