| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriele S Kaminski Schierle, Claire H Michel, Laura Gasparin. Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy. Microscopy research and technique. vol 79. issue 8. 2018-02-26. PMID:27324149. |
advanced imaging of tau pathology in alzheimer disease: new perspectives from super resolution microscopy and label-free nanoscopy. |
2018-02-26 |
2023-08-13 |
Not clear |
| Jing Dong, Wei Qin, Cuibai Wei, Yi Tang, Qi Wang, Jianping Ji. A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28269784. |
a novel psen1 k311r mutation discovered in chinese families with late-onset alzheimer's disease affects amyloid-β production and tau phosphorylation. |
2018-02-26 |
2023-08-13 |
Not clear |
| Lixia Yu, Weiguang Wang, Wei Pang, Zhonghai Xiao, Yugang Jiang, Yan Hon. Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28269786. |
oxidative stress is implicated in the pathogenesis of alzheimer's disease (ad) and other tauopathies and participates in their development by promoting hyperphosphorylation of microtubule-associated protein tau. |
2018-02-26 |
2023-08-13 |
mouse |
| Stephanie M Williams, Philip Schulz, Terrone L Rosenberry, Richard J Caselli, Michael R Sierk. Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 1. 2018-02-26. PMID:28372328. |
oligomeric forms of amyloid-β (aβ), tau, and tdp-43 play important roles in alzheimer's disease (ad), and therefore are promising biomarkers. |
2018-02-26 |
2023-08-13 |
human |
| Patrick Gavin Kehoe, Elliott Hibbs, Laura E Palmer, J Scott Miner. Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology. Journal of Alzheimer's disease : JAD. vol 58. issue 1. 2018-02-26. PMID:28387670. |
angiotensin-iii is increased in alzheimer's disease in association with amyloid-β and tau pathology. |
2018-02-26 |
2023-08-13 |
human |
| Beatriz García, Carla Martín, Olivia García-Suárez, Bárbara Muñiz-Alonso, Helena Ordiales, Santiago Fernández-Menéndez, Jorge Santos-Juanes, Laura Lorente-Gea, Sonia Castañón, Ikerne Vicente-Etxenausia, Kelvin Manuel Piña Batista, Irune Ruiz-Díaz, María Cristina Caballero-Martínez, Jesús Merayo-Lloves, Isabel Guerra-Merino, Luis M Quirós, Iván Fernández-Veg. Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 1. 2018-02-26. PMID:28387673. |
heparan sulfate proteoglycans (hspgs) promote amyloid-β peptide and tau fibrillization in alzheimer's disease (ad) and provide resistance against proteolytic breakdown. |
2018-02-26 |
2023-08-13 |
Not clear |
| Stefania Forner, David Baglietto-Vargas, Alessandra C Martini, Laura Trujillo-Estrada, Frank M LaFerl. Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony. Trends in neurosciences. vol 40. issue 6. 2018-02-26. PMID:28494972. |
alzheimer's disease (ad) is characterized by memory loss, cognitive decline, and devastating neurodegeneration, not only as a result of the extracellular accumulation of beta-amyloid peptide (aβ) and intracellular accumulation of tau, but also as a consequence of the dysfunction and loss of synapses. |
2018-02-26 |
2023-08-13 |
Not clear |
| Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzma. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. vol 549. issue 7673. 2018-02-26. PMID:28959956. |
however, whether apoe independently influences tau pathology, the other major proteinopathy of alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. |
2018-02-26 |
2023-08-13 |
mouse |
| Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzma. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. vol 549. issue 7673. 2018-02-26. PMID:28959956. |
in individuals who are positive for amyloid-β pathology with symptomatic alzheimer disease who usually have tau pathology, ε4-carriers demonstrate greater rates of disease progression. |
2018-02-26 |
2023-08-13 |
mouse |
| Ravi Rajmohan, P Hemachandra Redd. Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27567878. |
amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of alzheimer's disease neurons. |
2018-02-23 |
2023-08-13 |
Not clear |
| Ravi Rajmohan, P Hemachandra Redd. Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27567878. |
amyloid-beta (aβ) and hyperphosphorylated tau are hallmark lesions of alzheimer's disease (ad). |
2018-02-23 |
2023-08-13 |
Not clear |
| Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Renu Sharma, Abhishek Shrivastava, Rashmi K Ambasta, Pravir Kuma. Stress-Induced Synaptic Dysfunction and Neurotransmitter Release in Alzheimer's Disease: Can Neurotransmitters and Neuromodulators be Potential Therapeutic Targets? Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27662312. |
compelling evidence suggests that soluble amyloid-β (aβ) and hyperphosphorylated tau serve as toxins in the dysfunction of synaptic plasticity and aberrant neurotransmitter (nt) release at synapses consequently causing a cognitive decline in alzheimer's disease (ad). |
2018-02-23 |
2023-08-13 |
Not clear |
| Qian Cai, Prasad Tamminen. Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 57. issue 4. 2018-02-23. PMID:27767992. |
alzheimer's disease (ad) is characterized by brain deposition of amyloid plaques and tau neurofibrillary tangles along with steady cognitive decline. |
2018-02-23 |
2023-08-13 |
Not clear |
| Clara Theunis, Oskar Adolfsson, Natalia Crespo-Biel, Kasia Piorkowska, Maria Pihlgren, David T Hickman, Valérie Gafner, Peter Borghgraef, Herman Devijver, Andrea Pfeifer, Fred Van Leuven, Andreas Muh. Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28035925. |
under still unknown circumstances, tau protein forms soluble oligomers and insoluble aggregates that are closely linked to the cause and progression of various brain pathologies, including alzheimer's disease. |
2018-02-23 |
2023-08-13 |
mouse |
| Clara Theunis, Oskar Adolfsson, Natalia Crespo-Biel, Kasia Piorkowska, Maria Pihlgren, David T Hickman, Valérie Gafner, Peter Borghgraef, Herman Devijver, Andrea Pfeifer, Fred Van Leuven, Andreas Muh. Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28035925. |
we conclude that the aci-5400 antibody binds to protein tau phosphorylated at s396 and favors a conformation that is typically present in the brain of tauopathy patients, including alzheimer's disease. |
2018-02-23 |
2023-08-13 |
mouse |
| Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wrigh. Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28059795. |
aggregation of tau protein into intracellular deposits is a pathognomonic feature of tauopathies such as alzheimer's disease (ad) and lowering tau is a prominent therapeutic strategy under development. |
2018-02-23 |
2023-08-13 |
mouse |
| Nady Braidy, Musthafa Mohamed Essa, Anne Poljak, Subash Selvaraju, Samir Al-Adawi, Thamilarasan Manivasagm, Arokiasamy Justin Thenmozhi, Lezanne Ooi, Perminder Sachdev, Gilles J Guillemi. Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease. Oncotarget. vol 7. issue 40. 2018-02-22. PMID:27486879. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal amyloid beta (aβ) aggregates, intracellular neurofibrillary tangles containing hyperphosphorylated tau protein, microglia-dominated neuroinflammation, and impairments in synaptic plasticity underlying cognitive deficits. |
2018-02-22 |
2023-08-13 |
mouse |
| Rachel H L H Rueli, Daniel J Torres, Andrea S T Dewing, Arlene C Kiyohara, Stephanie M Barayuga, Miyoko T Bellinger, Jane H Uyehara-Lock, Lon R White, Paula I Moreira, Marla J Berry, George Perry, Frederick P Bellinge. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802219. |
hyperphosphorylation of tau, which leads to formation of neurofibrillary tangles in alzheimer's disease, is increased by endoplasmic reticulum (er) stress. |
2018-02-22 |
2023-08-13 |
human |
| Rachel H L H Rueli, Daniel J Torres, Andrea S T Dewing, Arlene C Kiyohara, Stephanie M Barayuga, Miyoko T Bellinger, Jane H Uyehara-Lock, Lon R White, Paula I Moreira, Marla J Berry, George Perry, Frederick P Bellinge. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802219. |
these results indicate that selenate can alter phosphorylation of tau by increasing expression of sels in alzheimer's disease and potentially other neurodegenerative disorders. |
2018-02-22 |
2023-08-13 |
human |
| Julian Dronse, Klaus Fliessbach, Gérard N Bischof, Boris von Reutern, Jennifer Faber, Jochen Hammes, Georg Kuhnert, Bernd Neumaier, Oezguer A Onur, Juraj Kukolja, Thilo van Eimeren, Frank Jessen, Gereon R Fink, Thomas Klockgether, Alexander Drzezg. In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 2. 2018-02-22. PMID:27802224. |
in vivo patterns of tau pathology, amyloid-β burden, and neuronal dysfunction in clinical variants of alzheimer's disease. |
2018-02-22 |
2023-08-13 |
Not clear |