All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Anuradha Venkatramani, Dulal Pand. Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies. International journal of biological macromolecules. vol 133. 2019-11-14. PMID:31004638. abnormal functioning of tau is implicated in several neuronal disorders such as alzheimer's disease (ad) and parkinson's disease (pd), wherein tau forms insoluble aggregates and causes neurotoxicity. 2019-11-14 2023-08-13 Not clear
Heiko Braak, Kelly Del Tredic. Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 9. 2019-11-13. PMID:29982389. spreading of tau pathology in sporadic alzheimer's disease along cortico-cortical top-down connections. 2019-11-13 2023-08-13 Not clear
Heiko Braak, Kelly Del Tredic. Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 9. 2019-11-13. PMID:29982389. by using at8-immunocytochemistry that visualizes hyperphosphorylated tau protein, we examined neurofibrillary changes related to sporadic alzheimer's disease (ad) in n = 40 individuals at neurofibrillary tangle (nft) stages i-iv. 2019-11-13 2023-08-13 Not clear
Tetsuro Tago, Jun Toyohara, Ryuichi Harada, Shozo Furumoto, Nubuyuki Okamura, Yukitsuka Kudo, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kenji Ishi. Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site. Annals of nuclear medicine. vol 33. issue 6. 2019-11-11. PMID:30796626. amyloid-β plaques and neurofibrillary tangles composed of tau protein are the neuropathological hallmarks of alzheimer's disease. 2019-11-11 2023-08-13 Not clear
Tetsuro Tago, Jun Toyohara, Ryuichi Harada, Shozo Furumoto, Nubuyuki Okamura, Yukitsuka Kudo, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kenji Ishi. Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site. Annals of nuclear medicine. vol 33. issue 6. 2019-11-11. PMID:30796626. in recent years, marked progress has been made in alzheimer's disease research using tau ligands for positron emission tomography (pet). 2019-11-11 2023-08-13 Not clear
Shuo Qian, Jianlan Gu, Wufei Dai, Nana Jin, Dandan Chu, Qin Huang, Fei Liu, Wei Qia. Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice. Aging. vol 10. issue 9. 2019-11-08. PMID:30243024. these findings suggest that sirt1 may serve as a new drug target for alzheimer's disease related tauopathies and resveratrol may be used to correct dysregulated tau exon 10 with 3r-tau > 4r-tau. 2019-11-08 2023-08-13 mouse
Lewis D Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J Livese. Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways. Cell reports. vol 22. issue 13. 2019-11-05. PMID:29590627. in alzheimer's disease, neurofibrillary tangle pathology appears to spread along neuronal connections, proposed to be mediated by the release and uptake of abnormal, disease-specific forms of microtubule-binding protein tau mapt. 2019-11-05 2023-08-13 human
Tobey J Betthauser, Karly A Cody, Matthew D Zammit, Dhanabalan Murali, Alexander K Converse, Todd E Barnhart, Charles K Stone, Howard A Rowley, Sterling C Johnson, Bradley T Christia. In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 60. issue 1. 2019-11-04. PMID:29777006. in vivo characterization and quantification of neurofibrillary tau pet radioligand tau pet imaging has potential for elucidating changes in the deposition of neuropathological tau aggregates that are occurring during the progression of alzheimer disease (ad). 2019-11-04 2023-08-13 Not clear
Soumen Paul, Mohammad B Haskali, Jeih-San Liow, Sami S Zoghbi, Vanessa N Barth, Marcy Comly Kolodrubetz, Michelle R Bond, Cheryl L Morse, Robert L Gladding, Michael P Frankland, Nancy Kant, Lawrence Slieker, Sergey Shcherbinin, Hugh N Nuthall, Paolo Zanotti-Fregonara, John A Hanover, Cynthia Jesudason, Victor W Pike, Robert B Inni. Evaluation of a PET Radioligand to Image Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 60. issue 1. 2019-11-04. PMID:30213846. evaluation of a pet radioligand to image accumulation of hyperphosphorylated tau, a microtubule-associated protein, plays an important role in the progression of alzheimer disease. 2019-11-04 2023-08-13 Not clear
Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. glycosaminoglycans from alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. 2019-11-04 2023-08-13 Not clear
Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. although several processes regulated by hbgf are altered in alzheimer's disease, it is unknown whether the brain gag capacities to bind and regulate the function of hbgf or of other heparin binding proteins, as tau, are modified in this disease. 2019-11-04 2023-08-13 Not clear
Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. here, we show that total sulfated gags from hippocampus of alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including fgf-2, vegf, and bdnf while their capacity to bind to tau is remarkable increased. 2019-11-04 2023-08-13 Not clear
Luke Tait, Kyle Wedgwood, Krasimira Tsaneva-Atanasova, Jon T Brown, Marc Goodfello. Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells. Journal of theoretical biology. vol 449. 2019-10-31. PMID:29654854. the entorhinal cortex is a crucial component of our memory and spatial navigation systems and is one of the first areas to be affected in dementias featuring tau pathology, such as alzheimer's disease and frontotemporal dementia. 2019-10-31 2023-08-13 Not clear
Caiwei Guo, Hyun-Hwan Jeong, Yi-Chen Hsieh, Hans-Ulrich Klein, David A Bennett, Philip L De Jager, Zhandong Liu, Joshua M Shulma. Tau Activates Transposable Elements in Alzheimer's Disease. Cell reports. vol 23. issue 10. 2019-10-31. PMID:29874575. tau activates transposable elements in alzheimer's disease. 2019-10-31 2023-08-13 human
Caiwei Guo, Hyun-Hwan Jeong, Yi-Chen Hsieh, Hans-Ulrich Klein, David A Bennett, Philip L De Jager, Zhandong Liu, Joshua M Shulma. Tau Activates Transposable Elements in Alzheimer's Disease. Cell reports. vol 23. issue 10. 2019-10-31. PMID:29874575. integrating studies of human postmortem brain tissue and drosophila melanogaster models, we investigate te activation in association with tau pathology in alzheimer's disease (ad). 2019-10-31 2023-08-13 human
Ann Van der Jeugd, Arnaldo Parra-Damas, Raquel Baeta-Corral, Carlos M Soto-Faguás, Tariq Ahmed, Frank M LaFerla, Lydia Giménez-Llort, Rudi D'Hooge, Carlos A Saur. Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Scientific reports. vol 8. issue 1. 2019-10-29. PMID:29691439. accumulation of amyloid-β plaques and tau contribute to the pathogenesis of alzheimer's disease (ad), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. 2019-10-29 2023-08-13 mouse
Yoshiaki Nakayama, Shinji Sakamoto, Kazumi Tsuji, Takashi Ayaki, Fuminori Tokunaga, Hidefumi It. Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer's disease. Neuroscience letters. vol 703. 2019-10-29. PMID:30885635. identification of linear polyubiquitin chain immunoreactivity in tau pathology of alzheimer's disease. 2019-10-29 2023-08-13 Not clear
Yoshiaki Nakayama, Shinji Sakamoto, Kazumi Tsuji, Takashi Ayaki, Fuminori Tokunaga, Hidefumi It. Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer's disease. Neuroscience letters. vol 703. 2019-10-29. PMID:30885635. our results imply that linear polyubiquitination follows k48-linked polyubiquitination in abnormally accumulated tau proteins in alzheimer's disease, and imply involvement in its neurodegeneration. 2019-10-29 2023-08-13 Not clear
Jalayne J Arias, Ana M Tyler, Benjamin J Oster, Jason Karlawis. The Proactive Patient: Long-Term Care Insurance Discrimination Risks of Alzheimer's Disease Biomarkers. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics. vol 46. issue 2. 2019-10-28. PMID:30147000. previously diagnosed by symptoms alone, alzheimer's disease is now also defined by measures of amyloid and tau, referred to as "biomarkers." 2019-10-28 2023-08-13 Not clear
Rongwei Zhai, Joshua Rizak, Na Zheng, Xiaping He, Zhenhui Li, Yong Yin, Tao Su, Yingge He, Rongqiao He, Yuanye Ma, Meifeng Yang, Zhengbo Wang, Xintian H. Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates. Current Alzheimer research. vol 15. issue 14. 2019-10-28. PMID:30182853. formaldehyde (fa) has been implicated in alzheimer's disease (ad) pathology as an age-related factor and as a protein cross-linker known to aggregate amyloid-beta (aβ) and tau protein in vitro. 2019-10-28 2023-08-13 Not clear