| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Carlos Polanco, Chuanzhou Li, Liviu-Gabriel Bodea, Ramon Martinez-Marmol, Frederic A Meunier, Jürgen Göt. Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology. vol 14. issue 1. 2019-08-27. PMID:29242522. |
in alzheimer disease, the peptide amyloid-β (aβ) and the protein tau aggregate to form plaques and tangles, respectively, which comprise the histopathological hallmarks of this disease. |
2019-08-27 |
2023-08-13 |
human |
| Victor L Villemagne, Vincent Doré, Samantha C Burnham, Colin L Masters, Christopher C Row. Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions. Nature reviews. Neurology. vol 14. issue 4. 2019-08-27. PMID:29449700. |
imaging tau and amyloid-β proteinopathies in alzheimer disease and other conditions. |
2019-08-27 |
2023-08-13 |
Not clear |
| Victor L Villemagne, Vincent Doré, Samantha C Burnham, Colin L Masters, Christopher C Row. Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions. Nature reviews. Neurology. vol 14. issue 4. 2019-08-27. PMID:29449700. |
in the case of alzheimer disease (ad), extracellular amyloid-β (aβ) aggregates and intracellular tau neurofibrillary tangles are the two neuropathological hallmarks of the disease. |
2019-08-27 |
2023-08-13 |
Not clear |
| William Jagus. Imaging the evolution and pathophysiology of Alzheimer disease. Nature reviews. Neuroscience. vol 19. issue 11. 2019-08-27. PMID:30266970. |
technologies for imaging the pathophysiology of alzheimer disease (ad) now permit studies of the relationships between the two major proteins deposited in this disease - amyloid-β (aβ) and tau - and their effects on measures of neurodegeneration and cognition in humans. |
2019-08-27 |
2023-08-13 |
Not clear |
| Anwar M Masoud, Syed W Bihaqi, Bothaina Alansi, Miriam Dash, Gehad M Subaiea, William E Renehan, Nasser H Zawi. Altered microRNA, mRNA, and Protein Expression of Neurodegeneration-Related Biomarkers and Their Transcriptional and Epigenetic Modifiers in a Human Tau Transgenic Mouse Model in Response to Developmental Lead Exposure. Journal of Alzheimer's disease : JAD. vol 63. issue 1. 2019-08-26. PMID:29614648. |
amyloid deposits originating from the amyloid-β protein precursor (aβpp) and aggregates of the microtubule associated protein tau (mapt) are the hallmarks of alzheimer's disease (ad). |
2019-08-26 |
2023-08-13 |
mouse |
| Fanny Rodríguez-Cruz, Francisco Miguel Torres-Cruz, Hugo Christian Monroy-Ramírez, Jaime Escobar-Herrera, Gustavo Basurto-Islas, Jesús Avila, Francisco García-Sierr. Fragmentation of the Golgi Apparatus in Neuroblastoma Cells Is Associated with Tau-Induced Ring-Shaped Microtubule Bundles. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30124450. |
abnormal fibrillary aggregation of tau protein is a pathological condition observed in alzheimer's disease and other tauopathies; however, the presence and pathological significance of early non-fibrillary aggregates of tau remain under investigation. |
2019-08-26 |
2023-08-13 |
human |
| Leonardo Tariciotti, Matthew Casadei, Lawrence S Honig, Andrew F Teich, Guy M McKhann Ii, Giuseppe Tosto, Richard Mayeu. Clinical Experience with Cerebrospinal Fluid Aβ42, Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30149454. |
elevated total tau (ttau), 181-phosphorylated phosphorylated tau (ptau), and low amyloid-β42 (aβ42) in cerebrospinal fluid (csf) represent a diagnostic biomarker for alzheimer's disease (ad). |
2019-08-26 |
2023-08-13 |
Not clear |
| Jeremy F Strain, Robert X Smith, Helen Beaumont, Catherine M Roe, Brian A Gordon, Shruti Mishra, Babatunde Adeyemo, Jon J Christensen, Yi Su, John C Morris, Tammie L S Benzinger, Beau M Ance. Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions. Neurology. vol 91. issue 4. 2019-08-21. PMID:29959265. |
loss of white matter integrity reflects tau accumulation in alzheimer disease defined regions. |
2019-08-21 |
2023-08-13 |
Not clear |
| Jeremy F Strain, Robert X Smith, Helen Beaumont, Catherine M Roe, Brian A Gordon, Shruti Mishra, Babatunde Adeyemo, Jon J Christensen, Yi Su, John C Morris, Tammie L S Benzinger, Beau M Ance. Loss of white matter integrity reflects tau accumulation in Alzheimer disease defined regions. Neurology. vol 91. issue 4. 2019-08-21. PMID:29959265. |
white matter (wm) projections were assessed from alzheimer disease (ad) gray matter regions associated with β-amyloid (aβ), tau, or neurodegeneration to ascertain relationship between wm structural integrity with aβ and/or tau deposition. |
2019-08-21 |
2023-08-13 |
Not clear |
| Michele M Comerota, Batbayar Tumurbaatar, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30120733. |
tau oligomers are emerging as a key contributor to the synaptic dysfunction that drives cognitive decline associated with the clinical manifestation and progression of alzheimer's disease (ad). |
2019-08-20 |
2023-08-13 |
mouse |
| Katherine Y Peng, Rocío Pérez-González, Melissa J Alldred, Chris N Goulbourne, Jose Morales-Corraliza, Mariko Saito, Mitsuo Saito, Stephen D Ginsberg, Paul M Mathews, Efrat Lev. Apolipoprotein E4 genotype compromises brain exosome production. Brain : a journal of neurology. vol 142. issue 1. 2019-08-20. PMID:30496349. |
in addition to being the greatest genetic risk factor for alzheimer's disease, expression of the ɛ4 allele of apolipoprotein e can lead to cognitive decline during ageing that is independent of alzheimer's amyloid-β and tau pathology. |
2019-08-20 |
2023-08-13 |
mouse |
| Erin E Congdon, Jessica E Chukwu, Dov B Shamir, Jingjing Deng, Devyani Ujla, Hameetha B R Sait, Thomas A Neubert, Xiang-Peng Kong, Einar M Sigurdsso. Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy. EBioMedicine. vol 42. 2019-08-20. PMID:30910484. |
since pathological tau protein is primarily intraneuronal in alzheimer's disease, the most efficacious antibodies should work both intra- and extracellularly. |
2019-08-20 |
2023-08-13 |
human |
| Richard Y-C Huang, Roxana E Iacob, Sethu Sankaranarayanan, Ling Yang, Michael Ahlijanian, Li Tao, Adrienne A Tymiak, Guodong Che. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of the American Society for Mass Spectrometry. vol 29. issue 1. 2019-08-19. PMID:28971440. |
fibrillization of the microtubule-associated protein tau has been recognized as one of the signature pathologies of the nervous system in alzheimer's disease, progressive supranuclear palsy, and other tauopathies. |
2019-08-19 |
2023-08-13 |
Not clear |
| Shorena Janelidze, Niklas Mattsson, Erik Stomrud, Olof Lindberg, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30054439. |
to measure csf levels of biomarkers reflecting microglia and astrocytes activation, neuroinflammation, and cerebrovascular changes and study their associations with the core biomarkers of alzheimer disease (ad) pathology (β-amyloid [aβ] and tau), structural imaging correlates, and clinical disease progression over time. |
2019-08-19 |
2023-08-13 |
Not clear |
| Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, John C Morris, Jason J Hassensta. Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30068637. |
influence of tau pet, amyloid pet, and hippocampal volume on cognition in alzheimer disease. |
2019-08-19 |
2023-08-13 |
Not clear |
| Olga Zolochevska, Nicole Bjorklund, Randall Woltjer, John E Wiktorowicz, Giulio Taglialatel. Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology. Journal of Alzheimer's disease : JAD. vol 65. issue 2. 2019-08-19. PMID:30103319. |
some individuals, here referred to as non-demented with alzheimer's neuropathology (ndan), retain their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic alzheimer's disease (ad). |
2019-08-19 |
2023-08-13 |
human |
| Inge M W Verberk, Rosalinde E Slot, Sander C J Verfaillie, Hans Heijst, Niels D Prins, Bart N M van Berckel, Philip Scheltens, Charlotte E Teunissen, Wiesje M van der Flie. Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes. Annals of neurology. vol 84. issue 5. 2019-08-19. PMID:30196548. |
we investigated the association of plasma amyloid beta (abeta)40, abeta42, and total tau (ttau) with the presence of alzheimer pathological changes in cognitively normal individuals with subjective cognitive decline (scd). |
2019-08-19 |
2023-08-13 |
Not clear |
| Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, Jonathan Graff-Radford, Robert I Reid, Val J Lowe, Samantha M Zuk, Matthew L Senjem, Christopher G Schwarz, Jeffrey L Gunter, Kejal Kantarci, Mary M Machulda, Michelle M Mielke, Ronald C Petersen, David S Knopman, Clifford R Jac. Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging. Annals of neurology. vol 84. issue 5. 2019-08-19. PMID:30264411. |
recent availability of amyloid and tau positron emission tomography (pet) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of alzheimer disease (ad) pathologies. |
2019-08-19 |
2023-08-13 |
Not clear |
| Chengyu Li, Tetsuya Takahashi, Tejashwi Shrestha, Eiji Kinoshita, Tomoyasu Matsubara, Masayasu Matsumoto, Hirofumi Maruyam. 4',6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 66. issue 10. 2019-08-16. PMID:30106598. |
dapi was positive in 3r/4r (3-repeat/4-repeat) tau deposits in alzheimer's disease, myotonic dystrophy, and neurodegeneration with brain iron accumulation, and in 4r tau deposits in corticobasal degeneration, but negative in 4r tau deposits in frontotemporal dementia with parkinsonism-17 and progressive supranuclear palsy. |
2019-08-16 |
2023-08-13 |
Not clear |
| Elizabeta B Mukaetova-Ladinska, Zeinab Abdell-All, Joana Andrade, Joaquim Alves da Silva, Irina Boksha, Gulnur Burbaeva, Raj N Kalaria, John T O Brie. Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer's Disease: An Explorative Study. Current Alzheimer research. vol 15. issue 9. 2019-08-15. PMID:29623842. |
platelet tau protein as a potential peripheral biomarker in alzheimer's disease: an explorative study. |
2019-08-15 |
2023-08-13 |
Not clear |