| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Radu Constantinescu, Lars Rosengren, Barbro Eriksson, Kaj Blennow, Markus Axelsso. Cerebrospinal fluid neurofilament light and tau protein as mortality biomarkers in parkinsonism. Acta neurologica Scandinavica. vol 140. issue 2. 2019-10-14. PMID:31070772. |
the cerebrospinal fluid (csf) neurodegeneration biomarkers such as neurofilament light chain (nf-l), total tau (t-tau), and the tau pathology marker phosphorylated tau (p-tau) are related to mortality in other neurological disorders (eg, amyotrophic lateral sclerosis, alzheimer's disease), but have not been investigated in this respect in parkinsonian disorders. |
2019-10-14 |
2023-08-13 |
Not clear |
| Yuetiva Deming, Logan Dumitrescu, Lisa L Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A Gifford, William S Bush, Lori B Chibnik, Shubhabrata Mukherjee, Philip L De Jager, Walter Kukull, Matt Huentelman, Paul K Crane, Susan M Resnick, C Dirk Keene, Thomas J Montine, Gerard D Schellenberg, Jonathan L Haines, Henrik Zetterberg, Kaj Blennow, Eric B Larson, Sterling C Johnson, Marilyn Albert, Abhay Moghekar, Jorge L Del Aguila, Maria Victoria Fernandez, John Budde, Jason Hassenstab, Anne M Fagan, Matthias Riemenschneider, Ronald C Petersen, Lennart Minthon, Michael J Chao, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Elaine R Peskind, Gail Li, Lea K Davis, Julia M Sealock, Nancy J Cox, Alison M Goate, David A Bennett, Julie A Schneider, Angela L Jefferson, Carlos Cruchaga, Timothy J Hohma. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta neuropathologica. vol 136. issue 6. 2019-10-09. PMID:29967939. |
cerebrospinal fluid (csf) levels of amyloid-β 42 (aβ42) and tau have been evaluated as endophenotypes in alzheimer's disease (ad) genetic studies. |
2019-10-09 |
2023-08-13 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). |
2019-10-09 |
2023-08-13 |
rat |
| Kurt A Jellinge. Different patterns of hippocampal tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30088091. |
different patterns of hippocampal tau pathology in alzheimer's disease and part. |
2019-10-08 |
2023-08-13 |
Not clear |
| Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. |
epitope determines efficacy of therapeutic anti-tau antibodies in a functional assay with human alzheimer tau. |
2019-10-08 |
2023-08-13 |
human |
| Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. |
in alzheimer's disease (ad) and other tauopathies, the cytosolic protein tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. |
2019-10-08 |
2023-08-13 |
human |
| Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. |
tau filaments from multiple cases of sporadic and inherited alzheimer's disease adopt a common fold. |
2019-10-08 |
2023-08-13 |
Not clear |
| Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. |
the ordered assembly of tau protein into abnormal filaments is a defining characteristic of alzheimer's disease (ad) and other neurodegenerative disorders. |
2019-10-08 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Tau Protein Dysfunction after Brain Ischemia. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30282370. |
thus, we hypothesize that the changes in pattern of phosphorylation of tau protein are critical to microtubule function especially in neurons, and contribute to the neurodegeneration following brain ischemia-reperfusion episodes with alzheimer's disease phenotype. |
2019-10-08 |
2023-08-13 |
Not clear |
| Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, J V Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Row. Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320587. |
risk of alzheimer's disease in obstructive sleep apnea syndrome: amyloid-β and tau imaging. |
2019-10-08 |
2023-08-13 |
Not clear |
| Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, J V Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Row. Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320587. |
an association between obstructive sleep apnea (osa) and alzheimer's disease has been suggested but little is known about amyloid-β and tau deposition in this syndrome. |
2019-10-08 |
2023-08-13 |
Not clear |
| Lisa Müller-Ehrenberg, Joost M Riphagen, Frans R J Verhey, Alexander T Sack, Heidi I L Jacob. Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's disease : JAD. vol 66. issue 2. 2019-10-08. PMID:30320590. |
measures of amyloid-β (aβ) and phosphorylated tau (p-tau) concentrations in cerebrospinal fluid are extensively used for diagnostic and research purposes in alzheimer's disease (ad) as correlates of cortical thinning and cognitive outcomes. |
2019-10-08 |
2023-08-13 |
human |
| Hsin-Yi Wu, Po-Cheng Kuo, Yi-Ting Wang, Hao-Tai Lin, Allyson D Roe, Bo Y Wang, Chia-Li Han, Bradley T Hyman, Yu-Ju Chen, Hwan-Ching Ta. β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals. Journal of neuropathology and experimental neurology. vol 77. issue 9. 2019-10-07. PMID:30016458. |
a synergy between β-amyloid (aβ) and tau appears to occur in alzheimer disease (ad), but the mechanisms of interaction, and potential locations, are little understood. |
2019-10-07 |
2023-08-13 |
mouse |
| Yuta Takaichi, Yasuhisa Ano, James K Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy. Journal of neuropathology and experimental neurology. vol 77. issue 10. 2019-10-03. PMID:30107539. |
specifically, hyperphosphorylated tau (hp-tau) accumulates in alzheimer disease, frontotemporal dementia with parkinsonism linked to chromosome 17, and progressive supranuclear palsy; furthermore, phosphorylated α-synuclein (p-αsyn) accumulates in parkinson disease, dementia with lewy bodies, and multiple system atrophy. |
2019-10-03 |
2023-08-13 |
mouse |
| Youssra K Al-Hilaly, Saskia J Pollack, Janet E Rickard, Michael Simpson, Ana-Caroline Raulin, Thomas Baddeley, Pascale Schellenberger, John M D Storey, Charles R Harrington, Claude M Wischik, Louise C Serpel. Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT). Journal of molecular biology. vol 430. issue 21. 2019-10-03. PMID:30121297. |
alzheimer's disease is a tauopathy characterized by pathological fibrillization of tau protein to form the paired helical filaments (phfs), which constitute neurofibrillary tangles. |
2019-10-03 |
2023-08-13 |
Not clear |
| Tsuneya Ikezu, Cidi Chen, Annina M DeLeo, Ella Zeldich, M Daniele Fallin, Nicholas M Kanaan, Kathryn L Lunetta, Carmela R Abraham, Mark W Logue, Lindsay A Farre. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29516269. |
tau phosphorylation is impacted by rare akap9 mutations associated with alzheimer disease in african americans. |
2019-10-02 |
2023-08-13 |
human |
| Tsuneya Ikezu, Cidi Chen, Annina M DeLeo, Ella Zeldich, M Daniele Fallin, Nicholas M Kanaan, Kathryn L Lunetta, Carmela R Abraham, Mark W Logue, Lindsay A Farre. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 2. 2019-10-02. PMID:29516269. |
we studied the effect of two rare mutations (rs144662445 and rs149979685) in the a-kinase anchoring protein 9 (akap9) gene, previously associated with alzheimer disease (ad) in african americans (aa), on post-translational modifications of ad-related pathogenic molecules, amyloid precursor protein (app) and microtubule-associated protein tau using lymphoblastoid cell lines (lcls) from 11 aa subjects with at least one akap9 mutation and 17 aa subjects lacking these mutations. |
2019-10-02 |
2023-08-13 |
human |
| João Vaz-Silva, Patrícia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares-Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO journal. vol 37. issue 20. 2019-10-01. PMID:30166454. |
emerging studies implicate tau as an essential mediator of neuronal atrophy and cognitive impairment in alzheimer's disease (ad), yet the factors that precipitate tau dysfunction in ad are poorly understood. |
2019-10-01 |
2023-08-13 |
Not clear |
| Andrés Norambuena, Horst Wallrabe, Rui Cao, Dora Bigler Wang, Antonia Silva, Zdenek Svindrych, Ammasi Periasamy, Song Hu, Rudolph E Tanzi, Doo Yeon Kim, George S Bloo. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. The EMBO journal. vol 37. issue 22. 2019-10-01. PMID:30348864. |
amyloid-β oligomers, which are precursors of amyloid plaques in alzheimer's disease brain and stimulate mtorc1 protein kinase activity at the plasma membrane but not at lysosomes, block this nutrient-induced mitochondrial activity (nima) by a mechanism dependent on tau, which forms neurofibrillary tangles in alzheimer's disease brain. |
2019-10-01 |
2023-08-13 |
Not clear |
| Kenjiro On. Alzheimer's disease as oligomeropathy. Neurochemistry international. vol 119. 2019-09-30. PMID:28821400. |
alzheimer's disease (ad) is the most common age-related neurodegenerative disorder and is characterized by pathological aggregates of amyloid β-protein (aβ) and tau protein. |
2019-09-30 |
2023-08-13 |
mouse |