All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ana Laura Calderon-Garcidueñas, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987180. alzheimer disease neuropathology is characterized by the extracellular accumulation of aβ peptide and intracellular aggregation of hyperphosphorylated tau. 2018-01-29 2023-08-13 Not clear
Eleanor K Pickett, Robert M Koffie, Susanne Wegmann, Christopher M Henstridge, Abigail G Herrmann, Marti Colom-Cadena, Alberto Lleo, Kevin R Kay, Melissa Vaught, Roy Soberman, Dominic M Walsh, Bradley T Hyman, Tara L Spires-Jone. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258414. alzheimer's disease (ad) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of amyloid-β (aβ) peptide in senile plaques and intracellular accumulation of tau in neurofibrillary tangles. 2018-01-26 2023-08-13 mouse
Eric E Brown, Yusuke Iwata, Jun Ku Chung, Philip Gerretsen, Ariel Graff-Guerrer. Tau in Late-Life Depression: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 54. issue 2. 2018-01-26. PMID:27497481. a lifetime history of major depressive disorder (mdd) increases the risk of developing alzheimer's disease, of which neurofibrillary tangles due to abnormal tau proteins are a hallmark. 2018-01-26 2023-08-13 Not clear
Merina Varghese, Ismael Santa-Maria, Lap Ho, Libby Ward, Shrishailam Yemul, Lauren Dubner, Hanna Księżak-Reding, Giulio Maria Pasinett. Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain. Journal of Alzheimer's disease : JAD. vol 54. issue 2. 2018-01-26. PMID:27567821. the release of paired helical filaments (phfs) from neurons into the extracellular space may contribute to the propagation of tau pathology across brain regions in alzheimer's disease (ad) and other tauopathies. 2018-01-26 2023-08-13 Not clear
Siân Baker, Juan Carlos Polanco, Jϋrgen Göt. Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice. Journal of Alzheimer's disease : JAD. vol 54. issue 3. 2018-01-26. PMID:27567840. in alzheimer's disease, the distribution of neurofibrillary tangles, a histological hallmark comprised of phosphorylated forms of the protein tau, follows a distinct pattern through anatomically connected brain regions. 2018-01-26 2023-08-13 mouse
J D White, M J Eimerbrink, H B Hayes, A Hardy, E A Van Enkevort, J L Peterman, M J Chumley, G W Boeh. Hippocampal Aβ expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural brain research. vol 313. 2018-01-25. PMID:27449203. alzheimer's disease is marked by the accumulation of the amyloid-beta (aβ) peptide, and increases in phosphorylation of the microtubule associated protein, tau. 2018-01-25 2023-08-13 Not clear
X Medda, L Mertens, S Versweyveld, A Diels, L Barnham, A Bretteville, A Buist, A Verheyen, I Royaux, A Ebneth, A Cabrera-Socorr. Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format. Journal of biomolecular screening. vol 21. issue 8. 2018-01-24. PMID:26984927. tau aggregation is the pathological hallmark that best correlates with the progression of alzheimer's disease (ad). 2018-01-24 2023-08-13 human
Philip S J Weston, Ross W Paterson, John Dickson, Anna Barnes, Jamshed B Bomanji, Irfan Kayani, Michael P Lunn, Catherine J Mummery, Jason D Warren, Martin N Rossor, Nick C Fox, Henrik Zetterberg, Jonathan M Schot. Diagnosing Dementia in the Clinical Setting: Can Amyloid PET Provide Additional Value Over Cerebrospinal Fluid? Journal of Alzheimer's disease : JAD. vol 54. issue 4. 2018-01-24. PMID:27567830. cerebrospinal fluid (csf) measures of amyloid and tau are the first-line alzheimer's disease biomarkers in many clinical centers. 2018-01-24 2023-08-13 Not clear
Emma Mead, Dimitra Kestoras, Yolanda Gibson, Lucy Hamilton, Ross Goodson, Sophie Jones, Sarah Eversden, Peter Davies, Michael O'Neill, Michael Hutton, Philip Szekeres, Joanna Wola. Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation. Journal of Alzheimer's disease : JAD. vol 54. issue 4. 2018-01-24. PMID:27589517. intracellular neurofibrillary tangles (nfts) are the hallmark of alzheimer's disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. 2018-01-24 2023-08-13 Not clear
Marat A Mukhamedyarov, Albert A Rizvanov, Eduard Z Yakupov, Andrey L Zefirov, Andrey P Kiyasov, Helton J Reis, Antônio L Teixeira, Luciene B Vieira, Luciana M Lima, Ilnur I Salafutdinov, Elena O Petukhova, Svetlana F Khaiboullina, Karen A Schlauch, Vincent C Lombardi, András Palotá. Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 54. issue 4. 2018-01-24. PMID:27589530. alzheimer's disease (ad) is a devastating and progressive form of dementia that is typically associated with a build-up of amyloid-β plaques and hyperphosphorylated and misfolded tau protein in the brain. 2018-01-24 2023-08-13 human
Annie M Racine, Lindsay R Clark, Sara E Berman, Rebecca L Koscik, Kimberly D Mueller, Derek Norton, Christopher R Nicholas, Kaj Blennow, Henrik Zetterberg, Bruno Jedynak, Murat Bilgel, Cynthia M Carlsson, Bradley T Christian, Sanjay Asthana, Sterling C Johnso. Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 54. issue 4. 2018-01-24. PMID:27589532. in 469 late middle-aged participants from the wisconsin registry for alzheimer's prevention(mean age 63.8±7 years at testing; 67% female; 39% apoe4+), we examined relationships between a cogstate abbreviated battery(cab) of seven tests and demographic characteristics, traditional paper-based neuropsychological tests as well as a composite cognitive impairment index, cognitive impairment status(determined by consensus review), and biomarkers for amyloid and tau(csf phosphorylated-tau/aβ42 and global pet-pib burden) and neural injury(csf neurofilament light protein). 2018-01-24 2023-08-13 human
Ágnes Kasza, Ákos Hunya, Zsuzsa Frank, Ferenc Fülöp, Zsolt Török, Gábor Balogh, Miklós Sántha, Árpád Bálind, Sándor Bernáth, Katie L I M Blundell, Chrisostomos Prodromou, Ibolya Horváth, Hans-Joachim Zeiler, Philip L Hooper, László Vigh, Botond Penk. Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 2. 2018-01-23. PMID:27163800. alzheimer's disease (ad) is thought to be caused by amyloid-β peptide that triggers tau hyperphosphorylation, which is neurotoxic. 2018-01-23 2023-08-13 mouse
Camilla Steen Jensen, Erik Portelius, Volkert Siersma, Peter Høgh, Lene Wermuth, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Anja Hviid Simonse. Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 42. issue 3-4. 2018-01-23. PMID:27643858. cerebrospinal fluid amyloid beta and tau concentrations are not modulated by 16 weeks of moderate- to high-intensity physical exercise in patients with alzheimer disease. 2018-01-23 2023-08-13 Not clear
Ji Zhang, Suqing Wang, Wei Huang, David A Bennett, Dennis W Dickson, Dengshun Wang, Rui Wan. Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice Brains. Molecular neurobiology. vol 53. issue 8. 2018-01-22. PMID:26386840. alzheimer's disease (ad) is characterized by intracellular and extracellular protein aggregates, including microtubule-associated protein tau and cleavage product of amyloid precursor protein, β-amyloid (aβ). 2018-01-22 2023-08-13 mouse
Einav Tayeb-Fligelman, Meytal Landa. X-Ray Structural Study of Amyloid-Like Fibrils of Tau Peptides Bound to Small-Molecule Ligands. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975245. atomic structures of tau involved in alzheimer's disease complexed with small molecule binders are the first step to define the tau pharmacophore, leading the way to a structure-based design of improved diagnostics and therapeutics. 2018-01-22 2023-08-13 Not clear
Niki Nanavaty, Lauren Lin, Samantha H Hinckley, Jeff Kure. Detection and Quantification Methods for Fibrillar Products of In Vitro Tau Aggregation Assays. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975246. alzheimer's disease is characterized in part by the intracellular misfolding and aggregation of tau protein. 2018-01-22 2023-08-13 Not clear
Janet E Rickard, David Horsley, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975248. aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. 2018-01-22 2023-08-13 Not clear
Stefani N Thomas, Austin J Yan. Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975250. mass spectrometry analysis of lysine posttranslational modifications of tau protein from alzheimer's disease brain. 2018-01-22 2023-08-13 Not clear
Stefani N Thomas, Austin J Yan. Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975250. the abnormal posttranslational modification and accumulation of the microtubule-associated protein tau has been implicated in the pathogenesis of alzheimer's disease (ad), and it is thought that the primary mode of regulation of tau occurs through ptms. 2018-01-22 2023-08-13 Not clear
Haoling Qi, Clément Despres, Sudhakaran Prabakaran, François-Xavier Cantrelle, Béatrice Chambraud, Jeremy Gunawardena, Guy Lippens, Caroline Smet-Nocca, Isabelle Landrie. The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein. Methods in molecular biology (Clifton, N.J.). vol 1523. 2018-01-22. PMID:27975251. tau is found aggregated in the neurons of alzheimer's disease patients. 2018-01-22 2023-08-13 rat