All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Omar A Halawa, Jennifer R Gatchel, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Gad A Marshal. Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-03-30. PMID:30704519. inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in alzheimer's disease. 2020-03-30 2023-08-13 Not clear
Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor G Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis D Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee, Norbert Zilk. A walk through tau therapeutic strategies. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30767766. tau neuronal and glial pathologies drive the clinical presentation of alzheimer's disease and related human tauopathies. 2020-03-30 2023-08-13 human
Kyle R Christensen, Thomas G Beach, Geidy E Serrano, Nicholas M Kanaa. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30819250. the deposition of tau pathology in alzheimer's disease (ad) may occur first in axons of neurons and then progress back into the cell bodies to form neurofibrillary tangles, however, studies have not directly analyzed this relationship in relatively discrete circuits within the human hippocampus. 2020-03-30 2023-08-13 human
Yann Fichou, Youssra K Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrie. The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30823892. this field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from alzheimer's and pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. 2020-03-30 2023-08-13 human
Garrett S Gibbons, Soo-Jung Kim, John L Robinson, Lakshmi Changolkar, David J Irwin, Leslie M Shaw, Virginia M-Y Lee, John Q Trojanowsk. Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30832741. detection of alzheimer's disease (ad) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (ftld-tau). 2020-03-30 2023-08-13 Not clear
Garrett S Gibbons, Soo-Jung Kim, John L Robinson, Lakshmi Changolkar, David J Irwin, Leslie M Shaw, Virginia M-Y Lee, John Q Trojanowsk. Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30832741. pathological tau aggregates in alzheimer's disease (ad) and frontotemporal lobar degeneration-tau (ftld-tau) adopt distinct conformations differentiated by the ad-tau specific monoclonal antibody (mab) gt-38 that are not readily visualized using phosphorylation-specific anti-tau mabs. 2020-03-30 2023-08-13 Not clear
Cinthya Aguero, Maeva Dhaynaut, Marc D Normandin, Ana C Amaral, Nicolas J Guehl, Ramesh Neelamegam, Marta Marquie, Keith A Johnson, Georges El Fakhri, Matthew P Frosch, Teresa Gomez-Isl. Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30857558. [f-18]-mk-6240, a novel tau positron emission tomography (pet) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of alzheimer disease. 2020-03-30 2023-08-13 human
Cinthya Aguero, Maeva Dhaynaut, Marc D Normandin, Ana C Amaral, Nicolas J Guehl, Ramesh Neelamegam, Marta Marquie, Keith A Johnson, Georges El Fakhri, Matthew P Frosch, Teresa Gomez-Isl. Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30857558. our data indicate that mk-6240 strongly binds to neurofibrillary tangles in alzheimer disease but does not seem to bind to a significant extent to tau aggregates in non-alzheimer tauopathies, suggesting that it may have a limited utility for the in vivo detection of these pathologies. 2020-03-30 2023-08-13 human
Hanna Cho, Jae Yong Choi, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Clifford R Jack, Chul Hyoung Lyo. Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 60. issue 11. 2020-03-30. PMID:30926651. progressive tau accumulation in alzheimer disease: 2-year follow-up study. 2020-03-30 2023-08-13 Not clear
Hanna Cho, Jae Yong Choi, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Clifford R Jack, Chul Hyoung Lyo. Progressive Tau Accumulation in Alzheimer Disease: 2-Year Follow-up Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 60. issue 11. 2020-03-30. PMID:30926651. tau pet enables in vivo visualization and quantitation of tau accumulation in alzheimer disease (ad). 2020-03-30 2023-08-13 Not clear
Brent Aulston, Qing Liu, Patrick Reilly, Shauna H Yua. An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons. Journal of visualized experiments : JoVE. issue 147. 2020-03-30. PMID:31180362. aberrant aggregation of the protein tau is pathogenically involved in a number of neurodegenerative diseases, including alzheimer's disease (ad). 2020-03-30 2023-08-13 mouse
Takashi Saito, Naomi Mihira, Yukio Matsuba, Hiroki Sasaguri, Shoko Hashimoto, Sneha Narasimhan, Bin Zhang, Shigeo Murayama, Makoto Higuchi, Virginia M Y Lee, John Q Trojanowski, Takaomi C Said. Humanization of the entire murine The Journal of biological chemistry. vol 294. issue 34. 2020-03-30. PMID:31273083. humanization of the entire murine in cortical regions of brains from individuals with preclinical or clinical alzheimer's disease (ad), extracellular β-amyloid (aβ) deposition precedes the aggregation of pathological intracellular tau (the product of the gene microtubule-associated protein tau ( 2020-03-30 2023-08-13 Not clear
Tushar Dubey, Subashchandrabose Chinnathamb. Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease. Archives of biochemistry and biophysics. vol 676. 2020-03-30. PMID:31622587. amyloid-β and tau are the hallmarks proteins of several neuronal dysfunctions resulting in alzheimer's disease. 2020-03-30 2023-08-13 Not clear
Tushar Dubey, Subashchandrabose Chinnathamb. Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease. Archives of biochemistry and biophysics. vol 676. 2020-03-30. PMID:31622587. tau is a microtubule-associated protein known to be involved in progression of alzheimer's disease. 2020-03-30 2023-08-13 Not clear
Kate E Foley, Hongtian Stanley Yang, Leah C Graham, Gareth R Howel. Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice. BMC genomics. vol 20. issue 1. 2020-03-30. PMID:31726991. specifically, with alzheimer's disease, targeting to reduce amyloid beta plaques and phosphorylated tau aggregates in clinical trials has not yielded results to slow symptomology, suggesting a new approach is needed. 2020-03-30 2023-08-13 mouse
Fares Bassil, Hannah J Brown, Shankar Pattabhiraman, Joe E Iwasyk, Chantal M Maghames, Emily S Meymand, Timothy O Cox, Dawn M Riddle, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology. Neuron. vol 105. issue 2. 2020-03-30. PMID:31759806. studies have shown an overlap of aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of alzheimer's disease (ad) and parkinson's disease (pd) with dementia (pdd) patients, with increased pathological burden correlating with severity of cognitive and motor symptoms. 2020-03-30 2023-08-13 mouse
Michael S Rafi. Tau PET Imaging for Staging of Alzheimer's Disease in Down Syndrome. Developmental neurobiology. vol 79. issue 7. 2020-03-27. PMID:30536948. tau pet imaging for staging of alzheimer's disease in down syndrome. 2020-03-27 2023-08-13 Not clear
Claudia Cicognola, Gunnar Brinkmalm, Jessica Wahlgren, Erik Portelius, Johan Gobom, Nicholas C Cullen, Oskar Hansson, Lucilla Parnetti, Radu Constantinescu, Kristin Wildsmith, Hsu-Hsin Chen, Thomas G Beach, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Kina Höglun. Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease. Acta neuropathologica. vol 137. issue 2. 2020-03-27. PMID:30547227. novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in alzheimer's disease. 2020-03-27 2023-08-13 human
Claudia Cicognola, Gunnar Brinkmalm, Jessica Wahlgren, Erik Portelius, Johan Gobom, Nicholas C Cullen, Oskar Hansson, Lucilla Parnetti, Radu Constantinescu, Kristin Wildsmith, Hsu-Hsin Chen, Thomas G Beach, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Kina Höglun. Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease. Acta neuropathologica. vol 137. issue 2. 2020-03-27. PMID:30547227. tau pathology in brain and increased tau concentration in the cerebrospinal fluid (csf) are hallmarks of alzheimer's disease (ad). 2020-03-27 2023-08-13 human
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors Hw Schere. Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. eLife. vol 8. 2020-03-26. PMID:30720432. heparin-induced tau filaments are polymorphic and differ from those in alzheimer's and pick's diseases. 2020-03-26 2023-08-13 human