| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenyin Wang, Valeria Saar, Ka Lai Leung, Liang Chen, Garry Won. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiology of disease. vol 109. issue Pt A. 2018-06-25. PMID:28982592. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques consisting of amyloid-β peptide (aβ) aggregates and neurofibrillary tangles formed by aggregation of hyperphosphorylated microtubule-associated protein tau. |
2018-06-25 |
2023-08-13 |
human |
| J O'Callaghan, H Holmes, N Powell, J A Wells, O Ismail, I F Harrison, B Siow, R Johnson, Z Ahmed, A Fisher, S Meftah, M J O'Neill, T K Murray, E C Collins, K Shmueli, M F Lythgo. Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease. NeuroImage. vol 159. 2018-06-22. PMID:28797738. |
tissue magnetic susceptibility mapping as a marker of tau pathology in alzheimer's disease. |
2018-06-22 |
2023-08-13 |
mouse |
| J O'Callaghan, H Holmes, N Powell, J A Wells, O Ismail, I F Harrison, B Siow, R Johnson, Z Ahmed, A Fisher, S Meftah, M J O'Neill, T K Murray, E C Collins, K Shmueli, M F Lythgo. Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease. NeuroImage. vol 159. 2018-06-22. PMID:28797738. |
alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as 'tauopathies', by the presence of aggregated tau protein in the brain. |
2018-06-22 |
2023-08-13 |
mouse |
| Masato Hosokawa, Yoshinori Tanaka, Tetsuaki Arai, Hiromi Kondo, Haruhiko Akiyama, Masato Hasegaw. Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice. Experimental animals. vol 67. issue 1. 2018-06-22. PMID:28845019. |
moreover, recent findings indicate that grn mutations are associated with other neurodegenerative disorders with tau pathology, including alzheimer's disease. |
2018-06-22 |
2023-08-13 |
mouse |
| Ying Yao, Xianchun Chen, Yuting Bao, Yangsheng W. Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:28990074. |
excessive tau protein phosphorylation is important in the pathogenesis and early abnormal signal transduction of alzheimer's disease. |
2018-06-22 |
2023-08-13 |
Not clear |
| Ying Yao, Xianchun Chen, Yuting Bao, Yangsheng W. Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:28990074. |
the results of the present study demonstrated that puerarin may attenuate aβ1‑42‑induced tau hyperphosphorylation in sh‑sy5y cells, by inhibiting the expression of gsk‑3β and activating the wnt/β‑catenin signaling pathway; therefore, puerarin may exert protective effects against alzheimer's disease. |
2018-06-22 |
2023-08-13 |
Not clear |
| Mahmood Haj-Yahya, Hilal A Lashue. Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. Journal of the American Chemical Society. vol 140. issue 21. 2018-06-21. PMID:29684271. |
the microtubule-associated protein tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of alzheimer's disease (ad). |
2018-06-21 |
2023-08-13 |
Not clear |
| V Velickaite, V Giedraitis, K Ström, I Alafuzoff, H Zetterberg, L Lannfelt, L Kilander, E-M Larsson, M Ingelsso. Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease. BMC geriatrics. vol 17. issue 1. 2018-06-20. PMID:28886705. |
the alzheimer's disease (ad) brain displays atrophy with amyloid-β (aβ) and tau deposition, whereas decreased aβ42 and increased tau are measured in cerebrospinal fluid (csf). |
2018-06-20 |
2023-08-13 |
Not clear |
| E G B Vijverberg, A C M Pijnenburg, P Scheltens, Y A L Pijnenbur. [Chronic traumatic encephalopathy: an old acquaintance in athletes]. Nederlands tijdschrift voor geneeskunde. vol 161. 2018-06-18. PMID:28181891. |
- chronic traumatic encephalopathy (cte) is a neurodegenerative disease caused by repetitive head injuries like those seen in sports such as boxing, american football and soccer.- the clinical features of cte are a range of cognitive, psychiatric and motor symptoms, and histopathology involves deposits of hyperphosphorylated tau protein and the presence of tar dna-binding protein (tdp-43) with relatively little beta-amyloid.- cte is difficult to differentiate clinically from alzheimer's disease, frontotemporal dementia and psychiatric disorders because of the major symptom overlap between these conditions.- the most important risk factors for developing cte are the cumulative effect of repetitive head injuries, with or without clinical symptoms, and the duration of exposure to the repetitive injuries (the sporting career).- there is no treatment for cte at present and the strategy must be primarily geared to prevention.- in view of the large number of people, including those in the netherlands, who take part in sports in which head injuries may occur, research into cte is of major societal importance. |
2018-06-18 |
2023-08-13 |
Not clear |
| Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, Atsushi Iwat. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 45. 2018-06-18. PMID:29042514. |
alzheimer's disease (ad) is a chronic neurodegenerative disease characterized by pathology of accumulated amyloid β (aβ) and phosphorylated tau proteins in the brain. |
2018-06-18 |
2023-08-13 |
Not clear |
| Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Ten. Visual Ratings of Medial Temporal Lobe Atrophy Correlate with CSF Tau Indices in Clinical Variants of Early-Onset Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 44. issue 1-2. 2018-06-15. PMID:28675901. |
visual ratings of medial temporal lobe atrophy correlate with csf tau indices in clinical variants of early-onset alzheimer disease. |
2018-06-15 |
2023-08-13 |
Not clear |
| Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Ten. Visual Ratings of Medial Temporal Lobe Atrophy Correlate with CSF Tau Indices in Clinical Variants of Early-Onset Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 44. issue 1-2. 2018-06-15. PMID:28675901. |
prior studies of late-onset alzheimer disease (ad) have reported that cerebrospinal fluid (csf) tau levels correlate with hippocampal/medial temporal lobe atrophy. |
2018-06-15 |
2023-08-13 |
Not clear |
| H Hamodat, M K Cash, J D Fisk, S Darves. Cholinesterases in normal and Alzheimer's disease primary olfactory gyrus. Neuropathology and applied neurobiology. vol 43. issue 7. 2018-06-14. PMID:28644906. |
alzheimer's disease (ad) is characterized by cholinergic dysfunction and deposition of β-amyloid (aβ) plaques and tau neurofibrillary tangles (nfts) in the brain. |
2018-06-14 |
2023-08-13 |
human |
| Marta Marquié, Eline E Verwer, Avery C Meltzer, Sally Ji Who Kim, Cinthya Agüero, Jose Gonzalez, Sara J Makaretz, Michael Siao Tick Chong, Prianca Ramanan, Ana C Amaral, Marc D Normandin, Charles R Vanderburg, Stephen N Gomperts, Keith A Johnson, Matthew P Frosch, Teresa Gómez-Isl. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta neuropathologica communications. vol 5. issue 1. 2018-06-13. PMID:29047416. |
[f-18]-av-1451 is a novel positron emission tomography (pet) tracer with high affinity to neurofibrillary tau pathology in alzheimer's disease (ad). |
2018-06-13 |
2023-08-13 |
human |
| Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Pol. Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28774322. |
tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of alzheimer's disease. |
2018-06-12 |
2023-08-13 |
mouse |
| Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Pol. Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28774322. |
in alzheimer's disease (ad), pathological tau accumulation correlates with cognitive decline. |
2018-06-12 |
2023-08-13 |
mouse |
| Maud Gratuze, Jacinthe Julien, Françoise Morin, André Marette, Emmanuel Plane. Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28779908. |
differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of alzheimer's disease-like tau pathology fed with western diet. |
2018-06-12 |
2023-08-13 |
mouse |
| Maud Gratuze, Jacinthe Julien, Françoise Morin, André Marette, Emmanuel Plane. Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28779908. |
tau is a microtubule-associated protein that becomes pathological when it undergoes hyperphosphorylation and aggregation as seen in alzheimer's disease (ad). |
2018-06-12 |
2023-08-13 |
mouse |
| Harutsugu Tatebe, Takashi Kasai, Takuma Ohmichi, Yusuke Kishi, Tomoshi Kakeya, Masaaki Waragai, Masaki Kondo, David Allsop, Takahiko Tokud. Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28866979. |
quantification of plasma phosphorylated tau to use as a biomarker for brain alzheimer pathology: pilot case-control studies including patients with alzheimer's disease and down syndrome. |
2018-06-12 |
2023-08-13 |
Not clear |
| Laura Gil, Concetta Federico, Fernando Pinedo, Francesca Bruno, Ana B Rebolledo, Juan J Montoya, Isabel M Olazabal, Isidre Ferrer, Salvatore Saccon. Aging dependent effect of nuclear tau. Brain research. vol 1677. 2018-06-11. PMID:28974363. |
human at100 nuclear tau, endowed by phosphorylation in thr212/ser214, was recently shown to decline in cornus ammonis 1 (ca1) and dentate gyrus (dg) in alzheimer's disease (ad), but a defined function for this nuclear tau remains unclear. |
2018-06-11 |
2023-08-13 |
human |