Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Clifford R Jack, Heather J Wiste, Christopher G Schwarz, Val J Lowe, Matthew L Senjem, Prashanthi Vemuri, Stephen D Weigand, Terry M Therneau, Dave S Knopman, Jeffrey L Gunter, David T Jones, Jonathan Graff-Radford, Kejal Kantarci, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Peterse. Longitudinal tau PET in ageing and Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 5. 2019-07-08. PMID:29538647. |
among all tau pet meta-regions of interest, sample size estimates were smallest for a temporal lobe composite within cognitively unimpaired abnormal amyloid and for the late alzheimer's disease meta-region of interest within cognitively impaired abnormal amyloid. |
2019-07-08 |
2023-08-13 |
Not clear |
Pei-Pei Guan, Pu Wan. Integrated communications between cyclooxygenase-2 and Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-07-08. PMID:30020833. |
elevated levels of cyclooxygenase-2 (cox-2) and prostaglandins (pgs) are involved in the pathogenesis of alzheimer's disease (ad), which is characterized by the accumulation of β-amyloid protein (aβ) and tau hyperphosphorylation. |
2019-07-08 |
2023-08-13 |
Not clear |
Lary C Walker, David G Lynn, Yury O Chernof. A standard model of Alzheimer's disease? Prion. vol 12. issue 5-6. 2019-07-08. PMID:30220236. |
by affirming markers of abnormal aβ and tau proteins as the essential pathobiological signature of alzheimer's disease, the framework tacitly reinforces the amyloid (aβ) cascade as the leading theory of alzheimer pathogenesis. |
2019-07-08 |
2023-08-13 |
Not clear |
Lary C Walker, David G Lynn, Yury O Chernof. A standard model of Alzheimer's disease? Prion. vol 12. issue 5-6. 2019-07-08. PMID:30220236. |
in light of recent evidence that the cascade is driven by the misfolding and templated aggregation of aβ and tau, we believe that an empirically grounded standard model of alzheimer's pathogenesis is within reach. |
2019-07-08 |
2023-08-13 |
Not clear |
A Ahnaou, D Moechars, L Raeymaekers, R Biermans, N V Manyakov, A Bottelbergs, C Wintmolders, K Van Kolen, T Van De Casteele, J A Kemp, W H Drinkenbur. Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer's disease pathology. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29079799. |
emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of alzheimer's disease pathology. |
2019-07-05 |
2023-08-13 |
mouse |
Shannon E Rose, Harald Frankowski, Allison Knupp, Bonnie J Berry, Refugio Martinez, Stephanie Q Dinh, Lauren T Bruner, Sherry L Willis, Paul K Crane, Eric B Larson, Thomas Grabowski, Martin Darvas, C Dirk Keene, Jessica E Youn. Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds. Journal of neuropathology and experimental neurology. vol 77. issue 5. 2019-07-05. PMID:29474672. |
additionally, neurons differentiated from these hipscs are functional and produce measurable alzheimer disease-relevant analytes (aβ and tau). |
2019-07-05 |
2023-08-13 |
human |
Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
early increase of csf strem2 in alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. |
2019-07-05 |
2023-08-13 |
Not clear |
Korey Kam, Ankit Parekh, Ram A Sharma, Andreia Andrade, Monica Lewin, Bresne Castillo, Omonigho M Bubu, Nicholas J Chua, Margo D Miller, Anna E Mullins, Lidia Glodzik, Lisa Mosconi, Nadia Gosselin, Kulkarni Prathamesh, Zhe Chen, Kaj Blennow, Henrik Zetterberg, Nisha Bagchi, Bianca Cavedoni, David M Rapoport, Indu Ayappa, Mony J de Leon, Eva Petkova, Andrew W Varga, Ricardo S Osori. Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30791922. |
sleep oscillation-specific associations with alzheimer's disease csf biomarkers: novel roles for sleep spindles and tau. |
2019-07-05 |
2023-08-13 |
Not clear |
Tirth K Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A McKee, Patrick W Sheehan, Erik S Musiek, Chengjie Xiong, Dean Coble, David M Holtzma. Dural lymphatics regulate clearance of extracellular tau from the CNS. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30813965. |
alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (aβ) protein and intracellular aggregates of tau protein. |
2019-07-05 |
2023-08-13 |
Not clear |
Hemi Malkk. Alzheimer disease: BACE1 inhibition could block CSF tau increase. Nature reviews. Neurology. vol 13. issue 1. 2019-07-03. PMID:27808264. |
alzheimer disease: bace1 inhibition could block csf tau increase. |
2019-07-03 |
2023-08-13 |
Not clear |
Henrik Zetterber. Tauomics and Kinetics in Human Neurons and Biological Fluids. Neuron. vol 97. issue 6. 2019-07-03. PMID:29566788. |
(2018) combine proteomics and a stable isotope labeling method to examine different forms of tau and their kinetics in human neurons, brain, and cerebrospinal fluid and how these properties relate to clinical state and pathology in alzheimer's disease. |
2019-07-03 |
2023-08-13 |
human |
Aurélien Lathuilière, Pamela Valdés, Stéphanie Papin, Matthias Cacquevel, Catherine Maclachlan, Graham W Knott, Andreas Muhs, Paolo Paganetti, Bernard L Schneide. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Scientific reports. vol 7. issue 1. 2019-07-02. PMID:29051562. |
tau pathology is associated with cognitive decline in alzheimer's disease, and missense tau mutations cause frontotemporal dementia. |
2019-07-02 |
2023-08-13 |
mouse |
Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
up-regulation of casein kinase 1ε is involved in tau pathogenesis in alzheimer's disease. |
2019-07-01 |
2023-08-13 |
mouse |
Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
hyperphosphorylation of tau and imbalanced expression of 3r-tau and 4r-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in alzheimer's disease (ad) brain is not fully understood. |
2019-07-01 |
2023-08-13 |
mouse |
Giacomo Koch, Francesco Di Lorenzo, Stefano Loizzo, Caterina Motta, Sara Travaglione, Monica Baiula, Roberto Rimondini, Viviana Ponzo, Sonia Bonnì, Sofia Toniolo, Fabrizio Sallustio, Marco Bozzali, Carlo Caltagirone, Gabriele Campana, Alessandro Martoran. CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29062035. |
csf tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in apoe4-positive alzheimer's disease. |
2019-07-01 |
2023-08-13 |
human |
Chelsea T Tiernan, Elliott J Mufson, Nicholas M Kanaan, Scott E Count. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29378005. |
tau oligomer pathology in nucleus basalis neurons during the progression of alzheimer disease. |
2019-07-01 |
2023-08-13 |
human |
Chelsea T Tiernan, Elliott J Mufson, Nicholas M Kanaan, Scott E Count. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29378005. |
although tau is the primary constituent of neurofibrillary tangles (nfts), evidence suggests that its toxic moiety is oligomeric in alzheimer disease (ad). |
2019-07-01 |
2023-08-13 |
human |
Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Lakshmi Changolkar, Dawn M Riddle, Susan N Leight, David J Irwin, John Q Trojanowski, Virginia M Y Le. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29415231. |
detection of alzheimer disease (ad)-specific tau pathology in ad and nonad tauopathies by immunohistochemistry with novel conformation-selective tau antibodies. |
2019-07-01 |
2023-08-13 |
Not clear |
Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Lakshmi Changolkar, Dawn M Riddle, Susan N Leight, David J Irwin, John Q Trojanowski, Virginia M Y Le. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29415231. |
here, we report the identification of novel tau monoclonal antibodies (mabs) that selectively bind to an alzheimer disease (ad)-specific conformation of pathological tau. |
2019-07-01 |
2023-08-13 |
Not clear |
Karishma Bhasne, Sanjana Sebastian, Neha Jain, Samrat Mukhopadhya. Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau. Journal of molecular biology. vol 430. issue 16. 2019-07-01. PMID:29704492. |
amyloidogenic intrinsically disordered proteins, α-synuclein and tau are linked to parkinson's disease and alzheimer's disease, respectively. |
2019-07-01 |
2023-08-13 |
Not clear |