All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Michael J Pontecorvo, Michael D Devous, Ian Kennedy, Michael Navitsky, Ming Lu, Nicholas Galante, Stephen Salloway, P Murali Doraiswamy, Sudeepti Southekal, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Stephen P Truocchio, Abhinay D Joshi, Sergey Shcherbinin, Brian Teske, Adam S Fleisher, Mark A Mintu. A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31009046. the advent of tau-targeted pet tracers such as flortaucipir (18f) (flortaucipir, also known as 18f-av-1451 or 18f-t807) have made it possible to investigate the sequence of development of tau in relationship to age, amyloid-β, and to the development of cognitive impairment due to alzheimer's disease. 2020-03-12 2023-08-13 human
Michael J Pontecorvo, Michael D Devous, Ian Kennedy, Michael Navitsky, Ming Lu, Nicholas Galante, Stephen Salloway, P Murali Doraiswamy, Sudeepti Southekal, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Stephen P Truocchio, Abhinay D Joshi, Sergey Shcherbinin, Brian Teske, Adam S Fleisher, Mark A Mintu. A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31009046. taken together, these results provide a preliminary characterization of the longitudinal spread of tau in alzheimer's disease and suggest that the amount and location of tau may have implications both for the spread of tau and the cognitive deterioration that may occur over an 18-month period. 2020-03-12 2023-08-13 human
Marie Albert, Georges Mairet-Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Sébastien Carrier, Emilie Skrobala, Isabelle Landrieu, Anne Michel, Mathieu Schmitt, Martin Citron, Patrick Downey, Jean-Philippe Courade, Luc Buée, Morvane Coli. Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31038156. here, we addressed two fundamental questions: (i) can this anti-tau antibody neutralize the pathological species present in alzheimer's disease brains; and (ii) can it block the cell-to-cell spread of tau seeds in vivo? 2020-03-12 2023-08-13 mouse
Marie Albert, Georges Mairet-Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Sébastien Carrier, Emilie Skrobala, Isabelle Landrieu, Anne Michel, Mathieu Schmitt, Martin Citron, Patrick Downey, Jean-Philippe Courade, Luc Buée, Morvane Coli. Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31038156. first, antibody d effectively prevented the induction of tau pathology in the brains of transgenic mice that had been injected with human alzheimer's disease brain extracts, showing that it could effectively neutralize the pathological species present in these extracts. 2020-03-12 2023-08-13 mouse
Marie Albert, Georges Mairet-Coello, Clément Danis, Sarah Lieger, Raphaëlle Caillierez, Sébastien Carrier, Emilie Skrobala, Isabelle Landrieu, Anne Michel, Mathieu Schmitt, Martin Citron, Patrick Downey, Jean-Philippe Courade, Luc Buée, Morvane Coli. Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31038156. in contrast, an amino-terminal tau antibody, which was less effective at blocking tau seeding in vitro showed less efficacy in reducing alzheimer's disease patient tau driven pathology in the transgenic mouse model. 2020-03-12 2023-08-13 mouse
David Howett, Andrea Castegnaro, Katarzyna Krzywicka, Johanna Hagman, Deepti Marchment, Richard Henson, Miguel Rio, John A King, Neil Burgess, Dennis Cha. Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31121601. path-integration performance correlated with alzheimer's disease molecular pathology, with levels of csf amyloid-β and total tau contributing independently to distance error. 2020-03-12 2023-08-13 human
Victoria J Butler, Dominique A Salazar, David Soriano-Castell, Miguel Alves-Ferreira, Frank J A Dennissen, Mihir Vohra, Juan A Oses-Prieto, Kathy H Li, Austin L Wang, Beibei Jing, Biao Li, Alex Groisman, Edgar Gutierrez, Sean Mooney, Alma L Burlingame, Kaveh Ashrafi, Eva-Maria Mandelkow, Sandra E Encalada, Aimee W Ka. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Human molecular genetics. vol 28. issue 9. 2020-03-11. PMID:30590647. a novel variant in mapt resulting in an alanine to threonine substitution at position 152 (a152t tau) has recently been described as a significant risk factor for both frontotemporal lobar degeneration and alzheimer's disease. 2020-03-11 2023-08-13 mouse
Cun-Jian Shi, Wan Peng, Jin-Hua Zhao, Hua-Li Yang, Lai-Liang Qu, Cheng Wang, Ling-Yi Kong, Xiao-Bing Wan. Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors. European journal of medicinal chemistry. vol 187. 2020-03-10. PMID:31865017. accumulation of tau protein aggregation plays a crucial role in neurodegenerative diseases, such as alzheimer's disease (ad). 2020-03-10 2023-08-13 mouse
Antoine Leuzy, Konstantinos Chiotis, Laetitia Lemoine, Per-Göran Gillberg, Ove Almkvist, Elena Rodriguez-Vieitez, Agneta Nordber. Tau PET imaging in neurodegenerative tauopathies-still a challenge. Molecular psychiatry. vol 24. issue 8. 2020-03-09. PMID:30635637. the accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as tauopathies, of which alzheimer's disease (ad) is the most common. 2020-03-09 2023-08-13 Not clear
Taro Saito, Toshiya Oba, Sawako Shimizu, Akiko Asada, Koichi M Iijima, Kanae And. Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262. Human molecular genetics. vol 28. issue 18. 2020-03-09. PMID:31174206. hyperphosphorylation of the microtubule-associated protein tau is associated with many neurodegenerative diseases, including alzheimer's disease. 2020-03-09 2023-08-13 drosophila_melanogaster
Ian Fyf. Alzheimer disease-associated gene increases tau pathology. Nature reviews. Neurology. vol 16. issue 3. 2020-03-09. PMID:32001836. alzheimer disease-associated gene increases tau pathology. 2020-03-09 2023-08-13 Not clear
Ian Fyf. Imaging shows predictive power of tau pathology in Alzheimer disease. Nature reviews. Neurology. vol 16. issue 3. 2020-03-09. PMID:32051573. imaging shows predictive power of tau pathology in alzheimer disease. 2020-03-09 2023-08-13 Not clear
Taro Yanagawa, Masaki Takao, Masami Yasuda, Tomoya Kamide, Hiroki Sato, Kaima Suzuki, Toshiki Ikeda, Yuichiro Kikkawa, Hiroki Kurit. Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy. Clinical neurology and neurosurgery. vol 176. 2020-03-05. PMID:30554091. to evaluate the clinical and histopathological features of elderly patients with subcortical intracerebral hemorrhage (ich), and to analyze the presence of cerebral amyloid angiopathy (caa) and alzheimer's disease (ad) type pathologic changes using amyloid beta (aβ) and tau immunohistochemistry. 2020-03-05 2023-08-13 Not clear
Ye Tian, Lanxia Meng, Zhentao Zhan. What is strain in neurodegenerative diseases? Cellular and molecular life sciences : CMLS. vol 77. issue 4. 2020-03-05. PMID:31531680. neurodegenerative diseases, such as alzheimer's disease and parkinson's disease, are characterized by the aggregation of misfolded proteins, including aβ, tau and α-synuclein. 2020-03-05 2023-08-13 Not clear
Jürgen Götz, Glenda Halliday, Rebecca M Nisbe. Molecular Pathogenesis of the Tauopathies. Annual review of pathology. vol 14. 2020-03-04. PMID:30355155. in this review, we describe the biochemical and histological differences in tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. 2020-03-04 2023-08-13 Not clear
Frederik J R Rombouts, Lieven Declercq, José-Ignacio Andrés, Astrid Bottelbergs, Lu Chen, Laura Iturrino, Joseph E Leenaerts, Jonas Mariën, Fengbin Song, Cindy Wintmolders, Stijn Wuyts, Chunfang A Xia, Paula Te Riele, Guy Bormans, Rik Vandenberghe, Hartmuth Kolb, Diederik Moechar. Discovery of N-(4-[ Journal of medicinal chemistry. vol 62. issue 6. 2020-03-03. PMID:30810314. discovery of n-(4-[ in alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. 2020-03-03 2023-08-13 rat
Xingsheng Shu, Yilin Zhang, Meiqi Li, Xiaoyan Huang, Yangfan Yang, Junhui Zeng, Yingying Zhao, Xiaomei Wang, Weizhen Zhang, Ying Yin. Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling. Neuropharmacology. vol 153. 2020-03-03. PMID:31015047. the glucagon-like-peptide 1 receptor (glp-1r) agonists, including liraglutide, can ameliorate neurodegenerative features in models of alzheimer's disease and diabetes by decreasing tau hyperphosphorylation in the brain. 2020-03-03 2023-08-13 mouse
Félix Hernández, Raquel Cuadros, Ivanna Ollá, Carlos García, Isidre Ferrer, George Perry, Jesús Avil. Differences in structure and function between human and murine tau. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 8. 2020-03-03. PMID:31189515. the latter did not bind to tau from brain extracts taken from patients with alzheimer's disease (ad). 2020-03-03 2023-08-13 mouse
E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). 2020-03-02 2023-08-13 mouse
Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D Ye, Yang Y. Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30475772. formyl peptide receptor 2 deficiency improves cognition and attenuates tau hyperphosphorylation and astrogliosis in a mouse model of alzheimer's disease. 2020-03-02 2023-08-13 mouse