All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G Herrmann, Rosemary J Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L Spires-Jones, Joris De Wit, Patrik Verstreke. Tau association with synaptic vesicles causes presynaptic dysfunction. Nature communications. vol 8. 2018-11-19. PMID:28492240. tau is implicated in more than 20 neurodegenerative diseases, including alzheimer's disease. 2018-11-19 2023-08-13 rat
Zhangyu Guo, Yanxing Chen, Yan-Fang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhan. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Scientific reports. vol 7. 2018-11-16. PMID:28382978. long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced alzheimer's rat model. 2018-11-16 2023-08-13 human
V Guru KrishnaKumar, Ashim Paul, Ehud Gazit, Daniel Sega. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29311706. intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of alzheimer's disease (ad), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. 2018-11-16 2023-08-13 Not clear
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. 2018-11-16 2023-08-13 Not clear
Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. the best known out of these diseases is alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. 2018-11-16 2023-08-13 Not clear
Daniel Miguel Ángel Villalobos Acosta, Brenda Chimal Vega, José Correa Basurto, Leticia Guadalupe Fragoso Morales, Martha Cecilia Rosales Hernánde. Recent Advances by In Silico and In Vitro Studies of Amyloid-β 1-42 Fibril Depicted a S-Shape Conformation. International journal of molecular sciences. vol 19. issue 8. 2018-11-16. PMID:30115846. aβ1-42, together with the tau protein are two principal hallmarks of alzheimer's disease (ad) that are related to disease genesis and progression. 2018-11-16 2023-08-13 Not clear
Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M Wander, Victoria Madden, Ashutosh Tripathy, Chao-Xing Yuan, Todd J Cohe. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Scientific reports. vol 7. 2018-11-13. PMID:28287136. tau acetylation has recently emerged as a dominant post-translational modification (ptm) in alzheimer's disease (ad) and related tauopathies. 2018-11-13 2023-08-13 Not clear
Marina Chemerovski-Glikman, Moran Frenkel-Pinter, Ragad Mdah, Amjaad Abu-Mokh, Ehud Gazit, Daniel Sega. Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 40. 2018-11-12. PMID:28544138. inhibiting the toxic aggregation of amyloid-β and the tau protein, the key pathological agents involved in alzheimer's, is a leading approach in modulating disease progression. 2018-11-12 2023-08-13 Not clear
Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. synthesis of thiophene-based optical ligands that selectively detect tau pathology in alzheimer's disease. 2018-11-12 2023-08-13 Not clear
Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therése Klingstedt, Nigel J Cairns, K Peter R Nilsso. Synthesis of Thiophene-Based Optical Ligands That Selectively Detect Tau Pathology in Alzheimer's Disease. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 67. 2018-11-12. PMID:28926133. here, the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (btvbts) that can be utilized for selective assignment of tau aggregates in brain tissue with alzheimer's disease (ad) pathology is reported. 2018-11-12 2023-08-13 Not clear
Laura M Taylor, Pamela J McMillan, Nicole F Liachko, Timothy J Strovas, Bernardino Ghetti, Thomas D Bird, C Dirk Keene, Brian C Kraeme. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29409526. both ttbk1 and ttbk2 were initially identified as tau kinases and ttbk1 has been shown to phosphorylate tau epitopes commonly observed in alzheimer's disease and other tauopathies. 2018-11-09 2023-08-13 human
Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. prion-like propagation of post-translationally modified tau in alzheimer's disease: a hypothesis. 2018-11-08 2023-08-13 Not clear
Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. the microtubule-associated protein tau plays a key role in the neuropathology of alzheimer's disease by forming intracellular neurofibrillary tangles. 2018-11-08 2023-08-13 Not clear
Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chian. Untangling the Tauopathy for Alzheimer's disease and parkinsonism. Journal of biomedical science. vol 25. issue 1. 2018-11-08. PMID:29991349. tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including alzheimer's disease (ad), and various parkinsonism. 2018-11-08 2023-08-13 Not clear
Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E Ehrlich, Philip L De Jager, David A Bennett, Eric E Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M Iijim. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome medicine. vol 10. issue 1. 2018-11-06. PMID:29598827. integrated biology approach reveals molecular and pathological interactions among alzheimer's aβ42, tau, trem2, and tyrobp in drosophila models. 2018-11-06 2023-08-13 drosophila_melanogaster
Shu-Hui Xin, Lin Tan, Xipeng Cao, Jin-Tai Yu, Lan Ta. Clearance of Amyloid Beta and Tau in Alzheimer's Disease: from Mechanisms to Therapy. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29626319. clearance of amyloid beta and tau in alzheimer's disease: from mechanisms to therapy. 2018-11-06 2023-08-13 Not clear
Heike J Wobst, Franziska Denk, Peter L Oliver, Achilleas Livieratos, Tonya N Taylor, Maria H Knudsen, Nora Bengoa-Vergniory, David Bannerman, Richard Wade-Martin. Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific reports. vol 7. 2018-11-05. PMID:28233851. the microtubule-associated protein tau is implicated in various neurodegenerative diseases including alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. 2018-11-05 2023-08-13 mouse
Yang Jiang, Bing Xu, Jing Chen, Yi Sui, Li Ren, Jing Li, Huiyu Zhang, Liqing Guo, Xiaohong Su. Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30102687. micro-rna-137 inhibits tau hyperphosphorylation in alzheimer's disease and targets the cacna1c gene in transgenic mice and human neuroblastoma sh-sy5y cells. 2018-11-05 2023-08-13 mouse
Joseph C Masde. Tau and Cortical Thickness in Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2018-10-30. PMID:28241165. tau and cortical thickness in alzheimer disease. 2018-10-30 2023-08-13 Not clear
Nour K Majbour, Davide Chiasserini, Nishant N Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi, Omar M A El-Agna. Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease. Scientific reports. vol 7. 2018-10-29. PMID:28071698. several studies reported an association between csf alpha-synuclein (α-syn) and tau in alzheimer's disease (ad), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical ad csf biomarkers. 2018-10-29 2023-08-13 Not clear