| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas E Cope, Timothy Rittman, Robin J Borchert, P Simon Jones, Deniz Vatansever, Kieren Allinson, Luca Passamonti, Patricia Vazquez Rodriguez, W Richard Bevan-Jones, John T O'Brien, James B Row. Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29293892. |
conversely, in psp, unlike in alzheimer's disease, those nodes that accrued pathological tau were those that displayed graph metric properties associated with increased metabolic demand and a lack of trophic support rather than strong functional connectivity. |
2019-05-30 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezg. Networks of tau distribution in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29315361. |
networks of tau distribution in alzheimer's disease. |
2019-05-30 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezg. Networks of tau distribution in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29315361. |
see whitwell (doi:10.1093/brain/awy001) for a scientific commentary on this article.a stereotypical anatomical propagation of tau pathology has been described in alzheimer's disease. |
2019-05-30 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezg. Networks of tau distribution in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29315361. |
twenty-two 18f-av-1451 pet scans of patients with amnestic alzheimer's disease (mean age = 66.00 ± 7.22 years, 14 males/eight females) were spatially normalized, intensity standardized to the cerebellum, and z-transformed using the mean and deviation image of a healthy control sample to assess alzheimer's disease-related tau pathology. |
2019-05-30 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezg. Networks of tau distribution in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29315361. |
using the data-driven approach of an independent component analysis, we observed a set of independently coherent tau pathology networks in alzheimer's disease, which were associated with disease progression and coincided with functional networks previously reported to be impaired in alzheimer's disease. |
2019-05-30 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezg. Networks of tau distribution in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29315361. |
together, our results provide novel information regarding the impact of tau pathology networks on the mechanistic pathway of alzheimer's disease. |
2019-05-30 |
2023-08-13 |
Not clear |
| Gaëlle Dominguez, Marie-Lise Maddelein, Mélanie Pucelle, Yvan Nicaise, Claude-Alain Maurage, Charles Duyckaerts, Olivier Cuvillier, Marie-Bernadette Delisl. Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29615132. |
alzheimer's disease (ad) is characterized by the accumulation of β-amyloid (aβ) peptides and hyperphosphorylated tau protein accompanied by neuronal loss. |
2019-05-30 |
2023-08-13 |
Not clear |
| Caterina Giacomini, Chuay-Yeng Koo, Natalia Yankova, Ignatius A Tavares, Selina Wray, Wendy Noble, Diane P Hanger, Jonathan D H Morri. A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29730992. |
in alzheimer's disease (ad) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. |
2019-05-30 |
2023-08-13 |
mouse |
| Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs, Margot van Winsen, Martin H Koldijk, David Zuijdgeest, Marianne Borgers, Koen Dockx, Esther J M Stoop, Wenli Yu, Els C Brinkman-van der Linden, Kimberley Ummenthum, Kristof van Kolen, Marc Mercken, Stefan Steinbacher, Donata de Marco, Jeroen J Hoozemans, Ian A Wilson, Wouter Koudstaal, Jaap Goudsmi. A common antigenic motif recognized by naturally occurring human V Acta neuropathologica communications. vol 6. issue 1. 2019-05-30. PMID:29855358. |
a common antigenic motif recognized by naturally occurring human v misfolding and aggregation of tau protein are closely associated with the onset and progression of alzheimer's disease (ad). |
2019-05-30 |
2023-08-13 |
human |
| b' Spomenka Ki\\xc4\\x91emet-Piska\\xc4\\x8d, Mirjana Babi\\xc4\\x87 Leko, Antonela Bla\\xc5\\xbeekovi\\xc4\\x87, Lea Langer Horvat, Nata\\xc5\\xa1a Klepac, Zdenko Sonicki, Danijela Kolenc, Patrick R Hof, Marina Boban, Ninoslav Mimica, Fran Borove\\xc4\\x8dki, Goran \\xc5\\xa0imi\\xc4\\x8. Evaluation of cerebrospinal fluid phosphorylated tau CNS neuroscience & therapeutics. vol 24. issue 8. 2019-05-29. PMID:29453935.' |
evaluation of cerebrospinal fluid phosphorylated tau the diagnosis of either alzheimer's disease (ad) or vascular dementia (vad) is still largely based on clinical guidelines and exclusion of other diseases that may lead to dementia. |
2019-05-29 |
2023-08-13 |
Not clear |
| Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29562506. |
multi-faceted role of melatonin in neuroprotection and amelioration of tau aggregates in alzheimer's disease. |
2019-05-28 |
2023-08-13 |
Not clear |
| Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29562506. |
alzheimer's disease (ad) is one of the major age related neurodegenerative diseases whose pathology arises due to the presence of two distinct protein aggregates, viz., amyloid-β plaques in extracellular matrix and tau neurofibrillary tangles in neurons. |
2019-05-28 |
2023-08-13 |
Not clear |
| Katerina A Tetzloff, Jonathan Graff-Radford, Peter R Martin, Nirubol Tosakulwong, Mary M Machulda, Joseph R Duffy, Heather M Clark, Matthew L Senjem, Christopher G Schwarz, Anthony J Spychalla, Daniel A Drubach, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29614676. |
regional distribution, asymmetry, and clinical correlates of tau uptake on [18f]av-1451 pet in atypical alzheimer's disease. |
2019-05-28 |
2023-08-13 |
Not clear |
| Katerina A Tetzloff, Jonathan Graff-Radford, Peter R Martin, Nirubol Tosakulwong, Mary M Machulda, Joseph R Duffy, Heather M Clark, Matthew L Senjem, Christopher G Schwarz, Anthony J Spychalla, Daniel A Drubach, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29614676. |
despite common pathology, alzheimer's disease (ad) can have multiple clinical presentations which pathological studies suggest result from differences in the regional distribution of tau pathology. |
2019-05-28 |
2023-08-13 |
Not clear |
| Christopher M Lee, Heidi I L Jacobs, Marta Marquié, John A Becker, Nicolas V Andrea, David S Jin, Aaron P Schultz, Matthew P Frosch, Teresa Gómez-Isla, Reisa A Sperling, Keith A Johnso. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29614677. |
on target 18f-flortaucipir (ftp) binding of alzheimer's disease tau aggregates and off-target binding of melanocytes have been demonstrated with autoradiography. |
2019-05-28 |
2023-08-13 |
Not clear |
| Jianlan Gu, Nana Jin, Denglei Ma, Dandan Chu, Khalid Iqbal, Cheng-Xin Gong, Fei Li. Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. Journal of Alzheimer's disease : JAD. vol 62. issue 4. 2019-05-28. PMID:29614685. |
impairment of cerebral glucose uptake/metabolism in individuals with alzheimer's disease (ad) is believed to lead to downregulation of protein o-glcnacylation, which contributes to tau pathogenesis through tau hyperphosphorylation. |
2019-05-28 |
2023-08-13 |
human |
| Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dind. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European journal of medicinal chemistry. vol 169. 2019-05-28. PMID:30877973. |
however, in some overlapping cases, known as alzheimer with parkinson disease or vice versa, alpha-synuclein deposition in ad and tau deposition in pd patients are found. |
2019-05-28 |
2023-08-13 |
Not clear |
| Robert A Stern, Charles H Adler, Kewei Chen, Michael Navitsky, Ji Luo, David W Dodick, Michael L Alosco, Yorghos Tripodis, Dhruman D Goradia, Brett Martin, Diego Mastroeni, Nathan G Fritts, Johnny Jarnagin, Michael D Devous, Mark A Mintun, Michael J Pontecorvo, Martha E Shenton, Eric M Reima. Tau Positron-Emission Tomography in Former National Football League Players. The New England journal of medicine. vol 380. issue 18. 2019-05-28. PMID:30969506. |
the neuropathological diagnosis is based on a specific pattern of tau deposition with minimal amyloid-beta deposition that differs from other disorders, including alzheimer's disease. |
2019-05-28 |
2023-08-13 |
Not clear |
| Rosa Crespo, Wouter Koudstaal, Adrian Apetr. In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening. Journal of visualized experiments : JoVE. issue 141. 2019-05-23. PMID:30531722. |
aggregation of tau protein and formation of paired helical filaments is a hallmark of alzheimer's disease and other tauopathies. |
2019-05-23 |
2023-08-13 |
Not clear |
| Zhuohao He, Jing L Guo, Jennifer D McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A Coulter, Ted Abel, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Le. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine. vol 24. issue 1. 2019-05-22. PMID:29200205. |
amyloid-β plaques enhance alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. |
2019-05-22 |
2023-08-13 |
mouse |