| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandro Antón-Fernández, Guillermo Aparicio-Torres, Silvia Tapia, Javier DeFelipe, Alberto Muño. Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation. Neurobiology of disease. vol 97. issue Pt A. 2018-02-21. PMID:27793637. |
morphometric alterations of golgi apparatus in alzheimer's disease are related to tau hyperphosphorylation. |
2018-02-21 |
2023-08-13 |
Not clear |
| Tian-Syuan Lin, Han-Jung Tsai, Chih-Han Lee, Yan-Qing Song, Rih-Sheng Huang, Hsiu-Mei Hsieh-Li, Mei-Chih Liang, Yenshou Li. An Improved Drugs Screening System Reveals that Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106556. |
the presence of amyloid-β (aβ) plaque and tau protein hyperphosphorylation in brain tissue is the pathological hallmark of alzheimer's disease (ad). |
2018-02-21 |
2023-08-13 |
mouse |
| Dorene M Rentz, Elizabeth C Mormino, Kathryn V Papp, Rebecca A Betensky, Reisa A Sperling, Keith A Johnso. Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain imaging and behavior. vol 11. issue 2. 2018-02-20. PMID:27738998. |
cognitive resilience in clinical and preclinical alzheimer's disease: the association of amyloid and tau burden on cognitive performance. |
2018-02-20 |
2023-08-13 |
human |
| Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. |
dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. |
2018-02-20 |
2023-08-13 |
rat |
| Tiina Laiterä, Jussi Paananen, Seppo Helisalmi, Timo Sarajärvi, Joel Huovinen, Marjo Laitinen, Tuomas Rauramaa, Irina Alafuzoff, Anne M Remes, Hilkka Soininen, Annakaisa Haapasalo, Juha E Jääskeläinen, Ville Leinonen, Mikko Hiltune. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-β Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27802227. |
in alzheimer's disease (ad) patients, diffuse aggregates of amyloid-β (aβ) and neurofibrillary hyperphosphorylated tau are detected in the neocortex of the brain, while similar accumulation of aβ is also detected in inph. |
2018-02-20 |
2023-08-13 |
Not clear |
| Nicola Voyle, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard J B Dobson, Steven J Kiddl. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27834776. |
the search for a biomarker of alzheimer's disease (ad) pathology (amyloid-β (aβ) and tau) is ongoing, with the best markers currently being measurements of aβ and tau in cerebrospinal fluid (csf) and via positron emission tomography (pet) scanning. |
2018-02-20 |
2023-08-13 |
Not clear |
| Samir Abu Rumeileh, Francesca Lattanzio, Michelangelo Stanzani Maserati, Romana Rizzi, Sabina Capellari, Piero Parch. Diagnostic Accuracy of a Combined Analysis of Cerebrospinal Fluid t-PrP, t-tau, p-tau, and Aβ42 in the Differential Diagnosis of Creutzfeldt-Jakob Disease from Alzheimer's Disease with Emphasis on Atypical Disease Variants. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27886009. |
according to recent studies, the determination of cerebrospinal fluid (csf) total tau (t-tau)/phosphorylated tau (p-tau) ratio and total prion protein (t-prp) levels significantly improves the accuracy of the diagnosis of alzheimer's disease (ad) in atypical cases with clinical or laboratory features mimicking creutzfeldt-jakob disease (cjd). |
2018-02-20 |
2023-08-13 |
Not clear |
| Andrea Slachevsky, Leonardo Guzmán-Martínez, Carolina Delgado, Pablo Reyes, Gonzalo A Farías, Carlos Muñoz-Neira, Eduardo Bravo, Mauricio Farías, Patricia Flores, Cristian Garrido, James T Becker, Oscar L López, Ricardo B Maccion. Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 55. issue 4. 2018-02-20. PMID:27911301. |
intracellular neurofibrillary tangles are part of the core pathology of alzheimer's disease (ad), which are mainly composed of hyperphosphorylated tau protein. |
2018-02-20 |
2023-08-13 |
Not clear |
| İrem Lütfiye Atasoy, Erdinç Dursun, Duygu Gezen-Ak, Derya Metin-Armağan, Melek Öztürk, Selma Yılmaze. Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. Journal of chemical neuroanatomy. vol 80. 2018-02-20. PMID:27914953. |
intracellular aggregation of hyperphosphorylated tau in neurofibrillary tangles (nfts) is a major neuropathological hallmark of taupathies such as alzheimer's disease. |
2018-02-20 |
2023-08-13 |
Not clear |
| Jingdun Xie, Haitao Wang, Ting Lin, Bingtian B. Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease. BioMed research international. vol 2017. 2018-02-16. PMID:28473983. |
the main hallmarks of alzheimer's disease (ad) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). |
2018-02-16 |
2023-08-13 |
Not clear |
| Claire L Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterberg, Mikko Hiltunen, Malcolm Ward, Ian Pik. Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates. Journal of Alzheimer's disease : JAD. vol 55. issue 1. 2018-02-15. PMID:27636850. |
aberrant tau phosphorylation is a hallmark in alzheimer's disease (ad), believed to promote formation of paired helical filaments, the main constituent of neurofibrillary tangles in the brain. |
2018-02-15 |
2023-08-13 |
human |
| Piotr Lewczuk, Natalia Lelental, Ingolf Lachmann, Max Holzer, Katharina Flach, Sebastian Brandner, Sebastiaan Engelborghs, Charlotte E Teunissen, Henrik Zetterberg, José Luis Molinuevo, Barbara Mroczko, Kaj Blennow, Julius Popp, Lucilla Parnetti, Davide Chiasserini, Armand Perret-Liaudet, Philipp Spitzer, Juan Manuel Maler, Johannes Kornhube. Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer's Disease: Analytical and Diagnostic Characterization. Journal of Alzheimer's disease : JAD. vol 55. issue 1. 2018-02-15. PMID:27662295. |
non-phosphorylated tau as a potential biomarker of alzheimer's disease: analytical and diagnostic characterization. |
2018-02-15 |
2023-08-13 |
Not clear |
| Bettina Maria Foidl, Patricia Do-Dinh, Bianca Hutter-Schmid, Harald R Bliem, Christian Humpe. Cholinergic neurodegeneration in an Alzheimer mouse model overexpressing amyloid-precursor protein with the Swedish-Dutch-Iowa mutations. Neurobiology of learning and memory. vol 136. 2018-02-15. PMID:27670619. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder that is mainly characterized by beta-amyloid (aβ) plaque deposition, tau pathology and dysfunction of the cholinergic system causing memory impairment. |
2018-02-15 |
2023-08-13 |
mouse |
| Chandra Sekhar Kuruva, P Hemachandra Redd. Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal. Drug discovery today. vol 22. issue 2. 2018-02-15. PMID:27794478. |
multiple cellular changes have been identified as being involved in alzheimer's disease (ad) pathogenesis, including mitochondrial damage, synaptic loss, amyloid beta (aβ) production and/or accumulation, inflammatory responses, and phosphorylated tau formation and/or accumulation. |
2018-02-15 |
2023-08-13 |
Not clear |
| Adam M Franks, Regina Guzzo, Shawndra Barker, Rebecca King-Mallor. Progressive Supranuclear Palsy - A Case Study from the Perspective of a Primary Care Physician Son. The West Virginia medical journal. vol 113. issue 1. 2018-02-15. PMID:29373002. |
progressive supranuclear palsy (psp) is a rare geriatric pathology, from the abnormal deposition of the tau protein, combining the motor tremor and bradykinesia of parkinson's disease with the cognitive defects of alzheimer's disease. |
2018-02-15 |
2023-08-13 |
Not clear |
| Joana B Pereira, Eric Westman, Oskar Hansso. Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease. Neurobiology of aging. vol 58. 2018-02-14. PMID:28692877. |
the aggregation and deposition of amyloid-β (aβ) peptides into plaques is an early event in alzheimer's disease (ad), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (csf) or plasma using neurofilament light (nfl), neurogranin (ng), total tau (t-tau), and phosphorylated tau (p-tau) levels. |
2018-02-14 |
2023-08-13 |
human |
| Jieyun Sun, Xiong Zhang, Chen Wang, Zhipeng Teng, Yu L. Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer's Disease Mice. The American journal of Chinese medicine. vol 45. issue 8. 2018-02-14. PMID:29132216. |
curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/gsk-3β in n2a/app695swe cells and app/ps1 double transgenic alzheimer's disease mice. |
2018-02-14 |
2023-08-13 |
mouse |
| Jieyun Sun, Xiong Zhang, Chen Wang, Zhipeng Teng, Yu L. Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3β in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer's Disease Mice. The American journal of Chinese medicine. vol 45. issue 8. 2018-02-14. PMID:29132216. |
in our previous studies, curcumin has been confirmed to play a neuroprotective role in alzheimer's disease (ad), but its effects on caveolin-1, tau and their correlation, and the mechanism is still unknown. |
2018-02-14 |
2023-08-13 |
mouse |
| T Nishikawa, T Takahashi, M Nakamori, N Hosomi, H Maruyama, Y Miyazaki, Y Izumi, M Matsumot. The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments. Neuropathology and applied neurobiology. vol 42. issue 7. 2018-02-12. PMID:26501932. |
neurofibrillary tangles (nfts), a cardinal pathological feature of neurodegenerative disorders, such as alzheimer's disease (ad) are primarily composed of hyper-phosphorylated tau protein. |
2018-02-12 |
2023-08-13 |
Not clear |
| Mari Kim, Manivannan Subramanian, Yun-Ho Cho, Gye-Hyeong Kim, Eunil Lee, Joong-Jean Par. Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-12. PMID:29217196. |
the accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of alzheimer's disease (ad). |
2018-02-12 |
2023-08-13 |
human |