| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeenat Mirza, Nisreen Raje. Identification of Electrophysiological Changes in Alzheimer's Disease: A Microarray Based Transcriptomics and Molecular Pathway Analysis Study. CNS & neurological disorders drug targets. vol 16. issue 9. 2019-03-25. PMID:29065845. |
involvement of amyloid beta and tau proteins in pathogenesis of alzheimer's disease (ad) has been studied extensively. |
2019-03-25 |
2023-08-13 |
Not clear |
| Val J Lowe, Heather J Wiste, Matthew L Senjem, Stephen D Weigand, Terry M Therneau, Bradley F Boeve, Keith A Josephs, Ping Fang, Mukesh K Pandey, Melissa E Murray, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Michelle M Mielke, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Clifford R Jac. Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. Brain : a journal of neurology. vol 141. issue 1. 2019-03-25. PMID:29228201. |
widespread brain tau and its association with ageing, braak stage and alzheimer's dementia. |
2019-03-25 |
2023-08-13 |
human |
| Val J Lowe, Heather J Wiste, Matthew L Senjem, Stephen D Weigand, Terry M Therneau, Bradley F Boeve, Keith A Josephs, Ping Fang, Mukesh K Pandey, Melissa E Murray, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Michelle M Mielke, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Clifford R Jac. Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. Brain : a journal of neurology. vol 141. issue 1. 2019-03-25. PMID:29228201. |
hierarchical clustering and clinical characteristic-based categorizations both showed different patterns of tau signal between groups such as greater tau signal in frontal regions in younger onset alzheimer's disease dementia participants (most of whom had a dysexecutive clinical presentation). |
2019-03-25 |
2023-08-13 |
human |
| David J Irwin, Corey T McMillan, Sharon X Xie, Katya Rascovsky, Vivianna M Van Deerlin, H Branch Coslett, Roy Hamilton, Geoffrey K Aguirre, Edward B Lee, Virginia M Y Lee, John Q Trojanowski, Murray Grossma. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a journal of neurology. vol 141. issue 1. 2019-03-25. PMID:29228211. |
tau = 9, tdp-43 = 14, or fus = 1 proteinopathy) or alzheimer's pathology (n = 2). |
2019-03-25 |
2023-08-13 |
Not clear |
| Chiara Lanzillotta, Antonella Tramutola, Shelby Meier, Frederick Schmitt, Eugenio Barone, Marzia Perluigi, Fabio Di Domenico, Jose F Abisambr. Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models. Journal of Alzheimer's disease : JAD. vol 62. issue 1. 2019-03-25. PMID:29439332. |
ds individuals have an increased risk of developing alzheimer's disease (ad)-like pathology and dementia by the age of 40 due to the triplication of several genes involved in the formation of amyloid plaques and tau tangles. |
2019-03-25 |
2023-08-13 |
mouse |
| Jonathan Vogelgsang, Dirk Wedekind, Caroline Bouter, Hans-W Klafki, Jens Wiltfan. Reproducibility of Alzheimer's Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions. Journal of Alzheimer's disease : JAD. vol 62. issue 1. 2019-03-25. PMID:29439341. |
dementia due to alzheimer's disease (ad) is characterized by elevated csf levels of total tau (ttau) and phospho-181-tau (ptau) and low csf amyloid-β42 (aβ42). |
2019-03-25 |
2023-08-13 |
human |
| Kuglae Kim, Jeong Seok Cha, Jin-Sik Kim, Jinsook Ahn, Nam-Chul Ha, Hyun-Soo Ch. Crystal structure of GSK3β in complex with the flavonoid, morin. Biochemical and biophysical research communications. vol 504. issue 2. 2019-03-25. PMID:30197003. |
in alzheimer's disease (ad), gsk3β has been implicated in hyperphosphorylation of tau proteins in the neuron, which is a hallmark of ad. |
2019-03-25 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Stanisław J Czuczwa. Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype. International journal of molecular sciences. vol 19. issue 12. 2019-03-25. PMID:30545070. |
recent knowledge on the activation of alzheimer's disease-related genes and proteins-e.g., amyloid protein precursor and tau protein-as well as brain ischemia and alzheimer's disease neuropathology indicate that similar processes contribute to neuronal death and disintegration of brain tissue in both disorders. |
2019-03-25 |
2023-08-13 |
Not clear |
| Cyril Laurent, Luc Buée, David Blu. Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies? Biomedical journal. vol 41. issue 1. 2019-03-22. PMID:29673549. |
tau and neuroinflammation: what impact for alzheimer's disease and tauopathies? |
2019-03-22 |
2023-08-13 |
Not clear |
| Molood Alsadat Vakilinezhad, Azadeh Amini, Hamid Akbari Javar, Batool Faegheh Baha'addini Beigi Zarandi, Hashem Montaseri, Rassoul Dinarvan. Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer's disease animal model by reducing Tau hyperphosphorylation. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 26. issue 2. 2019-03-22. PMID:30386982. |
nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in alzheimer's disease animal model by reducing tau hyperphosphorylation. |
2019-03-22 |
2023-08-13 |
Not clear |
| Hualong Wang, Xia Liu, Shengdi Chen, Keqiang Y. Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 52. 2019-03-22. PMID:30530690. |
alzheimer's disease (ad) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (nft) containing truncated and hyperphosphorylated tau, extensive neuronal loss, and chronic neuroinflammation. |
2019-03-22 |
2023-08-13 |
mouse |
| Hilary A Weismiller, Rachel Murphy, Guanghong Wei, Buyong Ma, Ruth Nussinov, Martin Margitta. Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms. The Journal of biological chemistry. vol 293. issue 45. 2019-03-19. PMID:30242125. |
the intracellular deposition of fibrils composed of the microtubule-associated protein tau is a characteristic feature of alzheimer's disease (ad) and other fatal neurodegenerative disorders collectively known as tauopathies. |
2019-03-19 |
2023-08-13 |
Not clear |
| Michael Nshanian, Carter Lantz, Piriya Wongkongkathep, Thomas Schrader, Frank-Gerrit Klärner, Anika Blümke, Clément Despres, Michael Ehrmann, Caroline Smet-Nocca, Gal Bitan, Joseph A Lo. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. Journal of the American Society for Mass Spectrometry. vol 30. issue 1. 2019-03-18. PMID:30062477. |
native top-down mass spectrometry (ms) and ion mobility spectrometry (ims) were applied to characterize the interaction of a molecular tweezer assembly modulator, clr01, with tau, a protein believed to be involved in a number of neurodegenerative disorders, including alzheimer's disease. |
2019-03-18 |
2023-08-13 |
Not clear |
| Matthew Hamm, Thomas B Ladd, Yona Levites, Todd E Golde, Benoit I Giasson, Jada Lewi. Designing antibodies against LRRK2-targeted tau epitopes. PloS one. vol 13. issue 9. 2019-03-18. PMID:30261006. |
we have recently demonstrated that the putative tau kinase leucine-rich repeat kinase 2 is capable of phosphorylating tau at threonines 169 and 175 in vitro, and it has been previously shown that hyperphosphorylation at threonine 175 occurs in filamentous tau species from alzheimer's brain tissue. |
2019-03-18 |
2023-08-13 |
mouse |
| Elaine Wan Ling Chan, Sangeetha Krishnansamy, Cindy Wong, Sook Yee Ga. The NLRP3 inflammasome is involved in the neuroprotective mechanism of neural stem cells against microglia-mediated toxicity in SH-SY5Y cells via the attenuation of tau hyperphosphorylation and amyloidogenesis. Neurotoxicology. vol 70. 2019-03-18. PMID:30408495. |
the cognitive impairment caused by alzheimer's disease (ad) is associated with beta-amyloid (aβ) and tau proteins, and is accompanied by inflammation. |
2019-03-18 |
2023-08-13 |
Not clear |
| Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi, D Allan Butterfiel. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free radical biology & medicine. vol 114. 2019-03-13. PMID:28807816. |
mtor in down syndrome: role in aß and tau neuropathology and transition to alzheimer disease-like dementia. |
2019-03-13 |
2023-08-13 |
human |
| Ilya M Nasrallah, Yin Jie Chen, Meng-Kang Hsieh, Jeffrey S Phillips, Kylie Ternes, Grace E Stockbower, Yvette Sheline, Corey T McMillan, Murray Grossman, David A Wol. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 2. 2019-03-12. PMID:28747523. |
nonamnestic alzheimer disease (ad) variants, including posterior cortical atrophy and the logopenic variant of primary progressive aphasia, differ from amnestic ad in distributions of tau aggregates and neurodegeneration. |
2019-03-12 |
2023-08-13 |
Not clear |
| Mathiyazahan Dhivya Bharathi, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Mashoque Ahmad Rather, Chidambaram Saravana Babu, Musthafa Mohamed Essa, Gilles J Guillemi. Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model. Neurotoxicity research. vol 35. issue 2. 2019-03-11. PMID:30242626. |
the neuroprotective role of tannoid principles of emblica officinalis (eot), an indian and chinese traditional medicinal plant against memory loss in aluminum chloride-induced in vivo model of alzheimer's disease through attenuating ache activity, oxidative stress, amyloid and tau toxicity, and apoptosis, was recently reported in our lab. |
2019-03-11 |
2023-08-13 |
Not clear |
| Cheril Tapia-Rojas, Nibaldo C Inestros. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of neurochemistry. vol 144. issue 4. 2019-03-08. PMID:29240990. |
alzheimer's disease (ad) is a neurodegenerative pathology characterized by aggregates of amyloid-β (aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. |
2019-03-08 |
2023-08-13 |
mouse |
| b' Maja Jazvin\\xc5\\xa1\\xc4\\x87ak Jembrek, Neda Slade, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. The interactions of p53 with tau and A\\xc3\\x9f as potential therapeutic targets for Alzheimer\'s disease. Progress in neurobiology. vol 168. 2019-03-08. PMID:29733887.' |
the interactions of p53 with tau and aß as potential therapeutic targets for alzheimer's disease. |
2019-03-08 |
2023-08-13 |
Not clear |