| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Félix Hernández, Raquel Cuadros, Ivanna Ollá, Carlos García, Isidre Ferrer, George Perry, Jesús Avil. Differences in structure and function between human and murine tau. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 8. 2020-03-03. PMID:31189515. |
the latter did not bind to tau from brain extracts taken from patients with alzheimer's disease (ad). |
2020-03-03 |
2023-08-13 |
mouse |
| E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. |
in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). |
2020-03-02 |
2023-08-13 |
mouse |
| Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D Ye, Yang Y. Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30475772. |
formyl peptide receptor 2 deficiency improves cognition and attenuates tau hyperphosphorylation and astrogliosis in a mouse model of alzheimer's disease. |
2020-03-02 |
2023-08-13 |
mouse |
| Hasan A M M Almansoub, Hui Tang, Ying Wu, Ding-Qi Wang, Yacoubou Abdoul Razak Mahaman, Na Wei, Yusra A M Almansob, Wei He, Dan Li. Tau Abnormalities and the Potential Therapy in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30507581. |
tau abnormalities and the potential therapy in alzheimer's disease. |
2020-03-02 |
2023-08-13 |
Not clear |
| Charisse N Winston, Brent Aulston, Edward M Rockenstein, Anthony Adame, Olga Prikhodko, Kishan N Dave, Priyanka Mishra, Robert A Rissman, Shauna H Yua. Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30584143. |
progressive accumulation of aggregation-prone proteins, amyloid-β (aβ) and hyperphosphorylated tau (p-tau), are the defining hallmarks of alzheimer's disease (ad). |
2020-03-02 |
2023-08-13 |
mouse |
| Payam Emami Khoonsari, Ganna Shevchenko, Stephanie Herman, Julia Remnestål, Vilmantas Giedraitis, RoseMarie Brundin, Malin Degerman Gunnarsson, Lena Kilander, Henrik Zetterberg, Peter Nilsson, Lars Lannfelt, Martin Ingelsson, Kim Kultim. Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30614806. |
alzheimer's disease (ad) is diagnosed based on a clinical evaluation as well as analyses of classical biomarkers: aβ42, total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (csf). |
2020-03-02 |
2023-08-13 |
Not clear |
| Gad A Marshall, Jennifer R Gatchel, Nancy J Donovan, Martha C Muniz, Aaron P Schultz, J Alex Becker, Jasmeer P Chhatwal, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30689584. |
regional tau correlates of instrumental activities of daily living and apathy in mild cognitive impairment and alzheimer's disease dementia. |
2020-03-02 |
2023-08-13 |
Not clear |
| Gad A Marshall, Jennifer R Gatchel, Nancy J Donovan, Martha C Muniz, Aaron P Schultz, J Alex Becker, Jasmeer P Chhatwal, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30689584. |
instrumental activities of daily living (iadl) impairment and apathy occur in early-stage alzheimer's disease (ad) and are associated with regional atrophy and hypometabolism in vivo and greater tau burden at autopsy. |
2020-03-02 |
2023-08-13 |
Not clear |
| Cecilia S Lindestam Arlehamn, John Pham, Roy N Alcalay, April Frazier, Evan Shorr, Chelsea Carpenter, John Sidney, Rekha Dhanwani, Julian Agin-Liebes, Francesca Garretti, Amy W Amara, David G Standaert, Elizabeth J Phillips, Simon A Mallal, Bjoern Peters, David Sulzer, Alessandro Sett. Widespread Tau-Specific CD4 T Cell Reactivity in the General Population. Journal of immunology (Baltimore, Md. : 1950). vol 203. issue 1. 2020-03-02. PMID:31085590. |
tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders, including parkinson disease (pd) and related parkinsonisms, alzheimer disease, traumatic brain injury, and even in normal aging. |
2020-03-02 |
2023-08-13 |
Not clear |
| Justyna Chojdak-Łukasiewicz, Małgorzata Małodobra-Mazur, Anna Zimny, Leszek Noga, Bogusław Paradowsk. Plasma tau protein and Aβ42 level as markers of cognitive impairment in patients with Parkinson's disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 29. issue 1. 2020-03-02. PMID:31990459. |
tau protein and amyloid beta are well-known non-specific biomarkers in alzheimer's disease (ad). |
2020-03-02 |
2023-08-13 |
Not clear |
| Nan Cai, Jiajie Chen, Decheng Bi, Liang Gu, Lijun Yao, Xiuting Li, Hui Li, Hong Xu, Zhangli Hu, Qiong Liu, Xu X. Specific Degradation of Endogenous Tau Protein and Inhibition of Tau Fibrillation by Tanshinone IIA through the Ubiquitin-Proteasome Pathway. Journal of agricultural and food chemistry. vol 68. issue 7. 2020-03-02. PMID:31995984. |
alzheimer's disease (ad) is a common neurodegenerative disease which is partly characterized by the aggregation of hyperphosphorylated tau proteins forming neurofibrillary tangles that promote ad pathogenesis. |
2020-03-02 |
2023-08-13 |
mouse |
| Xiao-Long Hu, Cui Guo, Ji-Qin Hou, Jia-Hao Feng, Xiao-Qi Zhang, Fei Xiong, Wen-Cai Ye, Hao Wan. Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:29944335. |
glycogen synthase kinase-3β (gsk-3β) is a key enzyme in hyperphosphorylation of tau proteins and is a promising therapeutic target in alzheimer's disease (ad). |
2020-02-26 |
2023-08-13 |
Not clear |
| Xian Zhang, Timothy Y Huang, Joel Yancey, Hong Luo, Yun-Wu Zhan. Role of Rab GTPases in Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30261139. |
alzheimer's disease (ad) comprises two major pathological hallmarks: extraneuronal deposition of β-amyloid (aβ) peptides ("senile plaques") and intraneuronal aggregation of the microtubule-associated protein tau ("neurofibrillary tangles"). |
2020-02-26 |
2023-08-13 |
Not clear |
| Dandan Chu, Fei Li. Pathological Changes of Tau Related to Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30346708. |
pathological changes of tau related to alzheimer's disease. |
2020-02-26 |
2023-08-13 |
Not clear |
| Hanbi Kim, Jong Uk Lee, Soohyun Kim, Sojin Song, Sang Jun Si. A Nanoplasmonic Biosensor for Ultrasensitive Detection of Alzheimer's Disease Biomarker Using a Chaotropic Agent. ACS sensors. vol 4. issue 3. 2020-02-26. PMID:30747516. |
blood-based diagnosis (hemodiagnosis) of alzheimer's disease (ad) is emerging as a promising alternative to cerebrospinal-fluid-based methods because blood contains various kinds of ad biomarkers, including amyloid beta 1-40, 1-42, and τ (tau) protein. |
2020-02-26 |
2023-08-13 |
human |
| Hanbi Kim, Jong Uk Lee, Soohyun Kim, Sojin Song, Sang Jun Si. A Nanoplasmonic Biosensor for Ultrasensitive Detection of Alzheimer's Disease Biomarker Using a Chaotropic Agent. ACS sensors. vol 4. issue 3. 2020-02-26. PMID:30747516. |
this platform also can analyze disease from mild cognitive impairment using standardized blood biomarker tau protein, which is related to alzheimer's disease. |
2020-02-26 |
2023-08-13 |
human |
| Hongmei Li, Chia-Chen Liu, Hui Zheng, Timothy Y Huan. Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis. Translational neurodegeneration. vol 7. 2020-02-25. PMID:30603085. |
amyloid, tau, pathogen infection and antimicrobial protection in alzheimer's disease -conformist, nonconformist, and realistic prospects for ad pathogenesis. |
2020-02-25 |
2023-08-13 |
Not clear |
| Guy Lippens, Benoît Gigan. Elucidating Tau function and dysfunction in the era of cryo-EM. The Journal of biological chemistry. vol 294. issue 24. 2020-02-25. PMID:31088912. |
the first structures of tau fibrils, a molecular hallmark of alzheimer's disease (ad), were based on fibrils from the brain of an individual with ad and, along with similar patient-derived structures, have set the gold standard for the field. |
2020-02-25 |
2023-08-13 |
Not clear |
| Fan Yang, Samadrita Roy Chowdhury, Heidi I L Jacobs, Keith A Johnson, Joyita Dutt. A longitudinal model for tau aggregation in Alzheimer's disease based on structural connectivity. Information processing in medical imaging : proceedings of the ... conference. vol 11492. 2020-02-25. PMID:31156312. |
a longitudinal model for tau aggregation in alzheimer's disease based on structural connectivity. |
2020-02-25 |
2023-08-13 |
mouse |
| Fan Yang, Samadrita Roy Chowdhury, Heidi I L Jacobs, Keith A Johnson, Joyita Dutt. A longitudinal model for tau aggregation in Alzheimer's disease based on structural connectivity. Information processing in medical imaging : proceedings of the ... conference. vol 11492. 2020-02-25. PMID:31156312. |
tau tangles are a pathological hallmark of alzheimer?s disease (ad) with strong correlations existing between tau aggregation and cognitive decline. |
2020-02-25 |
2023-08-13 |
mouse |