All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Julika J Götz, Jürgen Göt. Experimental Models of Tauopathy - From Mechanisms to Therapies. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096051. another aspect is the emerging role of tau in the translational machinery and the finding that the somatodendritic accumulation of tau in alzheimer's disease may in part be due to the induction of the de novo synthesis of tau by amyloid-β via the fyn/erk/s6 pathway. 2020-04-08 2023-08-13 mouse
Mikio Shoj. Cerebrospinal Fluid and Plasma Tau as a Biomarker for Brain Tauopathy. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096052. cerebrospinal fluid (csf) tau and phosphorylated tau (ptau) are definite biomarkers of alzheimer's disease (ad). 2020-04-08 2023-08-13 Not clear
Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Sarah B Berman, Takeshi Ikeuchi, Hiroshi Mori, Hiroyuki Shimada, Mikio Shoji, Kazushi Suzuki, James Noble, Martin Farlow, Jasmeer Chhatwal, Neill R Graff-Radford, Stephen Salloway, Peter R Schofield, Colin L Masters, Ralph N Martins, Antoinette O'Connor, Nick C Fox, Johannes Levin, Mathias Jucker, Audrey Gabelle, Sylvain Lehmann, Chihiro Sato, Randall J Bateman, Eric McDad. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature medicine. vol 26. issue 3. 2020-04-07. PMID:32161412. a soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited alzheimer's disease. 2020-04-07 2023-08-13 Not clear
Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Sarah B Berman, Takeshi Ikeuchi, Hiroshi Mori, Hiroyuki Shimada, Mikio Shoji, Kazushi Suzuki, James Noble, Martin Farlow, Jasmeer Chhatwal, Neill R Graff-Radford, Stephen Salloway, Peter R Schofield, Colin L Masters, Ralph N Martins, Antoinette O'Connor, Nick C Fox, Johannes Levin, Mathias Jucker, Audrey Gabelle, Sylvain Lehmann, Chihiro Sato, Randall J Bateman, Eric McDad. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature medicine. vol 26. issue 3. 2020-04-07. PMID:32161412. development of tau-based therapies for alzheimer's disease requires an understanding of the timing of disease-related changes in tau. 2020-04-07 2023-08-13 Not clear
Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Sarah B Berman, Takeshi Ikeuchi, Hiroshi Mori, Hiroyuki Shimada, Mikio Shoji, Kazushi Suzuki, James Noble, Martin Farlow, Jasmeer Chhatwal, Neill R Graff-Radford, Stephen Salloway, Peter R Schofield, Colin L Masters, Ralph N Martins, Antoinette O'Connor, Nick C Fox, Johannes Levin, Mathias Jucker, Audrey Gabelle, Sylvain Lehmann, Chihiro Sato, Randall J Bateman, Eric McDad. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature medicine. vol 26. issue 3. 2020-04-07. PMID:32161412. we quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four decades of disease progression in dominantly inherited alzheimer's disease. 2020-04-07 2023-08-13 Not clear
Irene Sintini, Christopher G Schwarz, Peter R Martin, Jonathan Graff-Radford, Mary M Machulda, Matthew L Senjem, Robert I Reid, Anthony J Spychalla, Daniel A Drubach, Val J Lowe, Clifford R Jack, Keith A Josephs, Jennifer L Whitwel. Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease. Human brain mapping. vol 40. issue 5. 2020-04-06. PMID:30549156. regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical alzheimer's disease. 2020-04-06 2023-08-13 Not clear
Yung-Chih Kuo, Chang-Li Chen, Rajendiran Rajes. Optimized liposomes with transactivator of transcription peptide and anti-apoptotic drugs to target hippocampal neurons and prevent tau-hyperphosphorylated neurodegeneration. Acta biomaterialia. vol 87. 2020-04-06. PMID:30716553. the optimized tat-ngf-ra-curc-qu-cl/pa-lip can be a capable drug delivery system to cross the bbb and protect alzheimer's disease brains from tau hyperphosphorylation. 2020-04-06 2023-08-13 rat
Yung-Chih Kuo, Chang-Li Chen, Rajendiran Rajes. Optimized liposomes with transactivator of transcription peptide and anti-apoptotic drugs to target hippocampal neurons and prevent tau-hyperphosphorylated neurodegeneration. Acta biomaterialia. vol 87. 2020-04-06. PMID:30716553. the optimized tat-ngf-ra-curc-qu-cl/pa-lip efficaciously down-regulated the expressions of phosphorylated extracellular signal-regulated protein kinase 1/2 (p-erk1/2), c-jun n-terminal protein kinase, p38, tau at serine 202 and caspase-3, and up-regulated the expressions of p-erk5 and p-cyclic adenosine monophosphate response element-binding protein in alzheimer's disease wistar rat model. 2020-04-06 2023-08-13 rat
Shweta Kishor Sonawane, Abhishek Ankur Balmik, Debjyoti Boral, Sureshkumar Ramasamy, Subashchandrabose Chinnathamb. Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers. Archives of biochemistry and biophysics. vol 675. 2020-04-06. PMID:31568753. overall, the potential of baicalein in dissolving the preformed tau oligomers as well as mature fibrils can be of utmost importance in therapeutics for alzheimer's disease. 2020-04-06 2023-08-13 Not clear
Carina Wattmo, Kaj Blennow, Oskar Hansso. Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer's disease. BMC neurology. vol 20. issue 1. 2020-04-03. PMID:31918679. cerebro-spinal fluid biomarker levels: phosphorylated tau (t) and total tau (n) as markers for rate of progression in alzheimer's disease. 2020-04-03 2023-08-13 Not clear
Carina Wattmo, Kaj Blennow, Oskar Hansso. Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer's disease. BMC neurology. vol 20. issue 1. 2020-04-03. PMID:31918679. we investigated the potential associations between cerebro-spinal fluid (csf) levels of phosphorylated tau (p-tau) and total tau (t-tau) with short-term response to cholinesterase inhibitor (chei) treatment, longitudinal outcome and progression rates in alzheimer's disease (ad). 2020-04-03 2023-08-13 Not clear
Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P Hange. A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response. Acta neuropathologica communications. vol 7. issue 1. 2020-04-02. PMID:30606258. human tauopathies including alzheimer's disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. 2020-04-02 2023-08-13 human
Yari Carlomagno, Dah-Eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M Avendano, Monica Castanedes-Casey, Kelly M Hinkle, Karen Jansen-West, Lillian M Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D Fryer, Dennis W Dickson, Leonard Petrucelli, Casey Coo. Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant. Acta neuropathologica communications. vol 7. issue 1. 2020-04-02. PMID:30674342. pathogenic mutations in the tau gene (microtubule associated protein tau, mapt) are linked to the onset of tauopathy, but the a152t variant is unique in acting as a risk factor for a range of disorders including alzheimer's disease (ad), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and dementia with lewy bodies (dlb). 2020-04-02 2023-08-13 mouse
Irene Sintini, Peter R Martin, Jonathan Graff-Radford, Matthew L Senjem, Christopher G Schwarz, Mary M Machulda, Anthony J Spychalla, Daniel A Drubach, David S Knopman, Ronald C Petersen, Val J Lowe, Clifford R Jack, Keith A Josephs, Jennifer L Whitwel. Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease. NeuroImage. Clinical. vol 23. 2020-04-02. PMID:31004914. the aims of this study were: to examine regional rates of change in tau-pet uptake and grey matter volume in atypical alzheimer's disease (ad); to investigate the role of age in such changes; to describe multimodal regional relationships between tau accumulation and atrophy. 2020-04-02 2023-08-13 Not clear
Solomiia Boyko, Xu Qi, Tien-Hao Chen, Krystyna Surewicz, Witold K Surewic. Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions. The Journal of biological chemistry. vol 294. issue 29. 2020-04-02. PMID:31097543. recent studies have indicated that tau, a protein involved in alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid-liquid phase separation (llps). 2020-04-02 2023-08-13 Not clear
Govinda Sharma, Anni Huo, Taeko Kimura, Seiji Shiozawa, Reona Kobayashi, Naruhiko Sahara, Minaka Ishibashi, Shinsuke Ishigaki, Taro Saito, Kanae Ando, Shigeo Murayama, Masato Hasegawa, Gen Sobue, Hideyuki Okano, Shin-Ichi Hisanag. Tau isoform expression and phosphorylation in marmoset brains. The Journal of biological chemistry. vol 294. issue 30. 2020-04-02. PMID:31171723. hyperphosphorylated tau is a major component of neurofibrillary tangles, a pathological hallmark of alzheimer's disease (ad). 2020-04-02 2023-08-13 mouse
Martin Margitta. Driving tau into phase-separated liquid droplets. The Journal of biological chemistry. vol 294. issue 29. 2020-04-02. PMID:31324714. liquid-liquid phase separation of tau protein has been implicated in normal biological function as well as neurodegenerative diseases, including alzheimer's. 2020-04-02 2023-08-13 Not clear
Darío Tejera, Michael T Henek. In Vivo Phagocytosis Analysis of Amyloid Beta. Methods in molecular biology (Clifton, N.J.). vol 2034. 2020-04-01. PMID:31392693. alzheimer's disease (ad) pathology is characterized by the presence of extracellular amyloid beta (aβ), tau hyperphosphorylation, and neuroinflammation. 2020-04-01 2023-08-13 Not clear
Hongli Liu, Xuewei Liu, Shuangyan Zhou, Xiaoli An, Huanxiang Liu, Xiaojun Ya. Disclosing the Template-Induced Misfolding Mechanism of Tau Protein by Studying the Dissociation of the Boundary Chain from the Formed Tau Fibril Based on a Steered Molecular Dynamics Simulation. ACS chemical neuroscience. vol 10. issue 3. 2020-03-31. PMID:30665304. the level of tau aggregation into neurofibrillary tangles, including paired helical filament (phf) and straight filament (sf), is closely associated with alzheimer's disease. 2020-03-31 2023-08-13 Not clear
Jonas Elias Schweig, Hailan Yao, Kyle Coppola, Chao Jin, Fiona Crawford, Michael Mullan, Daniel Pari. Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation The Journal of biological chemistry. vol 294. issue 36. 2020-03-31. PMID:31324720. moreover, syk hyperactivation occurs in a subset of activated microglia, in dystrophic neurites surrounding aβ deposits, and in neurons affected by tau pathology both in individuals with alzheimer's disease (ad) and in ad mouse models. 2020-03-31 2023-08-13 mouse