| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ahnaou, D Moechars, L Raeymaekers, R Biermans, N V Manyakov, A Bottelbergs, C Wintmolders, K Van Kolen, T Van De Casteele, J A Kemp, W H Drinkenbur. Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer's disease pathology. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29079799. |
emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of alzheimer's disease pathology. |
2019-07-05 |
2023-08-13 |
mouse |
| Shannon E Rose, Harald Frankowski, Allison Knupp, Bonnie J Berry, Refugio Martinez, Stephanie Q Dinh, Lauren T Bruner, Sherry L Willis, Paul K Crane, Eric B Larson, Thomas Grabowski, Martin Darvas, C Dirk Keene, Jessica E Youn. Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds. Journal of neuropathology and experimental neurology. vol 77. issue 5. 2019-07-05. PMID:29474672. |
additionally, neurons differentiated from these hipscs are functional and produce measurable alzheimer disease-relevant analytes (aβ and tau). |
2019-07-05 |
2023-08-13 |
human |
| Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
early increase of csf strem2 in alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. |
2019-07-05 |
2023-08-13 |
Not clear |
| Korey Kam, Ankit Parekh, Ram A Sharma, Andreia Andrade, Monica Lewin, Bresne Castillo, Omonigho M Bubu, Nicholas J Chua, Margo D Miller, Anna E Mullins, Lidia Glodzik, Lisa Mosconi, Nadia Gosselin, Kulkarni Prathamesh, Zhe Chen, Kaj Blennow, Henrik Zetterberg, Nisha Bagchi, Bianca Cavedoni, David M Rapoport, Indu Ayappa, Mony J de Leon, Eva Petkova, Andrew W Varga, Ricardo S Osori. Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30791922. |
sleep oscillation-specific associations with alzheimer's disease csf biomarkers: novel roles for sleep spindles and tau. |
2019-07-05 |
2023-08-13 |
Not clear |
| Tirth K Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A McKee, Patrick W Sheehan, Erik S Musiek, Chengjie Xiong, Dean Coble, David M Holtzma. Dural lymphatics regulate clearance of extracellular tau from the CNS. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30813965. |
alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (aβ) protein and intracellular aggregates of tau protein. |
2019-07-05 |
2023-08-13 |
Not clear |
| Hemi Malkk. Alzheimer disease: BACE1 inhibition could block CSF tau increase. Nature reviews. Neurology. vol 13. issue 1. 2019-07-03. PMID:27808264. |
alzheimer disease: bace1 inhibition could block csf tau increase. |
2019-07-03 |
2023-08-13 |
Not clear |
| Henrik Zetterber. Tauomics and Kinetics in Human Neurons and Biological Fluids. Neuron. vol 97. issue 6. 2019-07-03. PMID:29566788. |
(2018) combine proteomics and a stable isotope labeling method to examine different forms of tau and their kinetics in human neurons, brain, and cerebrospinal fluid and how these properties relate to clinical state and pathology in alzheimer's disease. |
2019-07-03 |
2023-08-13 |
human |
| Aurélien Lathuilière, Pamela Valdés, Stéphanie Papin, Matthias Cacquevel, Catherine Maclachlan, Graham W Knott, Andreas Muhs, Paolo Paganetti, Bernard L Schneide. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects. Scientific reports. vol 7. issue 1. 2019-07-02. PMID:29051562. |
tau pathology is associated with cognitive decline in alzheimer's disease, and missense tau mutations cause frontotemporal dementia. |
2019-07-02 |
2023-08-13 |
mouse |
| Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
up-regulation of casein kinase 1ε is involved in tau pathogenesis in alzheimer's disease. |
2019-07-01 |
2023-08-13 |
mouse |
| Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
hyperphosphorylation of tau and imbalanced expression of 3r-tau and 4r-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in alzheimer's disease (ad) brain is not fully understood. |
2019-07-01 |
2023-08-13 |
mouse |
| Giacomo Koch, Francesco Di Lorenzo, Stefano Loizzo, Caterina Motta, Sara Travaglione, Monica Baiula, Roberto Rimondini, Viviana Ponzo, Sonia Bonnì, Sofia Toniolo, Fabrizio Sallustio, Marco Bozzali, Carlo Caltagirone, Gabriele Campana, Alessandro Martoran. CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29062035. |
csf tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in apoe4-positive alzheimer's disease. |
2019-07-01 |
2023-08-13 |
human |
| Chelsea T Tiernan, Elliott J Mufson, Nicholas M Kanaan, Scott E Count. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29378005. |
tau oligomer pathology in nucleus basalis neurons during the progression of alzheimer disease. |
2019-07-01 |
2023-08-13 |
human |
| Chelsea T Tiernan, Elliott J Mufson, Nicholas M Kanaan, Scott E Count. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29378005. |
although tau is the primary constituent of neurofibrillary tangles (nfts), evidence suggests that its toxic moiety is oligomeric in alzheimer disease (ad). |
2019-07-01 |
2023-08-13 |
human |
| Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Lakshmi Changolkar, Dawn M Riddle, Susan N Leight, David J Irwin, John Q Trojanowski, Virginia M Y Le. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29415231. |
detection of alzheimer disease (ad)-specific tau pathology in ad and nonad tauopathies by immunohistochemistry with novel conformation-selective tau antibodies. |
2019-07-01 |
2023-08-13 |
Not clear |
| Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Lakshmi Changolkar, Dawn M Riddle, Susan N Leight, David J Irwin, John Q Trojanowski, Virginia M Y Le. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29415231. |
here, we report the identification of novel tau monoclonal antibodies (mabs) that selectively bind to an alzheimer disease (ad)-specific conformation of pathological tau. |
2019-07-01 |
2023-08-13 |
Not clear |
| Karishma Bhasne, Sanjana Sebastian, Neha Jain, Samrat Mukhopadhya. Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau. Journal of molecular biology. vol 430. issue 16. 2019-07-01. PMID:29704492. |
amyloidogenic intrinsically disordered proteins, α-synuclein and tau are linked to parkinson's disease and alzheimer's disease, respectively. |
2019-07-01 |
2023-08-13 |
Not clear |
| Hye-Jin Park, Kang-Woo Lee, Stephanie Oh, Run Yan, Jie Zhang, Thomas G Beach, Charles H Adler, Michael Voronkov, Steven P Braithwaite, Jeffry B Stock, M Maral Mouradia. Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 77. issue 2. 2019-06-28. PMID:29281045. |
hyperphosphorylated tau aggregates are characteristic of tauopathies including progressive supranuclear palsy (psp) and alzheimer disease (ad), but factors contributing to pathologic tau phosphorylation are not well understood. |
2019-06-28 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Emrah Düzel, Frank Jessen, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Christian Haass, Marc Suárez-Calvet, Anne M Fagan, Katrina Paumier, Tammie Benzinger, Colin L Masters, John C Morris, Robert Perneczky, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Stefan Teipel, Ingo Kilimann, Alfredo Ramirez, Martin Rossor, Mathias Jucker, Jasmeer Chhatwal, Annika Spottke, Henning Boecker, Frederic Brosseron, Peter Falkai, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J Spruth, Christiana Franke, Anja Schneider, Barbara Kofler, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel Ángel Araque Caballero, Coraline Metzger, Daniel Bittner, Michael Weiner, Jae-Hong Lee, Stephen Salloway, Adrian Danek, Alison Goate, Peter R Schofield, Randall J Bateman, Michael Ewer. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29462334. |
as a marker of disease stage, we applied estimated years from symptom onset in autosomal dominantly inherited alzheimer's disease and cerebrospinal fluid tau levels in sporadic alzheimer's disease cases. |
2019-06-28 |
2023-08-13 |
human |
| Remika Mito, David Raffelt, Thijs Dhollander, David N Vaughan, J-Donald Tournier, Olivier Salvado, Amy Brodtmann, Christopher C Rowe, Victor L Villemagne, Alan Connell. Reply: Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease? Brain : a journal of neurology. vol 141. issue 6. 2019-06-28. PMID:29668851. |
reply: cortical tau pathology: a major player in fibre-specific white matter reductions in alzheimer's disease? |
2019-06-28 |
2023-08-13 |
Not clear |
| Kirsty E McAleese, Lauren Walker, Sean J Colloby, John-Paul Taylor, Alan J Thomas, Charles DeCarli, Johannes Attem. Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease? Brain : a journal of neurology. vol 141. issue 6. 2019-06-28. PMID:29668888. |
cortical tau pathology: a major player in fibre-specific white matter reductions in alzheimer's disease? |
2019-06-28 |
2023-08-13 |
Not clear |