All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Frances C Quevenco, Maria G Preti, Jiri M G van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J Schreiner, Stefanie C Steininger, Rafael Meyer, Irene B Meier, Adam M Brickman, Sandra E Leh, Anton F Gietl, Alfred Buck, Roger M Nitsch, Klaas P Pruessmann, Peter C M van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G Unschul. Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease. Alzheimer's research & therapy. vol 9. issue 1. 2017-10-17. PMID:28359293. the incidence of alzheimer's disease (ad) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (aβ), hyperphosphorylated tau, and iron. 2017-10-17 2023-08-13 human
R Martínez-Pérez, I Paredes, P M Munarriz, B Paredes, J F Alé. Chronic traumatic encephalopathy: The unknown disease. Neurologia (Barcelona, Spain). vol 32. issue 3. 2017-10-16. PMID:25534950. although it shares certain histopathological findings with alzheimer disease, chronic traumatic encephalopathy has a more specific presentation (hyperphosphorylated tau protein deposited as neurofibrillary tangles, associated with neuropil threads and sometimes with beta-amyloid plaques). 2017-10-16 2023-08-13 Not clear
Felipe G Serrano, Cheril Tapia-Rojas, Francisco J Carvajal, Pedro Cisternas, Elisabet Viayna, Irene Sola, Diego Munoz-Torrero, Nibaldo C Inestros. Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages. Current Alzheimer research. vol 13. issue 9. 2017-10-16. PMID:26502813. alzheimer's disease (ad) is a neurodegenerative disorder in which the amyloid-β (aβ) peptide plays a key role in synaptic impairment and memory decline associated with neuronal dysfunction and intra-neuronal accumulation of hyperphosphorylated tau protein. 2017-10-16 2023-08-13 mouse
Marco Magistri, Dmitry Velmeshev, Madina Makhmutova, Prutha Patel, Gregory C Sartor, Claude-Henry Volmar, Claes Wahlestedt, Mohammad Ali Faghih. The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. Current Alzheimer research. vol 13. issue 9. 2017-10-16. PMID:27117003. the bet-bromodomain inhibitor jq1 reduces inflammation and tau phosphorylation at ser396 in the brain of the 3xtg model of alzheimer's disease. 2017-10-16 2023-08-13 Not clear
Susan Fromholt, Christian Reitano, Hilda Brown, Jada Lewis, David R Borchel. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimer's research & therapy. vol 8. 2017-10-16. PMID:27593210. in alzheimer's disease, therapies that silence the expression of tau could be a viable strategy to slow disease progression. 2017-10-16 2023-08-13 mouse
Andrzej Stanisław Ciepla. Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions. PloS one. vol 12. issue 9. 2017-10-16. PMID:28922400. carrying no information about side chain-side chain interactions, this function nonetheless identifies basic features of the secondary and tertiary structure, establishes sequence correlates of the metamorphic and ph-driven equilibria, relates binding affinities and folding rate constants to secondary structure preferences, and manifests common patterns of backbone density distribution in amyloidogenic regions of alzheimer's amyloid β and tau, parkinson's α-synuclein and prions. 2017-10-16 2023-08-13 Not clear
Patrick Gavin Kehoe, Steffenny Wong, Noura Al Mulhim, Laura Elyse Palmer, J Scott Miner. Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology. Alzheimer's research & therapy. vol 8. issue 1. 2017-10-13. PMID:27884212. angiotensin-converting enzyme 2 is reduced in alzheimer's disease in association with increasing amyloid-β and tau pathology. 2017-10-13 2023-08-13 human
Nicole Maphis, Shanya Jiang, Guixiang Xu, Olga N Kokiko-Cochran, Saktimayee M Roy, Linda J Van Eldik, D Martin Watterson, Bruce T Lamb, Kiran Bhaska. Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology. Alzheimer's research & therapy. vol 8. issue 1. 2017-10-13. PMID:27974048. hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of alzheimer's disease and related tauopathies. 2017-10-13 2023-08-13 mouse
Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, An-Ning Wan. Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study. Experimental gerontology. vol 84. 2017-10-12. PMID:27612601. accumulation of amyloid-β (aβ) peptide and deposition of hyperphosphorylated tau protein are two major pathological hallmarks of alzheimer's disease (ad). 2017-10-12 2023-08-13 mouse
Elyse Rosa, Sujeivan Mahendram, Yazi D Ke, Lars M Ittner, Stephen D Ginsberg, Margaret Fahnestoc. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of aging. vol 48. 2017-10-12. PMID:27676333. tau downregulates bdnf expression in animal and cellular models of alzheimer's disease. 2017-10-12 2023-08-13 mouse
Elyse Rosa, Sujeivan Mahendram, Yazi D Ke, Lars M Ittner, Stephen D Ginsberg, Margaret Fahnestoc. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of aging. vol 48. 2017-10-12. PMID:27676333. in alzheimer's disease, soluble tau accumulates and deposits as neurofibrillary tangles (nfts). 2017-10-12 2023-08-13 mouse
Elyse Rosa, Sujeivan Mahendram, Yazi D Ke, Lars M Ittner, Stephen D Ginsberg, Margaret Fahnestoc. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of aging. vol 48. 2017-10-12. PMID:27676333. therefore, alzheimer's disease treatments targeting aβ alone may not be effective without considering the impact of tau pathology on neurotrophic pathways. 2017-10-12 2023-08-13 mouse
Joseph C Masde. Future Directions in Imaging Neurodegeneration. Current neurology and neuroscience reports. vol 17. issue 1. 2017-10-12. PMID:28210978. for instance, amyloid imaging is being used not only to determine who has excess amyloid in the brain but also to investigate whether removing it may slow the deposition of tau and delay cognitive impairment in alzheimer's disease. 2017-10-12 2023-08-13 Not clear
Emilie Audouard, Sarah Houben, Caterina Masaracchia, Zehra Yilmaz, Valérie Suain, Michèle Authelet, Robert De Decker, Luc Buée, Alain Boom, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo. The American journal of pathology. vol 186. issue 10. 2017-10-11. PMID:27497324. high-molecular-weight paired helical filaments from alzheimer brain induces seeding of wild-type mouse tau into an argyrophilic 4r tau pathology in vivo. 2017-10-11 2023-08-13 mouse
Emilie Audouard, Sarah Houben, Caterina Masaracchia, Zehra Yilmaz, Valérie Suain, Michèle Authelet, Robert De Decker, Luc Buée, Alain Boom, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo. The American journal of pathology. vol 186. issue 10. 2017-10-11. PMID:27497324. in alzheimer disease, the development of tau pathology follows neuroanatomically connected pathways, suggesting that abnormal tau species might recruit normal tau by passage from cell to cell. 2017-10-11 2023-08-13 mouse
Emilie Audouard, Sarah Houben, Caterina Masaracchia, Zehra Yilmaz, Valérie Suain, Michèle Authelet, Robert De Decker, Luc Buée, Alain Boom, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo. The American journal of pathology. vol 186. issue 10. 2017-10-11. PMID:27497324. herein, we analyzed the effect of stereotaxic brain injection of human alzheimer high-molecular-weight paired helical filaments (phfs) in the dentate gyrus of wild-type and mutant tau thy-tau22 mice. 2017-10-11 2023-08-13 mouse
Emilie Audouard, Sarah Houben, Caterina Masaracchia, Zehra Yilmaz, Valérie Suain, Michèle Authelet, Robert De Decker, Luc Buée, Alain Boom, Karelle Leroy, Kunie Ando, Jean-Pierre Brio. High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo. The American journal of pathology. vol 186. issue 10. 2017-10-11. PMID:27497324. our results indicate thus that injection of human wild-type alzheimer phf seeded aggregation of wild-type murine tau into an argyrophilic 4r tau pathology, and constitutes an interesting model independent of expression of a mutant tau protein. 2017-10-11 2023-08-13 mouse
Shozo Furumoto, Tetsuro Tago, Ryuichi Harada, Yukitsuka Kudo, Nobuyuki Okamur. 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features. Current Alzheimer research. vol 14. issue 2. 2017-10-10. PMID:27334944. non-invasive detection of tau deposits in the brain can be used to diagnose, monitor, and predict alzheimer's disease progression. 2017-10-10 2023-08-13 human
Shozo Furumoto, Tetsuro Tago, Ryuichi Harada, Yukitsuka Kudo, Nobuyuki Okamur. 18F-Labeled 2-Arylquinoline Derivatives for Tau Imaging: Chemical, Radiochemical, Biological and Clinical Features. Current Alzheimer research. vol 14. issue 2. 2017-10-10. PMID:27334944. in this review, we provide an overview of the pathology and potential imaging of tau in alzheimer's disease, development of a thk series among tau tracers, and the chemical, radiochemical, biological, and clinical features of tau probes. 2017-10-10 2023-08-13 human
Lingyun Wang, Feng Ya. Deprotonation states of the two active site water molecules regulate the binding of protein phosphatase 5 with its substrate: A molecular dynamics study. Protein science : a publication of the Protein Society. vol 26. issue 10. 2017-10-10. PMID:28726316. protein phosphatase 5 (pp5), mainly localized in human brain, can dephosphorylate tau protein whose high level of phosphorylation is related to alzheimer's disease. 2017-10-10 2023-08-13 human