| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer's Disease: A Hypothesis. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:29982964. |
the microtubule-associated protein tau plays a key role in the neuropathology of alzheimer's disease by forming intracellular neurofibrillary tangles. |
2018-11-08 |
2023-08-13 |
Not clear |
| Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chian. Untangling the Tauopathy for Alzheimer's disease and parkinsonism. Journal of biomedical science. vol 25. issue 1. 2018-11-08. PMID:29991349. |
tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including alzheimer's disease (ad), and various parkinsonism. |
2018-11-08 |
2023-08-13 |
Not clear |
| Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E Ehrlich, Philip L De Jager, David A Bennett, Eric E Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M Iijim. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome medicine. vol 10. issue 1. 2018-11-06. PMID:29598827. |
integrated biology approach reveals molecular and pathological interactions among alzheimer's aβ42, tau, trem2, and tyrobp in drosophila models. |
2018-11-06 |
2023-08-13 |
drosophila_melanogaster |
| Shu-Hui Xin, Lin Tan, Xipeng Cao, Jin-Tai Yu, Lan Ta. Clearance of Amyloid Beta and Tau in Alzheimer's Disease: from Mechanisms to Therapy. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29626319. |
clearance of amyloid beta and tau in alzheimer's disease: from mechanisms to therapy. |
2018-11-06 |
2023-08-13 |
Not clear |
| Heike J Wobst, Franziska Denk, Peter L Oliver, Achilleas Livieratos, Tonya N Taylor, Maria H Knudsen, Nora Bengoa-Vergniory, David Bannerman, Richard Wade-Martin. Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy. Scientific reports. vol 7. 2018-11-05. PMID:28233851. |
the microtubule-associated protein tau is implicated in various neurodegenerative diseases including alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau. |
2018-11-05 |
2023-08-13 |
mouse |
| Yang Jiang, Bing Xu, Jing Chen, Yi Sui, Li Ren, Jing Li, Huiyu Zhang, Liqing Guo, Xiaohong Su. Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30102687. |
micro-rna-137 inhibits tau hyperphosphorylation in alzheimer's disease and targets the cacna1c gene in transgenic mice and human neuroblastoma sh-sy5y cells. |
2018-11-05 |
2023-08-13 |
mouse |
| Joseph C Masde. Tau and Cortical Thickness in Alzheimer Disease. JAMA neurology. vol 74. issue 4. 2018-10-30. PMID:28241165. |
tau and cortical thickness in alzheimer disease. |
2018-10-30 |
2023-08-13 |
Not clear |
| Nour K Majbour, Davide Chiasserini, Nishant N Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma van de Berg, Lucilla Parnetti, Paolo Calabresi, Omar M A El-Agna. Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease. Scientific reports. vol 7. 2018-10-29. PMID:28071698. |
several studies reported an association between csf alpha-synuclein (α-syn) and tau in alzheimer's disease (ad), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical ad csf biomarkers. |
2018-10-29 |
2023-08-13 |
Not clear |
| Ankita Pathak, Ankit Rohilla, Tanya Gupta, Md Jawaid Akhtar, Md Rafi Haider, Kalicharan Sharma, Kashif Haider, M Shahar Ya. DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective. European journal of medicinal chemistry. vol 158. 2018-10-29. PMID:30243157. |
modern research had proposed that the over expression of dyrk1a (dual specificity tyrosine phosphorylation regulated kinase1a, a family of protein kinases, positioned within the down's syndrome critical region (dscr) on human chromosome 21causes phosphorylation of app protein resulting in its cleavage to aβ 40, 42 and tau proteins (regulated by beta and gamma secretase) which plays critical role in early onset of alzheimer's disease (ad) detected in down's syndrome (ds), leading to permanent functional and structural deformities which results ultimately into neuro-degeneration and neuronal death. |
2018-10-29 |
2023-08-13 |
human |
| Rik Ossenkoppele, Gil D Rabinovici, Ruben Smith, Hanna Cho, Michael Schöll, Olof Strandberg, Sebastian Palmqvist, Niklas Mattsson, Shorena Janelidze, Alexander Santillo, Tomas Ohlsson, Jonas Jögi, Richard Tsai, Renaud La Joie, Joel Kramer, Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, Jae Y Choi, Young H Ryu, Chul H Lyoo, Oskar Hansso. Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. vol 320. issue 11. 2018-10-29. PMID:30326496. |
the positron emission tomography (pet) tracer [18f]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of alzheimer disease (ad), but its diagnostic utility is unclear. |
2018-10-29 |
2023-08-13 |
Not clear |
| Andrea Magri, Angela Messin. Interactions of VDAC with Proteins Involved in Neurodegenerative Aggregation: An Opportunity for Advancement on Therapeutic Molecules. Current medicinal chemistry. vol 24. issue 40. 2018-10-25. PMID:28571556. |
in particular, the principal isoform vdac1 represents the main mitochondrial docking site of many misfolded proteins, such as amyloid β and tau in alzheimer's disease, α-synuclein in parkinson's disease and several sod1 mutants in amyotrophic lateral sclerosis. |
2018-10-25 |
2023-08-13 |
Not clear |
| Sarah S Darwish, Mohammad Abdel-Halim, Mohamed Salah, Ashraf H Abadi, Walter Becker, Matthias Enge. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. European journal of medicinal chemistry. vol 157. 2018-10-22. PMID:30193214. |
the protein kinase dyrk1a modulates several processes relevant to the development or progression of alzheimer's disease (ad), e. g. through phosphorylation of tau protein, amyloid precursor protein (app) as well as proteins involved in the regulation of alternative splicing of tau pre-mrna. |
2018-10-22 |
2023-08-13 |
Not clear |
| Zhongbao Zhang, Zhibin Liang, Longfei Yin, Qing X Li, Zhongyi W. Distribution of Four Bioactive Flavonoids in Maize Tissues of Five Varieties and Correlation with Expression of the Biosynthetic Genes. Journal of agricultural and food chemistry. vol 66. issue 40. 2018-10-19. PMID:30240197. |
c-glycosylflavones are neuroprotective against β-amyloid-induced tau hyperphosphorylation and neurotoxicity in sh-sy5y cells, which is relevant to alzheimer's disease prevention and treatment. |
2018-10-19 |
2023-08-13 |
Not clear |
| Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E Ehrnhoefe. A validated antibody panel for the characterization of tau post-translational modifications. Molecular neurodegeneration. vol 12. issue 1. 2018-10-18. PMID:29157277. |
aberrant ptms such as hyperphosphorylation result in tau aggregation and the formation of neurofibrillary tangles, which are a hallmark of alzheimer's disease (ad). |
2018-10-18 |
2023-08-13 |
human |
| Biyue Zhu, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Chen. Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models. Chemical communications (Cambridge, England). vol 54. issue 82. 2018-10-17. PMID:30204164. |
synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in alzheimer's models. |
2018-10-17 |
2023-08-13 |
mouse |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
predicted sequence of cortical tau and amyloid-β deposition in alzheimer disease spectrum. |
2018-10-16 |
2023-08-13 |
human |
| Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum. Neurobiology of aging. vol 68. 2018-10-16. PMID:29751288. |
we investigated sequential order between tau and amyloid-β (aβ) deposition in alzheimer disease spectrum using a conditional probability method. |
2018-10-16 |
2023-08-13 |
human |
| Faten A Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, Li Ga. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 40. 2018-10-16. PMID:30232263. |
alzheimer's disease (ad), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. |
2018-10-16 |
2023-08-13 |
Not clear |
| T West, Y Hu, P B Verghese, R J Bateman, J B Braunstein, I Fogelman, K Budur, H Florian, N Mendonca, D M Holtzma. Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies. The journal of prevention of Alzheimer's disease. vol 4. issue 4. 2018-10-11. PMID:29181488. |
tau neurofibrillary tangles are found in the brains of patients suffering from alzheimer's disease and other tauopathies. |
2018-10-11 |
2023-08-13 |
human |
| Young Kyoung Jang, Chul Hyoung Lyoo, Seongbeom Park, Seung Jun Oh, Hanna Cho, Minyoung Oh, Young Hoon Ryu, Jae Yong Choi, Gil D Rabinovici, Hee Jin Kim, Seung Hwan Moon, Hyemin Jang, Jin San Lee, William J Jagust, Duk L Na, Jae Seung Kim, Sang Won Se. Head to head comparison of [ European journal of nuclear medicine and molecular imaging. vol 45. issue 3. 2018-10-09. PMID:29143870. |
head to head comparison of [ tau accumulation is a core pathologic change in various neurodegenerative diseases including alzheimer's disease and frontotemporal lobar degeneration-tau. |
2018-10-09 |
2023-08-13 |
Not clear |