All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jennifer Abbas. Alzheimer Blood Test Using Tau Biomarker Is in Development. JAMA. vol 323. issue 14. 2020-04-21. PMID:32286632. alzheimer blood test using tau biomarker is in development. 2020-04-21 2023-08-13 Not clear
Duraiswamy Basavan, Nehru S S Chalichem, Mohan K S Kuma. Phytoconstituents and their Possible Mechanistic Profile for Alzheimer's Disease - A Literature Review. Current drug targets. vol 20. issue 3. 2020-04-20. PMID:30101703. alzheimer's disease (ad) is one of such diseases whose origin is enigmatic, having an impact on later stage of life drastically due to irreparable damage of cognition, characterised by the presence of neurotoxic amyloid-beta (aβ) plaques and hyper phosphorylated tau protein as fibrillary tangles. 2020-04-20 2023-08-13 human
Cristina Vergara, Sarah Houben, Valérie Suain, Zehra Yilmaz, Robert De Decker, Virginie Vanden Dries, Alain Boom, Salwa Mansour, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30599077. amyloid-β pathology enhances pathological fibrillary tau seeding induced by alzheimer phf in vivo. 2020-04-20 2023-08-13 Not clear
Cristina Vergara, Sarah Houben, Valérie Suain, Zehra Yilmaz, Robert De Decker, Virginie Vanden Dries, Alain Boom, Salwa Mansour, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30599077. neuropathological analysis in alzheimer's disease (ad) and experimental evidence in transgenic models overexpressing frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) mutant tau suggest that amyloid-β pathology enhances the development of tau pathology. 2020-04-20 2023-08-13 Not clear
Shanshan Li, Weiyun Li, Xuewei Wu, Jing Li, Jing Yang, Chunlong Tu, Xuesong Ye, Shucai Lin. Olfactory deficit is associated with mitral cell dysfunction in the olfactory bulb of P301S tau transgenic mice. Brain research bulletin. vol 148. 2020-04-17. PMID:30902575. neurofibrillary tangles consisting of hyperphosphorylated tau (p-tau) are the neuropathological hallmark of alzheimer's disease (ad), and olfaction disorder is an early symptom of ad. 2020-04-17 2023-08-13 mouse
Tobey J Betthause. AD molecular: Imaging tau aggregates with positron emissions tomography. Progress in molecular biology and translational science. vol 165. 2020-04-17. PMID:31481160. this chapter describes the development and characterization of several positron emission tomography radioligands used to detect tau pathophysiology in vivo, and how these ligands are being used in clinical aging and neurodegenerative disease research with a focus on imaging tau aggregates in alzheimer's disease. 2020-04-17 2023-08-13 Not clear
Adam P Mecc. AD molecular: Molecular imaging of Alzheimer's disease: PET imaging of neurotransmitter systems. Progress in molecular biology and translational science. vol 165. 2020-04-17. PMID:31481161. current understanding of alzheimer's disease (ad) pathogenesis relies on the observed accumulations of amyloid β and phosphorylated tau aggregates that are thought to play key roles in initiating or propagating disease. 2020-04-17 2023-08-13 Not clear
Qiong-Qiong Yao, Liu Hong, Si Wu, Sarah Perret. Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis. Physical chemistry chemical physics : PCCP. vol 22. issue 14. 2020-04-17. PMID:32207466. the self-assembly of tau protein into amyloid structures is associated with alzheimer's disease and other tauopathies. 2020-04-17 2023-08-13 Not clear
Dhiraj Kumar, Pravir Kuma. An In-Silico Investigation of Key Lysine Residues and Their Selection for Clearing off Aβ and Holo-AβPP Through Ubiquitination. Interdisciplinary sciences, computational life sciences. vol 11. issue 4. 2020-04-16. PMID:30194628. herein, (1) we identified the aggregation prone sequence in aβ40 and aβ42 as 'hhqklvffae' and 'sgyevhhqklvffaedvg/kgaiiglmvggv' respectively with critical lysine (k) at 16 and 28 for stabilizing the aggregates; (2) elucidated the interaction pattern of aβpp with other alzheimer's related proteins bace1, apoe, snca, apbb1, casp8, nae1, adam10, and psen1 to describe the pathophysiology; (3) found apoe as commonly interacting factor between amyloid beta and tau for governing ad pathogenesis; (4) reported k224, k351, k363, k377, k601, k662, k751, and k763 as potential putative lysine for facilitating aβpp clearance through ubiquitination thereby arresting aβ formation; and (5) observed conserved glutamine (q), glutamic acid (e), and alpha-helical conformation as few crucial factors for lysine selectivity in the ubiquitination of aβpp. 2020-04-16 2023-08-13 Not clear
Laura Lorente-Gea, Beatriz García, Carla Martín, Helena Ordiales, Olivia García-Suárez, Kelvin M Piña-Batista, Jesús Merayo-Lloves, Luís M Quirós, Iván Fernández-Veg. Heparan Sulfate Proteoglycans Undergo Differential Expression Alterations in Alzheimer Disease Brains. Journal of neuropathology and experimental neurology. vol 79. issue 5. 2020-04-16. PMID:32232475. previous studies have reported that heparan sulfate proteoglycans (hspgs) promote amyloid-beta peptide and tau fibrillization in alzheimer disease (ad) and provide resistance against proteolytic breakdown. 2020-04-16 2023-08-13 Not clear
Marine Tournissac, Philippe Bourassa, Ruben D Martinez-Cano, Tra-My Vu, Sébastien S Hébert, Emmanuel Planel, Frédéric Calo. Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation. Molecular metabolism. vol 22. 2020-04-13. PMID:30770297. repeated cold exposures protect a mouse model of alzheimer's disease against cold-induced tau phosphorylation. 2020-04-13 2023-08-13 mouse
Suzanne L Baker, Theresa M Harrison, Anne Maass, Renaud La Joie, William J Jagus. Effect of Off-Target Binding on Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 60. issue 10. 2020-04-13. PMID:30877180. effect of off-target binding on measuring early tau accumulation is important in studying aging and alzheimer disease and is only as accurate as the signal-to-noise ratio of the tracer. 2020-04-13 2023-08-13 Not clear
M Grundma. Editorial: Tau Based Therapeutics: Alternative Approaches in the War on Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 6. issue 3. 2020-04-13. PMID:31062822. editorial: tau based therapeutics: alternative approaches in the war on alzheimer's disease. 2020-04-13 2023-08-13 Not clear
Xiaoming Wang, Chunyan Chang, Dongxue Wang, Shanchao Hon. Systematic profiling of SH3-mediated Tau-Partner interaction network in Alzheimer's disease by integrating in silico analysis and in vitro assay. Journal of molecular graphics & modelling. vol 90. 2020-04-13. PMID:31112821. the aberrant assembly of microtubule-associated protein tau (τ) into insoluble aggregates is closely related to alzheimer's disease (ad), which is elicited from tau phosphorylation events and regulated by the specific intermolecular recognition between the proline-rich pxxp motifs of tau and the sh3 domains of its diverse partner proteins/kinases. 2020-04-13 2023-08-13 Not clear
Whitney Wharton, Alexander L Kollhoff, Umesh Gangishetti, Danielle D Verble, Samsara Upadhya, Henrik Zetterberg, Veena Kumar, Kelly D Watts, Andrea J Kippels, Marla Gearing, J Christina Howell, Monica W Parker, William T H. Interleukin 9 alterations linked to alzheimer disease in african americans. Annals of neurology. vol 86. issue 3. 2020-04-13. PMID:31271450. compared to older caucasians, older african americans have higher risks of developing alzheimer disease (ad) and lower cerebrospinal fluid (csf) tau biomarker levels. 2020-04-13 2023-08-13 Not clear
Christina Ising, Carmen Venegas, Shuangshuang Zhang, Hannah Scheiblich, Susanne V Schmidt, Ana Vieira-Saecker, Stephanie Schwartz, Shadi Albasset, Róisín M McManus, Dario Tejera, Angelika Griep, Francesco Santarelli, Frederic Brosseron, Sabine Opitz, James Stunden, Maximilian Merten, Rakez Kayed, Douglas T Golenbock, David Blum, Eicke Latz, Luc Buée, Michael T Henek. NLRP3 inflammasome activation drives tau pathology. Nature. vol 575. issue 7784. 2020-04-13. PMID:31748742. alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline 2020-04-13 2023-08-13 Not clear
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-10. PMID:32002968. ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. 2020-04-10 2023-08-13 Not clear
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-10. PMID:32002968. the best known out of these diseases is alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. 2020-04-10 2023-08-13 Not clear
Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewer. Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-04-09. PMID:31953405. functional brain architecture is associated with the rate of tau accumulation in alzheimer's disease. 2020-04-09 2023-08-13 human
Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewer. Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-04-09. PMID:31953405. in alzheimer's diseases (ad), tau pathology is strongly associated with cognitive decline. 2020-04-09 2023-08-13 human