| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huiying Yan, Lina Feng, Mingquan L. The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer's Disease. Drug design, development and therapy. vol 17. 2023-12-01. PMID:38024535. |
the role of traditional chinese medicine natural products in β-amyloid deposition and tau protein hyperphosphorylation in alzheimer's disease. |
2023-11-29 |
2023-12-07 |
Not clear |
| Sehong Min, Rodrigo Mohallem, Uma K Aryal, Tamara L Kinzer-Ursem, Jean-Christophe Roche. Effects of Neighboring Phosphorylation Events on the Affinities of pT181-Tau Antibodies. Analytical chemistry. 2023-11-28. PMID:38014879. |
a tau variant phosphorylated on threonine 181 (pt181-tau) has been widely investigated as a potential alzheimer's disease (ad) biomarker in cerebrospinal fluid (csf) and blood. |
2023-11-28 |
2023-11-29 |
human |
| Harshitha Santhosh Kumar, James Moore, Adrian C Steiner, Emmanuel Sotirakis, Benjamin Schärli, Patricia Isnard-Petit, Kader Thiam, David P Wolfer, Erik C Böttge. Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain. Cellular and molecular life sciences : CMLS. vol 80. issue 12. 2023-11-27. PMID:38010524. |
to experimentally challenge the role of protein homeostasis in the accumulation of alzheimer's associated protein aβ and levels of associated tau phosphorylation, we disturbed proteostasis in single app knock-in mouse models of ad building upon rps9 d95n, a recently identified mammalian ram mutation which confers heightened levels of error-prone translation together with an increased propensity for random protein aggregation and which is associated with accelerated aging. |
2023-11-27 |
2023-11-29 |
mouse |
| He-Zhou Huang, Wen-Qing Ai, Na Wei, Ling-Shuang Zhu, Zhi-Qiang Liu, Chao-Wen Zhou, Man-Fei Deng, Wen-Tao Zhang, Jia-Chen Zhang, Chun-Qing Yang, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Jun Jia, Jing Wang, Fang-Fang Liu, Ke Li, Qi Xu, Mei Yuan, Hengye Man, Ziyuan Guo, Youming Lu, Kai Shu, Ling-Qiang Zhu, Dan Li. Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. Protein & cell. 2023-11-27. PMID:38011644. |
senktide blocks aberrant rtn3 interactome to retard memory decline and tau pathology in social isolated alzheimer's disease mice. |
2023-11-27 |
2023-11-29 |
mouse |
| Melanie Shulman, Jessica Kong, John O'Gorman, Elena Ratti, Rajasimhan Rajagovindan, Louis Viollet, Ellen Huang, Sanjiv Sharma, Annie M Racine, Julie Czerkowicz, Danielle Graham, Yumeng Li, Heike Hering, Samantha Budd Haeberlei. TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease. Nature aging. 2023-11-27. PMID:38012285. |
in alzheimer's disease, the spread of aberrantly phosphorylated tau is an important criterion in the braak staging of disease severity and correlates with disease symptomatology. |
2023-11-27 |
2023-11-29 |
human |
| Hideki Matsumoto, Kenji Tagai, Hironobu Endo, Kiwamu Matsuoka, Yuhei Takado, Naomi Kokubo, Hitoshi Shimada, Tetsuya Goto, Tazuko K Goto, Makoto Higuch. Association of Tooth Loss with Alzheimer's Disease Tau Pathologies Assessed by Positron Emission Tomography. Journal of Alzheimer's disease : JAD. vol 96. issue 3. 2023-11-26. PMID:37980663. |
association of tooth loss with alzheimer's disease tau pathologies assessed by positron emission tomography. |
2023-11-26 |
2023-11-28 |
mouse |
| Hideki Matsumoto, Kenji Tagai, Hironobu Endo, Kiwamu Matsuoka, Yuhei Takado, Naomi Kokubo, Hitoshi Shimada, Tetsuya Goto, Tazuko K Goto, Makoto Higuch. Association of Tooth Loss with Alzheimer's Disease Tau Pathologies Assessed by Positron Emission Tomography. Journal of Alzheimer's disease : JAD. vol 96. issue 3. 2023-11-26. PMID:37980663. |
a previous study of an alzheimer's disease (ad) model mouse suggests that tooth loss induces denervation of the mesencephalic trigeminal nucleus and neuroinflammation, possibly leading to accelerated tau dissemination from the nearby locus coeruleus (lc). |
2023-11-26 |
2023-11-28 |
mouse |
| Takeshi Kawarabayashi, Takumi Nakamura, Kazuya Miyashita, Tatsuya Segawa, Isamu Fukamachi, Takashi Sugawara, Hironori Oka, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Kouki Makioka, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoj. Clinical Evaluation of Cerebrospinal Fluid p217tau and Neurofilament Light Chain Levels in Patients with Alzheimer's Disease or Other Neurological Diseases. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007650. |
the cerebrospinal fluid (csf) levels of tau phosphorylated at threonine 217 (p217tau) or 181 (p181tau), and neurofilament light chain (nfl) are definite biomarkers of tauopathy and neurodegeneration in alzheimer's disease (ad). |
2023-11-26 |
2023-11-28 |
Not clear |
| Elisa Giunti, Roberto Collu, Sarah Daley, Henry Querfurth, Peter Morin, Richard Killick, Rachel D Melamed, Weiming Xi. Reduction of Phosphorylated Tau in Alzheimer's Disease Induced Pluripotent Stem Cell-Derived Neuro-Spheroids by Rho-Associated Coiled-Coil Kinase Inhibitor Fasudil. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007655. |
reduction of phosphorylated tau in alzheimer's disease induced pluripotent stem cell-derived neuro-spheroids by rho-associated coiled-coil kinase inhibitor fasudil. |
2023-11-26 |
2023-11-28 |
Not clear |
| Katerina A Tetzloff, Joseph R Duffy, Heather M Clark, Nha Trang Thu Pham, Mary M Machulda, Hugo Botha, Clifford R Jack, Dennis W Dickson, Val J Lowe, Keith A Josephs, Jennifer L Whitwell, Rene L Utiansk. Amyloid and Tau PET Positivity in Progressive Agrammatic Aphasia and Apraxia of Speech. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007664. |
these patients typically have an underlying 4-repeat tauopathy, although they sometimes show evidence of amyloid-β and tau deposition on pet, suggesting alzheimer's disease (ad). |
2023-11-26 |
2023-11-28 |
Not clear |
| Thea J Rosewood, Kwangsik Nho, Shannon L Risacher, Sujuan Gao, Li Shen, Tatiana Foroud, Andrew J Saykin, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Genome-Wide Association Analysis across Endophenotypes in Alzheimer's Disease: Main Effects and Disease Stage-Specific Interactions. Genes. vol 14. issue 11. 2023-11-25. PMID:38002954. |
ad endophenotypes based on amyloid-β, tau, and neurodegeneration (a/t/n) biomarkers and cognitive performance were selected from the alzheimer's disease neuroimaging initiative (adni) cohort (n = 1565). |
2023-11-25 |
2023-11-28 |
Not clear |
| Dan Tang, Chang Sun, Jumei Yang, Lili Fan, Yonggang Wan. Advances in the Study of the Pathology and Treatment of Alzheimer's Disease and Its Association with Periodontitis. Life (Basel, Switzerland). vol 13. issue 11. 2023-11-25. PMID:38004343. |
the two main pathological features of alzheimer's disease are the extracellular deposition of β-amyloid (aβ) to form senile plaques and the intracellular aggregation of hyperphosphorylated tau protein to form neurofibrillary tangles (nfts). |
2023-11-25 |
2023-11-28 |
Not clear |
| Hansol Lee, Jessie Fanglu Fu, Kyla Gaudet, Annie G Bryant, Julie C Price, Rachel E Bennett, Keith A Johnson, Bradley T Hyman, Trey Hedden, David H Salat, Yi-Fen Yen, Susie Y Huan. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-11-24. PMID:38000018. |
aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and alzheimer's disease. |
2023-11-24 |
2023-11-28 |
mouse |
| Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. |
synaptic loss is closely associated with tau aggregation and microglia activation in later stages of alzheimer's disease (ad). |
2023-11-24 |
2023-11-28 |
Not clear |
| Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih-Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E Tanzi, Changning Wang, Can Zhan. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-11-22. PMID:37990786. |
considerable evidence suggests that hdac6 is closely related to amyloid and tau pathology, the two primary hallmarks of alzheimer's disease (ad). |
2023-11-22 |
2023-11-29 |
Not clear |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-21. PMID:37986964. |
temporal tau asymmetry spectrum influences divergent behavior and language patterns in alzheimer's disease. |
2023-11-21 |
2023-11-29 |
human |
| Kyan Younes, Viktorija Smith, Emily Johns, Mackenzie L Carlson, Joseph Winer, Zihuai He, Victor W Henderson, Michael D Greicius, Christina B Young, Elizabeth C Mormin. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-21. PMID:37986964. |
this cross-sectional study investigated the correlation between temporal tau pet asymmetry and behavior assessed using the neuropsychiatric inventory, and composite scores for memory, executive function, and language; using data from the alzheimer's disease neuroimaging initiative (adni) dataset. |
2023-11-21 |
2023-11-29 |
human |
| Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Cher. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. The Journal of clinical investigation. 2023-11-21. PMID:37988169. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (ptau), and microglia activation. |
2023-11-21 |
2023-11-29 |
mouse |
| Xiao Xue Zeng, Jie Bangzhe Zen. Systems Medicine as a Strategy to Deal with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-11-19. PMID:37980671. |
the traits of alzheimer's disease (ad) include amyloid plaques made of aβ1-40 and aβ1-42, and neurofibrillary tangles by the hyperphosphorylation of tau protein. |
2023-11-19 |
2023-11-29 |
Not clear |
| Ahmet Sarper Bozkurt, Şenay Görücü Yílma. Ferroptotic Potency of ISM1 Expression in the Drug-Induced Alzheimer's Disease-Like Phenotype Under the Influence of Betulin. Journal of Alzheimer's disease : JAD. 2023-11-19. PMID:37980676. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by two main pathological mechanisms, mostly hyperphosphorylated tau and amyloid-β toxicity. |
2023-11-19 |
2023-11-29 |
Not clear |