All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flin. Zinc Exacerbates Tau Pathology in a Tau Mouse Model. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914030. hyperphosphorylated tau protein is a key pathology in alzheimer's disease (ad), frontotemporal dementia, chronic traumatic encephalopathy, and parkinson's disease. 2019-07-15 2023-08-13 mouse
Diana Furcila, Javier DeFelipe, Lidia Alonso-Nanclare. A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914033. the main pathological hallmarks in alzheimer's disease (ad) are the presence of extracellular amyloid plaques, primarily consisting of amyloid-β (aβ) peptide, and the accumulation of paired helical filaments of hyperphosphorylated tau protein (phf-tau) within neurons. 2019-07-15 2023-08-13 Not clear
b' Ales Bartos, Lenka Fialov\\xc3\\xa1, Jana \\xc5\\xa0varcov\\xc3\\xa. Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29966192.' lower serum antibodies against tau protein and heavy neurofilament in alzheimer's disease. 2019-07-15 2023-08-13 Not clear
Grazia Daniela Femminella, Genevieve Taylor-Davies, James Scott, Paul Ediso. Do Cardiometabolic Risk Factors Influence Amyloid, Tau, and Neuronal Function in APOE4 Carriers and Non-Carriers in Alzheimer's Disease Trajectory? Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29966204. do cardiometabolic risk factors influence amyloid, tau, and neuronal function in apoe4 carriers and non-carriers in alzheimer's disease trajectory? 2019-07-15 2023-08-13 human
Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlar. Targeting metals rescues the phenotype in an animal model of tauopathy. Metallomics : integrated biometal science. vol 10. issue 9. 2019-07-15. PMID:30168573. this highlights the potential utility of targeting metal ions as a novel therapeutic strategy for diseases in which tau pathology is a feature, which includes conditions such as frontotemporal dementia and alzheimer's disease. 2019-07-15 2023-08-13 mouse
Mara Ten Kate, Ellen Dicks, Pieter Jelle Visser, Wiesje M van der Flier, Charlotte E Teunissen, Frederik Barkhof, Philip Scheltens, Betty M Tijm. Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline. Brain : a journal of neurology. vol 141. issue 12. 2019-07-15. PMID:30351346. in all alzheimer's disease dementia datasets we consistently identified four atrophy subtypes: (i) medial-temporal predominant atrophy with worst memory and language function, older age, lowest csf tau levels and highest amount of vascular lesions; (ii) parieto-occipital atrophy with poor executive/attention and visuospatial functioning and high csf tau; (iii) mild atrophy with best cognitive performance, young age, but highest csf tau levels; and (iv) diffuse cortical atrophy with intermediate clinical, cognitive and biological features. 2019-07-15 2023-08-13 human
Yoko Shigemoto, Daichi Sone, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Noriko Sato, Hiroshi Matsud. Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients. Brain and behavior. vol 8. issue 12. 2019-07-15. PMID:30358161. association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and alzheimer's disease spectrum patients. 2019-07-15 2023-08-13 Not clear
Yoko Shigemoto, Daichi Sone, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Noriko Sato, Hiroshi Matsud. Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients. Brain and behavior. vol 8. issue 12. 2019-07-15. PMID:30358161. alzheimer's disease (ad) is characterized by accumulation of extracellular amyloid-β and intracellular tau neurofibrillary tangles. 2019-07-15 2023-08-13 Not clear
Mahsa Mayeli, Seyed Mohammad Mirshahvalad, Vajiheh Aghamollaii, Abbas Tafakhori, Amirhussein Abdolalizadeh, Farzaneh Rahman. Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions. Journal of neuropathology and experimental neurology. 2019-07-15. PMID:31305887. globally normalized 18f-fdg-pet values and levels of nfl and tau were obtained from 149 patients with mild cognitive impairment (mci) from the baseline cohort of the alzheimer's disease neuroimaging initiative database. 2019-07-15 2023-08-13 Not clear
Mahsa Mayeli, Seyed Mohammad Mirshahvalad, Vajiheh Aghamollaii, Abbas Tafakhori, Amirhussein Abdolalizadeh, Farzaneh Rahman. Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions. Journal of neuropathology and experimental neurology. 2019-07-15. PMID:31305887. we adopted a stepwise partial correlation model using plasma nfl, plasma tau, csf nfl, and regional cerebral metabolic rate of glucose (cmrglc) as main variables, and age, sex, and alzheimer's disease rating scale (adas) as covariates. 2019-07-15 2023-08-13 Not clear
Christiane M Nday, Despoina Eleftheriadou, Graham Jackso. Magnetic chrysin silica nanomaterials behavior in an amyloidogenic environment. Hellenic journal of nuclear medicine. vol 22 Suppl. 2019-07-12. PMID:30877722. alzheimer's disease (ad) is a progressive neurodegenerative disorder associated with brain damage induced by β-amyloid and tau accumulation. 2019-07-12 2023-08-13 rat
E Karypidou, P Megagiannis, D Papaoikonomou, N Pelteki, O Gkatzima, M Tsolak. Callosal Angle and Evans Index predict beta amyloid and tau protein in patients with dementia. Hellenic journal of nuclear medicine. vol 22 Suppl. 2019-07-12. PMID:30877723. aβ and tau protein have been widely investigated for the diagnosis of dementia entities, most commonly alzheimer's disease (ad). 2019-07-12 2023-08-13 Not clear
Georgios Liakaki. Biochemical diagnosis of vascular cognitive impairment associated with subcortical small vessels disease. Hellenic journal of nuclear medicine. vol 22 Suppl. 2019-07-12. PMID:30877737. diagnostic biomarkers for alzheimer disease include reduction of cerebrospinal fluid amyloid-β (aβ)42 and of the ratio aβ42/aβ40 sometimes with increased total tau levels. 2019-07-12 2023-08-13 Not clear
Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. preclinical studies have shown that anesthesia might accelerate the clinical progression of alzheimer's disease (ad) and can have an impact on tau pathology, a hallmark of ad. 2019-07-11 2023-08-13 mouse
Clifford R Jack, Heather J Wiste, Terry M Therneau, Stephen D Weigand, David S Knopman, Michelle M Mielke, Val J Lowe, Prashanthi Vemuri, Mary M Machulda, Christopher G Schwarz, Jeffrey L Gunter, Matthew L Senjem, Jonathan Graff-Radford, David T Jones, Rosebud O Roberts, Walter A Rocca, Ronald C Peterse. Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia. JAMA. vol 321. issue 23. 2019-07-09. PMID:31211344. a national institute on aging and alzheimer's association workgroup proposed a research framework for alzheimer disease in which biomarker classification of research participants is labeled at(n) for amyloid, tau, and neurodegeneration biomarkers. 2019-07-09 2023-08-13 human
Michele M Comerota, Balaji Krishnan, Giulio Taglialatel. Near infrared light decreases synaptic vulnerability to amyloid beta oligomers. Scientific reports. vol 7. issue 1. 2019-07-08. PMID:29118388. synaptic dysfunction due to the disrupting binding of amyloid beta (aβ) and tau oligomers is one of the earliest impairments in alzheimer's disease (ad), driving initial cognitive deficits and clinical manifestation. 2019-07-08 2023-08-13 mouse
Hameetha Rajamohamedsait, Suhail Rasool, Wajitha Rajamohamedsait, Yan Lin, Einar M Sigurdsso. Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice. Scientific reports. vol 7. issue 1. 2019-07-08. PMID:29213096. amyloid-β (aβ) and tau pathologies are intertwined in alzheimer's disease, and various immunotherapies targeting these hallmarks are in clinical trials. 2019-07-08 2023-08-13 mouse
Arjune Sen, Valentina Capelli, Masud Husai. Cognition and dementia in older patients with epilepsy. Brain : a journal of neurology. vol 141. issue 6. 2019-07-08. PMID:29506031. recent studies in alzheimer's disease and late-onset epilepsy also suggest common pathological links mediated by underlying vascular changes and/or tau pathology. 2019-07-08 2023-08-13 Not clear
Clifford R Jack, Heather J Wiste, Christopher G Schwarz, Val J Lowe, Matthew L Senjem, Prashanthi Vemuri, Stephen D Weigand, Terry M Therneau, Dave S Knopman, Jeffrey L Gunter, David T Jones, Jonathan Graff-Radford, Kejal Kantarci, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Peterse. Longitudinal tau PET in ageing and Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29538647. longitudinal tau pet in ageing and alzheimer's disease. 2019-07-08 2023-08-13 Not clear
Clifford R Jack, Heather J Wiste, Christopher G Schwarz, Val J Lowe, Matthew L Senjem, Prashanthi Vemuri, Stephen D Weigand, Terry M Therneau, Dave S Knopman, Jeffrey L Gunter, David T Jones, Jonathan Graff-Radford, Kejal Kantarci, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Peterse. Longitudinal tau PET in ageing and Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29538647. among all tau pet meta-regions of interest, sample size estimates were smallest for a temporal lobe composite within cognitively unimpaired abnormal amyloid and for the late alzheimer's disease meta-region of interest within cognitively impaired abnormal amyloid. 2019-07-08 2023-08-13 Not clear