Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G Herrmann, Rosemary J Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L Spires-Jones, Joris De Wit, Patrik Verstreke. Tau association with synaptic vesicles causes presynaptic dysfunction. Nature communications. vol 8. 2018-11-19. PMID:28492240. |
tau is implicated in more than 20 neurodegenerative diseases, including alzheimer's disease. |
2018-11-19 |
2023-08-13 |
rat |
Zhangyu Guo, Yanxing Chen, Yan-Fang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhan. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Scientific reports. vol 7. 2018-11-16. PMID:28382978. |
long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced alzheimer's rat model. |
2018-11-16 |
2023-08-13 |
human |
V Guru KrishnaKumar, Ashim Paul, Ehud Gazit, Daniel Sega. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29311706. |
intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of alzheimer's disease (ad), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. |
2018-11-16 |
2023-08-13 |
Not clear |
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2018-11-16 |
2023-08-13 |
Not clear |
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
the best known out of these diseases is alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. |
2018-11-16 |
2023-08-13 |
Not clear |
Daniel Miguel Ángel Villalobos Acosta, Brenda Chimal Vega, José Correa Basurto, Leticia Guadalupe Fragoso Morales, Martha Cecilia Rosales Hernánde. Recent Advances by In Silico and In Vitro Studies of Amyloid-β 1-42 Fibril Depicted a S-Shape Conformation. International journal of molecular sciences. vol 19. issue 8. 2018-11-16. PMID:30115846. |
aβ1-42, together with the tau protein are two principal hallmarks of alzheimer's disease (ad) that are related to disease genesis and progression. |
2018-11-16 |
2023-08-13 |
Not clear |
Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M Wander, Victoria Madden, Ashutosh Tripathy, Chao-Xing Yuan, Todd J Cohe. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Scientific reports. vol 7. 2018-11-13. PMID:28287136. |
tau acetylation has recently emerged as a dominant post-translational modification (ptm) in alzheimer's disease (ad) and related tauopathies. |
2018-11-13 |
2023-08-13 |
Not clear |
Marina Chemerovski-Glikman, Moran Frenkel-Pinter, Ragad Mdah, Amjaad Abu-Mokh, Ehud Gazit, Daniel Sega. Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 40. 2018-11-12. PMID:28544138. |
inhibiting the toxic aggregation of amyloid-β and the tau protein, the key pathological agents involved in alzheimer's, is a leading approach in modulating disease progression. |
2018-11-12 |
2023-08-13 |
Not clear |
Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. |
synthesis of thiophene-based optical ligands that selectively detect tau pathology in alzheimer's disease. |
2018-11-12 |
2023-08-13 |
Not clear |
Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. |
here, the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (btvbts) that can be utilized for selective assignment of tau aggregates in brain tissue with alzheimer's disease (ad) pathology is reported. |
2018-11-12 |
2023-08-13 |
Not clear |
Laura M Taylor, Pamela J McMillan, Nicole F Liachko, Timothy J Strovas, Bernardino Ghetti, Thomas D Bird, C Dirk Keene, Brian C Kraeme. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29409526. |
both ttbk1 and ttbk2 were initially identified as tau kinases and ttbk1 has been shown to phosphorylate tau epitopes commonly observed in alzheimer's disease and other tauopathies. |
2018-11-09 |
2023-08-13 |
human |
Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. |
prion-like propagation of post-translationally modified tau in alzheimer's disease: a hypothesis. |
2018-11-08 |
2023-08-13 |
Not clear |
Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. |
the microtubule-associated protein tau plays a key role in the neuropathology of alzheimer's disease by forming intracellular neurofibrillary tangles. |
2018-11-08 |
2023-08-13 |
Not clear |
Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chian. Untangling the Tauopathy for Alzheimer's disease and parkinsonism. Journal of biomedical science. vol 25. issue 1. 2018-11-08. PMID:29991349. |
tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including alzheimer's disease (ad), and various parkinsonism. |
2018-11-08 |
2023-08-13 |
Not clear |
Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E Ehrlich, Philip L De Jager, David A Bennett, Eric E Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M Iijim. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome medicine. vol 10. issue 1. 2018-11-06. PMID:29598827. |
integrated biology approach reveals molecular and pathological interactions among alzheimer's aβ42, tau, trem2, and tyrobp in drosophila models. |
2018-11-06 |
2023-08-13 |
drosophila_melanogaster |
Shu-Hui Xin, Lin Tan, Xipeng Cao, Jin-Tai Yu, Lan Ta. Clearance of Amyloid Beta and Tau in Alzheimer's Disease: from Mechanisms to Therapy. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29626319. |
clearance of amyloid beta and tau in alzheimer's disease: from mechanisms to therapy. |
2018-11-06 |
2023-08-13 |
Not clear |
Heike J Wobst, Franziska Denk, Peter L Oliver, Achilleas Livieratos, Tonya N Taylor, Maria H Knudsen, Nora Bengoa-Vergniory, David Bannerman, Richard Wade-Martin. Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific reports. vol 7. 2018-11-05. PMID:28233851. |
the microtubule-associated protein tau is implicated in various neurodegenerative diseases including alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. |
2018-11-05 |
2023-08-13 |
mouse |
Yang Jiang, Bing Xu, Jing Chen, Yi Sui, Li Ren, Jing Li, Huiyu Zhang, Liqing Guo, Xiaohong Su. Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30102687. |
micro-rna-137 inhibits tau hyperphosphorylation in alzheimer's disease and targets the cacna1c gene in transgenic mice and human neuroblastoma sh-sy5y cells. |
2018-11-05 |
2023-08-13 |
mouse |
Joseph C Masde. Tau and Cortical Thickness in Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2018-10-30. PMID:28241165. |
tau and cortical thickness in alzheimer disease. |
2018-10-30 |
2023-08-13 |
Not clear |
Nour K Majbour, Davide Chiasserini, Nishant N Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi, Omar M A El-Agna. Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease. Scientific reports. vol 7. 2018-10-29. PMID:28071698. |
several studies reported an association between csf alpha-synuclein (α-syn) and tau in alzheimer's disease (ad), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical ad csf biomarkers. |
2018-10-29 |
2023-08-13 |
Not clear |