| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rostislav Skrabana, Branislav Kovacech, Peter Filipcik, Norbert Zilka, Santosh Jadhav, Tomas Smolek, Eva Kontsekova, Michal Nova. Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28527208. |
our results underline the necessity of thiol-protecting conditions during the analysis of tau oligomers involved in the etiopathogenesis of various tauopathies including alzheimer's disease. |
2018-05-22 |
2023-08-13 |
mouse |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
plasma tau association with brain atrophy in mild cognitive impairment and alzheimer's disease. |
2018-05-22 |
2023-08-13 |
Not clear |
| Kacie D Deters, Shannon L Risacher, Sungeun Kim, Kwangsik Nho, John D West, Kaj Blennow, Henrik Zetterberg, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Andrew J Sayki. Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550246. |
peripheral (plasma) and central (cerebrospinal fluid, csf) measures of tau are higher in alzheimer's disease (ad) relative to prodromal stages and controls. |
2018-05-22 |
2023-08-13 |
Not clear |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 induces cell survival and has shown neuroprotection against amyloid and tau pathologies in alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Jennifer N Perusini, Stephanie A Cajigas, Omid Cohensedgh, Sean C Lim, Ina P Pavlova, Zoe R Donaldson, Christine A Denn. Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice. Hippocampus. vol 27. issue 10. 2018-05-18. PMID:28667669. |
alzheimer's disease (ad) is a prevalent neurodegenerative disorder characterized by amyloid-beta (aβ) plaques and tau neurofibrillary tangles. |
2018-05-18 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
alzheimer's disease advax(cpg)- adjuvanted multitep-based dual and single vaccines induce high-titer antibodies against various forms of tau and aβ pathological molecules. |
2018-05-15 |
2023-08-13 |
mouse |
| Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Nikolai Petrovsky, Michael G Agadjanyan, Anahit Ghochikya. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Scientific reports. vol 6. 2018-05-15. PMID:27363809. |
although β-amyloid (aβ) may be the primary driver of alzheimer's disease (ad) pathology, accumulation of pathological tau correlates with dementia in ad patients. |
2018-05-15 |
2023-08-13 |
mouse |
| Jie-Zhong Yu, Yan-Hua Li, Chun-Yun Liu, Qing Wang, Qing-Fang Gu, Hui-Qing Wang, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen M. Multitarget Therapeutic Effect of Fasudil in APP/PS1transgenic Mice. CNS & neurological disorders drug targets. vol 16. issue 2. 2018-05-15. PMID:27401064. |
therapeutic strategies targeting alzheimer's disease-related molecule β- amyloid (aβ), tau protein and β-site amyloid precursor protein cleaving enzyme (bace) have been recently explored. |
2018-05-15 |
2023-08-13 |
mouse |
| Patrick Reilly, Charisse N Winston, Kelsey R Baron, Margarita Trejo, Edward M Rockenstein, Johnny C Akers, Najla Kfoury, Marc Diamond, Eliezer Masliah, Robert A Rissman, Shauna H Yua. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiology of disease. vol 106. 2018-05-15. PMID:28610892. |
tauopathies are a class of neurodegenerative diseases, including alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (nft). |
2018-05-15 |
2023-08-13 |
mouse |
| Joery Goossens, Maria Bjerke, Hanne Struyfs, Ellis Niemantsverdriet, Charisse Somers, Tobi Van den Bossche, Sara Van Mossevelde, Bart De Vil, Anne Sieben, Jean-Jacques Martin, Patrick Cras, Johan Goeman, Peter Paul De Deyn, Christine Van Broeckhoven, Julie van der Zee, Sebastiaan Engelborgh. No added diagnostic value of non-phosphorylated tau fraction (p-tau Alzheimer's research & therapy. vol 9. issue 1. 2018-05-15. PMID:28709448. |
no added diagnostic value of non-phosphorylated tau fraction (p-tau the alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers aβ |
2018-05-15 |
2023-08-13 |
Not clear |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Christian Humpe. Platelets: Their Potential Contribution to the Generation of Beta-amyloid Plaques in Alzheimer's Disease. Current neurovascular research. vol 14. issue 3. 2018-05-14. PMID:28677497. |
alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, caa), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. |
2018-05-14 |
2023-08-13 |
Not clear |
| Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giust. Synaptic Plasticity, Dementia and Alzheimer Disease. CNS & neurological disorders drug targets. vol 16. issue 3. 2018-05-11. PMID:28088900. |
consider the aging-dependent neurodegenerative disorder alzheimer's disease (ad) which is characterised at the neuropathological level by deposits of insoluble amyloid β-peptide (aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles. |
2018-05-11 |
2023-08-13 |
human |
| Jian-Jiao Chen, Bin Zhao, Jie Zhao, Shao L. Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer's Disease. Neural plasticity. vol 2017. 2018-05-08. PMID:28770113. |
mirnas released from exosomes appear to be associated with multiple neurodegenerative conditions linking to alzheimer's disease (ad) which is marked by hyperphosphorylated tau proteins and accumulation of a |
2018-05-08 |
2023-08-13 |
Not clear |
| Elena Zenaro, Gennj Piacentino, Gabriela Constanti. The blood-brain barrier in Alzheimer's disease. Neurobiology of disease. vol 107. 2018-05-07. PMID:27425887. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder characterized by the pathological accumulation of amyloid beta (aβ) peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein. |
2018-05-07 |
2023-08-13 |
Not clear |
| Kevin H Strang, Marshall S Goodwin, Cara Riffe, Brenda D Moore, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28760159. |
tauopathies are a group of neurodegenerative disorders, including alzheimer's disease, defined by the presence of brain pathological inclusions comprised of abnormally aggregated and highly phosphorylated tau protein. |
2018-05-07 |
2023-08-13 |
mouse |
| Kevin H Strang, Marshall S Goodwin, Cara Riffe, Brenda D Moore, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28760159. |
they also reveal epitope-specific differences in the biochemical properties of alzheimer's disease sarkosyl-insoluble tau. |
2018-05-07 |
2023-08-13 |
mouse |
| Ivan Koychev, Roger N Gunn, Azadeh Firouzian, Jennifer Lawson, Giovanna Zamboni, Basil Ridha, Barbara J Sahakian, James B Rowe, Alan Thomas, Lynn Rochester, Dominic Ffytche, Robert Howard, Henrik Zetterberg, Clare MacKay, Simon Loveston. PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 60. issue 1. 2018-05-07. PMID:28800330. |
pet tau and amyloid-β burden in mild alzheimer's disease: divergent relationship with age, cognition, and cerebrospinal fluid biomarkers. |
2018-05-07 |
2023-08-13 |
Not clear |
| Ivan Koychev, Roger N Gunn, Azadeh Firouzian, Jennifer Lawson, Giovanna Zamboni, Basil Ridha, Barbara J Sahakian, James B Rowe, Alan Thomas, Lynn Rochester, Dominic Ffytche, Robert Howard, Henrik Zetterberg, Clare MacKay, Simon Loveston. PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 60. issue 1. 2018-05-07. PMID:28800330. |
combining pet amyloid-β (aβ) and tau imaging may be critical for tracking disease progression in alzheimer's disease (ad). |
2018-05-07 |
2023-08-13 |
Not clear |
| Roberto Santangelo, Giordano Cecchetti, Maria Paola Bernasconi, Rosalinda Cardamone, Alessandra Barbieri, Patrizia Pinto, Gabriella Passerini, Francesco Scomazzoni, Giancarlo Comi, Giuseppe Magnan. Cerebrospinal Fluid Amyloid-β 42, Total Tau and Phosphorylated Tau are Low in Patients with Normal Pressure Hydrocephalus: Analogies and Differences with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 1. 2018-05-07. PMID:28826180. |
cerebrospinal fluid amyloid-β 42, total tau and phosphorylated tau are low in patients with normal pressure hydrocephalus: analogies and differences with alzheimer's disease. |
2018-05-07 |
2023-08-13 |
human |