| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinran Li, Long Chen, Sai Liu, Yuan Sun, Le Zhen, Zheying Zhu, Guangji Wang, Xinuo L. Hydrocortisone Mitigates Alzheimer's-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation. Cells. vol 12. issue 19. 2023-10-13. PMID:37830561. |
alzheimer's disease (ad), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. |
2023-10-13 |
2023-10-15 |
Not clear |
| Unnati Jain, Surabhi Johari, Priyanka Srivastav. Current Insights of Nanocarrier-Mediated Gene Therapeutics to Treat Potential Impairment of Amyloid Beta Protein and Tau Protein in Alzheimer's Disease. Molecular neurobiology. 2023-10-13. PMID:37831361. |
current insights of nanocarrier-mediated gene therapeutics to treat potential impairment of amyloid beta protein and tau protein in alzheimer's disease. |
2023-10-13 |
2023-10-15 |
Not clear |
| Markku Kurkine. Donanemab: Not two without a third. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-10-13. PMID:37831471. |
(2023) reported in a phase iii clinical trial that donanemab treatment of early symptomatic ad patients with amyloid and tau pathology provided 35% and 36% slowing of clinical progression and cognitive decline, respectively, as measured using the integrated alzheimer's disease rating scale (iadrs) and clinical dementia rating-sum of boxes (cdr-sb) psychometric tests. |
2023-10-13 |
2023-10-15 |
Not clear |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha. International review of neurobiology. vol 172. 2023-10-13. PMID:37833015. |
hallmark of alzheimer's disease include amyloid beta peptide and phosphorylated tau deposition in brain that could be aggravated following traumatic of concussive head injury. |
2023-10-13 |
2023-10-15 |
Not clear |
| Neil Graham, Karl Zimmerman, Amanda J Heslegrave, Ashvini Keshavan, Federico Moro, Samia Abed-Maillard, Adriano Bernini, Vincent Dunet, Elena Garbero, Giovanni Nattino, Arturo Chieregato, Enrico Fainardi, Camelia Baciu, Primoz Gradisek, Sandra Magnoni, Mauro Oddo, Guido Bertolini, Jonathan M Schott, Henrik Zetterberg, David Shar. Alzheimer's disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI. Journal of neurology, neurosurgery, and psychiatry. 2023-10-13. PMID:37833041. |
tau phosphorylated at serine-181 (p-tau181) is a well-validated alzheimer's disease marker that could potentially seed progressive neurodegeneration. |
2023-10-13 |
2023-10-15 |
Not clear |
| Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. |
amyloid-β (aβ) and hyper-phosphorylated tau are key hallmarks of alzheimer's disease (ad), with an accumulation of both proteins linked to hippocampal synaptic dysfunction. |
2023-10-12 |
2023-10-15 |
Not clear |
| Lianne Robinson, Eline Dreesen, Miguel Mondesir, Charles Harrington, Claude Wischik, Gernot Riede. Apathy-like behaviour in tau mouse models of Alzheimer's disease and frontotemporal dementia. Behavioural brain research. 2023-10-11. PMID:37820751. |
apathy-like behaviour in tau mouse models of alzheimer's disease and frontotemporal dementia. |
2023-10-11 |
2023-10-15 |
mouse |
| Susumu Iwaide, Yutaro Nakayama, James K Chambers, Kazuyuki Uchida, Daisuke Nakagawa, Yumi Yamanashi, Haruna Bando, Tomoaki Murakam. Senile plaques and phosphorylated tau deposition in a super-aged rhesus monkey (Macaca Mulatta). The Journal of veterinary medical science. 2023-10-11. PMID:37821381. |
pathological analyses revealed characteristic alzheimer's disease -related lesions: the aggregation of amyloid β (aβ) in the form of senile plaques and phosphorylated tau proteins. |
2023-10-11 |
2023-10-15 |
human |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
senescence, brain inflammation, and oligomeric tau drive cognitive decline in alzheimer's disease: evidence from clinical and preclinical studies. |
2023-10-10 |
2023-10-15 |
Not clear |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
aging, tau pathology, and chronic inflammation in the brain play crucial roles in synaptic loss, neurodegeneration, and cognitive decline in tauopathies, including alzheimer's disease. |
2023-10-10 |
2023-10-15 |
Not clear |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
highlights: senescence, oligomeric tau (tauo), and brain inflammation accelerate the aging process and promote the progression of tauopathies, including alzheimer's disease. |
2023-10-10 |
2023-10-15 |
Not clear |
| Christopher O Lew, Longfei Zhou, Maciej A Mazurowski, P Murali Doraiswamy, Jeffrey R Petrell. MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum. Radiology. vol 309. issue 1. 2023-10-10. PMID:37815445. |
mri-based deep learning assessment of amyloid, tau, and neurodegeneration biomarker status across the alzheimer disease spectrum. |
2023-10-10 |
2023-10-15 |
Not clear |
| John B O'Hara, Matthew Garlinghous. A - 28 Serial Evaluations of an Older Adult with Epilepsy and Incidental Findings of Early-Onset Alzheimer's Disease: a Case Study. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2023-10-09. PMID:37807148. |
patients with temporal lobe epilepsy (tle) and alzheimer's disease (ad) demonstrate increased β-amyloid and tau deposition, relative to patients with either tle or ad. |
2023-10-09 |
2023-10-15 |
Not clear |
| Nataliya Turchmanovych-Hienkel, Maureen Lac. A - 65 Neuropsychological Sequela of Late-Onset Epilepsy in Older Adults: a Case Study. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2023-10-09. PMID:37807189. |
late-onset epilepsy and alzheimer's disease (ad) appear to share pathological links mediated by vascular changes and tau pathology (sen et al., 2020). |
2023-10-09 |
2023-10-15 |
Not clear |
| Felix Carbonell, Carolann McNicoll, Alex P Zijdenbos, Barry J Bedel. Spatial association between distributed β-amyloid and tau varies with cognition. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808643. |
several pet studies have explored the relationship between β-amyloid load and tau uptake at the early stages of alzheimer's disease (ad) progression. |
2023-10-09 |
2023-10-15 |
human |
| Felix Carbonell, Carolann McNicoll, Alex P Zijdenbos, Barry J Bedel. Spatial association between distributed β-amyloid and tau varies with cognition. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808643. |
in the present study, we propose a new canonical distance correlation analysis (cdca) to generate distinctive spatial patterns of the cross-correlation structure between tau, as measured by [18f]flortaucipir pet, and β-amyloid, as measured by [18f]florbetapir pet, from the alzheimer's disease neuroimaging initiative (adni) study. |
2023-10-09 |
2023-10-15 |
human |
| Arthur Esquer, Frédéric Blanc, Nicolas Collongue. Immunotherapies Targeting Amyloid and Tau Protein in Alzheimer's Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion. Neurology and therapy. 2023-10-09. PMID:37812325. |
immunotherapies targeting amyloid and tau protein in alzheimer's disease: should we move away from diseases and focus on biological targets? |
2023-10-09 |
2023-10-15 |
Not clear |
| Raquel N Taddei, Romain Perbet, Anastasie Mate de Gerando, Anne E Wiedmer, Maria Sanchez-Mico, Theresa Connors Stewart, Angelica Gaona, Alexandra Melloni, Ana C Amaral, Karen Duff, Matthew P Frosch, Teresa Gómez-Isl. Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease. JAMA neurology. 2023-10-09. PMID:37812432. |
tau oligomer-containing synapse elimination by microglia and astrocytes in alzheimer disease. |
2023-10-09 |
2023-10-15 |
Not clear |
| Veera Raghavulu Bitra, Siva Reddy Challa, Paul C Adiukwu, Deepthi Rapak. Tau trajectory in Alzheimer's disease: Evidence from the connectome-based computational models. Brain research bulletin. 2023-10-09. PMID:37813312. |
tau trajectory in alzheimer's disease: evidence from the connectome-based computational models. |
2023-10-09 |
2023-10-15 |
Not clear |
| Jeyeon Lee, Brian J Burkett, Hoon-Ki Min, Matthew L Senjem, Ellen Dicks, Nick Corriveau-Lecavalier, Carly T Mester, Heather J Wiste, Emily S Lundt, Melissa E Murray, Aivi T Nguyen, Ross R Reichard, Hugo Botha, Jonathan Graff-Radford, Leland R Barnard, Jeffrey L Gunter, Christopher G Schwarz, Kejal Kantarci, David S Knopman, Bradley F Boeve, Val J Lowe, Ronald C Petersen, Clifford R Jack, David T Jone. Synthesizing images of tau pathology from cross-modal neuroimaging using deep learning. Brain : a journal of neurology. 2023-10-07. PMID:37804318. |
in-vivo tau positron emission tomography (pet) is an ideal target as a biomarker for alzheimer's disease diagnosis and treatment outcome measure. |
2023-10-07 |
2023-10-15 |
human |