| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
the brain areas demonstrating elevated tau pet binding overlapped with those seen in sporadic alzheimer's disease, but with a greater cortical involvement and greater levels of binding despite similar cognitive impairment. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
we demonstrate that tau pet binding is elevated in symptomatic individuals with dominantly inherited alzheimer's disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
tau pet uptake was tied to the onset of cognitive dysfunction, and there was a higher amount, and different regional pattern of binding compared to late onset, non-familial alzheimer's disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk L Na, Hee Jin Kim, Chul Hyoung Lyoo, Hana Cho, Sofia Finsterwalder, Marco Duering, Sang Won Seo, Michael Ewer. Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770704. |
functional connectivity associated with tau levels in ageing, alzheimer's, and small vessel disease. |
2019-12-10 |
2023-08-13 |
human |
| Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk L Na, Hee Jin Kim, Chul Hyoung Lyoo, Hana Cho, Sofia Finsterwalder, Marco Duering, Sang Won Seo, Michael Ewer. Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770704. |
in alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout the cortex, ensuing cognitive decline and dementia. |
2019-12-10 |
2023-08-13 |
human |
| Yu Yamazaki, Mitsuru Shinohara, Motoko Shinohara, Akari Yamazaki, Melissa E Murray, Amanda M Liesinger, Michael G Heckman, Elizabeth R Lesser, Joseph E Parisi, Ronald C Petersen, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770921. |
while the accumulation and aggregation of amyloid-β and tau are central events in the pathogenesis of alzheimer's disease, there is increasing evidence that cerebrovascular pathology is also abundant in alzheimer's disease brains. |
2019-12-10 |
2023-08-13 |
human |
| Yu Yamazaki, Mitsuru Shinohara, Motoko Shinohara, Akari Yamazaki, Melissa E Murray, Amanda M Liesinger, Michael G Heckman, Elizabeth R Lesser, Joseph E Parisi, Ronald C Petersen, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770921. |
importantly, the positive correlation between claudin-5 and synaptic markers, in particular synaptophysin, was present independent of insoluble amyloid-β40, amyloid-β42 and tau values, suggesting that loss of cortical tight junction proteins and synaptic degeneration is present, at least in part, independent of insoluble alzheimer's disease-related proteins. |
2019-12-10 |
2023-08-13 |
human |
| Yu Yamazaki, Mitsuru Shinohara, Motoko Shinohara, Akari Yamazaki, Melissa E Murray, Amanda M Liesinger, Michael G Heckman, Elizabeth R Lesser, Joseph E Parisi, Ronald C Petersen, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770921. |
further, our findings provide a neuropathological clue as to how endothelial tight junction pathology may contribute to alzheimer's disease pathogenesis in both synergistic and additive manners to typical amyloid-β and tau pathologies. |
2019-12-10 |
2023-08-13 |
human |
| Chao-Chao Yu, Tao Jiang, Ao-Fei Yang, Yan-Jun Du, Miao Wu, Li-Hong Kon. Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease. Neural plasticity. vol 2019. 2019-12-10. PMID:31093272. |
epigenetic modulation on tau phosphorylation in alzheimer's disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Chao-Chao Yu, Tao Jiang, Ao-Fei Yang, Yan-Jun Du, Miao Wu, Li-Hong Kon. Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease. Neural plasticity. vol 2019. 2019-12-10. PMID:31093272. |
tau hyperphosphorylation is a typical pathological change in alzheimer's disease (ad) and is involved in the early onset and progression of ad. |
2019-12-10 |
2023-08-13 |
Not clear |
| Rui Zheng, Zhong-Hao Zhang, Yu-Xi Zhao, Chen Chen, Shi-Zheng Jia, Xian-Chun Cao, Li-Ming Shen, Jia-Zuan Ni, Guo-Li Son. Transcriptomic Insights into the Response of the Olfactory Bulb to Selenium Treatment in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 12. 2019-12-10. PMID:31248178. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder characterized by the presence of extracellular senile plaques primarily composed of aβ peptides and intracellular neurofibrillary tangles (nfts) composed of hyperphosphorylated tau proteins. |
2019-12-10 |
2023-08-13 |
mouse |
| Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaer. Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology. NMR in biomedicine. vol 32. issue 2. 2019-12-06. PMID:30489666. |
longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of alzheimer's disease with amyloid and tau pathology. |
2019-12-06 |
2023-08-13 |
mouse |
| Eman M Khedr, Ragaa H Salama, Mohamed Abdel Hameed, Noha Abo Elfetoh, Peater Sei. Therapeutic Role of Transcranial Direct Current Stimulation in Alzheimer Disease Patients: Double-Blind, Placebo-Controlled Clinical Trial. Neurorehabilitation and neural repair. vol 33. issue 5. 2019-12-06. PMID:30940012. |
to explore the neuropsychological effects and levels of tau protein (tau), amyloid β 1-42 (aβ 1-42), and lipid peroxidase after 10 sessions of anodal transcranial direct current stimulation (tdcs) in patients with mild to moderate alzheimer disease (ad). |
2019-12-06 |
2023-08-13 |
Not clear |
| Qiuchen Zheng, Micheal T Kebede, Merc M Kemeh, Saadman Islam, Bethany Lee, Stuart D Bleck, Liliana A Wurfl, Noel D Laz. Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies. Molecules (Basel, Switzerland). vol 24. issue 12. 2019-12-06. PMID:31234523. |
the amyloid-β (aβ) peptide and tau protein are thought to play key neuropathogenic roles in alzheimer's disease (ad). |
2019-12-06 |
2023-08-13 |
Not clear |
| Yang-Ping Shentu, Yuda Huo, Xiao-Long Feng, James Gilbert, Qing Zhang, Zhen-Yu Liuyang, Xiu-Lian Wang, Guan Wang, Huan Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, You-Ming Lu, Jukka Westermarck, Heng-Ye Man, Rong Li. CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease. Cell reports. vol 24. issue 3. 2019-12-03. PMID:30021167. |
protein phosphatase 2a (pp2a) inhibition causes hyperphosphorylation of tau and app in alzheimer's disease (ad). |
2019-12-03 |
2023-08-13 |
mouse |
| Valeria Lifke, Gwendlyn Kollmorgen, Ekaterina Manuilova, Tobias Oelschlaegel, Lars Hillringhaus, Monika Widmann, Christine A F von Arnim, Markus Otto, Robert H Christenson, Jennifer L Powers, Leslie M Shaw, Oskar Hansson, James D Doecke, Qiao-Xin Li, Charlotte Teunissen, Hayrettin Tumani, Kaj Blenno. Elecsys Clinical biochemistry. vol 72. 2019-12-03. PMID:31129184. |
elecsys total tau (ttau) and phosphorylated 181p tau (ptau) are supportive diagnostic cerebrospinal fluid (csf) biomarkers for alzheimer's disease. |
2019-12-03 |
2023-08-13 |
Not clear |
| Tanguy Fenouil, Anthony Fourier, Isabelle Quadrio, Nathalie Streichenberger, Sergio Bernardini, Tomáš Zima, Armand Perret-Liaudet, David Meyrone. The standardization of cerebrospinal fluid markers and neuropathological diagnoses brings to light the frequent complexity of concomitant pathology in Alzheimer's disease: The next challenge for biochemical markers? Clinical biochemistry. vol 72. 2019-12-03. PMID:31194969. |
this brings new challenges to laboratory medicine in the field of cerebrospinal fluid (csf) markers of alzheimer's disease: how to further validate total tau, phospho-tau, aß40 and aß42 and new marker level cut-offs while autopsy rates are declining? |
2019-12-03 |
2023-08-13 |
Not clear |
| Giulia Sancesario, Sergio Bernardin. AD biomarker discovery in CSF and in alternative matrices. Clinical biochemistry. vol 72. 2019-12-03. PMID:31437430. |
core alzheimer's disease (ad) biomarkers are the cerebrospinal fluid (csf) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. |
2019-12-03 |
2023-08-13 |
Not clear |
| Neng-Wei Hu, Grant T Corbett, Steven Moore, Igor Klyubin, Tiernan T O'Malley, Dominic M Walsh, Frederick J Livesey, Michael J Rowa. Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity. Cell reports. vol 23. issue 7. 2019-12-02. PMID:29768194. |
extracellular forms of aβ and tau from ipsc models of alzheimer's disease disrupt synaptic plasticity. |
2019-12-02 |
2023-08-13 |
human |
| Taxiarchis Katsinelos, Marcel Zeitler, Eleni Dimou, Andromachi Karakatsani, Hans-Michael Müller, Eliana Nachman, Julia P Steringer, Carmen Ruiz de Almodovar, Walter Nickel, Thomas R Jah. Unconventional Secretion Mediates the Trans-cellular Spreading of Tau. Cell reports. vol 23. issue 7. 2019-12-02. PMID:29768203. |
the progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark of tauopathies, including alzheimer's disease. |
2019-12-02 |
2023-08-13 |
Not clear |