| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maud Gratuze, Jacinthe Julien, Franck R Petry, Françoise Morin, Emmanuel Plane. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology. Scientific reports. vol 7. 2019-07-17. PMID:28402338. |
abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of alzheimer's disease (ad). |
2019-07-17 |
2023-08-13 |
mouse |
| Alison K Ower, Christoforos Hadjichrysanthou, Luuk Gras, Jaap Goudsmit, Roy M Anderson, Frank de Wol. Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease. European journal of epidemiology. vol 33. issue 7. 2019-07-17. PMID:29071500. |
temporal association patterns and dynamics of amyloid-β and tau in alzheimer's disease. |
2019-07-17 |
2023-08-13 |
Not clear |
| Sarah L DeVos, Bianca T Corjuc, Caitlin Commins, Simon Dujardin, Riley N Bannon, Diana Corjuc, Benjamin D Moore, Rachel E Bennett, Mehdi Jorfi, Jose A Gonzales, Patrick M Dooley, Allyson D Roe, Rose Pitstick, Daniel Irimia, Matthew P Frosch, George A Carlson, Bradley T Hyma. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain : a journal of neurology. vol 141. issue 7. 2019-07-17. PMID:29733334. |
several studies have now supported the use of a tau lowering agent as a possible therapy in the treatment of tauopathy disorders, including alzheimer's disease. |
2019-07-17 |
2023-08-13 |
mouse |
| Sarah L DeVos, Bianca T Corjuc, Caitlin Commins, Simon Dujardin, Riley N Bannon, Diana Corjuc, Benjamin D Moore, Rachel E Bennett, Mehdi Jorfi, Jose A Gonzales, Patrick M Dooley, Allyson D Roe, Rose Pitstick, Daniel Irimia, Matthew P Frosch, George A Carlson, Bradley T Hyma. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain : a journal of neurology. vol 141. issue 7. 2019-07-17. PMID:29733334. |
in human alzheimer's disease, however, concurrent amyloid-β deposition appears to synergize and accelerate tau pathological changes. |
2019-07-17 |
2023-08-13 |
mouse |
| John L Robinson, Edward B Lee, Sharon X Xie, Lior Rennert, EunRan Suh, Colin Bredenberg, Carrie Caswell, Vivianna M Van Deerlin, Ning Yan, Ahmed Yousef, Howard I Hurtig, Andrew Siderowf, Murray Grossman, Corey T McMillan, Bruce Miller, John E Duda, David J Irwin, David Wolk, Lauren Elman, Leo McCluskey, Alice Chen-Plotkin, Daniel Weintraub, Steven E Arnold, Johannes Brettschneider, Virginia M-Y Lee, John Q Trojanowsk. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a journal of neurology. vol 141. issue 7. 2019-07-17. PMID:29878075. |
our data imply that increased age and apoe ɛ4 status are risk factors for co-pathologies independent of neurodegenerative disease; that neurodegenerative disease severity influences co-pathology as evidenced by the prevalence of co-pathology in high alzheimer's disease and neocortical lewy body disease, but not intermediate alzheimer's disease or limbic lewy body disease; and that tau and α-synuclein strains may also modify co-pathologies since tauopathies and synucleinopathies had differing co-pathologies and burdens. |
2019-07-17 |
2023-08-13 |
Not clear |
| Medellena Maria Glymour, Adam Mark Brickman, Mika Kivimaki, Elizabeth Rose Mayeda, Geneviève Chêne, Carole Dufouil, Jennifer Jaie Manl. Will biomarker-based diagnosis of Alzheimer's disease maximize scientific progress? Evaluating proposed diagnostic criteria. European journal of epidemiology. vol 33. issue 7. 2019-07-17. PMID:29948371. |
a recently published framework for the diagnosis of alzheimer's disease (ad) in research studies would allow diagnosis on the sole basis of two biomarkers (β-amyloid and pathologic tau), even in people with no objective or subjective memory or cognitive changes. |
2019-07-17 |
2023-08-13 |
Not clear |
| Melanie Dani, Melanie Wood, Ruth Mizoguchi, Zhen Fan, Zuzana Walker, Richard Morgan, Rainer Hinz, Maya Biju, Tarun Kuruvilla, David J Brooks, Paul Ediso. Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30052812. |
microglial activation correlates in vivo with both tau and amyloid in alzheimer's disease. |
2019-07-17 |
2023-08-13 |
human |
| Melanie Dani, Melanie Wood, Ruth Mizoguchi, Zhen Fan, Zuzana Walker, Richard Morgan, Rainer Hinz, Maya Biju, Tarun Kuruvilla, David J Brooks, Paul Ediso. Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30052812. |
all subjects with mild cognitive impairment and alzheimer's disease and eight of the controls had tau (18f-av1451) pet. |
2019-07-17 |
2023-08-13 |
human |
| Melanie Dani, Melanie Wood, Ruth Mizoguchi, Zhen Fan, Zuzana Walker, Richard Morgan, Rainer Hinz, Maya Biju, Tarun Kuruvilla, David J Brooks, Paul Ediso. Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30052812. |
there were significant widespread clusters of positive correlation between levels of microglial activation and tau aggregation in both the mild cognitive impairment (amyloid-positive and amyloid-negative) and alzheimer's disease subjects. |
2019-07-17 |
2023-08-13 |
human |
| Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreke. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. vol 97. issue 4. 2019-07-15. PMID:29398363. |
synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with tau, including alzheimer's disease. |
2019-07-15 |
2023-08-13 |
mouse |
| Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreke. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. vol 97. issue 4. 2019-07-15. PMID:29398363. |
in disease conditions, tau mislocalizes into pre- and postsynaptic compartments; here we show that, under pathological conditions, tau binds to presynaptic vesicles in alzheimer's disease patient brain. |
2019-07-15 |
2023-08-13 |
mouse |
| Chihiro Sato, Nicolas R Barthélemy, Kwasi G Mawuenyega, Bruce W Patterson, Brian A Gordon, Jennifer Jockel-Balsarotti, Melissa Sullivan, Matthew J Crisp, Tom Kasten, Kristopher M Kirmess, Nicholas M Kanaan, Kevin E Yarasheski, Alaina Baker-Nigh, Tammie L S Benzinger, Timothy M Miller, Celeste M Karch, Randall J Batema. Tau Kinetics in Neurons and the Human Central Nervous System. Neuron. vol 97. issue 6. 2019-07-15. PMID:29566794. |
in cognitively normal and alzheimer's disease participants, the production rate of tau positively correlates with the amount of amyloid plaques, indicating a biological link between amyloid plaques and tau physiology. |
2019-07-15 |
2023-08-13 |
human |
| Nasimudeen R Jabir, Fayaz Rahman Khan, Shams Tabre. Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease. CNS neuroscience & therapeutics. vol 24. issue 9. 2019-07-15. PMID:29770579. |
alzheimer's disease (ad) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (aβ) oligomers, and neurofibrillary tangles (nfts), comprising of hyperphosphorylated tau proteins. |
2019-07-15 |
2023-08-13 |
Not clear |
| Wen Hu, Yunn Chyn Tung, Yanchong Zhang, Fei Liu, Khalid Iqba. Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury. Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29889065. |
in this study, we employed western blots and immunohistochemistry to test, in triple-transgenic mouse model of alzheimer's disease (3xtg-ad), the effect of r-mtbi on tau hyperphosphorylation and activation of asparaginyl endopeptidase (aep), a cysteine proteinase which is known to be involved in tau hyperphosphorylation. |
2019-07-15 |
2023-08-13 |
mouse |
| Ioanna Chalatsa, Demetrios A Arvanitis, Eleni V Mikropoulou, Athina Giagini, Zeta Papadopoulou-Daifoti, Nektarios Aligiannis, Maria Halabalaki, Anthony Tsarbopoulos, Leandros A Skaltsounis, Despina Sanoudo. Beneficial Effects of Sideritis scardica and Cichorium spinosum against Amyloidogenic Pathway and Tau Misprocessing in Alzheimer's Disease Neuronal Cell Culture Models. Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29914017. |
beneficial effects of sideritis scardica and cichorium spinosum against amyloidogenic pathway and tau misprocessing in alzheimer's disease neuronal cell culture models. |
2019-07-15 |
2023-08-13 |
human |
| Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flin. Zinc Exacerbates Tau Pathology in a Tau Mouse Model. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914030. |
hyperphosphorylated tau protein is a key pathology in alzheimer's disease (ad), frontotemporal dementia, chronic traumatic encephalopathy, and parkinson's disease. |
2019-07-15 |
2023-08-13 |
mouse |
| Diana Furcila, Javier DeFelipe, Lidia Alonso-Nanclare. A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914033. |
the main pathological hallmarks in alzheimer's disease (ad) are the presence of extracellular amyloid plaques, primarily consisting of amyloid-β (aβ) peptide, and the accumulation of paired helical filaments of hyperphosphorylated tau protein (phf-tau) within neurons. |
2019-07-15 |
2023-08-13 |
Not clear |
| b' Ales Bartos, Lenka Fialov\\xc3\\xa1, Jana \\xc5\\xa0varcov\\xc3\\xa. Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29966192.' |
lower serum antibodies against tau protein and heavy neurofilament in alzheimer's disease. |
2019-07-15 |
2023-08-13 |
Not clear |
| Grazia Daniela Femminella, Genevieve Taylor-Davies, James Scott, Paul Ediso. Do Cardiometabolic Risk Factors Influence Amyloid, Tau, and Neuronal Function in APOE4 Carriers and Non-Carriers in Alzheimer's Disease Trajectory? Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29966204. |
do cardiometabolic risk factors influence amyloid, tau, and neuronal function in apoe4 carriers and non-carriers in alzheimer's disease trajectory? |
2019-07-15 |
2023-08-13 |
human |
| Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlar. Targeting metals rescues the phenotype in an animal model of tauopathy. Metallomics : integrated biometal science. vol 10. issue 9. 2019-07-15. PMID:30168573. |
this highlights the potential utility of targeting metal ions as a novel therapeutic strategy for diseases in which tau pathology is a feature, which includes conditions such as frontotemporal dementia and alzheimer's disease. |
2019-07-15 |
2023-08-13 |
mouse |