| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshiki Shigemitsu, Hidekazu Hiroak. Common molecular pathogenesis of disease-related intrinsically disordered proteins revealed by NMR analysis. Journal of biochemistry. vol 163. issue 1. 2018-01-19. PMID:28992347. |
these disease-related idps include aβ(1-42) [alzheimer's disease (ad)], tau (ad and tauopathy), α-synuclein (parkinson's disease) and p53 (cancer). |
2018-01-19 |
2023-08-13 |
Not clear |
| Navit Ogen-Shtern, Tamuz Ben David, Gerardo Z Lederkreme. Protein aggregation and ER stress. Brain research. vol 1648. issue Pt B. 2018-01-17. PMID:27037184. |
whether amyloid-β or tau in alzheimer's, α-synuclein in parkinson's, huntingtin in huntington's disease or other aggregation-prone proteins in many other neurodegenerative diseases, there is a shared pathway of oligomerization and aggregation into amyloid fibrils. |
2018-01-17 |
2023-08-13 |
Not clear |
| Sara Pinheiro, Joana Silva, Cristina Mota, João Vaz-Silva, Ana Veloso, Vítor Pinto, Nuno Sousa, João Cerqueira, Ioannis Sotiropoulo. Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26328538. |
previous studies have implicated sustained gc elevations in neurodegenerative mechanisms through gc-evoked hyperphosphorylation of the cytoskeletal protein tau while tau mislocation has recently been proposed as relevant in alzheimer's disease (ad) pathology. |
2018-01-16 |
2023-08-13 |
rat |
| Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
the spread of tau pathology correlates with cognitive decline in alzheimer's disease. |
2018-01-16 |
2023-08-13 |
mouse |
| Benjamin Hall, Elijah Mak, Simon Cervenka, Franklin I Aigbirhio, James B Rowe, John T O'Brie. In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings. Ageing research reviews. vol 36. 2018-01-16. PMID:28315409. |
in addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of aggregated hyperphosphorylated tau are one of the pathological hallmarks of alzheimer's disease and other neurodegenerative disorders. |
2018-01-16 |
2023-08-13 |
human |
| Benjamin Hall, Elijah Mak, Simon Cervenka, Franklin I Aigbirhio, James B Rowe, John T O'Brie. In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings. Ageing research reviews. vol 36. 2018-01-16. PMID:28315409. |
in this article, we provide a comprehensive discussion of tau pathophysiology, its quantification with novel pet radiotracers, as well as a systematic review of tau pet imaging in normal aging and various dementia conditions: mild cognitive impairment, alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, and lewy body dementia. |
2018-01-16 |
2023-08-13 |
human |
| Takeshi Kanno, Ayako Tsuchiya, Akito Tanaka, Tomoyuki Nishizak. Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation. Molecular neurobiology. vol 53. issue 7. 2018-01-15. PMID:26328540. |
glycogen synthase kinase-3β (gsk-3β) is a key element to phosphorylate tau and form neurofibrillary tangles (nfts) found in tauopathies including alzheimer's disease (ad). |
2018-01-15 |
2023-08-13 |
mouse |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26883430. |
atorvastatin, a hmg-coa reductase inhibitor, has been proven to improve learning and memory performance, reduce aβ and phosphorylated tau levels in mouse model of alzheimer's disease (ad). |
2018-01-12 |
2023-08-13 |
mouse |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 39. issue 4. 2018-01-12. PMID:28083916. |
acetylated tau in alzheimer's disease: an instigator of synaptic dysfunction underlying memory loss: increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. |
2018-01-12 |
2023-08-13 |
Not clear |
| Tara E Tracy, Li Ga. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 39. issue 4. 2018-01-12. PMID:28083916. |
a novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, k274, and k281, which are associated with dementia in alzheimer's disease (ad). |
2018-01-12 |
2023-08-13 |
Not clear |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
for instance, 5-ht2a/2b/2c, 5-ht4, and 5-ht6 receptors are involved in tau protein hyperphosphorylation in alzheimer's disease. |
2018-01-11 |
2023-08-13 |
Not clear |
| Julia Gerson, Diana L Castillo-Carranza, Urmi Sengupta, Riddhi Bodani, Donald S Prough, Douglas S DeWitt, Bridget E Hawkins, Rakez Kaye. Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice. Journal of neurotrauma. vol 33. issue 22. 2018-01-10. PMID:26729399. |
previously, we have shown increased levels of brain-derived tau oligomers in autopsy samples from patients diagnosed with alzheimer's disease. |
2018-01-10 |
2023-08-13 |
mouse |
| Rachelle Crescenzi, Catherine DeBrosse, Ravi P R Nanga, Matthew D Byrne, Guruprasad Krishnamoorthy, Kevin D'Aquilla, Hari Nath, Knashawn H Morales, Michiyo Iba, Hari Hariharan, Virginia M Y Lee, John A Detre, Ravinder Redd. Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus. vol 27. issue 3. 2018-01-09. PMID:27997993. |
tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include alzheimer's disease, corticobasal degeneration, frontotemporal dementia, and traumatic brain injury. |
2018-01-09 |
2023-08-13 |
mouse |
| Ying-Ying Ruan, Wei Zhai, Xiao-Meng Shi, Lu Zhang, Yan-Li H. Safflower yellow ameliorates cognition deficits and reduces tau phosphorylation in APP/PS1 transgenic mice. Metabolic brain disease. vol 31. issue 5. 2018-01-08. PMID:27311611. |
alzheimer's disease (ad), the most common cause of dementia worldwide, is mainly characterized by the aggregated β-amyloid (aβ) and hyperphosphorylated tau. |
2018-01-08 |
2023-08-13 |
mouse |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, William D Hopkins, John J Ely, Joseph M Erwin, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiology of aging. vol 59. 2018-01-08. PMID:28888720. |
alzheimer's disease (ad) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (aβ) into extracellular plaques, neurofibrillary tangles (nft) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. |
2018-01-08 |
2023-08-13 |
human |
| Hiroyuki Watanab. [Development of SPECT Probes for In Vivo Imaging of β-Amyloid and Tau Aggregates in the Alzheimer's Disease Brain]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 137. issue 11. 2018-01-08. PMID:29093372. |
[development of spect probes for in vivo imaging of β-amyloid and tau aggregates in the alzheimer's disease brain]. |
2018-01-08 |
2023-08-13 |
Not clear |
| Carla Abdelnour, Inger van Steenoven, Elisabet Londos, Frédéric Blanc, Bjørn Auestad, Milica G Kramberger, Henrik Zetterberg, Brit Mollenhauer, Mercè Boada, Dag Aarslan. Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 8. 2018-01-04. PMID:27296778. |
csf biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect alzheimer's disease neuropathology antemortem. |
2018-01-04 |
2023-08-13 |
Not clear |
| John T O'Brien, Clive Holmes, Matthew Jones, Roy Jones, Gill Livingston, Ian McKeith, Peter Mittler, Peter Passmore, Craig Ritchie, Louise Robinson, Elizabeth L Sampson, John-Paul Taylor, Alan Thomas, Alistair Burn. Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology. Journal of psychopharmacology (Oxford, England). vol 31. issue 2. 2018-01-04. PMID:28103749. |
many novel pharmacological approaches involving strategies to reduce amyloid and/or tau deposition in those with or at high risk of alzheimer's disease are in progress. |
2018-01-04 |
2023-08-13 |
Not clear |
| Merle Christine Hoenig, Gérard Nisal Bischof, Jochen Hammes, Jennifer Faber, Klaus Fliessbach, Thilo van Eimeren, Alexander Drzezg. Tau pathology and cognitive reserve in Alzheimer's disease. Neurobiology of aging. vol 57. 2018-01-03. PMID:28577411. |
tau pathology and cognitive reserve in alzheimer's disease. |
2018-01-03 |
2023-08-13 |
Not clear |
| Marcus Pickhardt, Jacek Biernat, Sabrina Hübschmann, Frank J A Dennissen, Thomas Timm, Annukka Aho, Eva-Maria Mandelkow, Eckhard Mandelko. Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy. Neurobiology of aging. vol 57. 2018-01-03. PMID:28600952. |
the aggregation of tau protein is a hallmark of neurodegenerative diseases including alzheimer's disease. |
2018-01-03 |
2023-08-13 |
Not clear |