| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 5. 2020-01-27. PMID:30753351. |
plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in alzheimer's disease. |
2020-01-27 |
2023-08-13 |
Not clear |
| Maarten Timmers, Ina Tesseur, Jennifer Bogert, Henrik Zetterberg, Kaj Blennow, Anne Börjesson-Hanson, Miquel Baquero, Mercè Boada, Christopher Randolph, Luc Tritsmans, Luc Van Nueten, Sebastiaan Engelborghs, Johannes Rolf Streffe. Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease. Neurobiology of aging. vol 79. 2020-01-27. PMID:31055223. |
relevance of the interplay between amyloid and tau for cognitive impairment in early alzheimer's disease. |
2020-01-27 |
2023-08-13 |
Not clear |
| Maarten Timmers, Ina Tesseur, Jennifer Bogert, Henrik Zetterberg, Kaj Blennow, Anne Börjesson-Hanson, Miquel Baquero, Mercè Boada, Christopher Randolph, Luc Tritsmans, Luc Van Nueten, Sebastiaan Engelborghs, Johannes Rolf Streffe. Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease. Neurobiology of aging. vol 79. 2020-01-27. PMID:31055223. |
amyloid β (aβ) and tau are key hallmark features of alzheimer's disease (ad) neuropathology. |
2020-01-27 |
2023-08-13 |
Not clear |
| Benita Jebarupa, Boby Mathew, Bindu Y Srinivasu, Aiswarya Sasikumaran, Smitha Joseph, Amit K Mandal, Tinku Thomas, Gopa Mitr. Understanding molecular features of aggregation-resistant tau conformer using oxidized monomer. Biochimica et biophysica acta. General subjects. vol 1863. issue 6. 2020-01-22. PMID:30853336. |
aggregation of tau into paired helical filament (phf) is a hallmark of alzheimer's disease (ad), and cys-mediated disulfide bond formation plays a vital role in tau fibrillation. |
2020-01-22 |
2023-08-13 |
Not clear |
| Aohuan Dan, Hai-Feng Che. Secondary structures transition of tau protein with intrinsically disordered proteins specific force field. Chemical biology & drug design. vol 93. issue 3. 2020-01-21. PMID:30259679. |
the pathological tau can aggregate into cross-beta amyloid as one of the hallmarks for alzheimer's disease (ad). |
2020-01-21 |
2023-08-13 |
Not clear |
| Teng Jiang, Peng-Yu Gong, Meng-Shan Tan, Xiao Xue, Shi Huang, Jun-Shan Zhou, Lan Tan, Ying-Dong Zhan. Soluble TREM1 concentrations are increased and positively correlated with total tau levels in the plasma of patients with Alzheimer's disease. Aging clinical and experimental research. vol 31. issue 12. 2020-01-20. PMID:30637597. |
soluble trem1 concentrations are increased and positively correlated with total tau levels in the plasma of patients with alzheimer's disease. |
2020-01-20 |
2023-08-13 |
human |
| Sung Yeon Park, Jieun Seo, Yang Sook Chu. Targeted Downregulation of Journal of Korean medical science. vol 34. issue 33. 2020-01-15. PMID:31436053. |
targeted downregulation of tauopathies, a class of neurodegenerative diseases that includes alzheimer's disease (ad), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. |
2020-01-15 |
2023-08-13 |
human |
| Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Cheryl Kirstein, William Swindell, Dorothy Ko, Mark S Kind. GM6 Attenuates Alzheimer's Disease Pathology in APP Mice. Molecular neurobiology. vol 56. issue 9. 2020-01-13. PMID:30798443. |
alzheimer's disease (ad) results in the deposition of amyloid β (aβ) peptide into amyloid fibrils and tau into neurofibrillary tangles. |
2020-01-13 |
2023-08-13 |
mouse |
| Charles Duyckaerts, Florence Clavaguera, Marie-Claude Potie. The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease. Current opinion in neurology. vol 32. issue 2. 2020-01-10. PMID:30724769. |
this study, taking the example of alzheimer's and parkinson's diseases, presents the experimental and human data that support the hypothesis that aβ, tau, and α-synuclein may seed and propagate the pathology and consider the potential clinical consequences. |
2020-01-10 |
2023-08-13 |
human |
| S Swarbrick, N Wragg, S Ghosh, Alexandra Stolzin. Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30734227. |
alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment. |
2020-01-09 |
2023-08-13 |
Not clear |
| Longfei Li, Yanli Jiang, Wen Hu, Yunn Chyn Tung, Chunling Dai, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Alterations of Tau in Alzheimer's Disease and 3xTg-AD Mouse Brains. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30734228. |
pathological alterations of tau in alzheimer's disease and 3xtg-ad mouse brains. |
2020-01-09 |
2023-08-13 |
mouse |
| Longfei Li, Yanli Jiang, Wen Hu, Yunn Chyn Tung, Chunling Dai, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Alterations of Tau in Alzheimer's Disease and 3xTg-AD Mouse Brains. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30734228. |
microtubule-associated protein tau in alzheimer's disease (ad) brain is hyperphosphorylated, truncated, and aggregated into neurofibrillary tangles. |
2020-01-09 |
2023-08-13 |
mouse |
| Brian Spencer, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Omar M A El-Agnaf, Changyoun Kim, Eliezer Masliah, Robert A Rissma. Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiology of disease. vol 127. 2020-01-09. PMID:30849508. |
neurodegenerative disorders of the aging population are characterized by progressive accumulation of neuronal proteins such as α-synuclein (α-syn) in parkinson's disease (pd) and amyloid ß (aß) and tau in alzheimer's disease (ad) for which no treatments are currently available. |
2020-01-09 |
2023-08-13 |
mouse |
| Janice C Malcolm, Lionel Breuillaud, Sonia Do Carmo, Hélène Hall, Lindsay A Welikovitch, Jennifer A Macdonald, Michel Goedert, A Claudio Cuell. Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy. Neurobiology of disease. vol 127. 2020-01-09. PMID:30905766. |
the assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. |
2020-01-09 |
2023-08-13 |
human |
| Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T Corbett, Graham Fraser, Michael S Perkinton, Dominic M Walsh, Andrew Billinton, Michael J Rowa. Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo. Neurobiology of disease. vol 127. 2020-01-09. PMID:30910746. |
soluble synaptotoxic aggregates of the main pathological proteins of alzheimer's disease, amyloid β-protein (aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (ltp). |
2020-01-09 |
2023-08-13 |
human |
| Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Göt. Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO journal. vol 38. issue 3. 2020-01-06. PMID:30538104. |
accumulation of the protein tau characterises alzheimer's disease and other tauopathies, including familial forms of frontotemporal dementia (ftd) that carry pathogenic tau mutations. |
2020-01-06 |
2023-08-13 |
human |
| David Coughlin, Sharon X Xie, Mendy Liang, Andrew Williams, Claire Peterson, Daniel Weintraub, Corey T McMillan, David A Wolk, Rizwan S Akhtar, Howard I Hurtig, H Branch Coslett, Roy H Hamilton, Andrew D Siderowf, John E Duda, Katya Rascovsky, Edward B Lee, Virginia M-Y Lee, Murray Grossman, John Q Trojanowski, David J Irwi. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of neurology. vol 85. issue 2. 2020-01-06. PMID:30549331. |
to use digital histology in a large autopsy cohort of lewy body disorder (lbd) patients with dementia to test the hypotheses that co-occurring alzheimer disease (ad) pathology impacts the anatomic distribution of α-synuclein (syn) pathology and that co-occurring neocortical tau pathology in lbds associates with worse cognitive performance and occurs in a pattern differing from ad. |
2020-01-06 |
2023-08-13 |
Not clear |
| Theresa M Harrison, Renaud La Joie, Anne Maass, Suzanne L Baker, Kaitlin Swinnerton, Laura Fenton, Taylor J Mellinger, Lauren Edwards, Julie Pham, Bruce L Miller, Gil D Rabinovici, William J Jagus. Longitudinal tau accumulation and atrophy in aging and alzheimer disease. Annals of neurology. vol 85. issue 2. 2020-01-06. PMID:30597624. |
longitudinal tau accumulation and atrophy in aging and alzheimer disease. |
2020-01-06 |
2023-08-13 |
Not clear |
| Theresa M Harrison, Renaud La Joie, Anne Maass, Suzanne L Baker, Kaitlin Swinnerton, Laura Fenton, Taylor J Mellinger, Lauren Edwards, Julie Pham, Bruce L Miller, Gil D Rabinovici, William J Jagus. Longitudinal tau accumulation and atrophy in aging and alzheimer disease. Annals of neurology. vol 85. issue 2. 2020-01-06. PMID:30597624. |
to determine the rate of tau accumulation in healthy older adults (oa) and patients with alzheimer disease (ad), as well as the relationship of tau accumulation to cortical atrophy. |
2020-01-06 |
2023-08-13 |
Not clear |
| Jong-Chan Park, Sun-Ho Han, Dahyun Yi, Min Soo Byun, Jun Ho Lee, Sukjin Jang, Kang Ko, So Yeon Jeon, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee, Inhee Mook-Jun. Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30668647. |
plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in alzheimer's disease. |
2020-01-06 |
2023-08-13 |
Not clear |