All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Vera I Wiersma, Wim van Hecke, Wiep Scheper, Martijn A J van Osch, Will J M Hermsen, Annemieke J M Rozemuller, Jeroen J M Hoozeman. Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27793194. in post-mortem brain tissue from patients with other neurodegenerative diseases characterized by protein misfolding, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau pathology (ftld-tau), increased activation of the unfolded protein response (upr) has been observed. 2017-10-25 2023-08-13 human
Benedicte Foveau, Steffen Albrecht, David A Bennett, José A Correa, Andrea C LeBlan. Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27931265. to examine this possibility, we examined the presence of casp6 activity, neurofibrillary tangle formation and amyloid deposition by immunohistochemistry with neoepitope antisera against the p20 subunit of active casp6 and tau cleaved by casp6 (tau∆casp6), phosphorylated tau paired helical filament (phf-1) antibodies and anti-β-amyloid antiserum, respectively, in brains from individuals with no or mild cognitive impairment and alzheimer disease (ad) dementia. 2017-10-25 2023-08-13 mouse
Wei Wang, Lu Lu, Qiao-Qi Wu, Jian-Ping Ji. Brain Amyloid-β Plays an Initiating Role in the Pathophysiological Process of the PS1V97L-Tg Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 52. issue 3. 2017-10-24. PMID:27079718. amyloid-β (aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation are major pathophysiological events in alzheimer's disease (ad). 2017-10-24 2023-08-13 mouse
Dawn H W Lau, Marte Hogseth, Emma C Phillips, Michael J O'Neill, Amy M Pooler, Wendy Noble, Diane P Hange. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27193083. critical residues involved in tau binding to fyn: implications for tau phosphorylation in alzheimer's disease. 2017-10-24 2023-08-13 human
Dawn H W Lau, Marte Hogseth, Emma C Phillips, Michael J O'Neill, Amy M Pooler, Wendy Noble, Diane P Hange. Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27193083. alzheimer's disease (ad) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. 2017-10-24 2023-08-13 human
Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not alzheimer disease-like -ultrastructural mapping of tau by edx. 2017-10-24 2023-08-13 human
Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. concomitant deposition of amyloid -beta protein (aβ) and neuronal tau as neurofibrillary tangles in the human brain is a hallmark of alzheimer disease (ad). 2017-10-24 2023-08-13 human
Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanriede. Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27984697. the major pathological hallmarks of alzheimer's disease (ad) are the progressive aggregation and accumulation of beta-amyloid (aβ) and hyperphosphorylated tau protein into neurotoxic deposits. 2017-10-24 2023-08-13 mouse
Sarah Westwood, Emanuela Leoni, Abdul Hye, Steven Lynham, Mizanur R Khondoker, Nicholas J Ashton, Steven J Kiddle, Alison L Baird, Ricardo Sainz-Fuertes, Rufina Leung, John Graf, Cristina Tan Hehir, David Baker, Cristina Cereda, Chantal Bazenet, Malcolm Ward, Madhav Thambisetty, Simon Loveston. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly. Journal of Alzheimer's disease : JAD. vol 52. issue 2. 2017-10-23. PMID:27031486. increasingly, clinical trials for alzheimer's disease (ad) are being conducted earlier in the disease phase and with biomarker confirmation using in vivo amyloid pet imaging or csf tau and aβ measures to quantify pathology. 2017-10-23 2023-08-13 human
Jeffrey L Dage, Alexandra M V Wennberg, David C Airey, Clinton E Hagen, David S Knopman, Mary M Machulda, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Michelle M Mielk. Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 12. 2017-10-23. PMID:27436677. we examined associations between plasma tau levels and alzheimer's disease (ad)-related magnetic resonance imaging (mri) and positron emission tomography (pet) neuroimaging measures among nondemented individuals. 2017-10-23 2023-08-13 Not clear
Idir Malki, François-Xavier Cantrelle, Yoann Sottejeau, Guy Lippens, Jean-Charles Lambert, Isabelle Landrie. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. The FEBS journal. vol 284. issue 19. 2017-10-20. PMID:28755476. bridging integrator 1 (bin1) gene is a genetic determinant of alzheimer's disease (ad) and has been reported to modulate alzheimer's pathogenesis through pathway(s) involving tau. 2017-10-20 2023-08-13 Not clear
Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwel. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. vol 16. issue 11. 2017-10-20. PMID:28919059. post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with alzheimer's disease. 2017-10-20 2023-08-13 Not clear
Laurent Lunven, Hugues Bonnet, Samir Yahiaoui, Wei Yi, Laurène Da Costa, Marine Peuchmaur, Ahcène Boumendjel, Sabine Chieric. Disruption of Fibers from the Tau Model AcPHF6 by Naturally Occurring Aurones and Synthetic Analogues. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27225823. the formation of tau aggregates is strongly linked to the neurodegenerative process in tauopathies such as alzheimer's disease (ad). 2017-10-19 2023-08-13 Not clear
Mathilde Wauters, Ruddy Wattiez, Laurence Ri. Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation. Biomolecules. vol 6. issue 3. 2017-10-18. PMID:27548242. this suggests that hyperphosphorylated tau protein could spread between neurons in pathological conditions such as alzheimer's disease. 2017-10-18 2023-08-13 Not clear
Mahmoud L Soliman, Jonathan D Geiger, Xuesong Che. Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 12. issue 1. 2017-10-18. PMID:27629410. the increased life expectancy of people living with hiv-1 who are taking effective anti-retroviral therapeutics is now accompanied by increased alzheimer's disease (ad)-like neurocognitive problems and neuropathological features such as increased levels of amyloid beta (aβ) and phosphorylated tau proteins. 2017-10-18 2023-08-13 Not clear
P Dourlen, F J Fernandez-Gomez, C Dupont, B Grenier-Boley, C Bellenguez, H Obriot, R Caillierez, Y Sottejeau, J Chapuis, A Bretteville, F Abdelfettah, C Delay, N Malmanche, H Soininen, M Hiltunen, M-C Galas, P Amouyel, N Sergeant, L Buée, J-C Lambert, B Dermau. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Molecular psychiatry. vol 22. issue 6. 2017-10-17. PMID:27113998. functional screening of alzheimer risk loci identifies ptk2b as an in vivo modulator and early marker of tau pathology. 2017-10-17 2023-08-13 mouse
Kuo-Hsuan Chang, Chih-Hsin Lin, Hsuan-Chiang Chen, Hsin-Yu Huang, Shu-Ling Chen, Te-Hsien Lin, Chintakunta Ramesh, Chin-Chang Huang, Hon-Chung Fung, Yih-Ru Wu, Hei-Jen Huang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li, Ching-Fa Ya. The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1. CNS neuroscience & therapeutics. vol 23. issue 1. 2017-10-17. PMID:27424519. neurofibrillary tangles formed from tau misfolding have long been considered one of the pathological hallmarks of alzheimer's disease (ad). 2017-10-17 2023-08-13 Not clear
Maud Gratuze, Jacinthe Julien, Françoise Morin, Frédéric Calon, Sébastien S Hébert, André Marette, Emmanuel Plane. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 47. 2017-10-17. PMID:27565300. high-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of alzheimer's disease-like tau pathology. 2017-10-17 2023-08-13 mouse
Maud Gratuze, Jacinthe Julien, Françoise Morin, Frédéric Calon, Sébastien S Hébert, André Marette, Emmanuel Plane. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 47. 2017-10-17. PMID:27565300. aggregates of hyperphosphorylated tau protein are a pathological hallmark of alzheimer's disease (ad). 2017-10-17 2023-08-13 mouse
Chun-Ling Dai, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization inhibits not only tau but also Aβ pathology. Alzheimer's research & therapy. vol 9. issue 1. 2017-10-17. PMID:28073379. accumulation of hyperphosphorylated tau protein is a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. 2017-10-17 2023-08-13 mouse