All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Olufemi D Akilo, Pradeep Kumar, Yahya E Choonara, Priyamvada Pradeep, Lisa C du Toit, Viness Pilla. Hypothesis: apo-lactoferrin-Galantamine Proteo-alkaloid Conjugate for Alzheimer's disease Intervention. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-15. PMID:29377514. alzheimer's disease (ad) is known to be caused by the accumulation of deformed beta amyloid and hyperphosphorylated tau proteins resulting into formation and aggregation of senile plaques and neurofibrillary tangles in the brain. 2019-10-15 2023-08-13 Not clear
Jessica E Chukwu, Jan T Pedersen, Lars Ø Pedersen, Christiane Volbracht, Einar M Sigurdsson, Xiang-Peng Kon. Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29670132. tau antibodies have shown therapeutic potential for alzheimer's disease and several are in clinical trials. 2019-10-15 2023-08-13 Not clear
Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including alzheimer's disease, frontotemporal dementia with parkinsonism, corticobasal degeneration, progressive supranuclear palsy, down syndrome, and pick's disease. 2019-10-14 2023-08-13 mouse
Marija Iljina, Alexander J Dear, Gonzalo A Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R Whiten, Thomas C T Michaels, Daan Frenkel, Christopher M Dobson, Tuomas P J Knowles, David Klenerma. Quantifying Co-Oligomer Formation by α-Synuclein. ACS nano. vol 12. issue 11. 2019-10-14. PMID:30371053. in addition, αs can form co-aggregates with its mutational variants and with other proteins such as amyloid-β (aβ) and tau, which are implicated in alzheimer's disease. 2019-10-14 2023-08-13 Not clear
Radu Constantinescu, Lars Rosengren, Barbro Eriksson, Kaj Blennow, Markus Axelsso. Cerebrospinal fluid neurofilament light and tau protein as mortality biomarkers in parkinsonism. Acta neurologica Scandinavica. vol 140. issue 2. 2019-10-14. PMID:31070772. the cerebrospinal fluid (csf) neurodegeneration biomarkers such as neurofilament light chain (nf-l), total tau (t-tau), and the tau pathology marker phosphorylated tau (p-tau) are related to mortality in other neurological disorders (eg, amyotrophic lateral sclerosis, alzheimer's disease), but have not been investigated in this respect in parkinsonian disorders. 2019-10-14 2023-08-13 Not clear
Yuetiva Deming, Logan Dumitrescu, Lisa L Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A Gifford, William S Bush, Lori B Chibnik, Shubhabrata Mukherjee, Philip L De Jager, Walter Kukull, Matt Huentelman, Paul K Crane, Susan M Resnick, C Dirk Keene, Thomas J Montine, Gerard D Schellenberg, Jonathan L Haines, Henrik Zetterberg, Kaj Blennow, Eric B Larson, Sterling C Johnson, Marilyn Albert, Abhay Moghekar, Jorge L Del Aguila, Maria Victoria Fernandez, John Budde, Jason Hassenstab, Anne M Fagan, Matthias Riemenschneider, Ronald C Petersen, Lennart Minthon, Michael J Chao, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Elaine R Peskind, Gail Li, Lea K Davis, Julia M Sealock, Nancy J Cox, Alison M Goate, David A Bennett, Julie A Schneider, Angela L Jefferson, Carlos Cruchaga, Timothy J Hohma. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta neuropathologica. vol 136. issue 6. 2019-10-09. PMID:29967939. cerebrospinal fluid (csf) levels of amyloid-β 42 (aβ42) and tau have been evaluated as endophenotypes in alzheimer's disease (ad) genetic studies. 2019-10-09 2023-08-13 Not clear
Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). 2019-10-09 2023-08-13 rat
Kurt A Jellinge. Different patterns of hippocampal tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30088091. different patterns of hippocampal tau pathology in alzheimer's disease and part. 2019-10-08 2023-08-13 Not clear
Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. epitope determines efficacy of therapeutic anti-tau antibodies in a functional assay with human alzheimer tau. 2019-10-08 2023-08-13 human
Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. in alzheimer's disease (ad) and other tauopathies, the cytosolic protein tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. 2019-10-08 2023-08-13 human
Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. tau filaments from multiple cases of sporadic and inherited alzheimer's disease adopt a common fold. 2019-10-08 2023-08-13 Not clear
Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. the ordered assembly of tau protein into abnormal filaments is a defining characteristic of alzheimer's disease (ad) and other neurodegenerative disorders. 2019-10-08 2023-08-13 Not clear
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Tau Protein Dysfunction after Brain Ischemia. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30282370. thus, we hypothesize that the changes in pattern of phosphorylation of tau protein are critical to microtubule function especially in neurons, and contribute to the neurodegeneration following brain ischemia-reperfusion episodes with alzheimer's disease phenotype. 2019-10-08 2023-08-13 Not clear
Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, J V Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Row. Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320587. risk of alzheimer's disease in obstructive sleep apnea syndrome: amyloid-β and tau imaging. 2019-10-08 2023-08-13 Not clear
Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, J V Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Row. Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320587. an association between obstructive sleep apnea (osa) and alzheimer's disease has been suggested but little is known about amyloid-β and tau deposition in this syndrome. 2019-10-08 2023-08-13 Not clear
Lisa Müller-Ehrenberg, Joost M Riphagen, Frans R J Verhey, Alexander T Sack, Heidi I L Jacob. Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320590. measures of amyloid-β (aβ) and phosphorylated tau (p-tau) concentrations in cerebrospinal fluid are extensively used for diagnostic and research purposes in alzheimer's disease (ad) as correlates of cortical thinning and cognitive outcomes. 2019-10-08 2023-08-13 human
Hsin-Yi Wu, Po-Cheng Kuo, Yi-Ting Wang, Hao-Tai Lin, Allyson D Roe, Bo Y Wang, Chia-Li Han, Bradley T Hyman, Yu-Ju Chen, Hwan-Ching Ta. β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals. Journal of neuropathology and experimental neurology. vol 77. issue 9. 2019-10-07. PMID:30016458. a synergy between β-amyloid (aβ) and tau appears to occur in alzheimer disease (ad), but the mechanisms of interaction, and potential locations, are little understood. 2019-10-07 2023-08-13 mouse
Yuta Takaichi, Yasuhisa Ano, James K Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy. Journal of neuropathology and experimental neurology. vol 77. issue 10. 2019-10-03. PMID:30107539. specifically, hyperphosphorylated tau (hp-tau) accumulates in alzheimer disease, frontotemporal dementia with parkinsonism linked to chromosome 17, and progressive supranuclear palsy; furthermore, phosphorylated α-synuclein (p-αsyn) accumulates in parkinson disease, dementia with lewy bodies, and multiple system atrophy. 2019-10-03 2023-08-13 mouse
Youssra K Al-Hilaly, Saskia J Pollack, Janet E Rickard, Michael Simpson, Ana-Caroline Raulin, Thomas Baddeley, Pascale Schellenberger, John M D Storey, Charles R Harrington, Claude M Wischik, Louise C Serpel. Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT). Journal of molecular biology. vol 430. issue 21. 2019-10-03. PMID:30121297. alzheimer's disease is a tauopathy characterized by pathological fibrillization of tau protein to form the paired helical filaments (phfs), which constitute neurofibrillary tangles. 2019-10-03 2023-08-13 Not clear
Tsuneya Ikezu, Cidi Chen, Annina M DeLeo, Ella Zeldich, M Daniele Fallin, Nicholas M Kanaan, Kathryn L Lunetta, Carmela R Abraham, Mark W Logue, Lindsay A Farre. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29516269. tau phosphorylation is impacted by rare akap9 mutations associated with alzheimer disease in african americans. 2019-10-02 2023-08-13 human