All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, Jonathan Graff-Radford, Robert I Reid, Val J Lowe, Samantha M Zuk, Matthew L Senjem, Christopher G Schwarz, Jeffrey L Gunter, Kejal Kantarci, Mary M Machulda, Michelle M Mielke, Ronald C Petersen, David S Knopman, Clifford R Jac. Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging. Annals of neurology. vol 84. issue 5. 2019-08-19. PMID:30264411. recent availability of amyloid and tau positron emission tomography (pet) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of alzheimer disease (ad) pathologies. 2019-08-19 2023-08-13 Not clear
Chengyu Li, Tetsuya Takahashi, Tejashwi Shrestha, Eiji Kinoshita, Tomoyasu Matsubara, Masayasu Matsumoto, Hirofumi Maruyam. 4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 66. issue 10. 2019-08-16. PMID:30106598. dapi was positive in 3r/4r (3-repeat/4-repeat) tau deposits in alzheimer's disease, myotonic dystrophy, and neurodegeneration with brain iron accumulation, and in 4r tau deposits in corticobasal degeneration, but negative in 4r tau deposits in frontotemporal dementia with parkinsonism-17 and progressive supranuclear palsy. 2019-08-16 2023-08-13 Not clear
Elizabeta B Mukaetova-Ladinska, Zeinab Abdell-All, Joana Andrade, Joaquim Alves da Silva, Irina Boksha, Gulnur Burbaeva, Raj N Kalaria, John T O Brie. Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer's Disease: An Explorative Study. Current Alzheimer research. vol 15. issue 9. 2019-08-15. PMID:29623842. platelet tau protein as a potential peripheral biomarker in alzheimer's disease: an explorative study. 2019-08-15 2023-08-13 Not clear
Elizabeta B Mukaetova-Ladinska, Zeinab Abdell-All, Joana Andrade, Joaquim Alves da Silva, Irina Boksha, Gulnur Burbaeva, Raj N Kalaria, John T O Brie. Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer's Disease: An Explorative Study. Current Alzheimer research. vol 15. issue 9. 2019-08-15. PMID:29623842. cerebrospinal fluid (csf) measures of tau and amyloid proteins have now been largely accepted to be a diagnostic tool to aid the clinical diagnosis of alzheimer's disease (ad), but csf is not routinely obtained in most clinical settings. 2019-08-15 2023-08-13 Not clear
Ianara Mendonça da Costa, Marco Aurelio de Moura Freire, José Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araújo, Bianca Norrara, Isleânia Maria Marques Moreira Rosa, Eduardo Pereira de Azevedo, Amália Cinthia Meneses do Rego, Irami Araújo Filho, Fausto Pierdoná Guze. Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review. Current neuropharmacology. vol 17. issue 5. 2019-08-14. PMID:29338678. the formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of alzheimer's disease (ad). 2019-08-14 2023-08-13 Not clear
Shengnuo Fan, Yuqiu Zheng, Xuan Liu, Wenli Fang, Xiaoyu Chen, Wang Liao, Xiuna Jing, Ming Lei, Enxiang Tao, Qiulan Ma, Xingmei Zhang, Rui Guo, Jun Li. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug delivery. vol 25. issue 1. 2019-08-14. PMID:30107760. alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. 2019-08-14 2023-08-13 mouse
Cristina Lois, Ivan Gonzalez, Keith A Johnson, Julie C Pric. PET imaging of tau protein targets: a methodology perspective. Brain imaging and behavior. vol 13. issue 2. 2019-08-12. PMID:29497982. the two neuropathological hallmarks of alzheimer's disease (ad) are amyloid-[formula: see text] plaques and neurofibrillary tangles of tau protein. 2019-08-12 2023-08-13 Not clear
Timo Jan Oberstein, Lava Taha, Philipp Spitzer, Janina Hellstern, Martin Herrmann, Johannes Kornhuber, Juan Manuel Male. Imbalance of Circulating T Frontiers in immunology. vol 9. 2019-08-12. PMID:29915582. imbalance of circulating t the neuropathological hallmarks of alzheimer's disease (ad), i.e., neuritic plaques and neurofibrillary tangles, consist of beta amyloid peptides (aβ) and hyperphosphorylated tau. 2019-08-12 2023-08-13 Not clear
Sung-Chun Tang, Kai-Chien Yang, Chih-Hao Chen, Shieh-Yueh Yang, Ming-Jang Chiu, Chau-Chung Wu, Jiann-Shing Jen. Plasma β-Amyloids and Tau Proteins in Patients with Vascular Cognitive Impairment. Neuromolecular medicine. vol 20. issue 4. 2019-08-12. PMID:30242618. increases in plasma of β-amyloids (aβ) and tau proteins have been noted in patients with alzheimer's dementia (ad). 2019-08-12 2023-08-13 Not clear
Borislav Dejanovic, Melanie A Huntley, Ann De Mazière, William J Meilandt, Tiffany Wu, Karpagam Srinivasan, Zhiyu Jiang, Vineela Gandham, Brad A Friedman, Hai Ngu, Oded Foreman, Richard A D Carano, Ben Chih, Judith Klumperman, Corey Bakalarski, Jesse E Hanson, Morgan Shen. Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies. Neuron. vol 100. issue 6. 2019-08-08. PMID:30392797. synapse loss and tau pathology are hallmarks of alzheimer's disease (ad) and other tauopathies, but how tau pathology causes synapse loss is unclear. 2019-08-08 2023-08-13 mouse
Alexandra Litvinchuk, Ying-Wooi Wan, Dan B Swartzlander, Fading Chen, Allysa Cole, Nicholas E Propson, Qian Wang, Bin Zhang, Zhandong Liu, Hui Zhen. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415998. complement c3ar inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and alzheimer's disease. 2019-08-08 2023-08-13 mouse
Alexandra Litvinchuk, Ying-Wooi Wan, Dan B Swartzlander, Fading Chen, Allysa Cole, Nicholas E Propson, Qian Wang, Bin Zhang, Zhandong Liu, Hui Zhen. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415998. strong evidence implicates the complement pathway as an important contributor to amyloid pathology in alzheimer's disease (ad); however, the role of complement in tau modulation remains unclear. 2019-08-08 2023-08-13 mouse
Jessica E Chukwu, Erin E Congdon, Einar M Sigurdsson, Xiang-Peng Kon. Structural characterization of monoclonal antibodies targeting C-terminal Ser mAbs. vol 11. issue 3. 2019-08-08. PMID:30794086. structural characterization of monoclonal antibodies targeting c-terminal ser targeting tau with immunotherapies is currently the most common approach taken in clinical trials of patients with alzheimer's disease. 2019-08-08 2023-08-13 Not clear
Hyo Sil Kim, Sang Hun Lee, Inhee Cho. On-chip plasmonic immunoassay based on targeted assembly of gold nanoplasmonic particles. The Analyst. vol 144. issue 8. 2019-08-08. PMID:30882805. using the proposed nonenzymatic immunoassay, we detected amyloid β (aβ) and tau proteins, representative biomarkers of alzheimer's disease, in femtomolar levels. 2019-08-08 2023-08-13 Not clear
Lindsay R Clark, Sara E Berman, Derek Norton, Rebecca L Koscik, Erin Jonaitis, Kaj Blennow, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Cynthia M Carlsso. Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid. Neurology. vol 90. issue 15. 2019-08-07. PMID:29523644. compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive csf markers of β-amyloid (aβ) or tau to adults without an alzheimer disease (ad)-associated biomarker profile. 2019-08-07 2023-08-13 Not clear
Eider M Arenaza-Urquijo, Prashanthi Vemur. Resistance vs resilience to Alzheimer disease: Clarifying terminology for preclinical studies. Neurology. vol 90. issue 15. 2019-08-07. PMID:29592885. preventing or delaying alzheimer disease (ad) through lifestyle interventions will come from a better understanding of the mechanistic underpinnings of (1) why a significant proportion of elderly remain cognitively normal with ad pathologies (adp), i.e., amyloid or tau; and (2) why some elderly individuals do not have significant adp. 2019-08-07 2023-08-13 Not clear
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoeh. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular neurodegeneration. vol 14. issue 1. 2019-08-07. PMID:30917861. aggregation of tau proteins is a distinct hallmark of tauopathies and has been a focus of research and clinical trials for alzheimer's disease. 2019-08-07 2023-08-13 mouse
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoeh. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular neurodegeneration. vol 14. issue 1. 2019-08-07. PMID:30917861. recent reports have pointed towards a toxic effect of soluble or oligomeric tau in the spreading of tau pathology in alzheimer's disease. 2019-08-07 2023-08-13 mouse
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoeh. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Molecular neurodegeneration. vol 14. issue 1. 2019-08-07. PMID:30917861. here we investigated the effects of expressing human tau repeat domain (taurd) with pro- or anti-aggregant mutations in regulatable transgenic mouse models of alzheimer's disease on the functional neuronal networks and the structural connectivity strength. 2019-08-07 2023-08-13 mouse
Tharick A Pascoal, Monica Shin, Min Su Kang, Mira Chamoun, Daniel Chartrand, Sulantha Mathotaarachchi, Idriss Bennacef, Joseph Therriault, Kok Pin Ng, Robert Hopewell, Reda Bouhachi, Hung-Hsin Hsiao, Andrea L Benedet, Jean-Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa-Net. In vivo quantification of neurofibrillary tangles with [ Alzheimer's research & therapy. vol 10. issue 1. 2019-08-06. PMID:30064520. in vivo quantification of neurofibrillary tangles with [ imaging agents capable of quantifying the brain's tau aggregates will allow a more precise staging of alzheimer's disease (ad). 2019-08-06 2023-08-13 Not clear