| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara D Reis, Brígida R Pinho, Jorge M A Oliveir. Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. Molecular neurobiology. vol 54. issue 8. 2018-08-06. PMID:27660272. |
indeed, available data, together with insights from effects on tau and alpha-synuclein in models of alzheimer's and parkinson's diseases, indicates that hsp70 modulators may lead to different effects on the proteostasis of different mutant and wild-type client proteins. |
2018-08-06 |
2023-08-13 |
Not clear |
| Xiao-Xia Fang, Gao-Lin Sun, Yi Zhou, Yi-Hua Qiu, Yu-Ping Pen. TGF-β1 protection against Aβ1-42-induced hippocampal neuronal inflammation and apoptosis by TβR-I. Neuroreport. vol 29. issue 2. 2018-08-06. PMID:29200096. |
alzheimer's disease (ad), the most common chronic neurodegenerative disease, is pathologically characterized by the formation of neurofibrillary tangles because of hyperphosphorylation of tau protein and extracellular deposits of amyloid-β (aβ) protein termed senile plaques. |
2018-08-06 |
2023-08-13 |
Not clear |
| Mohamed Salama, Ali Shalash, Alshimaa Magdy, Marianne Makar, Tamer Roushdy, Mahmoud Elbalkimy, Hanan Elrassas, Passent Elkafrawy, Wael Mohamed, Mohamed B Abou Doni. Tubulin and Tau: Possible targets for diagnosis of Parkinson's and Alzheimer's diseases. PloS one. vol 13. issue 5. 2018-08-01. PMID:29742117. |
tubulin and tau: possible targets for diagnosis of parkinson's and alzheimer's diseases. |
2018-08-01 |
2023-08-13 |
human |
| Ari W Schaler, Natura Myek. Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline. Translational research : the journal of laboratory and clinical medicine. vol 193. 2018-07-31. PMID:29232559. |
alzheimer's disease and several variants of frontotemporal degeneration including progressive supranuclear palsy and corticobasal degeneration are characterized by the accumulation of abnormal tau protein into aggregates. |
2018-07-31 |
2023-08-13 |
mouse |
| Andrea Vergallo, Cecilia Carlesi, Cristina Pagni, Filippo Sean Giorgi, Filippo Baldacci, Lucia Petrozzi, Roberto Ceravolo, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccell. A single center study: Aβ42/p-Tau Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 10. 2018-07-30. PMID:28726050. |
a single center study: aβ42/p-tau abnormal levels of beta amyloid (aβ42) and tau protein concentrations in the cerebral spinal fluid (csf) have been largely described in alzheimer's disease (ad). |
2018-07-30 |
2023-08-13 |
Not clear |
| Benita Jebarupa, Monita Muralidharan, Bindu Y Srinivasu, Amit Kumar Mandal, Gopa Mitr. Effect of altered solution conditions on tau conformational dynamics: Plausible implication on order propensity and aggregation. Biochimica et biophysica acta. Proteins and proteomics. vol 1866. issue 5-6. 2018-07-30. PMID:29630971. |
also, during alzheimer's disease, misfolded tau detaches from microtubule and forms ordered filaments, which is the hallmark of the disease. |
2018-07-30 |
2023-08-13 |
Not clear |
| Chunyan Zhu, Bing Xu, Xiaohong Sun, Qiwen Zhu, Yi Su. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878757. |
targeting ccr3 to reduce amyloid-β production, tau hyperphosphorylation, and synaptic loss in a mouse model of alzheimer's disease. |
2018-07-27 |
2023-08-13 |
mouse |
| Anne Claire Kim, Sungsu Lim, Yun Kyung Ki. Metal Ion Effects on Aβ and Tau Aggregation. International journal of molecular sciences. vol 19. issue 1. 2018-07-27. PMID:29301328. |
amyloid and tau aggregation are implicated in manifold neurodegenerative diseases and serve as two signature pathological hallmarks in alzheimer's disease (ad). |
2018-07-27 |
2023-08-13 |
Not clear |
| Carlo Condello, Jan Stöeh. Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease. Neurobiology of disease. vol 109. issue Pt B. 2018-07-26. PMID:28359847. |
the progressive nature of alzheimer's disease (ad) is thought to occur, at least in part, by the self-replication and spreading of aβ and tau aggregates through a prion mechanism. |
2018-07-26 |
2023-08-13 |
Not clear |
| Xiaohui Ma, Linlin Liu, Jing Men. MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer's disease. Neuroscience letters. vol 661. 2018-07-26. PMID:28947385. |
microrna-125b promotes neurons cell apoptosis and tau phosphorylation in alzheimer's disease. |
2018-07-26 |
2023-08-13 |
human |
| Jesper Skov Neergaard, Katrine Dragsbæk, Claus Christiansen, Morten Asser Karsdal, Susanne Brix, Kim Henrikse. Two novel blood-based biomarker candidates measuring degradation of tau are associated with dementia: A prospective study. PloS one. vol 13. issue 4. 2018-07-25. PMID:29641555. |
truncated tau appears to be specifically related to disease pathology and recent studies have shown the presence and elevation of several truncated tau species in cerebrospinal fluid (csf) of subjects with alzheimer's disease (ad); however, the relevance of truncated tau measurements in blood is still being studied. |
2018-07-25 |
2023-08-13 |
human |
| Xuhua Li, Xuewei Dong, Guanghong Wei, Martin Margittai, Ruth Nussinov, Buyong M. The distinct structural preferences of tau protein repeat domains. Chemical communications (Cambridge, England). vol 54. issue 45. 2018-07-25. PMID:29774342. |
the tau fibrillar structures from the brain of an alzheimer's patient have a core with a c-shaped motif of the third and fourth repeat domains (r3-r4). |
2018-07-25 |
2023-08-13 |
Not clear |
| Lidia Bakota, Abdala Ussif, Gunnar Jeserich, Roland Brand. Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies. Molecular and cellular neurosciences. vol 84. 2018-07-24. PMID:28318914. |
the most common tauopathy is alzheimer's disease, where tau pathology correlates with sites of neurodegeneration. |
2018-07-24 |
2023-08-13 |
human |
| Rachel E Bennett, Ashley B Robbins, Miwei Hu, Xinrui Cao, Rebecca A Betensky, Tim Clark, Sudeshna Das, Bradley T Hyma. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 6. 2018-07-24. PMID:29358399. |
tau induces blood vessel abnormalities and angiogenesis-related gene expression in p301l transgenic mice and human alzheimer's disease. |
2018-07-24 |
2023-08-13 |
mouse |
| Wenchao Sun, Seongsoo Lee, Xiaoran Huang, Song Liu, Mohammed Inayathullah, Kwang-Min Kim, Hongxiang Tang, J Wesson Ashford, Jayakumar Rajada. Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Scientific reports. vol 6. 2018-07-23. PMID:27708431. |
attenuation of synaptic toxicity and mark4/par1-mediated tau phosphorylation by methylene blue for alzheimer's disease treatment. |
2018-07-23 |
2023-08-13 |
drosophila_melanogaster |
| S L Angulo, R Orman, S A Neymotin, L Liu, L Buitrago, E Cepeda-Prado, D Stefanov, W W Lytton, M Stewart, S A Small, K E Duff, H Moren. Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiology of disease. vol 108. 2018-07-23. PMID:28860088. |
the entorhinal cortex (ec) is affected early in alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. |
2018-07-23 |
2023-08-13 |
mouse |
| Masaaki Waragai, Masaru Moriya, Takeshi Noj. Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:28968236. |
although molecular positron emission tomography imaging of amyloid and tau proteins can facilitate the detection of preclinical alzheimer's disease (ad) pathology, it is not useful in clinical practice. |
2018-07-23 |
2023-08-13 |
human |
| Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapan. Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:29036814. |
deregulation of cyclin-dependent kinase 5 (cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of alzheimer's disease (ad). |
2018-07-23 |
2023-08-13 |
mouse |
| Loïc Dayon, Jérôme Wojcik, Antonio Núñez Galindo, John Corthésy, Ornella Cominetti, Aikaterini Oikonomidi, Hugues Henry, Eugenia Migliavacca, Gene L Bowman, Julius Pop. Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:29125490. |
cerebrospinal fluid (csf) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing alzheimer's disease (ad). |
2018-07-23 |
2023-08-13 |
human |
| Anna Ochalek, Balázs Mihalik, Hasan X Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyé. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation. Alzheimer's research & therapy. vol 9. issue 1. 2018-07-23. PMID:29191219. |
neurons derived from sporadic alzheimer's disease ipscs reveal elevated tau hyperphosphorylation, increased amyloid levels, and gsk3b activation. |
2018-07-23 |
2023-08-13 |
human |